"Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". ... Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet- ... Platelet-Derived+Growth+Factor+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... Heldin CH, Westermark B (April 1989). "Platelet-derived growth factor: three isoforms and two receptor types". Trends in ...

... , also termed CD140a, is a receptor located on the surface of a wide range of cell ... This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating ... cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. Activation of PDGFRA requires ... growth factors outside of the PDGFR family (non-PDGFs) activate PDGFRα indirectly. Non-PDGFs bind to their own receptors that ...

Platelet derived growth factor is a major inducer of CCL2 gene. CCR2 and CCR4 are two cell surface receptors that bind CCL2. ... Kim MS, Day CJ, Morrison NA (April 2005). "MCP-1 is induced by receptor activator of nuclear factor-κB ligand, promotes human ... In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and it is under control of nuclear factor κB (NFκB). In ... Foresti ML, Arisi GM, Katki K, Montañez A, Sanchez RM, Shapiro LA (December 2009). "Chemokine CCL2 and its receptor CCR2 are ...

... platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see ... "Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity ... "Structural and functional properties of platelet-derived growth factor and stem cell factor receptors". Cold Spring Harbor ... "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". ...

... inhibits growth of tumour cells by blocking subunit alpha of the platelet-derived growth factor receptor, a type of ... It is directed against the platelet-derived growth factor receptor alpha. It was removed from the United States and European ...

Yamamoto M, Toya Y, Jensen RA, Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor ... epidermal growth factor receptor, endothelin receptor type B, PDGFRB, PDGFRA, PTGS2, TRAF2, estrogen receptor alpha, caveolin 2 ... "Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors". The Journal of ... "Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I ...

... also regulates platelet-derived growth factor receptor-α (Pdgfrα) expression. This is responsible for lens fiber ... Foxe3, also known as Forkhead Box E3, is a transcription factor that is responsible for the formation of the lens placode, a ... Forkhead box protein E3 (FOXE3) also known as forkhead-related transcription factor 8 (FREAC-8) is a protein that in humans is ... 2010). "The immunodominant epitope of centromere-associated protein A displays homology with the transcription factor forkhead ...

"Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors". The Journal of ... This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ... Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene. The ... "Entrez Gene: GRB7 growth factor receptor-bound protein 7". Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, ...

"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor". J. Biol. Chem. ... 2004). "PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha ... 2003). "Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure ... 2005). "Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal ...

"Platelet-Derived Growth Factor Receptor β-Subtype Regulates Proliferation and Migration of Gonocytes". Endocrinology. 149 (12 ... "Identification and Distribution of a Novel Platelet-Derived Growth Factor Receptor β Variant: Effect of Retinoic Acid and ... Leukemia inhibitory factor (LIF), platelet-derived growth factor (PDGF)-BB, and RA. The production of PDGF-BB and E2 by ... "Interdependence of Platelet-Derived Growth Factor and Estrogen-Signaling Pathways in Inducing Neonatal Rat Testicular Gonocytes ...

"Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". ... "Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras". Proceedings of the National ... "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". The Journal of Biological Chemistry. 269 ... EPH receptor A2, ETV6, Epidermal growth factor receptor, Erythropoietin receptor, FRS2, Fas ligand, GAB1, GAB2, Glycoprotein ...

June 2008). "Imatinib mesylate for platelet-derived growth factor receptor-beta-positive Erdheim-Chester histiocytosis". Blood ... serum levels of interleukin-6/interleukin-6 soluble receptor and bisphosphonate treatment in Erdheim-Chester disease". Clinical ...

... targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor ... RTK targets of nintedanib include platelet-derived growth factor receptor (PDGFR) α and β; fibroblast growth factor receptor ( ... vascular endothelial growth factor receptor (VEGFR) 1, 2, and 3; and FLT3. Its use in IPF is predicated on its inhibition of ... The P-glycoprotein inhibitor ketoconazole is known to increase blood plasma levels of nintedanib by a factor of 1.8; other ...

1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor". Biochem. Biophys. Res. ... Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close ...

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene. The protein encoded by this gene is ... 2001). "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor". Nat. Cell Biol. 3 (5): 512-6. doi:10.1038/ ... 2005). "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial ... 2003). "Platelet-derived growth factor-D expression in developing and mature human kidneys". Kidney Int. 62 (6): 2043-54. doi: ...

December 2009). "Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling". ... SH2 domains of Src family kinases play an important role in binding to growth factor receptors as well as regulating the ... STAT activation by Src family kinases often occurs downstream of growth factor receptor kinases. It has been shown that Src ... "Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors". The Journal of ...

1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor". Biochem. Biophys. Res. ... "Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth". ... "Bimodal interaction of coatomer with the p24 family of putative cargo receptors". Science. 273 (5280): 1396-9. Bibcode:1996Sci ...

Endothelial precursor cells secrete platelet-derived growth factor (PDGF)-B and mesangial cells have receptors for PDGF. This ... mesangial cells can respond by producing several growth factors: TGF-1, VEGF and connective tissue growth factor. The mesangium ... Mice lacking the growth factor PDGF-B or PDGFRβ do not develop mesangial cells. When mesangial cells are absent the blood ... The transcription factor for PDGFRβ, Tbx18, is crucial for the development of mesangial cells. Without Tbx18 the development of ...

The PDGFRA gene encodes the platelet-derived growth factor receptor A (PDGFRA) which is a cell surface, RTK class III Receptor ... Appiah-Kubi K, Lan T, Wang Y, Qian H, Wu M, Yao X, Wu Y, Chen Y (2017). "Platelet-derived growth factor receptors (PDGFRs) ... The PDGFRB gene encodes the platelet-derived growth factor receptor B (PDGFRB) which, like PDGFRA, is a cell surface, RTK class ... FGFR1 is the gene for the fibroblast growth factor receptor 1, a cell surface receptor that similar to PDGFRA and PDGFRB, is ...

"Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity ... of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors ... 1999). "G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain- ... "The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange". Nature. 392 ( ...

From the alpha granules come molecules such as the platelet-derived growth factor, fibrinogen, and the von Willebrand factor ( ... The ADP secreted from the dense granules then binds to receptors on the membrane of platelets. However, to allow for platelet ... The platelet plug, also known as the hemostatic plug or platelet thrombus, is an aggregation of platelets formed during early ... This is accomplished by factor XIII, also known as fibrin stabilizing factor, an enzyme that crosslinks fibrin. Factor XIII is ...

It has also shown activity against the receptors for platelet derived growth factor and vascular endothelial growth factor. ... Non-receptor tyrosine kinase inhibitors, Piperazines, Catechol ethers, Quinolines, Aromatic nitriles, Anilines, Chloroarenes, ...

Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters ... Modulation of the epidermal growth factor receptor by platelet-derived growth factor and choleragen: effects on mitogenesis. ... Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1279- ... including platelet derived growth factor (PDGF) and insulin-like growthfactor-1 (IGF-1) signal transduction. He investigated ...

... platelet-derived growth factor (PDGF) and epidermal growth factor (EGF). It has not been described yet what role these ... 1995). "Pachydermoperiostosis, study of epidermal growth factor and steroid receptors". Br J Dermatol. 133 (1): 128-133. doi: ... 1992). "Circulating plasma levels of platelet-derived growth factor in patients with hypertrophic osteoarthropathy". Clin Exp ... such as Von Willebrand factor and vascular endothelial growth factor (VEGF). These substances could also have a role in PDP ...

... functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors ... "Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop ... Cbl gene CISH Epidermal growth factor receptor, Eukaryotic translation elongation factor 1 alpha 1, FLT1, GAB1, GIT1, Grb2, ... Bedrin MS, Abolafia CM, Thompson JF (July 1997). "Cytoskeletal association of epidermal growth factor receptor and associated ...

... transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid ... BMP targets and binds to mesenchymal cells and activates a transmembrane serine/threonine kinase receptor which will lead to ... A bone growth factor is a growth factor that stimulates the growth of bone tissue. Known bone growth factors include insulin- ... SMADS are transcription factors that will induce osteoblast growth. The majority of the substrates of platelet-derived growth ...

... functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors ... For example, when activated, fibroblast growth factor receptor 1 and epidermal growth factor receptor are RTKs that have ... Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor ... "Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop ...

"In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method ... Björke H, Andersson K (January 2006). "Measuring the affinity of a radioligand with its receptor using a rotating cell dish ...

Davis RJ, Czech MP (1985). "Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor ... Davis RJ, Czech MP (1985). "Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in ... Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores ... Members of the protein kinase D (PKD) family function in many extracellular receptor-mediated signal transduction pathways. The ...

"The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell ... The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor ... Rius J, Martínez-González J, Crespo J, Badimon L (Apr 2004). "Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL- ... Liu D, Jia H, Holmes DI, Stannard A, Zachary I (Nov 2003). "Vascular endothelial growth factor-regulated gene expression in ...

... receptor Platelet-derived growth factor Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM (May ... Platelet Activating Factor) Platelet+Activating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH ... cytoplasmic platelet-activating factor acetylhydrolase 2, and platelet-activating factor acetylhydrolase 1b. Cations are one ... an enzyme that catabolizes platelet-activating factor. It is an important mediator of bronchoconstriction. It causes platelets ...

Other well-known mitogenic growth factors include platelet derived growth factor (PDGF) and epidermal growth factor (EGF). ... transforming growth factor (TGF-𝝱). TGF-𝝱 works by binding to cell-surface receptors and activating the Smad gene regulatory ... This is not true for all growth factors, as some growth factors instead appear to cause mitogenic effects like growth ... Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. ...