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*  Serotonin-norepinephrine-dopamine reuptake inhibitor
Nichols, DE; Nichols, CD (2008). "Serotonin receptors". Chemical Reviews. 108 (5): 1614-41. doi:10.1021/cr078224o. PMID ... They are an extension of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors ( ... A serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of ... 2011). "SEP-225289 serotonin and dopamine transporter occupancy: A PET study". Journal of Nuclear Medicine. 52 (7): 1150-5. doi ...
*  5-HT2B receptor
Serotonin transporter: 5-HT2B receptors regulate serotonin release via the serotonin transporter, and are important both to ... 5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the ... Research claims serotonin 5-HT2B receptors have effect on liver regeneration. 5-HT receptor GRCh38: Ensembl release 89: ... "The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors". FEBS Letters. 352 (3): 393-9. ...
*  Reuptake inhibitor
Serotonin reuptake inhibitor Serotonin-norepinephrine reuptake inhibitor Norepinephrine-dopamine reuptake inhibitor Serotonin- ... Pechnick RN, Bresee CJ, Poland RE (2006). "The role of antagonism of NMDA receptor-mediated neurotransmission and inhibition of ... increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin ... Instead of binding to the active site on the serotonin transporter, they bind to an allosteric site, which exerts its effects ...
*  5-HT receptor
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand- ... The 7 general serotonin receptor classes include a total of 14 known serotonin receptors. The specific types have been ... 5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors are found in the central and peripheral nervous systems ... The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin ...
*  Serotonin syndrome
Nisijima K, Yoshino T, Yui K, Katoh S (January 2001). "Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the ... Serotonin toxicity has a rapid onset after the administration of a serotonergic drug and responds to serotonin blockade such as ... The cause of serotonin toxicity or accumulation is an important factor in determining the course of treatment. Serotonin is ... In cases of serotonin syndrome caused by monoamine oxidase inhibitors oxygenation will not help to dispatch serotonin. In such ...
*  5-HT2C receptor agonist
5-HT receptor 5-HT2 receptor 5-HT2C receptor Serotonin receptor agonist Serotonin antagonist Serotonin Lorcaserin Vabicaserin ... In the late 1960s, non-selective serotonin receptor antagonists demonstrated a relationship between serotonin receptors and ... The 5-HT2C receptors are one of three subtypes that belong to the serotonin 5-HT2 receptor subfamily along with 5-HT2A and 5- ... The serotonin receptor agonist mCPP has a significant affinity for 5-HT2C receptors. mCPP patients experience multiple side ...
*  Osemozotan
5-HT1A receptor stimulation influences the release of various neurotransmitters including serotonin, dopamine, norepinephrine, ... Ago, Y.; Nakamura, S.; Baba, A.; Matsuda, T. (2008). "Neuropsychotoxicity of abused drugs: effects of serotonin receptor ... It has been noted that sensitization of cocaine may stem from action of the 5-HT 1A receptor. While the role of 5-HT receptors ... With repeated exposure of Osemozotan at the 5-HT1A receptors, there seems to be no change in the number of receptors, which is ...
*  TPH1
Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (January 2003). "Synthesis of serotonin by a second ... 2002). "Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's ... TPH1 was first discovered to synthesize serotonin in 1988 and was thought that there only was a single TPH gene until 2003, ... including serotonin, melatonin, tryptamine, N-methyltryptamine, and N,N-dimethyltryptamine. TPH1 is expressed in the body, but ...
*  Serotonin receptor agonist
A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner ... Activation of the 5-HT2A receptor is also implicated in serotonin syndrome caused by indirect serotonin receptor agonists like ... which is an agonist of both the 5-HT2A receptor and many other serotonin receptors, has never been associated with serotonin ... Most of these drugs also act as agonists of other serotonin receptors. Not all 5-HT2A receptor agonists are psychoactive. The ...
*  Serotonin receptor antagonist
A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action at serotonin (5-HT) receptors. ... "Oral serotonin type 3-receptor antagonists for prevention of chemotherapy-induced emesis". American Journal of Health-System ... that although some non-selective serotonin antagonists may have an particular affinity for a specific 5-HT receptor (and thus ... and many other organs and has been used in hypertension and psychosis Serotonin receptor agonist Lindley, C.; Blower, P. (2000 ...
*  5-Methoxytryptamine
Wu PH, Gurevich N, Carlen PL (1988). "Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n- ... 5-HT2C receptors (Ki = 52.48 nM) 5-HT4 receptors (Ki = 501.18 nM) 5-HT6 receptors (Ki = 69.18 nM) 5-HT7 receptors (Ki = 5.01 nM ... 5-HT1B receptors (Ki = 35 nM) 5-HT1D receptors (Ki = 7.3 nM) 5-HT1E receptors (Ki = 3151 nM) 5-HT1F receptors (Ki = 1166 nM) 5- ... Roth, Brian (2006). The serotonin receptors. Humana Press. p. 133. ISBN 978-1-58829-568-2. S. Nigra / Domenech T, et al., 1997 ...
*  Phenoxybenzamine
... also has irreversible antagonist/weak partial agonist properties at the serotonin 5-HT2A receptor. Due to its ... ISBN 978-0-07-148869-3. B. Olivier; I. van Wijngaarden; W. Soudijn (10 July 1997). Serotonin Receptors and their Ligands. ... They are used as antihypertensives because they block alpha-receptor-mediated vasoconstriction. The block on alpha-2 receptors ... Based on known information about the structures of these receptors, it likely involves attack by the cysteine at position 3.36 ...
*  Serotonin
There are various serotonin receptors. Serotonin is metabolized mainly to 5-HIAA, chiefly by the liver. Metabolism involves ... The reason for this is social experience alters the proportion between serotonin receptors (5-HT receptors) that have opposing ... CS1 maint: Multiple names: authors list (link) "Serotonin, serotonin receptors and their actions in insects". Neurotransmitter ... Except for the 5-HT3 receptor, a ligand-gated ion channel, all other 5-HT receptors are G-protein-coupled receptors (also ...
*  Tertatolol
... has also been shown to act as a serotonin 5-HT1A and 5-HT1B receptor antagonist, similarly to propranolol and ... May 1993). "(-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain". Naunyn- ... Soudijn, W.; Olivier, Berend; Wijngaarden, I. van (1997). Serotonin receptors and their ligands. Amsterdam: Elsevier. ISBN 0- ... molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". Eur. J ...
*  Ketanserin
"Serotonin receptors in the human brain--IV. Autoradiographic mapping of serotonin-2 receptors". Neuroscience. 21 (1): 123-39. ... 5-HT2B receptors (Ki = ? nM) 5-HT6 receptors (Ki = ~300 nM) 5-HT7 receptors (Ki = ? nM) D1 receptors (~300 nM) D2 receptors (Ki ... With tritium (3H) radioactively labeled ketanserin is used as a radioligand for serotonin 5-HT2 receptors, e.g. in receptor ... α1-adrenergic receptors (Ki = ~40 nM) α2-adrenergic receptors = ~200 nM)[citation needed] 5-HT1D receptors (Ki = ? nM) ...
*  Cyanodothiepin
Olivier, B.; van Wijngaarden, I.; Soudijn, W. (1997). Serotonin Receptors and their Ligands. Elsevier. p. 332. ISBN 978-0-444- ... and D2 receptors; the H1 receptor has not been assayed, but cyanodothiepin is less sedating than the related drug cianopramine ... It also has moderate affinity for the muscarinic acetylcholine receptors and weak/negligible affinity for the α1-adrenergic, 5- ... inhibitor of the reuptake of serotonin that was never marketed. ...
*  Glemanserin
Berend Olivier (10 July 1997). Serotonin Receptors and Their Ligands. Elsevier. p. 167. ISBN 978-0-444-82041-9. Retrieved 6 May ... Glemanserin (INN) (developmental code name MDL-11,939) is a drug which acts as a potent and selective 5-HT2A receptor ... 1988). "Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5-HT2 receptors". Drug Development ... glemanserin resulted in the development of the widely used and even more potent and selective 5-HT2A receptor antagonist ...
*  2-Methyl-5-hydroxytryptamine
Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of ... "Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure- ... closely related to the neurotransmitter serotonin which acts as a moderately selective full agonist at the 5-HT3 receptor. 5- ... and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in ...
*  Impulsivity
5HT2A is the serotonin receptor gene. The serotonin 2A receptor gene has been associated with both hyper locomotion, ADHD, as ... HTR2B a serotonin receptor gene. CTNNA2 encodes for a brain-expressed α-catenin that has been associated with Excitement- ... Another theory suggests that binge eating involves reward seeking, as evidenced by decreased serotonin binding receptors of ... DRD4 is the dopamine D4 receptor gene and is associated with ADHD and novelty seeking behaviors. It has been proposed that ...
*  5-Carboxamidotryptamine
Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of ... It has negligible affinity for the 5-HT1E and 5-HT1F receptors. 5-CT binds strongest to the 5-HT1A receptor and it was once ... 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as ... Wright, CE; Angus, JA (1989). "5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in ...
*  5-HT1B receptor
"Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B". "5-hydroxytryptamine (serotonin) receptor 1B, G protein- ... The 5-HT1B receptor is a 5-HT receptor subtype. 5-HT1B receptors are widely distributed throughout the CNS with the highest ... "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor ... Tsai SJ, Wang YC, Chen JY, Hong CJ (2003). "Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A ...
*  5-MeO-DMT
Its pharmacological action is mainly through serotonin receptors. Specifically, it shows high affinity for the 5-HT2 and 5-HT1A ... December 2006). "The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse ...
*  Indirect agonist
Fenfluramine is an indirect agonist of serotonin receptors. Fenfluramine binds to the serotonin transporter, blocking serotonin ... Baumann MH, Ayestas MA, Dersch CM, Partilla JS, Rothman RB (2000). "Serotonin transporters, serotonin release, and the ... disrupting the compartmentalization of serotonin into vesicles and increasing the concentration of cytoplasmic serotonin ... Cocaine is a monoamine transporter blocker and, thus, an indirect agonist of dopamine receptors. Cocaine binds the dopamine ...
*  Indole alkaloid
Dihydroergotamine is more selective to α-adrenergic receptors and has a weaker effect on serotonin receptors. Ergometrine is an ... Because of structural similarities with serotonin, many tryptamines can interact with serotonin 5-HT receptors. The main effect ... Mitragynine is an agonist of the μ-opioid receptor. Harmal alkaloids are antagonists to the GABAA-receptor, and ibogaine - to ... The Serotonin Receptors. From Molecular Pharmacology to Human Therapeutics. Humana Press. p. 96. ISBN 1-58829-568-0. Richard A ...
*  5-MeO-DET
... inhibits serotonin reuptake with an IC50 value of 2.4 µM and activates 5-HT2A receptors with an EC50 value of 8.11 nM ... Richard A. Glennon; Peter K. Gessner (April 1979). "Serotonin receptor binding affinities of tryptamine analogs". Journal of ... "Quasi-atomistic Receptor Surrogates for the 5-HT2A Receptor: A 3D-QSAR Study on Hallucinogenic Substances". Quantitative ... "Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes". Psychopharmacology. ...
*  List of investigational anxiolytics
5-HT1A receptor partial agonist and serotonin reuptake inhibitor [20] AVN-101 - 5-HT6 receptor antagonist [21] BNC-210 (IW-2143 ... 5-HT2A receptor antagonist [4] Vilazodone (EMD-68843, SB-659746A; Viibryd) - 5-HT1A receptor partial agonist and serotonin ... 5-HT1A receptor agonist, 5-HT2A receptor antagonist [18] Verucerfont (GSK-561679, NBI-77860) - CRF1 receptor antagonist [19] ... Agomelatine (AGO-178; Valdoxan) - melatonin MT1 and MT2 receptor agonist, 5-HT2C receptor antagonist[1] Riluzole sublingual ( ...
*  7,N,N-TMT
2,N,N-TMT 5,N,N-TMT 7-Methyl-αET Glennon RA; Liebowitz SM; Mack EC (August 1978). "Serotonin receptor binding affinities of ... Glennon RA; Gessner PK (April 1979). "Serotonin receptor binding affinities of tryptamine analogues". Journal of Medicinal ... 7,N,N-Trimethyltryptamine (7-methyl-DMT, 7-TMT), is a tryptamine derivative which acts as an agonist of 5-HT2 receptors. In ... DOBU, DOAM). 7-TMT also weakly inhibits reuptake of serotonin but with little effect on dopamine or noradrenaline reuptake. ...