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*  PLGLB2
Characterization of cDNAs and recombinant fusion proteins". Eur. J. Biochem. 259 (3): 618-25. doi:10.1046/j.1432-1327.1999. ... Plasminogen-related protein B is a protein that in humans is encoded by the PLGLB2 gene. GRCh38: Ensembl release 89: ...
*  TopoTarget
APO010, also known as mega-FasLigand is a recombinant fusion protein. This protein was derived from the pro-apoptotic human Fas ... APO200 is a therapeutic recombinant protein that is developed from the ectodysplasin A-1 (EDA1) gene. This product is used to ... A current target is Heat Shock Protein 90 (HSP90). HSP90 is key in protein folding and maturation. TopoTarget is currently ... pg 20 The recombinant protein product targets the ErbB2/HER2 receptor, which is overexpressed in 30% of breast cancer and is ...
*  Belimumab
Atacicept is a recombinant fusion protein built with the extracellular ligand binding portion of TACI. It blocks activation of ... BR3-Fc is a recombinant fusion protein built with the extracellular ligand-binding portion of BAFF-R. It blocks activation of ... naming the protein TALL-1. The same protein was named BAFF in another paper published in June 1999; and in a paper published in ... isolation of over one thousand different antibodies to a single protein, BLyS". J. Mol. Biol. 334 (1): 103-18. doi:10.1016/j. ...
*  Atacicept
... is a recombinant fusion protein designed to inhibit B cells, thereby suppressing autoimmune disease. The designer ... The subcutaneously injected protein failed a phase II trial for multiple sclerosis. The trials of atacicept in people with MS ... a transmembrane receptor protein found predominantly on the surface of B cells. Like the monoclonal antibody belimumab, ... protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells - B-lymphocyte ...
*  Nuclear-inclusion-a endopeptidase
The enzyme is used encoded in vectors for the artificial expression of recombinant fusion proteins (see TEV protease). Fellers ...
*  TEV protease
One of the main uses of this protein is for removing affinity tags from purified recombinant fusion proteins. The reason for ... "Release of proteins and peptides from fusion proteins using a recombinant plant virus proteinase". Anal. Biochem. 216 (2): 413- ... Kapust RB, Waugh DS (July 2000). "Controlled intracellular processing of fusion proteins by TEV protease". Protein Expr. Purif ... Due to its high sequence specificity it is frequently used for the controlled cleavage of fusion proteins in vitro and in vivo ...
*  CD4 immunoadhesin
... is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region. It ... 2007). "Nonlinear pharmacokinetics of high-dose recombinant fusion protein CD4-IgG2 (PRO 542) observed in HIV-1-infected ... CD4 is a surface receptor for human immunodeficiency virus (HIV). The properties of the protein means that it has potential to ...
*  Human metapneumovirus
... on the Basis of a Novel Enzyme-Linked Immunosorbent Assay Utilizing hMPV Fusion Protein Expressed in Recombinant Vesicular ... Determined with a New Recombinant Fusion Protein Enzyme-Linked Immunosorbent Assay". Clinical and Vaccine Immunology. 20 (10): ... The HMPV fusion (F) protein encodes an RGD (Arg-Gly-Asp) motif that engages RGD-binding integrins as cellular receptors, then ... "Human Metapneumovirus Reinfection among Children in Thailand Determined by ELISA Using Purified Soluble Fusion Protein". The ...
*  Albinterferon
... (alb-IFN, trade name Albuferon) is a recombinant fusion protein drug consisting of interferon alpha (IFN-α) ... November 2002). "Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in ...
*  BDH1
... site-directed mutagenesis of a new recombinant fusion protein". Biochemistry. 39 (32): 9687-97. doi:10.1021/bi000274z. PMID ... The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement ... The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies ... Alternatively spliced transcript variants encoding the same protein have been described. 3-hydroxybutyrate dehydrogenase ...
*  Ruth Sonntag Nussenzweig
"TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite ... "Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity ... "Antibodies to Plasmodium circumsporozoite protein (CSP) inhibit sporozoite's cell traversal activity." Journal of Immunological ... "Immunogenicity of a Prime-Boost Vaccine Containing the Circumsporozoite Proteins of Plasmodium vivax in Rodents. Infection and ...
*  Luspatercept
... is a recombinant fusion protein derived from human activin receptor type IIb (ActRIIb) linked to a protein derived ...
*  IMP321
... is a 200 kDA soluble dimeric recombinant fusion protein of the extracellular portion of LAG3 with immunoglobulin, ... Li B, VanRoey M, Triebel F, Jooss K (June 1, 2008). "Lymphocyte activation gene-3 fusion protein increases the potency of a ... had successfully produced a soluble fusion protein of LAG3 and immunoglobulin around 1995 and had initially envisaged its use ... LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial". J Transl Med ...
*  Immunotoxin
Sometimes recombinant fusion proteins containing a toxin and a growth factor are also referred to as recombinant immunotoxins, ... A more specific name for this latter kind of protein is recombinant fusion toxin. They were originally produced by attaching ... An immunotoxin is a human-made protein that consists of a targeting portion linked to a toxin. When the protein binds to that ... The toxin is usually a cytotoxic protein derived from a bacterial or plant protein, from which the natural binding domain has ...
*  Transmembrane activator and CAML interactor
TACI is currently being targeted for autoimmunity and B cell malignancies via atacicept, a recombinant fusion protein that ... is a protein that in humans is encoded by the TNFRSF13B gene TNFRSF13B is a transmembrane protein of the TNF receptor ... These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B ... In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17. ...
*  Interleukin 2
Eisai markets a drug called denileukin diftitox (trade name Ontak), which is a recombinant fusion protein of the human IL-2 ... Amgen later entered the field with its own proprietary, mutated, recombinant protein and Cetus and Amgen were soon competing ... Aldesleukin is a form of recombinant interleukin-2. It is manufactured using recombinant DNA technology and is marketed as a ... Interking is a recombinant IL-2 with a serine at residue 125, sold by Shenzhen Neptunus. Various dosages of IL-2 across the ...
*  Thrombin
... is commonly included in linker regions of recombinant fusion protein constructs. Following purification of the fusion protein, ... Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to protein S leads to a modest increase in ... Thrombin bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is ... Recombinant thrombin is available as a powder for reconstitution into aqueous solution. It can be applied topically during ...
*  Dendritic cells- based cancer vaccines
The cells are incubated ex vivo in the presence of a recombinant fusion protein PA2024 containing a prostate antigen, prostate ... We can used specific TAAs, tumor lysates,created DC-cancer cell fusions, electroporation/transfection of DCs with total cancer ...
*  EGTA (chemical)
... in which recombinant fusion proteins are bound to calmodulin beads and eluted out by adding EGTA. EGTA is often employed in ... EGTA is used as a compound in elution buffer in the protein purification technique known as tandem affinity purification, ...
*  Aflibercept
... is a recombinant fusion protein consisting of vascular endothelial growth factor (VEGF)-binding portions from the ... leading to blood and protein leakage below the macula. Tumours need blood vessels sprouting into them when they become larger ...
*  Protein A/G
... is a recombinant fusion protein that combines IgG binding domains of both Protein A and Protein G. Protein A/G ... In addition to Protein A/G, other immunoglobulin-binding bacterial proteins such as Protein A, Protein G and Protein L are all ... The binding of Protein A/G is less pH-dependent than Protein A, but otherwise has the additive properties of Protein A and G. ... Mouse monoclonal antibodies commonly have a stronger affinity to the chimeric Protein A/G than to either Protein A or Protein G ...
*  Fusion protein
A recombinant fusion protein is a protein created through genetic engineering of a fusion gene. This typically involves ... Examples include: Gag-onc fusion protein Bcr-abl fusion protein Tpr-met fusion protein Antibodies are fusion proteins produced ... Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or ... The bcr-abl fusion protein is a well-known example of an oncogenic fusion protein, and is considered to be the primary ...
*  Factor IX
Recombinant), Fc Fusion Protein] Official Site". Simioni P, Tormene D, Tognin G, Gavasso S, Bulato C, Iacobelli NP, Finn JD, ... The factor IX protein is composed of four protein domains: the Gla domain, two tandem copies of the EGF domain and a C-terminal ... Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found ... A structure of the two EGF domains and the trypsin-like domain was determined for the pig protein. The structure of the Gla ...
*  Etanercept
... is a fusion protein produced by recombinant DNA. It fuses the TNF receptor to the constant end of the IgG1 antibody ... Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 ... The prototypic fusion protein was first synthesized and shown to be highly active and unusually stable as a modality for ... The effect is an artificially engineered dimeric fusion protein. Etanercept is a complex molecules containing 6 N-glycans, up ...
*  TROVE2
1990). "Antigenicity of a recombinant Ro (SS-A) fusion protein". Arthritis Rheum. 33 (1): 102-6. doi:10.1002/art.1780330114. ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... 60 kDa SS-A/Ro ribonucleoprotein is a protein that in humans is encoded by the TROVE2 gene. GRCh38: Ensembl release 89: ... 2005). "RNA chaperone activity of protein components of human Ro RNPs". RNA. 11 (7): 1084-94. doi:10.1261/rna.7263905. PMC ...
*  Phage display
Many genetic sequences are expressed in a bacteriophage library in the form of fusions with the bacteriophage coat protein, so ... "Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro". Proc. Natl. Acad. Sci. U.S.A. 89 (19 ... Phage display is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that ... a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to "display" the protein on ...