Factor IX
"Coagulation Factor IX (Recombinant), Fc Fusion Protein". Drug Information Portal. U.S. National Library of Medicine. " ... The factor IX protein is composed of four protein domains: the Gla domain, two tandem copies of the EGF domain and a C-terminal ... Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found ... A structure of the two EGF domains and the trypsin-like domain was determined for the pig protein. The structure of the Gla ...
PLGLB2
Characterization of cDNAs and recombinant fusion proteins". Eur. J. Biochem. 259 (3): 618-25. doi:10.1046/j.1432-1327.1999. ... Plasminogen-related protein B is a protein that in humans is encoded by the PLGLB2 gene. GRCh38: Ensembl release 89: ...
Efmoroctocog alfa
... is a recombinant human coagulation factor VIII, Fc fusion protein (rFVIIIFc). It is produced by recombinant ... "Eloctate (antihemophilic factor- recombinant, fc fusion protein kit". DailyMed. 4 August 2020. Archived from the original on 29 ... Recombinant proteins, All stub articles, Blood and blood forming organ drug stubs). ...
Moxetumomab pasudotox
Kreitman RJ, Pastan I (October 2011). "Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox". ... a condition in which fluid and proteins leak out of tiny blood vessels into surrounding tissues. Symptoms of capillary leak ...
Etanercept
... is a fusion protein produced by recombinant DNA. It fuses the TNF receptor to the constant end of the IgG1 antibody ... Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 ... The prototypic fusion protein was first synthesized and shown to be highly active and unusually stable as a modality for ... The fusion protein was developed by Bruce A. Beutler, an academic researcher then at the University of Texas Southwestern ...
TROVE2
1990). "Antigenicity of a recombinant Ro (SS-A) fusion protein". Arthritis Rheum. 33 (1): 102-6. doi:10.1002/art.1780330114. ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... 60 kDa SS-A/Ro ribonucleoprotein is a protein that in humans is encoded by the TROVE2 gene. GRCh38: Ensembl release 89: ... 2005). "RNA chaperone activity of protein components of human Ro RNPs". RNA. 11 (7): 1084-94. doi:10.1261/rna.7263905. PMC ...
Regulatory macrophages
November 2018). "Recombinant factor VIII Fc fusion protein drives regulatory macrophage polarization". Blood Advances. 2 (21): ... These cells can be distinguished based on the different expression levels of various surface proteins and the secretion of ...
Efanesoctocog alfa
"Altuviiio (antihemophilic factor- recombinant, fc-vwf-xten fusion protein-ehtl kit". DailyMed. 31 March 2023. Retrieved 7 May ... Recombinant proteins, Sanofi, All stub articles, Blood and blood forming organ drug stubs). ... Efanesoctocog alfa is a recombinant DNA-derived, Factor VIII concentrate indicated for use in adults and children with ...
TopoTarget
APO010, also known as mega-FasLigand is a recombinant fusion protein. This protein was derived from the pro-apoptotic human Fas ... APO200 is a therapeutic recombinant protein that is developed from the ectodysplasin A-1 (EDA1) gene. This product is used to ... A current target is Heat Shock Protein 90 (HSP90). HSP90 is key in protein folding and maturation. TopoTarget is currently ... pg 20 The recombinant protein product targets the ErbB2/HER2 receptor, which is overexpressed in 30% of breast cancer and is ...
Zearalenone
September 2020). "Bioluminescent detection of zearalenone using recombinant peptidomimetic Gaussia luciferase fusion protein". ... is developing specific peptide mimetic with the bioluminescent Gaussia luciferase fused as one protein that can bind ...
HaloTag
... ged fusion proteins can be expressed using standard recombinant protein expression techniques. Furthermore, there are ... Once the fusion protein has been expressed, there is a wide range of potential areas of experimentation including enzymatic ... Protein tag SNAP tag SpyTag Fluorescent proteins Los GV, Encell LP, McDougall MG, Hartzell DD, Karassina N, Zimprich C, et al ... HaloTag is a self-labeling protein tag. It is a 297 residue protein (33 kDa) derived from a bacterial enzyme, designed to ...
FLAG-tag
Einhauer A, Jungbauer A (2001). "The FLAG peptide, a versatile fusion tag for the purification of recombinant proteins". ... FLAG-tag, or FLAG octapeptide, or FLAG epitope, is a peptide protein tag that can be added to a protein using recombinant DNA ... FLAG-tag has been used to separate recombinant, overexpressed protein from wild-type protein expressed by the host organism. ... If there is no antibody against a given protein, adding a FLAG-tag to a protein allows the protein to be studied with an ...
Protein tag
Einhauer, A.; Jungbauer, A. (2001). "The FLAG™ peptide, a versatile fusion tag for the purification of recombinant proteins". ... Protein tags are peptide sequences genetically grafted onto a recombinant protein. Tags are attached to proteins for various ... This tag is used for protein purification of recombinant proteins and its fragments. It can be used in research labs and it is ... especially for recombinant proteins expressed in species such as E. coli, to assist in the proper folding in proteins and keep ...
COVID-19 vaccine clinical research
"Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Phase III (COVID-19)". ClinicalTrials.gov. 27 October 2021. NCT05096845. ... "Safety and Immunogenicity of Recombinant Protein RBD Fusion Dimer Vaccine Against the Virus That Cause COVID-19, Known as ... "Study of Recombinant Protein Vaccine with Adjuvant against COVID-19 in Adults 18 Years of Age and Older". pactr.samrc.ac.za. ... "Study of Recombinant Protein Vaccine With Adjuvant Against COVID-19 in Adults 18 Years of Age and Older (VAT00002)". ...
Immunotoxin
Sometimes recombinant fusion proteins containing a toxin and a growth factor are also referred to as recombinant immunotoxins, ... A more specific name for this latter kind of protein is recombinant fusion toxin. They were originally produced by attaching ... The toxin is usually an AB toxin, a cytotoxic protein derived from a bacterial or plant protein, from which the natural binding ... An immunotoxin is an artificial protein consisting of a targeting portion linked to a toxin. When the protein binds to that ...
TEV protease
One of the main uses of this protein is for removing affinity tags from purified recombinant fusion proteins. The reason for ... "Release of proteins and peptides from fusion proteins using a recombinant plant virus proteinase". Anal. Biochem. 216 (2): 413- ... Kapust RB, Waugh DS (July 2000). "Controlled intracellular processing of fusion proteins by TEV protease". Protein Expr. Purif ... "Efficient site-specific processing of fusion proteins by tobacco vein mottling virus protease in vivo and in vitro". Protein ...
Fusion protein
A recombinant fusion protein is a protein created through genetic engineering of a fusion gene. This typically involves ... Examples include: Gag-onc fusion protein Bcr-abl fusion protein Tpr-met fusion protein Antibodies are fusion proteins produced ... in contrast to genetic fusion prior to translation used in other recombinant technologies. Protein linkers aid fusion protein ... Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or ...
Atacicept
... is a recombinant fusion protein designed to inhibit B cells, thereby suppressing autoimmune disease. The designer ... The subcutaneously injected protein failed a phase II trial for multiple sclerosis. The trials of atacicept in people with MS ... a transmembrane receptor protein found predominantly on the surface of B cells. Like the monoclonal antibody belimumab, ... protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells - B-lymphocyte ...
Cancer vaccine targeting CD4+ T cells
This kind of vaccine can be realized by DNA recombinant fusion proteins expressed in E. coli. The protein MAGE-3 has already ... Two cohorts were analyzed: one receiving MAGE-3 protein alone, and one receiving MAGE-3 protein with adjuvant AS028. Of nine ... Clinical vaccination studies using full-length recombinant proteins have the advantage that this form of antigen potentially ... recombinant viral vaccines and recombinant bacterial vaccines. While most adoptive transfer experiments have been performed ...
Telitacicept
... recombinant TACI-Fc fusion protein, for the treatment of systemic lupus erythematosus". Drugs of Today. 58 (1): 23-32. doi: ... Telitacicept is a fusion protein that combines a recombinant transmembrane activator and calcium modulator and cyclophilin ...
Sporosarcina ureae
... and cell surface display of recombinant Sporosarcina ureae S-layer fusion proteins in Bacillus megaterium". Applied and ... Ilk, N.; Egelseer, E.M.; Sleytr, U.B. (2011). "S-layer fusion proteins-construction principles and applications". Current ... S-layers are composed of single proteins that form a predictable lattice structure and have potential applications in ...
NGR-hTNF (antitumor recombinant protein)
NGR-hTNF is a recombinant protein derived from the fusion between peptide CNGRCG and human tumor necrosis factor alpha (TNFα). ...
Nuclear-inclusion-a endopeptidase
The enzyme is used encoded in vectors for the artificial expression of recombinant fusion proteins (see TEV protease). Fellers ...
DHX8
... recombinant restriction-grade protease) cleavage site. HRV 3C is a highly purified recombinant 6XHis-fusion protein, that ... Protein DHX8 is part of a protein complex called spliceosome, which is in charge of pre-mRNA splicing. The spliceosome has ... One example of a purification approach for DHX8 is via a protein tag called GST-His grafted onto DHX8 protein is used. The N- ... DEAH-box helicase 8, is a protein that in humans is encoded by the DHX8 gene. This protein is member of the DEAH box ...
Sanofi
Zaltrap (Aflibercept), recombinant fusion protein, approved in metastatic colorectal cancer in combination with other agents in ... Zaltrap (Aflibercept), recombinant fusion protein, approved in metastatic colorectal cancer in combination with other agents in ... It used recombinant protein-based technology for Sanofi's flu vaccine along with GSK's pandemic technology and was seeking ... As of 2013[update], Sanofi was in a race with Amgen and Pfizer to win approval for a drug that inhibits PCSK9, a protein that ...
Biological therapy for inflammatory bowel disease
... a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate". ... The development of recombinant DNA technology in the 1970s shaped the modern understanding of what constitutes as biological ... Today, biological therapy most commonly refers to the use of proteins, such as monoclonal antibodies, to regulate the immune ... Certolizumab pegol is a recombinant antigen-binding fragment antibody that is attached to a 40kDa polyethylene glycol. The ...
Beta thalassemia
... is a recombinant fusion protein that is used as a treatment in adults with transfusion dependent beta thalassemia. It consists ... Washed red cells have been removed of plasma proteins that would have become a target of the patient's antibodies allowing the ... DNA contains both the instructions (genes) for stringing amino acids together into proteins, as well as stretches of DNA that ... Hemoblogin's normal alpha and beta subunits each have an iron-containing central portion (heme) that allows the protein chain ...
Thomas Schuler
Disc Disease by Using Stand Alone Anterior Lumbar Interbody Fusion Cages and Recombinant Human Bone Morphogenetic Protein-2: as ... of Anterior Lumbar Interbody Arthrodesis with Use of Interbody Fusion Cages and recombinant Human Bone Morphogenetic Protein-2 ... of Anterior Lumbar Interbody Arthrodesis with Use of Interbody Fusion Cages and Recombinant Human Bone Morphogenetic Protein-2 ... He performed the first hybrid multi-level cervical artificial disc replacement with spinal fusion in the country. He founded a ...
Bone morphogenetic protein 2
The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen ... Bone morphogenetic protein 2 is shown to stimulate the production of bone. Recombinant human protein (rhBMP-2) is currently ... Carragee EJ, Hurwitz EL, Weiner BK (June 2011). "A critical review of recombinant human bone morphogenetic protein-2 trials in ... Subach BR, Haid RW, Rodts GE, Kaiser MG (2001). "Bone morphogenetic protein in spinal fusion: overview and clinical update". ...
Albinterferon
... (alb-IFN, trade name Albuferon) is a recombinant fusion protein drug consisting of interferon alpha (IFN-α) ... November 2002). "Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in ...