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*  Iron overload
Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats. Pathol ... ISBN 0-07-470436-2. [page needed] Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule ... Transferrin Last reviewed on October 28, 2009. Pietrangelo, Antonello (2010). "Hereditary Hemochromatosis: Pathogenesis, ...
*  Hepcidin
... transferrin receptor 2, bone morphogenic protein 6 (BMP6), matriptase-2, neogenin, BMP receptors, and transferrin. ...
*  Transferrin
... bound to its receptor. Transferrin receptor complex. The liver is the main site of transferrin synthesis but other ... Beta-2 transferrin Transferrin receptor Total iron-binding capacity Transferrin saturation Ferritin GRCh38: Ensembl release 89 ... Transferrin and its receptor have been shown to diminish tumour cells when the receptor is used to attract antibodies. ... PDB: 1suv​; Cheng Y, Zak O, Aisen P, Harrison SC, Walz T (Feb 2004). "Structure of the human transferrin receptor-transferrin ...
*  Transferrin receptor
Earlier two transferrin receptors in humans, transferrin receptor 1 and transferrin receptor 2 had been characterized and until ... "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ... Transferrin receptor 1 Transferrin receptor 2 GAPDH Qian ZM, Li H, Sun H, Ho K (December 2002). "Targeted drug delivery via the ... "Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor ...
*  Lactoferrin
Exons of the lactoferrin gene in oxen have a similar size to the exons of other genes of the transferrin family, whereas the ... The lactoferrin receptor plays an important role in the internalization of lactoferrin; it also facilitates absorption of iron ... Lactoferrin is one of the transferrin proteins that transfer iron to the cells and control the level of free iron in the blood ... Liao Y, Lopez V, Shafizadeh TB, Halsted CH, Lönnerdal B (2007). "Cloning of a pig homologue of the human lactoferrin receptor: ...
*  Iron response element
In contrast, binding to multiple IREs in the 3' UTR of the transferrin receptor (involved in iron acquisition) leads to ... "A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA". ...
*  Human iron metabolism
... also acts as a transferrin receptor. Transferrin-bound ferric iron is recognized by these transferrin receptors, triggering a ... "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ... Most cell types take up iron primarily through receptor-mediated endocytosis via transferrin receptor 1 (TFR1), transferrin ... Du F, Qian C, Qian ZM, Wu XM, Xie H, Yung WH, Ke Y (Jun 2011). "Hepcidin directly inhibits transferrin receptor 1 expression in ...
*  Endosome
... iron is released from the transferrin, and then the iron-free transferrin (still bound to the transferrin receptor) returns ... 1983). "Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells". Journal of ... Dautry-Varsat, A. (Mar 1986). "Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor". ... and the iron transport protein transferrin. Internalization of these receptors from the plasma membrane occurs by receptor- ...
*  Gallium scan
Somatostatin receptors are overexpressed in many NETs, so that the 68Ga DOTA conjugated peptide is preferentially taken up in ... Gallium (III) (Ga3+) binds to transferrin, leukocyte lactoferrin, bacterial siderophores, inflammatory proteins, and cell- ... and remains due to binding with macrophage receptors). Ga-67 also attaches to the siderophore molecules of bacteria themselves ... Uptake is thought to be associated with a range of tumour properties including transferring receptors, anaerobic tumor ...
*  Iron-responsive element-binding protein
In low-iron conditions, IRE-BPs allow the cell to keep producing transferrin receptors. And more transferrin receptors make it ... they change shape and unbind the transferrin receptor mRNA. The transferrin receptor mRNA is rapidly degraded without the IRE- ... Since iron is tightly bound to transferrin, cells throughout the body have receptors for transferrin-iron complexes on their ... On its own, the IRE-BP binds to the IREs of ferritin and transferrin receptor mRNA. But, when iron binds to the IRE-BP, the IRE ...
*  Haemochromatosis type 3
... is a type of Iron overload disorder associated with deficiencies in transferrin receptor 2. It exhibits ... 2002). "Hemochromatosis due to mutations in transferrin receptor 2". Blood Cells Mol. Dis. 29 (3): 465-70. doi:10.1006/bcmd. ... May 2001). "New mutations inactivating transferrin receptor 2 in hemochromatosis type 3". Blood. 97 (9): 2555-60. doi:10.1182/ ...
*  Transferrin receptor 1
"Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ... Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is ... Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Lett. 518 (1 ... Transferrin receptor 2 Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000072274 - Ensembl, May 2017 GRCm38: ...
*  Transferrin receptor 2
2001). "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ... 1999). "Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family". J. Biol. Chem. 274 ... 2003). "Heterotypic interactions between transferrin receptor and transferrin receptor 2". Blood. 101 (5): 2008-14. doi:10.1182 ... although its role is minor compared to transferrin receptor 1. This gene is a member of the transferrin receptor-like family ...
*  Soluble transferrin receptor
... conventionally refers to the cleaved extracellular portion of transferrin receptor 1 that is ... has been reported as a soluble receptor for transferrin. It has been demonstrated to deliver more transferrin as compared to ... Blood testing of the soluble transferrin receptor (sTfR) is used as a measure of functional iron staus and the investigation of ... Ferguson, BJ; Skikne, BS; Simpson, KM; Baynes, RD; Cook, JD (April 1992). "Serum transferrin receptor distinguishes the anemia ...
*  Melanotransferrin
1986). "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor". Am. J. ... 1996). "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary ... This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in ... The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance ...
*  Ulcerative colitis
"Identification and characterization of the chicken transferrin receptor". The Biochemical Journal. 232 (3): 735-741. doi: ...
*  GABARAP
Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Letters. 518 ... Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory ... receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69-72. doi:10.1038/16264. PMID ... receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815-823. doi:10.1046/j.0022- ...
*  HFE (gene)
"Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ... The HFE protein interacts with the transferrin receptor TFRC. Its primary mode of action is the regulation of the iron storage ... functions to regulate circulating iron uptake by regulating the interaction of the transferrin receptor with transferrin. The ... an extracellular transferrin receptor-binding region (α1 and α2), a portion that resembles immunoglobulin molecules (α3), a ...
*  Bacteriocin
Farkas-Himsley H, Musclow CE (1986). "Bacteriocin receptors on malignant mammalian cells: are they transferrin receptors?". ... They often consist of a receptor binding domain, a translocation domain and a cytotoxic domain. Combinations of these domains ...
*  SH3BP4
2006). "TTP specifically regulates the internalization of the transferrin receptor". Cell. 123 (5): 875-88. doi:10.1016/j.cell. ... 1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". ... specifically controlling the internalization of a specific protein receptor. GRCh38: Ensembl release 89: ENSG00000130147 - ...
*  PLOS
"Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor". PLoS Biology. 1 (3): e1. doi:10.1371/journal.pbio ...
*  Glyceraldehyde 3-phosphate dehydrogenase
"The macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor". The Journal of ... "Characterization of glyceraldehyde-3-phosphate dehydrogenase as a novel transferrin receptor". The International Journal of ... 5-trisphosphate receptor to regulate intracellular Ca2+ signaling; Oct-1 to form the coactivator complex OCA-S, which is ... Transferrin on the surface of diverse cells and in extracellular fluid; Lactate dehydrogenase; Lactoferrin; Apurinic/ ...
*  Mir-320
Schaar DG, Medina DJ, Moore DF, Strair RK, Ting Y (2009). "miR-320 targets transferrin receptor 1 (CD71) and inhibits cell ...
*  Gambogic acid
2005). "A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid". Proceedings of the National ... a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB ... Gambogic acid has also been found to bind to transferrin receptor1 (TfR) and rapidly induce cell apoptosis without competing ... with the transferrin (Tf) binding site. A brief exposure to this compound resulted in a rapid start to apoptosis, including ...
*  Hemosiderosis
Lu JP, Hayashi K, Okada S, Awai M (1991). "Transferrin receptors and selective iron deposition in pancreatic B cells of iron- ... Selective iron deposition in the beta cells of pancreatic islets leads to diabetes due to distribution of transferrin receptor ... Brown induration Siderosis Lu JP, Hayashi K (1995). "Transferrin receptor distribution and iron deposition in the hepatic ...
*  Tej P. Singh
... a transferrin-cum-lactoferrin: crystal structure of camel apolactoferrin at 2.6 A resolution and structural basis of its dual ... endothelin receptor, endothelin converting enzyme, breast cancer regression proteins and matrix metanosomal proteins as well as ... exploited for making specific peptides to act as tight inhibitors of target enzymes and potent antagonists of target receptors ...
*  Blood-brain barrier
"Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor". Proc Natl ... However, vectors targeting BBB transporters, such as the transferrin receptor, have been found to remain entrapped in brain ... receptor-mediated transcytosis for insulin or transferrin; and the blocking of active efflux transporters such as p- ... It was reported that those natural substances such as albumin, α-1-fetoprotein or transferrin with elevated plasma ...