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*  Retinoic acid receptor
"Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids". Proc Natl Acad Sci USA. 90 (1 ... The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor that is activated ... by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, ... Retinoic acid receptors". Pharmacol Rev. 58 (4): 712-25. doi:10.1124/pr.58.4.4. PMID 17132850. Allenby G, Bocquel MT, Saunders ...
*  Retinoic acid receptor gamma
"A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7". Nucleic Acids ... Retinoic acid receptor gamma has been shown to interact with NCOR1. Retinoic acid receptor GRCh38: Ensembl release 89: ... RARG retinoic acid receptor, gamma". Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid ... plays an important role in the binding of retinoic acid by retinoic acid receptor gamma". The Journal of Biological Chemistry. ...
*  Retinoic acid receptor beta
... has been shown to interact with NR4A2. Retinoic acid receptor GRCh38: Ensembl release 89: ... "A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter". Molecular Endocrinology. 4 (11): ... "The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid". Human ... "Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene". Nature. 343 (6254): 177-80. doi: ...
*  Retinoic acid receptor alpha
Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR ... "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells". J. ... "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding ... Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear ...
*  Retinoic acid-inducible orphan G protein-coupled receptor
"Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". ... The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled ... "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and ... receptors whose expression is induced by retinoic acid. The exact function of these proteins has not been determined but they ...
*  SPRR1B
Suppression by retinoic acid receptor-selective retinoids". J. Biol. Chem. 271 (7): 3737-42. doi:10.1074/jbc.271.7.3737. PMID ...
*  Retinoid X receptor alpha
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of ... "Entrez Gene: RXRA retinoid X receptor, alpha". "Retinoic acid receptor RXR-alpha - Homo sapiens (Human)". UniProt. Na SY, Choi ... retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver ... "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/ ...
*  RARRES1
Retinoic acid receptor responder protein 1 is a protein that in humans is encoded by the RARRES1 gene. This gene was identified ... "Entrez Gene: RARRES1 retinoic acid receptor responder (tazarotene induced) 1". Jing C, El-Ghany MA, Beesley C, et al. (2002). " ... The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is ... a novel retinoic acid receptor-responsive gene in skin". J Invest Dermatol. 106 (2): 269-74. doi:10.1111/1523-1747.ep12340668. ...
*  Chemerin
"Entrez Gene: RARRES2 retinoic acid receptor responder (tazarotene induced) 2". Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, ... Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), tazarotene-induced gene 2 protein (TIG2), or RAR- ... These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor ... RARRES2 is thought to act as a cell surface receptor. Chemerin is a chemoattractant protein that acts as a ligand for the G ...
*  RARRES3
Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene. Retinoids exert biologic ... "Entrez Gene: RARRES3 retinoic acid receptor responder (tazarotene induced) 3". Oshiumi, Hiroyuki; Matsumoto Misako; Hatakeyama ... 2005). "Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter". Biochem. ... These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor ...
*  Signal transduction
Retinoic acid receptors are another subset of nuclear receptors. They can be activated by an endocrine-synthesized ligand that ... The binding of a signaling molecule with a receptor causes a change in the conformation of the receptor, known as receptor ... Certain intracellular receptors of the immune system are cytoplasmic receptors; recently identified NOD-like receptors (NLRs) ... Receptors can be roughly divided into two major classes: intracellular and extracellular receptors. Extracellular receptors are ...
*  Acute promyelocytic leukemia
The disease is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARα or RARA) gene and ... APL is unique among leukemias due to its sensitivity to all-trans retinoic acid (ATRA; tretinoin), the acid form of vitamin A. ... The RAR receptor is dependent on retinoic acid for regulation of transcription. Eight other rare gene rearrangements have been ... retinoic acid receptor-alpha (RARA) gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic ...
*  FABP6
Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer". J. Biol. Chem. 274 (42): 29749-54. doi: ... Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and ... FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include ... 1999). "Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. ...
*  COUP-TFI
... retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver ... "Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter- ... "Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling". Proceedings of the National Academy of Sciences of ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of ...
*  Palovarotene
... is a retinoic acid receptor gamma (RARγ) agonist licensed to Clementia Pharmaceuticals from Roche Pharmaceuticals ... Palovarotene is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential ... 2011). "Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-y agonists". Nature Medicine. 17 (4): ... a novel retinoic acid receptor gamma agonist for the treatment of emphysema". Current Opinion in Investigational Drugs. 10 (11 ...
*  MyoD
Froeschlé A, Alric S, Kitzmann M, Carnac G, Auradé F, Rochette-Egly C, Bonnieu A (July 1998). "Retinoic acid receptors and ... Davis RL, Cheng PF, Lassar AB, Thayer M, Tapscott S, Weintraub H (1989). "MyoD and achaete-scute: 4-5 amino acids distinguishes ... Wnts bind to the plasma membrane receptor Frizzled on the target cells. Several different intracellular pathways of signalling ... Nucleic Acids Res. 27 (2): 411-20. doi:10.1093/nar/27.2.411. PMC 148194 . PMID 9862959. Puri PL, Iezzi S, Stiegler P, Chen TT, ...
*  Male contraceptive
... of action includes blocking the conversion of vitamin A into its active form retinoic acid which binds to retinoic receptors ... "Oral Administration of a Retinoic Acid Receptor Antagonist Reversibly Inhibits Spermatogenesis in Mice". Endocrinology. 152 (6 ... Another way is blocking retionic receptors themselves, although it can also have serious side effects. Adjudin, a non-toxic ... which converts retinaldehyde into retionic acid in testes. Past attempts to do this failed because the blocking compounds were ...
*  NPAS2
Retinoic acid receptor alpha (RARα) and retinoid X receptor alpha (RXRα). In peripheral clocks, RARα and RXRα interact with ... This interaction depends upon humoral signaling by retinoic acid and serves to phase-shift the clock. Small heterodimer partner ... The predicted 824-amino acid human NPAS2 protein shares 87% sequence identity with mouse Npas2. The Npas2 gene has been found ... "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock ...
*  Retinoid X receptor
Retinoic acid receptor Retinoid X receptor alpha Retinoid X receptor beta Retinoid X receptor gamma Germain P, Chambon P, ... "Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids". Proc Natl Acad Sci USA. 90 (1 ... The retinoid X receptor (RXR) is a type of nuclear receptor that is activated by 9-cis retinoic acid, which is discussed ... 14-dihydro-retinoic acid, which is likely to be the major endogenous mammalian RXR-selective agonist. There are three retinoic ...
*  RAR-related orphan receptor
Solt LA, Griffin PR, Burris TP (June 2010). "Ligand regulation of retinoic acid receptor-related orphan receptors: implications ... Feng S, Xu S, Wen Z, Zhu Y (2015). "Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and ... "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta". Nature Structural Biology. 10 (10): 820-5. doi: ... These include all-trans retinoic acid binds with high affinity to ROR-β and -γ but not ROR-α. Finally the RORs may function as ...
*  Latexin family
TIG1 is up-regulated by retinoic acid receptor but not by retinoid X receptor-specific synthetic retinoids. TIG1 may be a ... a novel retinoic acid receptor-responsive gene in skin". J. Invest. Dermatol. 106 (2): 269-74. doi:10.1111/1523-1747.ep12340668 ... latexin and to a skin protein that is encoded by a retinoic acid receptor-responsive gene, TIG1. Tazarotene Induced Gene 1 ( ...
*  Bexarotene
... as opposed to the retinoic acid receptors, the other major target of retinoic acid (the acid form of vitamin A). By so doing it ... The retinoic acid receptors (RARs) regulate cell differentiation and proliferation whereas RXRs regulate apoptosis. Bexarotene ... Dawson, M. I.; Xia, Z. (2012). "The retinoid X receptors and their ligands". Biochimica et Biophysica Acta (BBA) - Molecular ... Rowe, A (February 1997). "Retinoid X receptors". The International Journal of Biochemistry & Cell Biology. 29 (2): 275-278. doi ...
*  Calcitriol receptor
... a promiscuous partner of retinoic acid and thyroid hormone receptors". EMBO J. 11 (4): 1409-18. PMC 556590 . PMID 1314167. Goto ... This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of ... pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and ... The calcitriol receptor, more commonly known as the vitamin D receptor (VDR) and also known as NR1I1 (nuclear receptor ...
*  FIP1L1
... gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor ... RARA, the Retinoic acid receptor alpha gene, is located on human chromosome 17 at position q21.2 (i.e. 17q21.2), consists of 17 ... A Chromosomal translocation of FIP1L1 (4q12) with the Retinoic acid receptor alpha gene, i.e. RARA, (17q12) at various points ... and encodes the nuclear retinoic acid receptor alpha (RARA) protein. The RARA protein, when ligand-bound, regulates the ...
*  TLX
"Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and ... "Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and ... Nuclear receptor TLX (homologue of the Drosophila tailless gene) also known as NR2E1 (Nuclear receptor subfamily 2 group E ... Liu HK, Belz T, Bock D, Takacs A, Wu H, Lichter P, Chai M, Schütz G (Sep 2008). "The nuclear receptor tailless is required for ...
*  AP-1 transcription factor
Retinoic Acid Inhibits Serum-stimulated Activator Protein-1 via ... Inagi R, Miyata T, Nangaku M, et al. (November 2002). " ... "Induction of the rat prodynorphin gene through Gs-coupled receptors may involve phosphorylation-dependent derepression and ... Due to the amino acid sequence and the periodicity of the helices, the leucine side chains are arranged along one face of the α ... which consist of clusters of negatively charged amino acids in its N-terminal half that are important for transcriptional ...