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*  Fosmid
1992). "Stable propagation of cosmid-sized human DNA inserts in an F-factor based vector". Nucleic Acids Res. 20 (5): 1083-1085 ... Highly repetitive in nature, human DNA is well known for its extreme instability in multicopy vector systems. It has been found ... Fosmid clones were used to help assess the accuracy of the Public Human Genome Sequence. The fertility plasmid or F-plasmid was ... The first step in sequencing entire genomes is cloning the genome into manageable units of some 50-200 kilobases in length. It ...
*  RNA editing
... in mRNAs effectively alters the amino acid sequence of the encoded protein so that it differs from that predicted ... Nucleic Acids Res. 21 (18): 4402. doi:10.1093/nar/21.18.4402. PMC 310088 . PMID 8415006. Bachellerie, J.-P. & Cavaille, J. ( ... duplexes arising from paired repetitive elements). There are many effects of A-to-I editing, arising from the fact that it ... Nucleic Acids Res. 25 (19): 3751-3759. doi:10.1093/nar/25.19.3751. PMC 146959 . PMID 9380494. CS1 maint: Multiple names: ...
*  Alignment-free sequence analysis
Jeffrey, HJ (April 25, 1990). "Chaos game representation of gene structure". Nucleic Acids Research. 18 (8): 2163-70. doi: ... He, D (2006). "Using suffix tree to discover complex repetitive patterns in DNA sequences". Conference proceedings : ... Annual ... possible number of k-mers for nucleotide sequence: 4k, while that for protein sequence: 20k) in sequences. Each k-mer count in ... Sequence analysis Multiple sequence alignment Phylogenomics Bioinformatics Metagenomics Next-generation sequencing Population ...
*  Edwin Southern
These and other studies on repetitive DNA sequences enabled him to suggest how non-coding chromosomal DNA may have evolved. ... Nucleic Acids Research. 20 (7): 1679-1684. doi:10.1093/nar/20.7.1679. PMC 312256 . PMID 1579459. Milner, N.; Mir, K. U.; ... had an unexpectedly simple repetitive structure based on a sequence of six nucleotides. In mouse satellite DNA he showed both ... Southern has done pioneering work on the organization of DNA sequences in chromosomes. Apart from studies on crab poly-AT ...
*  Ilham Shahmuradov
A database of plant promoter sequences". Nucleic Acids Research. 31 (1): 114-7. doi:10.1093/nar/gkg041. PMC 165488 . PMID ... Enhancer-like structures in middle repetitive DNA elements of eukaryotic genomes. Genetics (USSR/Russia), 22, 357-367 "AMEA-nın ... Shahmuradov IA, Solovyev VV (2003) PromH: promoters identification using orthologous genomic sequences. Nucl. Acids. Res., 31, ... Nucleic Acids Research. 33 (3): 1069-76. doi:10.1093/nar/gki247. PMC 549412 . PMID 15722481. Shahmuradov, I. A.; Gammerman, A. ...
*  Kaposi's sarcoma-associated herpesvirus
KSHV has a genome which is approximately 165,000 nucleic acid bases in length. KSHV is a rhadinovirus, and is remarkable since ... Each terminal repeat unit is 801 bp in length, has 85% G+C content and is oriented in a repetitive head-to-tail fashion. During ... Starting from these fragments, this research team was then able to sequence the entire genome of the virus less than two years ... and is a large double-stranded DNA virus with a protein covering that packages its nucleic acids, called the capsid, which is ...
*  ZFP36
Nucleic Acids Res. 19 (12): 3454. doi:10.1093/nar/19.12.3454. PMC 328350 . PMID 2062660. Lai WS, Stumpo DJ, Blackshear PJ (1990 ... "A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence". J Biol Chem. 265 (31): 19185-91 ... "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): ... It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2. TTP binds to AU-rich ...
*  Syndecan 1
Progress in Nucleic Acid Research and Molecular Biology. Progress in Nucleic Acid Research and Molecular Biology. 63: 109-38. ... Zhang L, David G, Esko JD (Nov 1995). "Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans". The ... induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proceedings of ... Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (Apr 1990). "Sequence of human syndecan indicates a novel gene family of integral ...
*  Flow-FISH
... that employs peptide nucleic acid probes of a 3'-CCCTAACCCTAACCCTAA-5' sequence labeled with a fluorescin fluorophore to stain ... A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. ... Flow-FISH (fluorescent in-situ hybridization) is a cytogenetic technique to quantify the copy number of specific repetitive ... allowing the probe to saturate its target repeat sequence (as it is not displaced from the target DNA by competing anti sense ...
*  Zinc finger
... instead zinc fingers are linked linearly in tandem to bind nucleic acid sequences of varying lengths. Zinc fingers often bind ... via Annual Reviews (subscription required) Miller J, McLachlan AD, Klug A (June 1985). "Repetitive zinc-binding domains in the ... Amino acid sequencing of TFIIIA revealed nine tandem sequences of 30 amino acids, including two invariant pairs of cysteine and ... These domains adopt a simple ββα fold and have the amino acid Sequence motif: X2-Cys-X2,4-Cys-X12-His-X3,4,5-His This class of ...
*  H3K27me3
... an epigenetic guardian of repetitive elements". Nucleic Acids Research. 32 (17): 5019-28. doi:10.1093/nar/gkh821. PMID 15448183 ... The histone mark H3K27me3 can be detected in a variety of ways: 1. Chromatin Immunoprecipitation Sequencing (ChIP-sequencing) ... Well positioned nucleosomes are seen to have enrichment of sequences. 3. Assay for transposase accessible chromatin sequencing ... 2. Micrococcal Nuclease sequencing (MNase-seq) is used to investigate regions that are bound by well positioned nucleosomes. ...
*  Index of genetics articles
Alternative splicing Altruism Alu family Alzheimer's disease Amber codon Ames test Amino acid Amino acid sequence Amino acids ... Norm of reaction Normal distribution Northern analysis Northern blot NPD Nu body Nuclear transfer Nuclease Nucleic acid ... element Regulator gene Relaxed mutant Renal cell cancer Renal cell carcinoma Renner complex Repeat sequences Repetitive DNA ... Self-assembly Self-fertilization Selfed Selfish DNA Sense strand Sequence Sequence assembly Sequence tagged site Sequencing Sex ...
*  RNA-dominant disease
... contained specific modified nucleic acids which target Ribonuclease and prompted H-mediated cleaving of intended RNA sequences ... Studies have found that they arise from repetitive non-coding RNA sequences, also known as toxic RNA, which inhibit RNA-binding ... These toxic RNA sequences consist of a varying number of repeats and have been observed to construct intermolecular hairpin ... It is generally noted that overall variation in the expression of affected genes and the number of repeat sequences of the RNA ...
*  ChIP-sequencing
Nucleic Acids Res 36(16) 5221-5231. Bernstein, BE; et al. (2005). "Genomic maps and comparative analysis of histone ... as long as a high-quality genome sequence is available for read mapping, and the genome doesn't have repetitive content that ... Sequencing, by contrast, is thought to have less bias, although the sequencing bias of different sequencing technologies is not ... There are many new sequencing methods used in this sequencing step. Some technologies that analyze the sequences can use ...
*  Contig
Staden R (1979). "A strategy of DNA sequencing employing computer programs". Nucleic Acids Research. 6: 2601-2610. doi:10.1093/ ... If one end read has a repetitive sequence, as long as its mate pair is located within a contig, its placement is known. The ... In bottom-up sequencing projects, a contig refers to overlapping sequence data (reads); in top-down sequencing projects, contig ... In this sequencing method, a low-resolution map is made prior to sequencing in order to provide a framework to guide the later ...
*  Eternal youth
On the ends of each chromosome are repetitive sequences of DNA, telomeres, that protect the chromosome from joining with other ... Nucleic Acids Res. 31 (5): 1576-1583. doi:10.1093/nar/gkg208. PMC 149817 . PMID 12595567. Renault V, Thornell LE, Eriksson PO, ...
*  Biomolecule
The particular series of amino acids that form a protein is known as that protein's primary structure. This sequence is ... Biomolecules include large macromolecules (or polyanions) such as proteins, carbohydrates, lipids, and nucleic acids, as well ... The secondary-structure elements are connected by "loop" or "coil" regions of non-repetitive conformation, which are sometimes ... They are also known as fatty acids Amino acids contain both amino and carboxylic acid functional groups. (In biochemistry, the ...
*  FAM107B
2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10. Conserved ... which is known for the Alu repetitive sequence. Model organisms have been used in the study of FAM107B function. A conditional ... It is 306 amino acids long. According to AceView, there are 27 spliced variants with 2 unspliced variants and 27 mRNAs of ...
*  CHD8
Epplen C, Epplen JT (Jan 1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes". Human ... Nucleic Acids Research. 37 (8): 2449-60. doi:10.1093/nar/gkp101. PMC 2677868 . PMID 19255092. Yates JA, Menon T, Thompson BA, ... "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain ...
*  DNA
... simulation software Meiosis Mitochondrial DNA Nuclear DNA Nucleic acid double helix Nucleic acid notation Nucleic acid sequence ... of human DNA consisting of non-coding repetitive sequences. The reasons for the presence of so much noncoding DNA in eukaryotic ... In addition to RNA and DNA, many artificial nucleic acid analogues have been created to study the properties of nucleic acids, ... Watson JD, Crick FH (April 1953). "Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid" (PDF). ...
*  No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing
Essentially this means that the highly repetitive sequences necessary for multiple sgRNA in a single plasmid are constrained by ... The amplification refractory mutation system (ARMS)". Nucleic Acids Res. 17: 2503-2516. doi:10.1093/nar/17.7.2503. PMC 317639 ... Of this sequence, at least 15 base pairs should be homologous to the target sequence at both the 5' and 3' ends to provide ... In this system, sequences matching foreign bacteriophage or plasmid DNA are incorporated as "spacer" sequences into the ...
*  Shotgun sequencing
DNA sequencing theory Staden, R (1979). "A strategy of DNA sequencing employing computer programs". Nucleic Acids Research. 6 ( ... Assembly of complex genomes is additionally complicated by the great abundance of repetitive sequences, meaning similar short ... Anderson, S (1981). "Shotgun DNA sequencing using cloned DNase I-generated fragments". Nucleic Acids Research. 9 (13): 3015-27 ... The classical shotgun sequencing was based on the Sanger sequencing method: this was the most advanced technique for sequencing ...
*  Virus-like particle
Attaching proteins, nucleic acids, or small molecules to the VLP surface, such as for targeting a specific cell type or for ... Production can begin as soon as the virus strain is sequenced and can take as little as 12 weeks, compared to 9 months for ... VLPs contain repetitive, high density displays of viral surface proteins that present conformational viral epitopes that can ... An alternative is to assemble the VLP and then use chemical crosslinkers, reactive unnatural amino acids or SpyTag/SpyCatcher ...
*  Gene
"Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid" (PDF). Nature. 171 (4356): 737-8. Bibcode: ... Telomeres are long stretches of repetitive sequence that cap the ends of the linear chromosomes and prevent degradation of ... The nucleotide sequence of a gene's DNA specifies the amino acid sequence of a protein through the genetic code. Sets of three ... The degree of sequence similarity between homologous genes is called conserved sequence. Most changes to a gene's sequence do ...
*  Frameshift mutation
The amino acid sequence encoded by the gene is then predicted. Despite the rules that govern the genetic code and the various ... Nucleic Acids Research. 37 (5): 1682-9. doi:10.1093/nar/gkn1042. PMC 2655659 . PMID 19155277. Hu, J; Ng, PC (9 February 2012 ... and is only practical in structural proteins or other repetitive genes. A third form of repair is revertant mosaicism, which is ... The nucleotide sequence of the suspected gene is provided from published gene sequences or from cloning and sequencing of the ...
*  F13B
"Complete cDNA sequence encoding the B subunit of human factor XIII". Nucleic Acids Res. 18 (9): 2817-8. doi:10.1093/nar/18.9. ... "Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments". Biochemistry. 25 (16 ... Nishimura DY, Leysens NJ, Murray JC (1992). "A dinucleotide repeat for the D1S53 locus". Nucleic Acids Res. 20 (5): 1167. doi: ... Bottenus RE, Ichinose A, Davie EW (Feb 1991). "Nucleotide sequence of the gene for the b subunit of human factor XIII". ...
*  Enterobacter cloacae
Nucleic Acids Res.18,6531-6535 (1990). 21.Stumpf AN, Roggenkamp A, Hoffmann H. Specificity of enterobacterial repetitive ... ARB: a software environment for sequence data. Nucleic Acids Res.32,1363-1371 (2004). 53.Stock I, Grüger T, Wiedemann B. ... The whole-genome shotgun sequencing project was submitted in 2011 to the Human Genome Sequencing Center (TX, USA; GenBank ... This latter strain is the first complete genome sequence of the E. cloacae species and the type strain is E. cloacae subsp. ...