... form of prolactin which exerts its antagonist effect by competing with prolactin to bind with prolactin receptors; thereby, ... The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. It is the ... The prolactin receptor (PRLR) is a membrane-bound protein of the cytokine receptor superfamily. In humans, it is encoded by a ... Prolactin Growth hormone Human placental lactogen Placental growth hormone S179D-hPRL Prolactin receptor antagonists such as ...

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in ... "Prolactin-Releasing Peptide Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter ... "Entrez Gene: PRLHR prolactin releasing hormone receptor". Hinuma S, Onda H, Fujino M (1999). "The quest for novel bioactive ...

"Prolactin". You and Your Hormones. Society for Endocrinology. Retrieved 7 November 2018. "SSTR2 somatostatin receptor 2 [Homo ... SST2A receptor and SST2B receptor are seen in some brain and spinal cord areas in a rodent. Somatostatin receptor 2a has a ... SST2A receptor is made up of 369 amino acids and 346 amino acids make up the SST2B receptor. Somatostatin receptor 2a and ... somatostatin receptor 2a (SSTR2A) and somatostatin receptor 2b (SSTR2B). In a rodent, somatostatin receptor 2a is longer ...

... blockade of cholinergic and α1adrenergic receptors; inhibition of nitric oxide synthetase; and elevation of prolactin levels. ... a partial agonist of the 5-HT1A receptor, and antagonist of the 5-HT3 and 5-HT7 receptors. However, it can also technically be ... NMDA receptor antagonists like ketamine and esketamine are rapid-acting antidepressants and seem to work via blockade of the ... Mirtazapine is reported to have fewer sexual side effects, most likely because it antagonizes 5-HT2 and 5-HT3 receptors and may ...

Rae-Venter, B.; Dao, T. L. (1983). "Hydrodynamic properties of rat hepatic prolactin receptors". Archives of Biochemistry and ... Rae-Venter, B.; Dao, T. L. (1982). "Kinetic properties of rat hepatic prolactin receptors". Biochemical and Biophysical ... Rae-Venter, B.; Nemoto, T.; Schneider, S. L.; Dao, T. L. (1981). "Prolactin binding by human mammary carcinoma: Relationship to ... estrogen receptor protein concentration and patient age". Breast Cancer Research and Treatment. 1 (3): 233-243. doi:10.1007/ ...

When prolactin binds to the receptor, it causes it to dimerize with another prolactin receptor. This results in the activation ... Human prolactin receptors are insensitive to mouse prolactin. Prolactin levels may be checked as part of a sex hormone workup, ... Hyperprolactinaemia Hypothalamic-pituitary-prolactin axis Male lactation Prolactin modulator Prolactin receptor Prolactin- ... and paracrine manners through the prolactin receptor and numerous cytokine receptors. Pituitary prolactin secretion is ...

Hypothalamic-pituitary-prolactin axis Lin, S. H. (2008). "Prolactin-Releasing Peptide". Orphan G Protein-Coupled Receptors and ... Its secretion is mediated by estrogen from placenta during pregnancy to elevate blood level of prolactin . While many prolactin ... The prolactin-releasing peptide identified in 1998 was a candidate for this function, however as of 2008 it appears its ... Prolactin-releasing hormone, also known as PRLH, is a hypothetical human hormone or hormone releasing factor. Existence of this ...

"Acetylation modulates prolactin receptor dimerization". Proceedings of the National Academy of Sciences. 107 (45): 19314-19319 ... STATs may also be tyrosine-phosphorylated directly by receptor tyrosine kinases - but since most receptors lack built-in kinase ... "Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling". Cellular and ... causes the receptors to dimerize, which brings the receptor-associated JAKs into close proximity. The JAKs then phosphorylate ...

Postel-Vinay MC (1996). "Growth hormone- and prolactin-binding proteins: soluble forms of receptors". Hormone Research. 45 (3-5 ... "A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and ... Two receptor molecules are pre-dimerized upon GH binding, so it always binds in a 1:2 ratio. Assays estimate that growth ... "GHR growth hormone receptor [Homo sapiens (human)]". NCBI. Fisker S (Feb 2006). "Physiology and pathophysiology of growth ...

Prolactin elevates the levels of IRF-1 via Jak-STAT pathway. IRF-1 is known to be a direct agonist of pIgR expression. ... "Entrez Gene: PIGR polymeric immunoglobulin receptor". Kaetzel CS (August 2005). "The polymeric immunoglobulin receptor: ... Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is an Fc ... The internalized receptor is transported to basolateral early endosomes. The following step of transporting the pIgR across the ...

GABAA receptors containing α2 mediate the anxiolytic actions and to a large degree the myorelaxant effects. GABAA receptors ... Diazepam also decreases prolactin release in rats. Benzodiazepines are positive allosteric modulators of the GABA type A ... down-regulation of receptor sites, and desensitisation of receptor sites to the effect of GABA. About one-third of individuals ... GABAA receptor positive allosteric modulators, Genentech brands, Glycine receptor antagonists, Hoffmann-La Roche brands, ...

Socolovsky M, Dusanter-Fourt I, Lodish HF (May 1997). "The prolactin receptor and severely truncated erythropoietin receptors ... Socolovsky M, Fallon AE, Lodish HF (Sep 1998). "The prolactin receptor rescues EpoR-/- erythroid progenitors and replaces EpoR ... Zang H, Sato K, Nakajima H, McKay C, Ney PA, Ihle JN (Jun 2001). "The distal region and receptor tyrosines of the Epo receptor ... replacing EpoR with prolactin receptor supports erythroid survival and differentiation in vitro. Together, these data suggest ...

... has also been shown to have effect on cannabinoid CB1 receptors. It significantly increases prolactin and ... It acts as a kappa opioid receptor agonist and is the first known compound acting on this receptor that is not an alkaloid. ... Kappa-opioid receptor agonists, D2-receptor agonists, Oneirogens, Terpenes and terpenoids, 3-Furyl compounds, Acetate esters, ... Research has shown that salvinorin A is a potent κ-opioid receptor (KOR) agonist (Ki = 2.4 nM, EC50 = 1.8 nM). It has a high ...

"Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release". Molecular ... As hormone receptors for sex steroids (steroid hormone receptors), ERs, androgen receptors (ARs), and progesterone receptors ( ... nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and ... Estrogen receptors (ERs) are a group of proteins found inside cells. They are receptors that are activated by the hormone ...

Interestingly, prolactin has the opposite effect. It increases the expression of cytotoxicity receptors on natural killer cells ... Rapid administration of corticosterone (the endogenous type I and type II receptor agonist) or RU28362 (a specific type II ... Mavoungou E, Bouyou-Akotet MK, Kremsner PG (February 2005). "Effects of prolactin and cortisol on natural killer (NK) cell ... Many of these functions are carried out by cortisol binding to glucocorticoid or mineralocorticoid receptors inside the cell, ...

Hypothalamic-pituitary-prolactin axis Vasoactive intestinal peptide receptor VPAC1 VPAC2 GRCh38: Ensembl release 89: ... VIP binds to both VPAC1 and VPAC2 receptors. When VIP binds to VPAC2 receptors, a G-alpha-mediated signaling cascade is ... VIP in the pituitary helps to regulate prolactin secretion; it stimulates prolactin release in the domestic turkey. ... The high concentration of VIP and VIP receptor containing neurons are primarily found in the ventrolateral aspect of the SCN, ...

This is because dopamine plays a primary role in regulating prolactin release by binding to D2 receptors on prolactin-secreting ... Thus, when tiapride blocks these receptors these cells are disinhibited and release more prolactin. The side-effect reported ... Efficacy at the D2 receptor is moderate, with 80 percent of receptors occupied even in the presence of excess tiapride ... and histamine H1 receptors. Compared to these drugs, tiapride has a relatively moderate affinity for its target receptors, ...

There are two pathways affected: the tumour necrosis factor receptor superfamily (TNFRSF) and the prolactin receptor pathway, ... Prolactin (PLR) on the other hand is up-regulated as a result of DiBP exposure. Prolactin has many roles, including roles in ... Hair WM, Gubbay O, Jabbour HN, Lincoln GA (July 2002). "Prolactin receptor expression in human testis and accessory tissues: ... "Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor ...

... "kappa-Opioid receptor agonist-induced prolactin release in primates is blocked by dopamine D(2)-like receptor agonists". ... δ-opioid receptor μ-opioid receptor Nociceptin receptor GRCh38: Ensembl release 89: ENSG00000082556 - Ensembl, May 2017 GRCm38 ... The κ-opioid receptor or kappa opioid receptor, abbreviated KOR or KOP for its ligand ketazocine, is a G protein-coupled ... Dysregulation of this receptor system has been implicated in alcohol and drug addiction. The KOR is a type of opioid receptor ...

It is a type of mitogen which is specific only to the receptors on certain types of cells. GH is a 191-amino acid, single-chain ... GH, human chorionic somatomammotropin, and prolactin belong to a group of homologous hormones with growth-promoting and ... Thus, GH exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway. Through ... Yi S, Bernat B, Pál G, Kossiakoff A, Li WH (July 2002). "Functional promiscuity of squirrel monkey growth hormone receptor ...

D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI (May 1999). "16K human prolactin inhibits vascular endothelial ... a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. ... Tyrosine kinase receptors, All stub articles, Transmembrane receptor stubs). ... Sato Y, Kanno S, Oda N, Abe M, Ito M, Shitara K, Shibuya M (May 2000). "Properties of two VEGF receptors, Flt-1 and KDR, in ...

The medial preoptic area of the hypothalamus contains receptors for estradiol, progesterone, prolactin, oxytocin, vasopressin ... Sensory receptors in pharynx mucosa, similar to touch receptors in the skin, sense foreign objects such as food that may result ... When an odorant is detected by receptors, the receptors in a sense break the odorant down and then the brain integrates the ... Sensory receptor, Proprioception, and Category:Sensory receptors), as a center for coordinating certain automatic reflexes. ...

D4 receptor agonists, Dimethylamino compounds, Dopamine receptor modulators, Lysergamides, Pfizer brands, Prolactin inhibitors ... and α1-adrenergic receptors. Cabergoline functions as an partial or full agonist at all of these receptors except for the 5-HT7 ... In-vitro rat studies show a direct inhibitory effect of cabergoline on the prolactin secretion in the lactotroph cells of the ... I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes". The Journal of ...

Khong, H. K.; Kuah, M. K.; Jaya-Ram, A.; Shu-Chien, A. C. (2009). "Prolactin receptor mRNA is upregulated in discus fish ( ... The release of prolactin triggers the cells in the alveoli to make milk. Prolactin also transfers to the breast milk. Some ... prolactin and growth hormone production, are essential. Growth hormone (GH) is structurally very similar to prolactin and ... This stage requires prolactin. Oxytocin is critical for the milk let-down reflex in response to suckling. Galactorrhea is milk ...

2005). "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor". Mol. Endocrinol. 19 (4): ... 2007). "Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells". Oncogene. 26 ...

2007). "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription ... 2005). "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor". Mol. Endocrinol. 19 (4): ... 1998). "A distal enhancer region in the human beta-casein gene mediates the response to prolactin and glucocorticoid hormones ...

... stimulate hyperplasia and hypertrophy of target cells and regulate their own receptors. Anterior pituitary produces prolactin, ... and prolactin (HPPTooltip hypothalamic-pituitary-prolactin axis) axes are branches. It is possible for the function of these ... Prolactin releasing hormone (PRH): stimulates PRL secretion · Prolactin inhibiting hormone (dopamine): inhibits PRL secretion ... These hormones are prolactin, growth hormone, TSH, adrenocorticotropic hormone, FSH and LH. They are all released by anterior ...

Psychiatric medicine is known to cause the brain to form more dopamine receptors for the dopamine blocking effect. The normal ... Additionally, it is thought that depression, drug addiction, high levels of prolactin, low testosterone, and uses of certain ... Increased serum prolactin (PRL) concentration in patients brains from psychiatric medicine can also affect sexuality. ... and alpha-2 receptor blockers like yohimbine. Anhedonia Dysorgasmia Dyspareunia Perelman MA (2011). "Anhedonia/PDOD: Overview ...

... but prolactin and its receptors are known to be involved in pseudopregnancy. The role of prolactin in maintaining ... The hormone prolactin produced regulates the activation and early maintenance of corpus luteum. The corpus luteum is known as a ... Prolactin is responsible for the behaviours seen during pseudopregnancy. Dogs may exhibit mothering of toys, nesting or ... For instance in the rodent, if chronic prolactin is administered the pseudopregnancy will continue, whereas the condition only ...

"Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer ... Prolactin induced protein (called GCDFP-15 in this context) in breast cyst fluid or breast tissue serves as marker of both ... Prolactin-induced protein has also been used for identification and detection of disseminated breast cancer cells. The PIP gene ... Prolactin-inducible protein also known as gross cystic disease fluid protein 15 (GCDFP-15), extra-parotid glycoprotein (EP-GP ...