Loading...
*  Thromboregulation
These signaling elements include thromboxane A2, receptor type α, phospholipase Cβ3, and IP3 receptors. Signalization in ... TX2 effects are mediated by G protein-coupled receptors, subtypes TPα and TPβ. Both receptors mediate phospholipase C ... PGE1 binds to IP receptors. IP receptors bind with ionophores that induce ADP and serotonin secretion. PGE1 inhibits the ... Thromboxane A2 (TX2) has a positive feedback in platelet activation. It is produced by the oxygenation of arachidonic acid by ...
*  Prostaglandin receptor
One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well. All ... Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as ... Prostanoid receptor Eicosanoid receptor Prostaglandin Tsuboi K, Sugimoto Y, Ichikawa A (2002). "Prostanoid receptor subtypes". ... There are 9 established prostanoid receptors. The following table gives these receptors: a) full name; b) shortened names; c) ...
*  Prostaglandin
... s ligate a sub-family of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors ... A thromboxane synthase (TxAS) has also been identified. Prostaglandin-F synthase (PGFS) catalyzes the formation of 9α,11β-PGF2α ... DP1-2 receptors bind to PGD2). The diversity of receptors means that prostaglandins act on an array of cells and have a wide ... Conversely, thromboxanes (produced by platelet cells) are vasoconstrictors and facilitate platelet aggregation. Their name ...
*  Ramatroban
... (INN) is a thromboxane receptor antagonist. It is also a DP2 receptor antagonist. It is indicated for the treatment ... Endo S, Akiyama K (November 1996). "[Thromboxane A2 receptor antagonist in asthma therapy]". Nippon Rinsho (in Japanese). 54 ( ... Fiedler VB, Seuter F, Perzborn E (December 1990). "Effects of the novel thromboxane antagonist Bay U 3405 on experimental ...
*  Thromboxane receptor
The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid receptor cloned. ... The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R ... These receptor down regulating events are triggered by the G protein-coupled receptor kinases mobilized during TP receptor ... "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases". J. ...
*  Thromboxane A2
Receptors that mediate TXA2 actions are thromboxane A2 receptors. The human TXA2 receptor (TP) is a typical G protein-coupled ... Smyth, Emer M (2010-04-01). "Thromboxane and the thromboxane receptor in cardiovascular disease". Clinical lipidology. 5 (2): ... Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot. Thromboxane A2 is also a ... Yamamoto, K.; Ebina, S.; Nakanishi, H.; Nakahata, N. (November 1995). "Thromboxane A2 receptor-mediated signal transduction in ...
*  Ifetroban
... is a potent and selective thromboxane receptor antagonist. Dockens, RC; Santone, KS; Mitroka, JG; Morrison, RA; Jemal ...
*  Terutroban
... is a selective antagonist of the thromboxane receptor. It blocks thromboxane induced platelet aggregation and ...
*  Terbogrel
... is an orally available thromboxane A2 receptor antagonist and a thromboxane A synthase inhibitor. The drug was ... a Dual-Acting Agent for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition". Acta Crystallographica. 56 (Pt 10 ... Capra V, Bäck M, Angiolillo DJ, Cattaneo M, Sakariassen KS (2014). "Impact of vascular thromboxane prostanoid receptor ... a Combined Thromboxane A2 Receptor and Synthase Inhibitor, in Healthy Subjects". British Journal of Clinical Pharmacology. 58 ( ...
*  Hepoxilin
... and TrXC3 do inhibit the binding of TXA2 to the human thromboxane receptor. HXA3 and HXB3 appear responsible for hyperalgesia ... also termed the capsaicin receptor or vanilloid receptor) and TRPA1 (Transient receptor potential cation channel, member A1) ... they competitively inhibit the binding of TXA2 to its thromboxane receptor, α isoform. Contrastingly, 15-lipoxgenase-derived ... HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries". AJP: Heart and Circulatory ...
*  Adenosine diphosphate receptor inhibitor
Activation of the glycoprotein IIb/IIIa receptors increases thromboxane production and prolonged platelet aggregation. ... P2Y12 receptor is a G-coupled receptor and is activated by adenosine diphosphate. ADP binds to the P2Y12 receptor that leads to ... The P2Y12 receptor is a surface bound protein found on blood platelets. They belong to G protein-coupled purinergic receptors ( ... These drugs antagonize the P2Y12 platelet receptors and therefore prevent the binding of ADP to the P2Y12 receptor. This leads ...
*  Thromboxane
... acts by binding to any of the thromboxane receptors, G-protein-coupled receptors coupled to the G protein Gq. ... The two major thromboxanes are thromboxane A2 and thromboxane B2. The distinguishing feature of thromboxanes is a 6-membered ... thromboxane synthase) in the synthesis of thromboxane. Ifetroban is a potent and selective thromboxane receptor antagonist. ... Picotamide has activity both as a thromboxane synthase inhibitor and as a thromboxane receptor antagonist. Ridogrel is another ...
*  Testosterone
Ajayi AA, Mathur R, Halushka PV (Jun 1995). "Testosterone increases human platelet thromboxane A2 receptor density and ... Testosterone also regulates the population of thromboxane A2 receptors on megakaryocytes and platelets and hence platelet ... Ajayi AA, Halushka PV (May 2005). "Castration reduces platelet thromboxane A2 receptor density and aggregability". QJM. 98 (5 ... The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind ...
*  12-Hydroxyeicosatetraenoic acid
HETE bind to and act as Competitive antagonists of the Thromboxane receptor which mediates the actions of Thromboxane A2 and ... if leukotriene B4 interacts with the GPR31 receptor; b) if BLT2 receptor antagonists interfere with the GPR31 receptor; and c) ... The BLT2 receptor, in contrast to the GPR31 receptor, appears to be expressed at a high level in a wide range of tissues ... The vasodilating effect on mouse mesenteric arteries appears due to 12S-HETE's ability to act as a Thromboxane receptor ...
*  Eicosanoid receptor
TXA2 (thromboxane): TP-(TXA2) (TBXA2R) - TBXA2R; TP is the receptor for thromboxane A2; relative potencies in binding to and ... The TP receptor is expressed in most human cells types as two alternatively spliced isoforms, TP receptor-α and TP receptor β, ... Prostanoids and Prostaglandin receptors Prostanoids are prostaglandins (PG), thromboxanes (TX), and prostacyclins (PGI). Seven ... A final prostanoid receptor, DP2, is structurally related to the chemotaxis class of receptors and unlike the other prostanoid ...
*  GRK6
"Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases". J. ... 1998). "β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor ... 2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function". J. Biol. ... 1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor ...
*  Picotamide
It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses ... Capra V, Bäck M, Angiolillo DJ, Cattaneo M, Sakariassen KS (2014). "Impact of vascular thromboxane prostanoid receptor ... to activation of the thromboxane receptor. Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis ...
*  Interleukin 10
Lack of IL-10 has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular ... IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, ... The receptor complex for IL-10 also requires the IL10R2 chain to initiate signalling. This ligand-receptor combination is found ... IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 ...
*  Eicosanoid
"In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition ... the cellular receptors (see Cell surface receptor) that they stimulate or, where noted, antagonize to attain this activity, ... Chiang N, Serhan CN, Dahlén SE, Drazen JM, Hay DW, Rovati GE, Shimizu T, Yokomizo T, Brink C (2006). "The lipoxin receptor ALX ... Eicosanoid receptors Edwards IJ, O'Flaherty JT (2008). "Omega-3 Fatty Acids and PPARgamma in Cancer". PPAR Research. 2008: ...
*  Platelet
... and thromboxane-A synthase. Platelets secrete thromboxane A2, which acts on the platelet's own thromboxane receptors on the ... These receptors trigger intraplatelet signaling, which converts GPIIb/IIIa receptors to their active form to initiate ... Platelet GP1b-IX-V receptor binds with VWF; and GPVI receptor and integrin alpha2beta1 bind with collagen. The intact ... ADP on the other hand binds to purinergic receptors on platelet surface. Since the thrombocytic purinergic receptor P2Y12 is ...
*  GRK5
"Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases". The Journal ... "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase- ... "Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C". The Journal ... "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function". The Journal of ...
*  GNA13
Becker KP, Garnovskaya M, Gettys T, Halushka PV (Jul 1999). "Coupling of thromboxane A2 receptor isoforms to Galpha13: effects ... "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proceedings of the ... "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". ... "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) ...
*  Dihydroxy-E,Z,E-PUFA
... interfere with the activation of the TXA2 receptor (Thromboxane receptor) by TXA2. The linotrins appear to have similar or ... Stimulating agents such as collagen depend to platelets to make and release thromboxane A2 (TXA2) to mediate and/or enhance ...
*  List of MeSH codes (D12.776.543)
... receptors, thromboxane a2, prostaglandin h2 MeSH D12.776.543.750.075.800 -- receptors, thromboxane MeSH D12.776.543.750.075.800 ... receptors, thromboxane a2, prostaglandin h2 MeSH D12.776.543.750.100.200.800 -- receptors, thromboxane MeSH D12.776.543.750. ... 100.200.800.500 -- receptors, thromboxane a2, prostaglandin h2 MeSH D12.776.543.750.100.220.100 -- receptor, endothelin a MeSH ... receptors, thromboxane a2, prostaglandin h2 MeSH D12.776.543.750.100.047.625 -- receptor, angiotensin, type 1 MeSH D12.776. ...
*  PRDX4
"Peroxiredoxin-4 interacts with and regulates the thromboxane A(2) receptor". FEBS Lett. 581 (20): 3863-8. doi:10.1016/j.febslet ...
*  Index of biochemistry articles
... thrombin receptor - thrombomodulin - thromboxane receptor - thylakoid - thyroid hormone receptor - thyrotropin - thyrotropin ... interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 receptor - intermediate ... G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc fusion protein - galanin - gamete - gamma- ... IgE receptor - IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - ...
*  Prostacyclin receptor
Kim SH, Choi JH, Park HS, Holloway JW, Lee SK, Park CS, Shin HD (May 2005). "Association of thromboxane A2 receptor gene ... The Prostacyclin receptor , also termed the prostaglandin I2 receptor or just IP, is a receptor belonging to the prostaglandin ... IP receptors also appear involved in suppressing non-allergic inflammatory responses. IP receptor-deficient mice exhibit a ... "Prostanoid Receptors: IP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...