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*  P2RX6
"Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor". Khakh BS, Burnstock G, Kennedy C, et al. (2001). " ... The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and ... Soto F, Garcia-Guzman M, Karschin C, Stühmer W (1996). "Cloning and tissue distribution of a novel P2X receptor from rat brain ... Current status of the nomenclature and properties of P2X receptors and their subunits". Pharmacol. Rev. 53 (1): 107-18. PMID ...
*  P2RX5
... purinergic receptor P2X, ligand-gated ion channel, 5". North RA (2002). "Molecular physiology of P2X receptors". Physiol ... 2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells". J. Invest. ... 2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal ... P2X receptor GRCh38: Ensembl release 89: ENSG00000083454 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000005950 - ...
*  P2RX1
... purinergic receptor P2X, ligand-gated ion channel, 1". North RA (2002). "Molecular physiology of P2X receptors". Physiol ... "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels. 3 (4): 283 ... Ennion SJ, Evans RJ (2002). "Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide ... P2X receptor GRCh38: Ensembl release 89: ENSG00000108405 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000020787 - ...
*  P2RX4
The P2X4 receptor has a typical P2X receptor structure. The zebrafish P2X4 receptor was the first purinergic receptor to be ... "Entrez Gene: P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4". Bo X, Kim M, Nori SL, Schoepfer R, Burnstock G, North ... The desensitization of P2X4 receptors is intermediate when compared to P2X1 and P2X2 receptors. P2X4 receptors respond to ATP, ... "Molecular and functional properties of P2X receptors--recent progress and persisting challenges". Purinergic Signalling. 8 (3 ...
*  P2RX2
... purinergic receptor P2X, ligand-gated ion channel, 2". North RA (2002). "Molecular physiology of P2X receptors". Physiol ... Purinergic receptor GRCh38: Ensembl release 89: ENSG00000187848 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... 1997). "Desensitization of the P2X(2) receptor controlled by alternative splicing". FEBS Lett. 404 (2-3): 294-8. doi:10.1016/ ... 2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not ...
*  P2RX3
... purinergic receptor P2X, ligand-gated ion channel, 3". North RA (2002). "Molecular physiology of P2X receptors". Physiol ... P2X purinoreceptor Purinergic receptor Ligand-gated ion channel Nociceptor GRCh38: Ensembl release 89: ENSG00000109991 - ... Brown DA, Yule DI (2007). "Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation ... P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene. The product of this gene belongs to the family of ...
*  P2RX7
One study in mice showed that blockade of P2X7 receptors attenuates onset of liver fibrosis. Purinergic receptor P2X receptor ... The P2X7 subunits can form homomeric receptors only with a typical P2X receptor structure. The P2X7 receptor is a ligand-gated ... Receptors Channels. 5 (6): 347-54. PMID 9826911. "Entrez Gene: P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7". ... Slater NM, Barden JA, Murphy CR (June 2000). "Distributional changes of purinergic receptor subtypes (P2X 1-7) in uterine ...
*  Pseudoapoptosis
P2X purinergic receptors are ATP-gated ion channels that become activated in the presence of extracellular adenosine ... Studies have shown to induce apoptotic-like cellular states through the activation of ATP-gated P2X7 receptors, but under ... When pertaining to apoptosis, prolonged activation of P2X7 receptors can stimulate stress responses resulting in activated ... "Pseudoapoptosis Induced By Brief Activation Of ATP-Gated P2X7 Receptors." Journal of Biological Chemistry 280.40 (2005): 33968- ...
*  Purinergic signalling
There are three known distinct classes of purinergic receptors, known as P1, P2X, and P2Y receptors. Cell signalling events ... In 2014, the first purinergic receptor in plants, DORN1, was discovered. The primitive P2X receptors of unicellular organisms ... In microglia, P2X and P2Y receptors are expressed. The P2Y6 receptor, which is primarily mediated by uridine diphosphate (UDP ... The purinergic signalling complex of a cell is sometimes referred to as the "purinome". Purinergic receptors, represented by ...
*  P2 receptor
... may refer to: P2Y receptors P2X receptors P is for purinergic, P2 refers to ATP receptors, as opposed to P1 ... P2X receptors are ATP activated channels that allows the passage of ions across cell membranes. P2Y receptors are ATP activated ... G protein-coupled receptors (GPCRs) that initiate an intracellular chain of reactions.. ...
*  Calcium channel opener
... and purinergic receptors of the P2X channel type. Calcium channel blocker Schramm M, Thomas G, Towart R, Franckowiak G (1983 ...
*  Purinergic receptor
There are three known distinct classes of purinergic receptors, known as P1, P2X, and P2Y receptors. P2X receptors are ligand- ... IUPHAR GPCR Database - Adenosine receptors IUPHAR GPCR Database - P2Y receptors Purinergic Receptors at the US National Library ... and ionotropic receptors (P2X and P2Z). In 2014, the first purinergic receptor in plants, DORN1, was discovered. ... P2 receptors) or adenosine (P1 receptors). P2 receptors have further been divided into five subclasses: P2X, P2Y, P2Z, P2U, and ...
*  P2X purinoreceptor
The ATP-gated P2X receptor cation channel family (TC# 1.A.7), or simply P2X receptor family, consists of cation-permeable ... Different subunits exhibit different sensitivities to purinergic agonists such as ATP, α,β-meATP and BzATP; and antagonists ... ENaC and P2X receptors have similar 3-D structures and are homologous.[15] P2X receptors are present in a diverse array of ... a homomeric P2X receptor made up of only P2X1 subunits is called a P2X1 receptor, and a heteromeric receptor containing P2X2 ...
*  P2RY10
"Entrez Gene: P2RY10 purinergic receptor P2Y, G-protein coupled, 10". Berchtold S, Ogilvie AL, Bogdan C, Mühl-Zürbes P, Ogilvie ... "Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases". FEBS Letters. ... "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". ... The protein encoded by this gene belongs to the family of G-protein coupled receptors that is preferentially activated by ...
*  PPADS
It appears to be relatively selective for P2X receptors, having no appreciable activity at α1 adrenergic, muscarinic M2 and M3 ... PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist. It is able to block ... PPADS tetrasodium salt, Santa Cruz Biotechnology Ziganshin, AU (December 1993). "PPADS selectively antagonizes P2X-purinoceptor ...
*  Gliotransmitter
ATP targets P2X receptors, P2Y, and A1 receptors. ATP has several functions as a gliotransmitter, including insertion of AMPA ... and remyelination by entering into the cell's extracellular space upon injury to activate purinergic receptors, which increase ... Its main target receptors include Kainate receptors, metabotropic glutamate receptors (mGluRs), and especially N-methyl D- ... aspartate receptors (NMDARs). NMDARs are glutamatergic receptors that play an important role in synaptic plasticity. Other ...
*  Rostral ventromedial medulla
Histological staining by another research group examined the distribution of purinergic receptor subtypes throughout the RVM. ... On-cells displayed a greater response to P2X agonists vs P2Y agonists. For example, α,β-methylene ATP, a P2X agonist, activated ... Close, L.N. (January 2009). "Purinergic Receptor Immunoreactivity in the Rostral Ventromedial Medulla". Neuroscience. 158 (2): ... NK1 agonism induced hypersensitivity is dependent on 5-HT3 receptors, and modulated by GABAA and NMDA receptors as well. ...
*  P2RY2
"Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2". Tokuyama Y, Hara M, Jones EM, et al. (1995). "Cloning of rat ... Bogdanov Y, Rubino A, Burnstock G (1998). "Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the ... 2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells". J. Invest. ... 2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal ...
*  P2Y receptor
P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as ATP, ADP, UTP, UDP and ... Ivar von Kügelgen: Pharmacology of mammalian P2X- and P2Y-receptors, BIOTREND Reviews No. 03, September 2008,© 2008 BIOTREND ... Human P2Y receptors have the following G protein coupling: The gaps in P2Y receptor numbering is due to that several receptors ... IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Purinergic P2 receptors ...
*  Neuroeffector junction
The post-junctional membrane beneath the varicosity can possess a patch about 1 μm2 of purinergic P2X1 receptors in high ... have been used to detect the packeted release of the neurotransmitter ATP acting on post-junctional P2X receptors to cause the ... Post-junctional receptors also include some ionotropic receptors such as nicotinic receptors in the central nervous system (CNS ... and the post junctional receptors include metabotropic receptors or slower acting ionotropic receptors. Almost all tissues that ...
*  P2RY1
"Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1". Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, ... James G, Butt AM (October 2001). "Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the ... Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G (June 2003). "Purinergic receptors are part of a functional signaling ... This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of ...