Sema 4D(Semaphorin 4D) functions through the PlexinB1 receptor and inhibits remyelination. Sema 3A (Semaphorin 3A) is present ... RBPJ-k blocks the Notch pathway and elicits a neurogenic program and Sox2 can also increase reprograming efficiency by causing ... MAG -Myelin-associated glycoprotein acts via the receptors NgR2, GT1b, NgR1, p75, TROY and LINGO1. OMgp -Oligodendrocyte myelin ... Nogo A functions via either its amino-Nogo terminus through an unknown receptor, or by its Nogo-66 terminus through NgR1, p75, ...

Up-regulation occurs, for example, when a cell is deficient in some kind of receptor. In this case, more receptor protein is ... Notch and Wnt in antiphase. Sex determination in the soma of a Drosophila requires the sensing of the ratio of autosomal genes ... and the expression of the receptor protein is decreased in order to protect the cell (see also tachyphylaxis). Gene Regulation ...

... including generating the mutant allele of retinoic acid receptor genes and studying the expression of receptor genes, Hox genes ... Nye, JS; Kopan, R; Axel, R (Sep 1994). "An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in ... Pratt, MA; Kralova, J; McBurney, MW (Dec 1990). "A dominant negative mutation of the alpha retinoic acid receptor gene in a ... Fahnestock, M; Koshland DE, Jr (Feb 1979). "Control of the receptor for galactose taxis in Salmonella typhimurium". Journal of ...

September 1999). "KDR receptor: a key marker defining hematopoietic stem cells". Science. 285 (5433): 1553-8. doi:10.1126/ ... notch 1 nrp-1 Nucleostemin OC.3 Oct-4 OST-PTP P-gp/MDR1 p21 p63 p75 PCLP PCNA PECAM PgP-1 phosphorylating-p38 Podocalyxin ... Baker CV, Sharpe CR, Torpey NP, Heasman J, Wylie CC (April 1995). "A Xenopus c-kit-related receptor tyrosine kinase expressed ... Testa U, Riccioni R, Diverio D, Rossini A, Lo Coco F, Peschle C (February 2004). "Interleukin-3 receptor in acute leukemia". ...

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner . Brain Behav Immun . 2018 Mar; 69: 48-56 ... De Vries found that the NMDA receptor subunit 1 is expressed on the endothelial cells lining the BBB and is involved in ... "The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier". Journal of ...

FOXO1 has been shown to interact with: androgen receptor, estrogen receptor alpha, CREB-binding protein, and tuberous sclerosis ... In HFD-fed mice, the combination of FOXO1 and Notch-1 haploinsufficiency was more effective at restoring insulin sensitivity ... Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D (July 2011). "Inhibition of Notch ... "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family". The Journal ...

However, with more new research suggests that tuft cells can also be activated by the taste receptor apparatus. These can also ... and knockdown of Notch results in increased numbers of tuft cells. The human gastrointestinal (GI) tract is full of tuft cells ... The clearance of helminth in mice that lacked taste receptor function (Trpm5 or/-gustducin KO) or enough tuft cells (Pou2f3 KO ... For example, tuft cells that are in the urethra respond to bitter compounds, through activation of the taste receptor. This ...

Notch signalling is a cell signalling pathway whose role is, among many others, to control the cell differentiation process in ... They are also the precursors of many hormones and regulate and modify their receptor mechanisms at the DNA level. There are ... The Notch proteins go through these organelles in their maturation process and can be subject to different types of ... In this second group we can also find disorders caused by mutations on the enzymes that control the glycosylation of Notch ...

"T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically ... Na SY, Lee SK, Han SJ, Choi HS, Im SY, Lee JW (May 1998). "Steroid receptor coactivator-1 interacts with the p50 subunit and ... Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E (July 2001). "Human Notch-1 inhibits NF-kappa B activity in the ... Schmitz ML, Krappmann D (2006). "Controlling NF-kappaB activation in T cells by costimulatory receptors". Cell Death Differ. 13 ...

biloba has leaves with a notch at the apex. This variety does not appear in the wild, and is only known in cultivation. It is ... November 2014). "Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review". Biochemical ... two polyphenolic compounds that have been demonstrated as peroxisome proliferator-activated receptor gamma (PPAR gamma) ...

There is no known cure for achondroplasia even though the cause of the mutation in the growth factor receptor has been found. ... The iliac wings are small and squared, with a narrow sciatic notch and horizontal acetabular roof. The tubular bones are short ... Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene that results in its protein ... Achondroplasia is caused by a mutation in fibroblast growth factor receptor 3 (FGFR3) gene. This gene encodes a protein called ...

OPCs express AMPA receptors and GABAA receptors and undergo small membrane depolarizations in response to presynaptic vesicular ... Kim H, Shin J, Kim S, Poling J, Park HC, Appel B (August 2008). "Notch-regulated oligodendrocyte specification from radial glia ... "PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells ... Nishiyama A, Lin XH, Giese N, Heldin CH, Stallcup WB (1996). "Co-localization of NG2 proteoglycan and PDGF alpha-receptor on ...

Sade H, Krishna S, Sarin A (January 2004). "The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated ... with enrichment in the luminal and in human epidermal growth factor receptor 2-positive subtypes (HER2 +). The three hotspot ... regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559-68. doi:10.1038/sj.onc.1207161. PMID ...

... of Langerhans isthmus Jacksonian seizure jaw jejunum joint joint capsule joint space jugular jugular foramen jugular notch ... plate cistern quadrigeminus quadriplegia radial artery radius radula rami communicantes ramus raphe raphe nuclei receptor layer ... temporalis muscle temporomandibular joint tendon tensor tympani muscle tensor veli palatini tentorial incisure tentorial notch ... tract mammogram mandible mandibular condyles mandibular foramen mandibular fossa mandibular nerve mandibular notch manubrium ...

She showed that self-renewal is regulated by Retinoic acid receptor gamma, and loss of this receptor has intrinsic and ... 1 June 1998). "The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells". Blood. 91 ( ... She returned to Australia in 2000, when she studied the roles of various retinoic acid receptors and their roles on ... Purton investigates the roles of retinoic acid receptors in haematopoiesis. She makes use of mouse models, cell assays and gene ...

In the case of FGF, four receptor subtypes can be activated by more than twenty different FGF ligands. Thus the functions of ... "FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis". The Journal of Neuroscience ... Receptor tyrosine kinase Granulocyte-colony stimulating factor (G-CSF) Granulocyte-macrophage colony stimulating factor (GM-CSF ... This 'acid box' motif interacts with the heparan sulfate binding site to prevent receptor activation in the absence of FGFs. ...

Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (May 1997). "A novel inhibitory receptor ( ... "Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells". Blood. 102 (10): 3815-21 ...

Receptors for signaling proteins are present in motile vesicles in cytonemes, and receptors for different signaling proteins ... Cohen M, Georgiou M, Stevenson NL, Miodownik M, Baum B (July 2010). "Dynamic filopodia transmit intermittent Delta-Notch ... Fifadara NH, Beer F, Ono S, Ono SJ (February 2010). "Interaction between activated chemokine receptor 1 and FcepsilonRI at ... They have been associated with wound closure, dorsal closure of Drosophila embryos, chemotaxis in Dictyostelium, Delta-Notch ...

c-Met is a tyrosine kinase receptor that is required for the survival and proliferation of migrating myoblasts. A lack of c-Met ... Delta1 expression in neural crest cells is necessary for muscle differentiation of the somites, through the Notch signaling ... 2005). "Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene". J Biol Chem ... Expression of skeletal alpha-actin is also regulated by the androgen receptor; steroids can thereby regulate myogenesis. ...

Notch signaling can aid in the development of all innate lymphoid cells, but in TOX-deficient cells, Notch target genes are ... Upregulation of effector function in cells lacking TOX is not always seen and it has been proposed that inhibitory receptor ... TOX was also found to bind Hes1, a Notch target gene, in embryonic kidney cells. Several ILC3 populations are reduced in the ... July 2007). "Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer". ...

Specific genes associations with TOF include: JAG1 codes for ligands within the Notch family of proteins and is highly ... FLT4 gene expression leads to Vascular endothelial growth factor receptor 3 (VEGFR-3) which helps vascularization. Mutations of ...

The Notch (N) gene expression precedes an upregulation of Dll in the cells that will become the center of the focus. This makes ... Higher transcription levels of Hh, along with other known associates of the Hh pathway, namely patched (Ptc) the Hh receptor, ... Reed, R. D.; Serfas, M.S. (2004). "Butterfly Wing Pattern Evolution Is Associated with Changes in a Notch/Distal-less Temporal ... In turn, this raises expression of its receptor Patched (Ptc) and transcription factor. Normally, in Drosophila, engrailed acts ...

... opioid receptors, acetylcholine receptors, and receptors for substance P. Stimulation of different receptors are involved in ... The stomach itself does not contract in the process of vomiting except for at the angular notch, nor is there any ... and is rich in muscarinic receptors and histamine H1 receptors. The cranial nerve X (vagus nerve) is activated when the pharynx ... Receptors on the floor of the fourth ventricle of the brain represent a chemoreceptor trigger zone, known as the area postrema ...

When Notch signaling is disrupted in zebrafish, neighboring cells no longer oscillate synchronously, indicating that Notch ... Studies indicate the importance of pathways involving Eph receptor and the Ephrin family of proteins, which coordinate border ... These genes include members of the FGF family, Wnt and Notch pathway, as well as targets of these pathways. The wavefront ... In particular, the cyclic activation of the Notch pathway appears to be of great importance in the wavefront-clock model. It ...

In 2012, her research identified that nearly 70% of patients with follicular lymphoma have lost the EphA7 receptor and she was ... 28 April 2010). "Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute ... October 2011). "The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma". Cell. Cambridge, Massachusetts: ...

The second phase involves activation of various growth factors, including EGFR (epidermal growth factor receptor) and c-Met. ... This communication can occur because of β-catenin and Notch-1 move to the nucleus of the hepatocyte approximately 15-30 minutes ...

The upper caudal fin lobe is longer than the lower lobe, and bears a notch in the trailing margin near the tip. The skin is ... longer nostrils contain more chemosensory receptors and can sample more water at a time, increasing the chances of detecting an ...

Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene. The protein encoded by ... Cleavage of PTPmu is similar to that identified for the Notch signaling pathway. PTPmu is first cleaved to yield two non- ... Koop EA, Lopes SM, Feiken E, Bluyssen HA, van der Valk M, Voest EE, Mummery CL, Moolenaar WH, Gebbink MF (2003). "Receptor ... Hiscox S, Jiang WG (1999). "Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and ...

2006). "Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals". BMC Cell Biol. 7:10. Webb, L ... Gray, P.W., Barrett, K., Chantry, D., Turner, M., and Feldmann, M. (1990). "Cloning of human tumour necrosis factor receptor ... "Defective antigen receptor mediated proliferation of B and T cells in the absence of Vav." Nature. 374: 467-470. $ joint first ...

Notch signaling has been shown to regulate the number of exocrine and endocrine cells in the pancreas, but not without the ... growth hormone secretagogue receptors) and mediates hunger. The exocrine progenitor cell develop into precursor cells ... Notch signaling allows the expansion of pancreatic progenitors by the process of lateral inhibition. These cells have been ... Kim, W.; Shin, Y. K.; Kim, B. J.; Egan, J. M. (2010). "Notch signaling in pancreatic endocrine cell and diabetes". Biochemical ...