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*  Diabetes insipidus
Central DI (CDI) is due to a lack of the hormone vasopressin (antidiuretic hormone). This can be due to damage to the ... When released, ADH binds to V2 G-protein coupled receptors within the distal convoluted tubules, increasing cyclic AMP, which ... Smith D, McKenna K, Moore K, Tormey W, Finucane J, Phillips J, Baylis P, Thompson CJ (2002). "Baroregulation of vasopressin ... Nephrogenic diabetes insipidus (NDI) occurs when the kidneys do not respond properly to vasopressin. Dipsogenic DI is due to ...
*  Vasopressin receptor
... antagonists (VRAs) are drugs that block vasopressin receptors. Most commonly VRAs are used to treat ... There are three subtypes of vasopressin receptor: V1A (V1), V1B (V3) and V2. V1 receptors (V1Rs) are found in high density on ... "Vasopressin and Oxytocin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... Vasopressin receptor antagonists Holmes CL, Landry DW, Granton JT (December 2003). "Science review: Vasopressin and the ...
*  Vasopressin receptor antagonist
A vasopressin receptor antagonist (VRA) is an agent that interferes with action at the vasopressin receptors. Most commonly ... act by directly blocking the action of vasopressin at its receptors (V1A, V1B and V2). These receptors have a variety of ... "Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands". ... V2 receptor antagonism increases plasma vasopressin concentration, which may cause unopposed hyperstimulation of the ...
*  Vasopressin receptor 2
... (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor ... "Vasopressin and Oxytocin Receptors: V2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... Vasopressin receptor antagonists that are selective for the V2 receptor include: Tolvaptan (FDA-approved) Lixivaptan Mozavaptan ... Faà V, Ventruto ML, Loche S, Bozzola M, Podda R, Cao A, Rosatelli MC (Sep 1994). "Mutations in the vasopressin V2-receptor gene ...
*  Vasopressin receptor 1A
V1a vasopressin receptor antidiuretic hormone receptor 1A SCCL vasopressin subtype 1a receptor V1-vascular vasopressin receptor ... Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major ... "Vasopressin and Oxytocin Receptors: AVPR1A". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... the vasopressin receptor AVPR1A distribution differs both between and within species; vasopressin production occurs in the ...
*  Vasopressin receptor 1B
Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein ... arginine vasopressin receptor 1B) gene. V1BR acts as a receptor for vasopressin. AVPR1B belongs to the subfamily of G-protein ... "Vasopressin and Oxytocin Receptors: V1B". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... Nelivaptan (SSR149415) and D-[Leu4-Lys8]-vasopressin are a specific antagonist and agonist for the vasopressin 1b receptor, ...
*  Angiotensin II receptor type 1
Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Molecular pharmacology and modeling of vasopressin receptors". Progress ... Angiotensin II receptor type 1 or AT1 receptor is the best characterized angiotensin receptor. It has vasopressor effects and ... The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II. The activated receptor in turn couples to ... "Angiotensin Receptors: AT1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
*  Species-typical behavior
Young, Larry J. (1999). "Oxytocin and Vasopressin Receptors and Species-Typical Social Behaviors". Hormones and Behavior. 36 (3 ... prairie voles are monogamous; they also have a high density of oxytocin receptors (OTRs) in a brain structure called the ... The way in which hormones alter these receptors is an important behavioral regulator. Consider the ways in which gonads affect ... In addition, an increase in maternal grooming has been shown to increase the number of glucocorticoid receptors in the brains ...
*  Aquaporin 2
When it is needed, vasopressin binds to the cell surface vasopressin receptor thereby activating a signaling pathway that ... Mutations in the vasopressin receptor cause a similar X-linked phenotype. Lithium, which is often used to treat bipolar ... Robben JH, Knoers NV, Deen PM (August 2006). "Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water ... Bouley R, Hasler U, Lu HA, Nunes P, Brown D (May 2008). "Bypassing vasopressin receptor signaling pathways in nephrogenic ...
*  Syndrome of inappropriate antidiuretic hormone secretion
Conivaptan - an antagonist of both V1A and V2 vasopressin receptors. Tolvaptan - an antagonist of the V2 vasopressin receptor.[ ... ADH activates V2 receptors on the basolateral membrane of principal cells in the renal collecting duct, initiating a cyclic AMP ... Because not all people with this syndrome have elevated levels of vasopressin, the term "syndrome of inappropriate antidiuresis ... needs update] Baylis, PH; Thompson, CJ (November 1988). "Osmoregulation of vasopressin secretion and thirst in health and ...
*  Mozavaptan
... (INN) is a vasopressin receptor antagonist marketed by Otsuka. In Japan, it was approved in October 2006 for ...
*  Testosterone
Delville Y, Mansour KM, Ferris CF (July 1996). "Testosterone facilitates aggression by modulating vasopressin receptors in the ... Studies have also found that testosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus. The ... The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind ... receptors reduces androgen receptor expression in the rat anteroventral periventricular nucleus and sexually dimorphic preoptic ...
*  Distal convoluted tubule
Arginine vasopressin receptor 2 is also expressed in the DCT. Thiazide diuretics inhibit Na+/Cl− reabsorption from the DCT by ...
*  C1QTNF1
... has been shown to interact with Arginine vasopressin receptor 2. GRCh38: Ensembl release 89: ENSG00000173918 - Ensembl ... a G-protein-coupled receptor interacting protein". Regul Pept. 109 (1-3): 173-9. doi:10.1016/S0167-0115(02)00201-X. PMID ... a G-protein-coupled receptor interacting protein". Regul. Pept. Netherlands. 109 (1-3): 173-9. doi:10.1016/S0167-0115(02)00201- ...
*  Osmotherapy
Vasopressin receptors activated by vasopressin are found on the basolateral membrane of the cells lining the collecting ducts ... Through the process of aquaresis, conivapten which is a vasopressin receptor antagonist improves serum sodium concentration ... Targets identified includes: NKCC1, SUR1/ TRPM4 channel, Vasopressin receptor antagonist. During early and reperfusion stage of ...
*  Beta-2 adrenergic receptor
Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Molecular pharmacology and modeling of vasopressin receptors". Progress ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-3 adrenergic ... This appears to be mediated by cAMP induced PKA phosphorylation of the receptor. Actions of the β2 receptor include: Heart ... The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor ...
*  Autosomal dominant polycystic kidney disease
Tolvaptan, an aquaretic drug, is a vasopressin receptor 2 (V2) antagonist. Pre-clinical studies had suggested that the molecule ... "The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors". Am. J. Physiol. Renal ... cAMP could be involved in the enlargement of ADPKD cysts, and studies on rodents confirmed the role of vasopressin in ...
*  Genetics of social behavior
An insightful study of vasopressin is its role in the stimulation of monogamous behavior. The V1a vasopressin receptor gene is ... Therefore, it is alteration of vasopressin receptor gene expression patterns is thought to affect social behavior, rather than ... In the male Drosophila ejaculate, there is a sex peptide (SP) which binds to the sex peptide receptor (SRP) in the female's fru ... cVA complexes with other proteins to form a ligand, which binds to the odorant receptor Or67d present in OSNs, which is ...
*  Coagulation
Desmopressin is used to improve platelet function by activating arginine vasopressin receptor 1A. Coagulation factor ... It is characterized by a defect in GPIIb/IIIa fibrinogen receptor complex. When GPIIb/IIIa receptor is dysfunctional, ... GPIb, the receptor for vWF, can be defective and lead to lack of primary clot formation (primary hemostasis) and increased ... The granules' contents activate a Gq-linked protein receptor cascade, resulting in increased calcium concentration in the ...
*  Parental brain
This increase correlates with increase in vasopressin receptors in this area of the paternal brain. With age, this effect is ... Kozorovitskiy, Y; Hughes, M; Lee, K; Gould, E (Sep 2006). "Fatherhood affects dendritic spines and vasopressin V1a receptors in ... "Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors ... Rat mothers who received low levels of maternal care as pups have lower levels of expression of the glucocorticoid receptor ...
*  Paternal brain
This increase correlates with increase in vasopressin receptors in this area of the paternal brain. With age, this effect is ... Wang, Z.; Ferris, C. F.; De Vries, G. J. (1994-01-04). "Role of septal vasopressin innervation in paternal behavior in prairie ... In prairie voles, the neuropeptide vasopressin was found to induce paternal behaviors in virgin-offspringless males suggesting ... sensitive to infants with changing hormonal levels and increased sensitivity to hormones by up-regulating hormonal receptors. ...
*  Social monogamy in mammalian species
Polygamous voles have a significantly smaller number of vasopressin receptors and remain shy even after mating. Thus, the ... which led to the identification of chemicals that fit into those receptors. In addition to its known role, vasopressin (which ... Vasopressin, a hormone that induces a male prairie vole (Microtus ochrogasters) to mate with one female and stay by her side in ... There is a significant difference in the distribution of protein receptors in the brains of monogamous and polygamous voles, ...
*  Merotocin
... is potent (EC50 < 0.1 nM) and highly selective (>1000-fold over the related vasopressin receptors). Carbetocin ... Yang Y, Li H, Ward R, Gao L, Wei JF, Xu TR (2014). "Novel oxytocin receptor agonists and antagonists: a patent review (2002 - ... "Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics". Journal of Neuroendocrinology ... is a peptidic agonist of the oxytocin receptor that was derived from oxytocin. It is under development by Ferring ...
*  Relcovaptan
... (SR-49059) is a non-peptide vasopressin receptor antagonist, selective for the V1a subtype. It has shown positive ... PMID 16794787 Decaux G, Soupart A, Vassart G. Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet. 2008 May 10; ... Lemmens-Gruber R, Kamyar M. Vasopressin antagonists. Cellular and Molecular Life Sciences. 2006 Aug;63(15):1766-79. ...
*  PF-184563
... an orally active V1a vasopressin receptor antagonist, in the prevention of dysmenorrhoea". Br. J. Obstet. Gynaecol. 107 (5): ... PF-184563 is a potent, selective non-peptidic antagonist of the V1a receptor. The compound was discovered by Pfizer in its ...
*  List of investigational anxiolytics
CB1 and 5-HT1A receptor modulator [24] SRX-246 - vasopressin V1A receptor antagonist [25] List of investigational drugs ... 5-HT1A receptor agonist, 5-HT2A receptor antagonist [4] Vilazodone (EMD-68843, SB-659746A; Viibryd) - 5-HT1A receptor partial ... 5-HT1A receptor agonist, 5-HT2A receptor antagonist [18] Verucerfont (GSK-561679, NBI-77860) - CRF1 receptor antagonist [19] ... Agomelatine (AGO-178; Valdoxan) - melatonin MT1 and MT2 receptor agonist, 5-HT2C receptor antagonist[1] Riluzole sublingual ( ...
*  Aquaretic
Synthetic aquaretics are vasopressin receptor antagonists, such conivaptan, tolvaptan, demeclocycline and OPC-31260, as well as ... "Acute Aquaresis by the Nonpeptide Arginine Vasopressin (AVP) Antagonist OPC-31260 Improves Hyponatremia in Patients with ...