... for example the retinoic acid receptor, retinoid X receptor and thyroid hormone receptor. Type III nuclear receptors ( ... September 2008). "Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor". PLOS Biology. 6 ( ... Some of these receptors such as FXR, LXR, and PPAR bind a number of metabolic intermediates such as fatty acids, bile acids and ... such as the androgen receptor, estrogen receptors, glucocorticoid receptor, and progesterone receptor. It has been noted that ...
Solt LA, Griffin PR, Burris TP (June 2010). "Ligand regulation of retinoic acid receptor-related orphan receptors: implications ... Feng S, Xu S, Wen Z, Zhu Y (2015). "Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and ... "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta". Nature Structural Biology. 10 (10): 820-5. doi: ... These include all-trans retinoic acid binds with high affinity to ROR-β and -γ but not ROR-α. Finally the RORs may function as ...
Froeschlé A, Alric S, Kitzmann M, Carnac G, Auradé F, Rochette-Egly C, Bonnieu A (July 1998). "Retinoic acid receptors and ... Davis RL, Cheng PF, Lassar AB, Thayer M, Tapscott S, Weintraub H (1989). "MyoD and achaete-scute: 4-5 amino acids distinguishes ... Nucleic Acids Res. 27 (2): 411-20. doi:10.1093/nar/27.2.411. PMC 148194. PMID 9862959. Puri PL, Iezzi S, Stiegler P, Chen TT, ... Retinoid X receptor alpha STAT3, and TCF3. GRCh38: Ensembl release 89: ENSG00000129152 - Ensembl, May 2017 GRCm38: Ensembl ...
Chung SS, Wang X, Roberts SS, Griffey SM, Reczek PR, Wolgemuth DJ (June 2011). "Oral administration of a retinoic Acid receptor ... of action includes blocking the conversion of vitamin A into its active form retinoic acid which binds to retinoic receptors ... Tash JS, Attardi B, Hild SA, Chakrasali R, Jakkaraj SR, Georg GI (June 2008). "A novel potent indazole carboxylic acid ... YCT529, a Vitamin A receptor antagonist, is in development by the startup YourChoice Pharmaceuticals as a male contraceptive. ...
Retinoic acid receptor alpha (RARα) and retinoid X receptor alpha (RXRα). In peripheral clocks, RARα and RXRα interact with ... This interaction depends upon humoral signaling by retinoic acid and serves to phase-shift the clock. Small heterodimer partner ... The predicted 824-amino acid human NPAS2 protein shares 87% sequence identity with mouse Npas2. The Npas2 gene has been found ... "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock ...
"All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta". Nat. Struct. Biol. 10 (10): 820-5. doi:10.1038/ ... RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear ... RAR-related orphan receptor beta has been shown to interact with NME1. RAR-related orphan receptor GRCh38: Ensembl release 89: ... "Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor". Proc. Natl. Acad. Sci. U.S.A. 93 ( ...
... as opposed to the retinoic acid receptors, the other major target of retinoic acid (the acid form of vitamin A). By so doing it ... The retinoic acid receptors (RARs) regulate cell differentiation and proliferation whereas RXRs regulate apoptosis. Bexarotene ... Dawson MI, Xia Z (January 2012). "The retinoid X receptors and their ligands". Biochimica et Biophysica Acta (BBA) - Molecular ... Rowe A (February 1997). "Retinoid X receptors". The International Journal of Biochemistry & Cell Biology. 29 (2): 275-278. doi: ...
... family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor ... "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J ... and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2 ... forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and ...
TIG1 is up-regulated by retinoic acid receptor but not by retinoid X receptor-specific synthetic retinoids. TIG1 may be a ... a novel retinoic acid receptor-responsive gene in skin". J. Invest. Dermatol. 106 (2): 269-74. doi:10.1111/1523-1747.ep12340668 ... latexin and to a skin protein that is encoded by a retinoic acid receptor-responsive gene, TIG1. Tazarotene Induced Gene 1 ( ...
"The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling". Cell. 122 (6): 835-47. doi:10.1016/ ... PRAME can inhibit retinoic acid signaling and retinoic acid mediated differentiation and apoptosis. PRAME overexpression in ... of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor". Immunity ...
It is a retinoid; more specifically, it is a fourth generation selective retinoic acid receptor (RAR)-γ agonist. Trifarotene ... Benzoic acids, 1-Pyrrolidinyl compounds, Orphan drugs, Anti-acne preparations, All stub articles, Dermatologic drug stubs). ...
... a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors". Proceedings of the National Academy ... and modulation of gene activation by receptors for retinoic acids and thyroid hormones". Annals of the New York Academy of ... Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the ... Liver X receptor beta has been shown to interact with NCOA6 and Retinoid X receptor alpha. GRCh38: Ensembl release 89: ...
... a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors". Proc. Natl. Acad. Sci. U.S.A. 91 (23 ... a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor". Proc. Natl. Acad. Sci. U.S. ... The liver X receptors are classified into subfamily 1 (thyroid hormone receptor-like) of the nuclear receptor superfamily, and ... Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier ...
... is selective for two types of retinoic acid receptors, RAR-γ and RAR-β. Like all retinoids, it affects the ability ... Acetylenic retinoid prodrug converted to the active metabolite, tazarotenic acid, with selective affinity for retinoic acid ... epidermal growth factor receptor, and various keratins. More than 99% of tazarotenic acid, the active metabolite of tazarotene ... for tazarotene is 26.1 L/kg and the VD for tazarotenic acid is 1.97 L/kg. Tazarotene is excreted from the body via feces and ...
Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000013588 - Ensembl, May 2017 ... The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays ... and named Retinoic Acid-Inducible Gene 1 (RAIG1). Its encoded protein was later named Retinoic acid-induced protein 3. This ... "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid". Genomics. 83 ( ...
May 2018). "Graves' ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital ...
... activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family". Proceedings of the ... Isotretinoin has a low affinity for retinoic acid receptors (RAR) and retinoid X receptors (RXR), but may be converted ... Further, the expression of dopamine receptors has indeed been shown to be regulated by retinoic acid. Isotretinoin has a number ... in addition to serotonin and glutamate receptors - is regulated by retinoic acid; schizophrenia and the retinoid cascade have ...
... retinoic acid, and vitamin D3 receptors". Cell. 65 (7): 1255-66. doi:10.1016/0092-8674(91)90020-Y. PMC 6159884. PMID 1648450. ... 2D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This VDR/RXR ... "Human vitamin D receptor-dependent transactivation in Saccharomyces cerevisiae requires retinoid X receptor". Mol. Endocrinol. ... This sequence binds the vitamin D receptor (VDR), when complexed with calcitriol (1,25(OH)2D), the active form of vitamin D, ...
Fauber BP, Magnuson S (2014). "Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or ... RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) ... orphan+nuclear+receptor+ROR-gamma at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... The RORγ protein is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear receptors. Although the ...
CAK also enhances transcription by phosphorylating retinoic acid and estrogen receptors. Phosphorylation of these receptors ... In leukemic cells, where DNA is damaged, CAK's ability to phosphorylate retinoic acid and estrogen receptors is decreased. ...
"Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice". Immunity. 12 (6): 721- ... Retinoic acid early inducible 1 (RAE-1) family of murine cell surface glycoproteins is composed of at least five members (RAE-1 ... However, they are constitutively expressed on some tumour cells and they can be upregulated by retinoic acid. Cerwenka, ... They function as stress-induced ligands for NKG2D receptor and their expression is low or absent on normal cells. ...
"Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice". Immunity. 12 (6): 721- ... All these proteins function as stress-induced ligands for NKG2D receptor. Malarkannan, Subramaniam (1998). "The molecular and ...
"Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and ... "Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and ... Nuclear receptor TLX (homologue of the Drosophila tailless gene) also known as NR2E1 (Nuclear receptor subfamily 2 group E ... Adult neural stem cells are nuclear receptor TLX-positive and TLX expression in these cells is crucial in maintaining their ...
"Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice". Immunity. 12 (6): 721-7 ... MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB ... a receptor for stress-inducible MICA". Science. 285 (5428): 727-9. doi:10.1126/science.285.5428.727. PMID 10426993. Groh V, ... class I specific receptors expressed on human natural killer (NK) cells". Molecular Immunology. 38 (9): 637-60. doi:10.1016/ ...
Naltner A, Ghaffari M, Whitsett JA, Yan C (2000). "Retinoic acid stimulation of the human surfactant protein B promoter is ... NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2 ... is a coactivator of the androgen receptor". Cancer Res. 60 (21): 5946-9. PMID 11085509. nuclear receptor coactivator 2 at the U ... "Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and ...
"A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors ... It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to ... Kozma SC, Redmond SM, Fu XC, Saurer SM, Groner B, Hynes NE (May 1988). "Activation of the receptor kinase domain of the trk ... Lalli E, Ohe K, Hindelang C, Sassone-Corsi P (2000). "Orphan receptor DAX-1 is a shuttling RNA binding protein associated with ...
Upham JW, Sehmi R, Hayes LM, Howie K, Lundahl J, Denburg JA (2002). "Retinoic acid modulates IL-5 receptor expression and ... Huston MM, Moore JP, Mettes HJ, Tavana G, Huston DP (1996). "Human B cells express IL-5 receptor messenger ribonucleic acid and ... The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for ... "Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway ...
Yan C, Naltner A, Conkright J, Ghaffari M (June 2001). "Protein-protein interaction of retinoic acid receptor alpha and thyroid ... Naltner A, Ghaffari M, Whitsett JA, Yan C (January 2000). "Retinoic acid stimulation of the human surfactant protein B promoter ... Naltner A, Wert S, Whitsett JA, Yan C (December 2000). "Temporal/spatial expression of nuclear receptor coactivators in the ... extensive identity of the deduced amino acid sequence with the human protein". Biochimica et Biophysica Acta (BBA) - Gene ...
"Epigenetic alteration of p16 and retinoic acid receptor beta genes in the development of epithelial ovarian carcinoma". Tumour ... "Prognostic Value of Promoter Hypermethylation of Retinoic Acid Receptor Beta (RARB) and CDKN2 (p16/MTS1) in Prostate Cancer". ... p16 comprises four ankyrin repeats, each spanning a length of 33 amino acid residues and, in the tertiary structure, forming a ... As a result, they are translated from different reading frames and therefore possess completely different amino acid sequences ...
One example is the cell route that coordinates the downregulation of retinoic acid receptor beta (RAR-β). Studies showed that ...
It is a highly selective retinoic acid receptor gamma (RARγ) agonist. It was approved for medical use in Canada in June 2022, ... Palovarotene is a retinoic acid receptor gamma (RARγ) agonist licensed to Clementia Pharmaceuticals from Roche Pharmaceuticals ... August 2012). "Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor". The ... Hind M, Stinchcombe S (November 2009). "Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of ...
The disease is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene and is ... APL is unique among leukemias due to its sensitivity to all-trans retinoic acid (ATRA; tretinoin), the acid form of vitamin A. ... The RAR receptor is dependent on retinoic acid for regulation of transcription. Eight other rare gene rearrangements have been ... Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) ...
Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer". J. Biol. Chem. 274 (42): 29749-29754. doi: ... Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and ... FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include ... 1999). "Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. ...
Corcoran J, Shroot B, Pizzey J, Maden M (July 2000). "The role of retinoic acid receptors in neurite outgrowth from different ... C286, (4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl) benzoic acid) is a potent, orally bioavailable retinoic acid ... "Regulation of myelination by exosome associated retinoic acid release from NG2-positive cells". Journal of Neuroscience. 39 (16 ... In contrast, signalling by RARα, RARγ or the retinoid X receptor (RXR) has no effect on this action. The RARβ agonist C286 can ...
Miki N, Ikuta M, Matsui T (April 2004). "Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor ... "Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic ... regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha". ... RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear ...
Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000167191 - Ensembl, May 2017 ... "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and ... The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on ... "GPRC5 Receptors: RAIG2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology ...
Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000170412 - Ensembl, May 2017 ... "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and ... The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on ... "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short ...
"Molecular Cloning and Characterization of Two Novel Retinoic Acid-Inducible Orphan G-Protein-Coupled Receptors (GPRC5B and ... a Novel Human MCH Receptor *". Journal of Biological Chemistry. 276 (23): 20125-20129. doi:10.1074/jbc.M102068200. ISSN 0021- ...