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*  Regrelor
... is classified as an purinergic P2 receptor (P2Y12) antagonist. Other compounds in the same mechanistic class include ... It is characterized as a reversible, competitive receptor antagonist. The IC50 for antagonism of ADP-induced (P2Y12-mediated) ... ADP-receptor antagonist, INS50589". Platelets. 18 (5): 346-56. ,access-date= requires ,url= (help) "Regrelor Disodium". en. ... Modifications to Dinucleoside Polyphosphates and Nucleotides that Confer Antagonist Properties at the Platelet P2Y12 Receptor ...
*  P2Y receptor
IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Purinergic P2 receptors ... P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as ATP, ADP, UTP, UDP and ... Human P2Y receptors have the following G protein coupling: The gaps in P2Y receptor numbering is due to that several receptors ... HUGO Gene Nomenclature Committee, Gene Family: Purinergic receptors P2Y (P2RY), retrieved 2017-01-26. Pasternack SM, von ...
*  P2 receptor
... may refer to: P2Y receptors P2X receptors P is for purinergic, P2 refers to ATP receptors, as opposed to P1 ... P2X receptors are ATP activated channels that allows the passage of ions across cell membranes. P2Y receptors are ATP activated ... G protein-coupled receptors (GPCRs) that initiate an intracellular chain of reactions.. ...
*  Purinergic signalling
... was shown to block P2X3 receptor signaling Burnstock, Geoffrey (June 2006). "Purinergic P2 receptors as targets for novel ... The purinergic signalling complex of a cell is sometimes referred to as the "purinome". Purinergic receptors, represented by ... Purinergic receptors are specific classes of membrane receptors that mediate various physiological functions such as the ... There are three known distinct classes of purinergic receptors, known as P1, P2X, and P2Y receptors. Cell signalling events ...
*  Multiple electrode aggregometry
Hechler, B; Gachet, C (1988). "P2 receptors and platelet function". Purinergic signalling. 27 (2011 September; 7(3)): 293-303. ... Thrombin receptor activating peptide-6 (TRAP-6) activates platelets through the thrombin receptor protease activated receptor-1 ... Activation of the P2Y1 receptor initiates platelet aggregation in response to ADP. The P2Y1 receptor is required for ADP- ... When it is added to saline-diluted whole blood in the test cuvette, it stimulates the ADP receptors on platelets, activating ...
*  ENTPD1
"Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8". Purinergic Signalling. 1 (2): 193-204. doi:10.1007/ ... NTPDase1 hydrolyzes P2 receptor ligands, namely ATP, ADP, UTP and UDP with similar efficacy. NTPDase1 can therefore affect P2 ... Kukulski F, Lévesque SA, Sévigny J (2011-01-01). "Impact of ectoenzymes on p2 and p1 receptor signaling". Advances in ... Yegutkin GG (May 2008). "Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling ...
*  Geoffrey Burnstock
Indeed, we owe our present understanding of purinergic signaling and the current classification of P2 receptors to Geoff ... Much of our understanding of purinergic signalling and the current classification of purinergic receptors is attributed to the ... Di Virgilio, F. (22 October 2012). "Purines, Purinergic Receptors, and Cancer". Cancer Research. 72 (21): 5441-5447. doi: ... He coined the term "purinergic signalling" in 1972 in a key paper that has since been cited more than 2,000 times by other key ...
*  Biochemical cascade
There are two main types of purinergic receptors, P1 binding to adenosine, and P2 binding to ATP or ADP, presenting different ... Therefore, there are four main transmembrane receptor types: G protein coupled receptors (GPCRs), tyrosine kinase receptors ( ... PAR1 and PAR4 receptors), platelet-derived thromboxane A2 (TxA2) (TP receptor) and ADP (P2Y1 and P2Y12 receptors) that is ... Adenosine acts by binding to purinergic receptors and influencing adenilyl cyclase activity and the formation of cAMP and PKA ...
*  List of MeSH codes (D12.776.543)
... receptor, adenosine a3 MeSH D12.776.543.750.720.700.720 -- receptors, purinergic p2 MeSH D12.776.543.750.725.500 -- receptor, ... receptors, purinergic p2 MeSH D12.776.543.750.100.800.100 -- receptors, serotonin, 5-ht1 MeSH D12.776.543.750.100.800.100.100 ... receptor, adenosine a3 MeSH D12.776.543.750.810.720 -- receptors, purinergic p2 MeSH D12.776.543.750.850.249 -- bacterial ... receptor, par-1 MeSH D12.776.543.750.810.150 -- receptors, cyclic amp MeSH D12.776.543.750.810.700 -- receptors, purinergic p1 ...
*  Ectonucleotidase
... s modulate P2 purinergic signaling. In addition, ectonucleotidases generate extracellular adenosine, which ... "Attenuating myocardial ischemia by targeting A2B adenosine receptors". Trends in Molecular Medicine. 19 (6): 345-354. doi: ... Beldi, G; Enjyoji, K; Wu, Y; Miller, L; Banz, Y; Sun, X; Robson, SC (Jan 1, 2008). "The role of purinergic signaling in the ... The contribution of ectonucleotidases in the modulation of purinergic signaling depends on the availability and preference of ...
*  Rhodopsin-like receptors
P2 purinoceptor InterPro: IPR002286 Purinergic receptor P2Y1 (P2RY1) Purinergic receptor P2Y2 (P2RY2) Purinergic receptor P2Y4 ... Succinate receptor 1 (SUCNR1, GPR91) P2 purinoceptor InterPro: IPR002286 Purinergic receptor P2Y12 (P2RY12) Purinergic receptor ... P2RY4) Purinergic receptor P2Y6 (P2RY6) Purinergic receptor P2Y8 (P2RY8) Purinergic receptor P2Y11 (P2RY11) Hydroxycarboxylic ... IPR002188 P2 purinoceptor InterPro: IPR002286 Purinergic receptor P2Y10 (P2RY10, P2Y10) Protease-activated receptor InterPro: ...
*  Index of biochemistry articles
... purinergic P1 receptor - purinergic P2 receptor - purinergic receptor - pyridine - pyrimidine - pyruvate - pyruvate oxidation ... interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 receptor - intermediate ... G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc fusion protein - galanin - gamete - gamma- ... IgE receptor - IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - ...
*  Purinergic receptor
P2 receptors) or adenosine (P1 receptors). P2 receptors have further been divided into five subclasses: P2X, P2Y, P2Z, P2U, and ... There are three known distinct classes of purinergic receptors, known as P1, P2X, and P2Y receptors. P2X receptors are ligand- ... IUPHAR GPCR Database - Adenosine receptors IUPHAR GPCR Database - P2Y receptors Purinergic Receptors at the US National Library ... The term purinergic receptor was originally introduced to illustrate specific classes of membrane receptors that mediate ...
*  P2RY14
This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated ... Müller CE (2003). "P2-pyrimidinergic receptors and their ligands". Curr. Pharm. Des. 8 (26): 2353-69. doi:10.2174/ ... 2003). "Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor ... Brunschweiger A, Müller CE (2006). "P2 receptors activated by uracil nucleotides--an update". Curr. Med. Chem. 13 (3): 289-312 ...
*  PPADS
It appears to be relatively selective for P2X receptors, having no appreciable activity at α1 adrenergic, muscarinic M2 and M3 ... PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist. It is able to block ... Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses". European ... histamine H1, and adenosine A1 receptors. PPADS tetrasodium salt, Santa Cruz Biotechnology Ziganshin, AU (December 1993). " ...
*  Rostral ventromedial medulla
Histological staining by another research group examined the distribution of purinergic receptor subtypes throughout the RVM. ... All on-cells showed a response to the non-specific P2 agonist uridine triphosphate (UTP). Activation of on cells by ATP was ... Close, L.N. (January 2009). "Purinergic Receptor Immunoreactivity in the Rostral Ventromedial Medulla". Neuroscience. 158 (2): ... NK1 agonism induced hypersensitivity is dependent on 5-HT3 receptors, and modulated by GABAA and NMDA receptors as well. ...
*  Adenosine receptor
The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ... "Towards a revised nomenclature for P1 and P2 receptors". Trends Pharmacol. Sci. 18 (3): 79-82. doi:10.1016/S0165-6147(96)01038- ... The adenosine A1 receptor has been found to be ubiquitous throughout the entire body. This receptor has an inhibitory function ... Adenosine receptors play a key role in the homeostasis of bone. The A1 receptor has been shown to stimulate osteoclast ...
*  P2RX7
One study in mice showed that blockade of P2X7 receptors attenuates onset of liver fibrosis. Purinergic receptor P2X receptor ... Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA (2003). "P2 receptors in bone--modulation of osteoclast formation ... The P2X7 subunits can form homomeric receptors only with a typical P2X receptor structure. The P2X7 receptor is a ligand-gated ... Receptors Channels. 5 (6): 347-54. PMID 9826911. "Entrez Gene: P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7". ...
*  P2RX1
... purinergic receptor P2X, ligand-gated ion channel, 1". North RA (2002). "Molecular physiology of P2X receptors". Physiol ... 2004). "Increased mitogenic and decreased contractile P2 receptors in smooth muscle cells by shear stress in human vessels with ... "A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors". Br. J. ... receptor form disulfide bonds and are involved in receptor trafficking to the cell surface". Mol. Pharmacol. 61 (2): 303-11. ...
*  Area postrema
Stimulation of the dopamine receptors in the area postrema activates these vomiting centers of the brain; this is why nausea is ... The results showed that most responses to ATP are excitatory and that they are mediated by particular P2 purinoceptors found in ... Kodama, N.; Funahashi, M.; Mitoh, Y.; Minagi, S.; Matsuo, R. (2007). "Purinergic modulation of area postrema neuronal ... The high density of dopamine receptors in the area postrema makes it very sensitive to the dopamine-enhancing drugs. ...
*  Astrocyte
... and neurokinin 1 receptor (NK1R), as well as activation of metabotropic glutamate receptors and release of BDNF. Persistent ... The resultant patterning along the neuraxis leads to segmentation of the neuroepithelium into progenitor domains (p0, p1 p2, p3 ... "Astrocytic purinergic signaling coordinates synaptic networks". Science. 310 (5745): 113-6. doi:10.1126/science.1116916. PMID ... and kainate subtypes of ionotropic glutamate receptors follows. It is the activation of these receptors that potentiates the ...