... nucleic acid - nucleic acid regulatory sequence - nucleic acid repetitive sequence - nucleic acid sequence homology - nucleon ... amino acid - amino acid receptor - amino acid sequence - amino acid sequence homology - aminobutyric acid - ammonia - AMPA ... sequence (biology) - sequence homology - sequence motif - sequencing - serine - serotonin - serotonin receptor - serpin - ... It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and ...
Nucleic Acids Res. 19 (12): 3454. doi:10.1093/nar/19.12.3454. PMC 328350. PMID 2062660. Lai WS, Stumpo DJ, Blackshear PJ (1990 ... "A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence". J Biol Chem. 265 (31): 19185-91 ... "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): ... It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2. TTP binds to AU-rich ...
Yi H, Jin L (April 2013). "Co-phylog: an assembly-free phylogenomic approach for closely related organisms". Nucleic Acids ... He D (2006). "Using suffix tree to discover complex repetitive patterns in DNA sequences". 2006 International Conference of the ... possible number of k-mers for nucleotide sequence: 4k, while that for protein sequence: 20k) in sequences. Each k-mer count in ... Jeffrey HJ (April 1990). "Chaos game representation of gene structure". Nucleic Acids Research. 18 (8): 2163-70. doi:10.1093/ ...
"Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments". Biochemistry. 25 (16 ... Nishimura DY, Leysens NJ, Murray JC (1992). "A dinucleotide repeat for the D1S53 locus". Nucleic Acids Res. 20 (5): 1167. doi: ... Nucleic Acids Res. 18 (9): 2817-8. doi:10.1093/nar/18.9.2817. PMC 330776. PMID 2339067. Bottenus RE, Ichinose A, Davie EW (Feb ... Grundmann U, Nerlich C, Rein T, Zettlmeissl G (Jun 1990). "Complete cDNA sequence encoding the B subunit of human factor XIII ...
ORF1 trimers have RNA-binding and nucleic acid chaperone activity that are necessary for retrotransposition. The second ORF of ... further impact genome variation through mispairing and unequal crossing over during meiosis due to its repetitive DNA sequences ... International Human Genome Sequencing Consortium) (February 2001). "Initial sequencing and analysis of the human genome". ... Nucleic Acids Research. 32 (13): 3846-55. doi:10.1093/nar/gkh698. PMC 506791. PMID 15272086. Li J, Kannan M, Trivett AL, Liao H ...
Alu+Repetitive+Sequences at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "NCBI Genbank DNA encoding ... Schmid, C. W (1998). "Does SINE evolution preclude Alu function?". Nucleic Acids Research. 26 (20): 4541-50. doi:10.1093/nar/ ... Vansant, G; Reynolds, W. F (1995). "The consensus sequence of a major Alu subfamily contains a functional retinoic acid ... Häsler, Julien; Strub, Katharina (2006). "Alu elements as regulators of gene expression". Nucleic Acids Research. 34 (19): 5491 ...
September 2009). "Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease". Nucleic Acids Res. 37 ... Repetitive DNA sequences, Zinc proteins). ... Nucleic Acids Res. 34 (Web Server issue): W516-23. doi:10.1093/ ... August 2010). "TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain". Nucleic Acids ... Nucleic Acids Res. 33 (18): 5978-5990. doi:10.1093/nar/gki912. PMC 1270952. PMID 16251401. Lee HJ, Kim E, Kim JS (December 2009 ...
These and other studies on repetitive DNA sequences enabled him to suggest how non-coding chromosomal DNA may have evolved. ... Nucleic Acids Research. 20 (7): 1679-1684. doi:10.1093/nar/20.7.1679. PMC 312256. PMID 1579459. Milner, N.; Mir, K. U.; ... had an unexpectedly simple repetitive structure based on a sequence of six nucleotides. In mouse satellite DNA he showed both ... Southern has done pioneering work on the organization of DNA sequences in chromosomes. Apart from studies on crab poly-AT ...
... is the process of determining the nucleic acid sequence - the order of nucleotides in DNA. It includes any ... Other challenges have to deal with repetitive sequences that often prevent complete genome assemblies because they occur in ... Sequencing of amino acid arrangement in a protein Sequence mining Sequence profiling tool Sequencing by hybridization - method ... RNA sequencing was one of the earliest forms of nucleotide sequencing. The major landmark of RNA sequencing is the sequence of ...
Nucleic Acids Research. 15 (3): 1173-1184. doi:10.1093/nar/15.3.1173. PMC 340516. PMID 3029699. Gerstein AS (2004-04-07). ... a sequence 100 kb away would have come near the known sequence on circularization, it permits jumping and sequencing in an ... Chromosome jumping is used to bypass regions difficult to clone, such as those containing repetitive DNA, that cannot be easily ... From a known sequence, a primer is designed to sequence across the circularized junction. This primer is used to jump 100 kb- ...
At each end of the chromosomes of most eukaryotic cells, there is a telomere: a region of repetitive nucleotide sequences which ... Nucleic Acids Research. 41 (9): 4913-4925. doi:10.1093/nar/gkt192. PMC 3643601. PMID 23535143. (Articles with short description ... Because telomeres are by nature repetitive, matching sequences are widely available. In proposed models for how BITS works, the ... a centromere proximal sequence of the same chromosome (T-loop), (ii) circular extrachromosomal telomeric sequences (C-circles ...
Progress in Nucleic Acid Research and Molecular Biology. Vol. 63. pp. 109-38. doi:10.1016/S0079-6603(08)60721-7. ISBN 978-0-12- ... Zhang L, David G, Esko JD (November 1995). "Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans". ... induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proceedings of ... Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (April 1990). "Sequence of human syndecan indicates a novel gene family of ...
... contained specific modified nucleic acids which target Ribonuclease and prompted H-mediated cleaving of intended RNA sequences ... Studies have found that they arise from repetitive non-coding RNA sequences, also known as toxic RNA, which inhibit RNA-binding ... These toxic RNA sequences consist of a varying number of repeats and have been observed to construct intermolecular hairpin ... It is generally noted that overall variation in the expression of affected genes and the number of repeat sequences of the RNA ...
It is eminent to avoid repetitive sequences when selecting fragments as these will exhibit the lowest amount of polymorphism ... November 1995). "AFLP: a new technique for DNA fingerprinting". Nucleic Acids Research. 23 (21): 4407-4414. doi:10.1093/nar/ ... Nucleic Acids Research. 29 (4): 25e-25. doi:10.1093/nar/29.4.e25. PMC 29632. PMID 11160945. Kilian A, Wenzl P, Huttner E, ... Simple Sequence Repeats (SSR). They also aimed to minimize cost and reliance on sequenced genomes to identify polymorphisms ...
Nucleic Acids Research. 34 (12): 3484-93. doi:10.1093/nar/gkl453. PMC 1524904. PMID 16870723. Zhang H, Li D, Zhao L, Fleming J ... study is also supported by a study on Lineage 4 relying on genomic aDNA sequences from Hungarian mummies more than 200 years ... The third generation (mycobacterial interspersed repetitive unit - 2) added a further nine loci to bring the total to 24. This ... However, the mycolic acid in the cell wall of M. tuberculosis does not absorb the stain. Instead, acid-fast stains such as ...
... basic and dimeric nucleic acid-binding proteins. Furthermore, it is conserved in most sequenced archeal genomes. The ... The genome of Sulfolobus is characterised by the presence of short tandem repeats, insertion and repetitive elements, it has a ... The complete sequence the genome of S. solfataricus was completed in 2001. On a single chromosome, there are 2,992,245 base ... The major motivation for sequencing these microorganisms is because of the thermostability of proteins that normally denature ...
... instead zinc fingers are linked linearly in tandem to bind nucleic acid sequences of varying lengths. Zinc fingers often bind ... via Annual Reviews (subscription required) Miller J, McLachlan AD, Klug A (June 1985). "Repetitive zinc-binding domains in the ... Amino acid sequencing of TFIIIA revealed nine tandem sequences of 30 amino acids, including two invariant pairs of cysteine and ... Such domains adopt a simple ββα fold and have the amino acid sequence motif: X2-Cys-X2,4-Cys-X12-His-X3,4,5-His This class of ...
It is not clear exactly how but this reduction happens at repetitive sequences along with general reduced DNA methylation. The ... Nucleic Acids Research. 41 (5): 2797-2806. doi:10.1093/nar/gkt012. PMC 3597678. PMID 23345616. "Histone H4K20 Review". ... The histone mark H4K20me can be detected in a variety of ways: 1. Chromatin Immunoprecipitation Sequencing (ChIP-sequencing) ... Well positioned nucleosomes are seen to have enrichment of sequences. 3. Assay for transposase accessible chromatin sequencing ...
Alternative splicing Altruism Alu family Alzheimer's disease Amber codon Ames test Amino acid Amino acid sequence Amino acids ... Norm of reaction Normal distribution Northern analysis Northern blot NPD Nu body Nuclear transfer Nuclease Nucleic acid ... element Regulator gene Relaxed mutant Renal cell cancer Renal cell carcinoma Renner complex Repeat sequences Repetitive DNA ... Self-assembly Self-fertilization Selfed Selfish DNA Sense strand Sequence Sequence assembly Sequence tagged site Sequencing Sex ...
Repetitive Alu sequences represent approximately 10% of the human genome. The presence of Alu elements in flanking introns of ... Nucleic Acids Research. 40 (7): 3131-3142. doi:10.1093/nar/gkr1009. PMC 3326292. PMID 22140119. Varela-Martínez E, Corsi GI, ... IRAlus, and other non-repetitive, but complementary, sequences were also found to promote circular RNA formation. On the other ... The 5' splice site sequence is then subjected to a nucleophilic attack by a downstream sequence called the branch point, ...
Staden R (1979). "A strategy of DNA sequencing employing computer programs". Nucleic Acids Research. 6 (7): 2601-2610. doi: ... If one end read has a repetitive sequence, as long as its mate pair is located within a contig, its placement is known. The ... In bottom-up sequencing projects, a contig refers to overlapping sequence data (reads); in top-down sequencing projects, contig ... Staden, R (1980). "A new computer method for the storage and manipulation of DNA gel reading data". Nucleic Acids Research. 8 ( ...
... that employs peptide nucleic acid probes of a 3'-CCCTAACCCTAACCCTAA-5' sequence labeled with a fluorescin fluorophore to stain ... A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. ... allowing the probe to saturate its target repeat sequence (as it is not displaced from the target DNA by competing anti sense ... is a cytogenetic technique to quantify the copy number of RNA or specific repetitive elements in genomic DNA of whole cell ...
Nucleic Acids Research. Oxford University Press (OUP). 45 (D1): D1040-D1045. doi:10.1093/nar/gkw982. ISSN 0305-1048. PMC ... Lin et al., 2022 localize Lr42 to AET1Gv20040300 by cloning and sequence- and functional-analyses. The following subspecies are ... "Hybrid assembly of the large and highly repetitive genome of Aegilops tauschii, a progenitor of bread wheat, with the mega- ... Sims, David; Sudbery, Ian; Ilott, Nicholas; Heger, Andreas; Ponting, Chris (2014). "Sequencing depth and coverage: key ...
On the ends of each chromosome are repetitive sequences of DNA, telomeres, that protect the chromosome from joining with other ... Nucleic Acids Res. 31 (5): 1576-1583. doi:10.1093/nar/gkg208. PMC 149817. PMID 12595567. Renault V, Thornell LE, Eriksson PO, ...
... an epigenetic guardian of repetitive elements". Nucleic Acids Research. 32 (17): 5019-28. doi:10.1093/nar/gkh821. PMC 521642. ... The histone mark H3K27me3 can be detected in a variety of ways: 1. Chromatin Immunoprecipitation Sequencing (ChIP-sequencing) ... Well positioned nucleosomes are seen to have enrichment of sequences. 3. Assay for transposase accessible chromatin sequencing ... 2. Micrococcal Nuclease sequencing (MNase-seq) is used to investigate regions that are bound by well positioned nucleosomes. ...
He is known for his discovery of repetitive, functional DNA sequences in bacteria which he named CRISPR (Clustered Regularly ... Molecular Microbiology and Nucleic Acids Research, before finally being accepted by Journal of Molecular Evolution in February ... Part of the sequence was reported previously by Yoshizumi Ishino in 1987. Mojica described the complete gene sequence repeats ... He continued research on these sequences throughout the 1990s, and in 2000, Mojica recognized that what had been reported as ...
The crRNA-foreign nucleic acid complex is then cleaved, however if there are mismatches between the spacer and the target DNA, ... Repetitive DNA sequences, Immune system, Bacterial proteins, Genome editing). ... Free energy changes of nucleic acids are also highly relevant in defining cleavage activity. Guide RNAs that bind to the DNA ... Despite low sequence similarity, the sequence similar to RNase H has a RuvC fold (one member of RNase H family) and the HNH ...
Epplen C, Epplen JT (January 1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes". ... Nucleic Acids Research. 37 (8): 2449-60. doi:10.1093/nar/gkp101. PMC 2677868. PMID 19255092. Yates JA, Menon T, Thompson BA, ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273-81. ... Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human ...
... because of their origin from the repetitive elements such as transposable sequences of the genome. However, later it was ... a leucine zipper protein involved in protein-protein interactions and a protein that binds to the terminus of nucleic acids. ... The adenine-rich sequence in LINE transcript base pairs with the cut strand to flag where the LINE will be inserted with ... Long strands of repetitive DNA can be found at each end of a LTR retrotransposon. These are termed long terminal repeats (LTRs ...
Essentially this means that the highly repetitive sequences necessary for multiple sgRNA in a single plasmid are constrained by ... The amplification refractory mutation system (ARMS)". Nucleic Acids Res. 17 (7): 2503-2516. doi:10.1093/nar/17.7.2503. PMC ... Of this sequence, at least 15 base pairs should be homologous to the target sequence at both the 5' and 3' ends to provide ... In this system, sequences matching foreign bacteriophage or plasmid DNA are incorporated as "spacer" sequences into the ...