The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone ... IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Thyrotropin+Receptors at ... resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene". The New England Journal of Medicine. 332 (3): ... Farid NR, Kascur V, Balazs C (Jul 2000). "The human thyrotropin receptor is highly mutable: a review of gain-of-function ...

... (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone. The ... "Thyrotropin-Releasing Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... Receptors,+Thyrotropin-Releasing+Hormone at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (CS1 ... Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: Cloning and regulation of its expression". pp. 341-63. doi: ...

Identification of thyrotropin receptors in human thymus". Journal of Clinical Investigation. 98 (10): 2228-34. doi:10.1172/ ...

... and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma)". Medical Science Monitor. ... SST2A receptor and SST2B receptor are seen in some brain and spinal cord areas in a rodent. Somatostatin receptor 2a has a ... SST2A receptor is made up of 369 amino acids and 346 amino acids make up the SST2B receptor. Somatostatin receptor 2a and ... somatostatin receptor 2a (SSTR2A) and somatostatin receptor 2b (SSTR2B). In a rodent, somatostatin receptor 2a is longer ...

"The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. ... Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE (1994). "The human thyrotropin receptor activates G- ... 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP ... Petit A, Geoffroy P, Bélisle S (1997). "Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 ...

2005). "Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway". EMBO J. 24 (7): 1364-74. doi:10.1038/ ... a GTPase activating protein for ARF6 implicated in receptor recycling and exocytosis. SCRIB is found in the cell membrane most ...

The thyrotropin receptor (TSH receptor) is the antigen for TSH receptor antibodies (TRAbs). It is a seven transmembrane G ... thyrotropin receptor antibodies (TRAb) and thyroglobulin antibodies (TgAb). TRAb's are subdivided into activating, blocking and ... Binding of the antibody to the amino terminus of the TSH receptor shows stimulatory activity, whereas binding to residues 261- ... These antibodies activate adenylate cyclase by binding to the TSH receptor. This causes the production of thyroid hormones and ...

"GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response". Molecular Endocrinology. 10 (9): ... Lefkowitz RJ (July 1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor ... "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2 ... Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated ...

Brokken LJ, Wiersinga WM, Prummel MF (2003). "Thyrotropin receptor autoantibodies are associated with continued thyrotropin ... Lechan, Ronald M.; Fekete, C (2004). "Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non- ... Prummel MF, Brokken LJ, Wiersinga WM (2004). "Ultra short-loop feedback control of thyrotropin secretion". Thyroid. 14 (10): ... Midgley JE, Hoermann R, Larisch R, Dietrich JW (2013). "Physiological states and functional relation between thyrotropin and ...

T3 could then bind to the thyroid hormone receptor in these neurons and affect the production of thyrotropin-releasing hormone ... Unlike gonadal steroid receptors, glucocorticoid receptors are very widespread throughout the brain; in the paraventricular ... Estrogen receptors (and progesterone receptors) are found mainly in neurons in the anterior and mediobasal hypothalamus, ... Estrogen receptor (ER) has been shown to transactivate other transcription factors in this manner, despite the absence of an ...

Adenosine modulates the preBötC output via activation of the A1 and A2A receptor subtypes. An adenosine A1 receptor agonist has ... Other markers for the preBötC include peptide hormone thyrotropin releasing hormone (TRH) and the glycoprotein reelin. In ... The suppression of muscarinic receptors and the activation of nicotinic receptors due to prenatal exposure to nicotine have ... µ-opioid receptors (µORs), as well as somatostatin (SST) and SST2a-type receptors. Of course, selectively does not mean ...

Valente, William (July 19, 1982). "Monoclonal antibodies to the thyrotropin receptor: Stimulating and blocking antibodies ... Studies have shown that blocking antibodies can bind to and prevent thyrotropin binding, resulting in reduced cAMP levels in ...

"The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". ... Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated ... Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated ... Sidhu A, Niznik HB (Nov 2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins". International ...

"The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". ... Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated ... Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated ... Zhang J, Pratt RE (Jun 1996). "The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus". The ...

"The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". ... G12/G13 alpha subunits G protein-coupled receptor Heterotrimeric G protein Rho family of GTPases GRCh38: Ensembl release 89: ... Becker KP, Garnovskaya M, Gettys T, Halushka PV (Jul 1999). "Coupling of thromboxane A2 receptor isoforms to Galpha13: effects ... Gilman, AG (1987). "G proteins: transducers of receptor-generated signals". Annual Review of Biochemistry. 56: 615-649. doi: ...

In Igsf1 deficient mice, the receptor for TRH is downregulated in the pituitary. This decrease could explain, at least in part ... TSH secretion is controlled by thyrotropin-releasing hormone (TRH), which is released by neurons in the hypothalamus of the ... How the loss of IGSF1 causes a decrease in TRH receptors is presently unknown. GRCh38: Ensembl release 89: ENSG00000147255 - ...

Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone ... Retinoid X receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear ... Retinoid X receptor Retinoid X receptor gamma has been shown to interact with ITGB3BP. GRCh38: Ensembl release 89: ... This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the ...

"A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta- ... Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear ... The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for ... Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor ...

1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families ... AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U (2001). "The angiotensin II AT2 receptor is an AT1 receptor antagonist". J. ... Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype ... Offermanns S, Simon MI (1995). "G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C". J. Biol. Chem ...

1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families ... Georgoussi Z, Carr C, Milligan G (1993). "Direct measurements of in situ interactions of rat brain opioid receptors with the ... Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go". J. Biol. Chem. 267 ( ... 2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2-3): 179-212. doi:10.1016/ ...

The basolateral membrane of follicular cells contains thyrotropin receptors which bind to thyroid-stimulating hormone (TSH) ...

Thyrotropin-releasing hormone (TRH) receptors are present in both the melanotropes of the pars intermedia and the corticotropes ... releasing dopamine which then binds to dopamine receptors on the melanotropes. Activation of these dopamine receptors leads to ... In these horses, the thyrotropin-releasing hormone stimulation test should either be used as an initial screening test, or to ... Kam YN, McKenzie K, Coyle M, Bertin FR (October 2021). "Repeatability of a thyrotropin-releasing hormone stimulation test for ...

... thyrotropin-releasing hormone [TRH], and oxytocin); and endocannabinoids. GPCRs that act as receptors for stimuli that have not ... transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors ( ... G protein-coupled receptors database List of MeSH codes (D12.776) Metabotropic receptor Orphan receptor Pepducins, a class of ... is a receptor that can bind with stimulative signal molecules, while inhibitory hormone receptor (Ri) is a receptor that can ...

"Functional expression of the thyrotropin receptor in C cells: new insights into their involvement in the hypothalamic-pituitary ... Barasch J, Gershon MD, Nunez EA, Tamir H, al-Awqati Q (December 1988). "Thyrotropin induces the acidification of the secretory ... They may also have a role in regulating thyroid hormones production locally, as they express thyrotropin-releasing hormone. ... Gkonos PJ, Tavianini MA, Liu CC, Roos BA (December 1989). "Thyrotropin-releasing hormone gene expression in normal thyroid ...

... to act on the D2 receptors of lactotrophs, causing inhibition of prolactin secretion. Thyrotropin-releasing hormone has a ... The D2 receptor is involved in the regulation of prolactin secretion, and agonists of the receptor such as bromocriptine and ... When prolactin binds to the receptor, it causes it to dimerize with another prolactin receptor. This results in the activation ... The hormone acts in endocrine, autocrine, and paracrine manners through the prolactin receptor and numerous cytokine receptors ...

"Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats ... Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G- ... heightens receptor activity. Thus, only the initial interaction with its unknown ligand and other membrane bound receptors is ... "Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily". Biochem ...

"Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats ... G protein-coupled receptors, All stub articles, Transmembrane receptor stubs). ... Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. LGR4 is ... "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4". Hsu SY, Liang SG, Hsueh AJ (1999). " ...

... polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor ... It may facilitate presentation by APC, enhance the binding affinity of the T-cell receptor, and activating specific T-cells. ... and Thyroid stimulating hormone receptor Antibodies (TRAb). The antibody attacks ultimately lead to hypothyroidism, which is ...

Dopamine acts on pituitary lactotroph D2 receptors to inhibit prolactin secretion while other peptides and hormones, such as ... thyrotropin releasing hormone (TRH), stimulate prolactin secretion. As a result, hyperprolactinemia may be caused by ... Prolactin secretion in the pituitary is normally suppressed by the brain chemical dopamine, which binds to dopamine receptors. ... two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas". Clinical Endocrinology. 53 (1): 53-60. doi ...

Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y (December 2002). "Neuroprotective effect and brain receptor binding of ... 2000). "A study of thyrotropin-releasing hormone for the treatment of spinal muscular atrophy: a preliminary report". American ... July 1994). "Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy". Journal of Child Neurology ... Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog, which mimics the ...