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*  Autonomously replicating sequence
If the genome fragment contained an origin of replication, cells were able to grow in a medium lacking histidine. These ... An autonomously replicating sequence (ARS) contains the origin of replication in the yeast genome. It contains four regions (A ... ORC protein complex (Origin Recognition Complex) is bound at the ARS throughout the cell cycle, allowing replicative proteins ... The A-Domain is highly conserved, any mutation abolishes origin function. Mutations on B1, B2, and B3 will diminish, but not ...
*  Origin of replication
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is ... DNA replication typically begins at a single origin of replication. In E. coli, the origin of replication-oriC-consists of ... which attach to a viral origin of replication if the T antigen is present. OriDB the DNA Replication Origin Database Origin of ... The segment of DNA that is copied starting from each unique replication origin is called a replicon. Origins of replication are ...
*  OriDB
Origin of replication Siow, CC; Nieduszynska, SR; Müller, CA; Nieduszynski, CA (Jan 2012). "OriDB, the DNA replication origin ... Each potential replication origin site is listed as confirmed, likely or dubious dependent upon the level of supporting data. ... The DNA Replication Origin Database (OriDB) provides access to collated published datasets that have predicted and/or confirmed ... Nieduszynski, CA; Hiraga, S; Ak, P; Benham, CJ; Donaldson, AD (Jan 2007). "OriDB: a DNA replication origin database". Nucleic ...
*  Nucleosome
Eaton ML, Galani K, Kang S, Bell SP, MacAlpine DM (April 2010). "Conserved nucleosome positioning defines replication origins ... In order to achieve the high level of control required to co-ordinate nuclear processes such as DNA replication, repair, and ... catalogued nucleosome positions in yeast and shown that nucleosomes are depleted in promoter regions and origins of replication ... Nucleosomes are quickly assembled onto newly synthesized DNA behind the replication fork. Histones H3 and H4 from dissembled ...
*  Cyclin-dependent kinase 1
6-Cdk1 complexes directly lead to replication origin initiation; however, they are inhibited by Sic1, preventing premature S ... Dutta A, Stillman B (1992). "cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA ... replication". EMBO J. 11 (6): 2189-99. PMC 556686 . PMID 1318195. Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge ...
*  Φ29 DNA polymerase
... this involves two replication origins and two distinct polymerase monomers. Synthesis is continual and involves a strand ... Truniger V, Blanco L, Salas M (1999). "Role of the "YxGG/A" motif of Phi29 DNA polymerase in protein-primed replication". J Mol ... Novel replication mechanism; multiple-strand displacement amplification. Random primers (hexamers) can be used, no need to ... Each 5' end is covalently linked to a terminal protein, which is essential in the replication process. A symmetrical mode of ...
*  HOXA13
"Selection of homeotic proteins for binding to a human DNA replication origin". Journal of Molecular Biology. 299 (3): 667-80. ...
*  HOXC10
"Selection of homeotic proteins for binding to a human DNA replication origin". Journal of Molecular Biology. 299 (3): 667-80. ... which may indicate this protein has a role in origin activation. HOXC10 is overexpressed in breast cancer and transcriptionally ...
*  Nuclear organization
As well, they are typically made up of self-interacting domains and contain early replication origins. B compartments, on the ... They are consisted mostly of LADs and contain late replication origins. The fact that compartments self-interact is consistent ... origins of replication, telomeres, and centromeres. As of yet, there is not much evidence towards the importance of specific ... These alterations can have a downstream effect on cellular functions such as cell cycle facilitation, DNA replication, nuclear ...
*  Schizosaccharomyces pombe
S. cerevisiae has small point centromere of 125 bp, and sequence-defined replication origins of about the same size. On the ... Mojardín, Laura; Vázquez, Enrique; Antequera, Francisco (November 2013). "Specification of DNA Replication Origins and Genomic ... DNA replication in yeast has been increasingly studied by many researchers. Further understanding of DNA replication, gene ... and degenerate replication origins of at least 1kb. The fission yeast is a single-celled fungus with simple, fully ...
*  Cell cycle
"Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression". Molecular Systems Biology ... DNA replication occurs during the C period. The D period refers to the stage between the end of DNA replication and the ... This confirms previous predictions from mathematical modeling of a global causal coordination between DNA replication origin ... phosphorylate proteins that make up the pre-replication complexes assembled during G1 phase on DNA replication origins. The ...
*  ORC2
... and is thought to be required for DNA replication from viral origin of replication. ORC2 has been shown to interact with: CDC6 ... an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". ... Schaarschmidt D, Ladenburger EM, Keller C, Knippers R (2002). "Human Mcm proteins at a replication origin during the G1 to S ... Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly ...
*  Thymineless death
... breakage of ongoing replication forks, futile DNA repair, replication origin destruction, and an addiction module. Ahmad, S. I ... and RecBCD-dependent replication origin destruction". The Journal of Biological Chemistry. 287 (28): 23958-70. doi:10.1074/jbc. ... "Thymineless death is associated with loss of essential genetic information from the replication origin". Molecular Microbiology ... Martín, C. M.; Guzmán, E. C. (2011). "DNA replication initiation as a key element in thymineless death". DNA Repair. 10 (1): 94 ...
*  Z curve
This and other similar studies were used to generate a program that could predict the origins of replication using the Z curve ... The Z-curve method has been used in many different areas of genome research, such as replication origin identification,, ab ... Zhang R, Zhang CT (2005). "Identification of replication origins in archaeal genomes based on the Z-curve method". Archaea. 1 ( ... Zhang, Ren; Zhang, Chun-Ting (2002-09-20). "Single replication origin of the archaeon Methanosarcina mazei revealed by the Z ...
*  Higher-order singular value decomposition
"Global Effects of DNA Replication and DNA Replication Origin Activity on Eukaryotic Gene Expression". Molecular Systems Biology ...
*  Control of chromosome duplication
Replication is initiated at multiple origins of replication on multiple chromosomes simultaneously so that the duration of S ... Replication in eukaryotes begins at replication origins, where complexes of initiator proteins bind and unwind the helix. In ... S-Cdks and G1/S Cdks act to activate replication origins. At the same time, S-Cdks suppress formation of new pre-RCs during S ... Before DNA replication can start, the pre-replicative complex assembles at origins to load helicase onto DNA. The complex ...
*  Replication timing
However, replication does not start at all the different origins at once. Rather, there is a defined temporal order in which ... Replication does not necessarily start at exactly the same origin sites every time, but the segments appear to replicate in the ... 2009) Decreased replication origin activity in temporal transition regions. J Cell Biol 187: 623-635. Gilbert DM (2001) Nuclear ... The temporal order of replication of all the segments in the genome, called its replication-timing program, can now be easily ...
*  D-loop
The more recently reported mode starts at a different origin within the D-loop region and uses coupled-strand replication with ... Fish, J.; Raule, N.; Attardi, G. (2004). "Discovery of a major D-loop replication origin reveals two modes of human mtDNA ... Replication of the mitochondrial DNA can occur in two different ways, both starting in the D-loop region. One way continues ... D-loop replication mtDNA control region Kasamatsu, H.; Robberson, D. L.; Vinograd, J. (1971). "A novel closed-circular ...
*  D-loop replication
Each D-loop contains an origin of replication for the heavy strand. Full circular DNA replication is initiated at that origin ... As the heavy strand replication reaches the origin of replication for the light strand, a new light strand will be synthesized ... Fish, Jennifer; Raule, Nicola; Attardi, Giuseppe (2004-12-17). "Discovery of a Major D-Loop Replication Origin Reveals Two ... The L (light) strand comprises lighter nucleotides (pyrimidines: thymine and cytosine). Replication begins with replication of ...
*  ORC1
Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly ... Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. The origin recognition complex ( ... of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication". ... "Localization of proteins bound to a replication origin of human DNA along the cell cycle". The EMBO Journal. 22 (16): 4294-303 ...
*  GC skew
... replication origin, and replication terminal. Most prokaryotes and archaea contain only one DNA replication origin. The GC skew ... GC or AT skew changes sign at the boundaries of the two replichores, which correspond to DNA replication origin or terminus. ... Other techniques should be combined with deviation in order to identify and locate the origin of the DNA replication with ... X and Y components can alone detect the replication origin and asymmetric composition of the strands. A combination of these ...
*  ORC6
Sibani S, Price GB, Zannis-Hadjopoulos M (2005). "Ku80 binds to human replication origins prior to the assembly of the ORC ... Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly ... Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene. The origin recognition ... "Entrez Gene: ORC6L origin recognition complex, subunit 6 like (yeast)". Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt ...
*  CUL4A
After promoting initiation of eukaryotic DNA replication at the origin, Cdt1 is inactivated by Geminin and targeted for ... "The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells". Nature Cell Biology. 12 (11 ... Only reduction of Geminin expression seems to induce re-replication in Cdt1-overexpressing cells. CRL4s also utilize Cdt2 and ... Due to its robust expression (particularly during DNA replication) and modular nature, CRL4A complexes can be co-opted or " ...
*  ORC4
Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC ... Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly ... Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene. The origin recognition ... a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247-51. doi: ...
*  ORC3
Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC ... Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly ... Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene. The origin recognition ... "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)". Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). " ...
*  Antonius Suwanto
... origin of replication, and transfer functions". Journal of Bacteriology. 174 (4): 1124-34. PMC 206405 . PMID 1735707. Teo, J. W ...
*  DnaA
Fuller RS, Funnell BE, Kornberg A (October 1984). "The dnaA protein complex with the E. coli chromosomal replication origin ( ... DnaA is a protein that activates initiation of DNA replication in bacteria. It is a replication initiation factor which ... DnaA accumulates during growth and then triggers the initiation of replication. Replication begins with active DnaA binding to ... When DNA replication is about to commence, DnaA occupies all of the high and low affinity binding sites. The denatured AT-rich ...