*Nicotinic agonist

Agonist Muscarinic acetylcholine receptor Muscarinic agonist Muscarinic antagonist Nicotinic acetylcholine receptor Nicotinic ... A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The ... The development of nicotinic acetylcholine receptor agonists has come a long way since then. The nicotinic acetylcholine ... Nicotinic acetylcholine receptors are receptors found in the central nervous system, the peripheral nervous systems and ...

*Muscle-type nicotinic receptor

The muscle-type nicotinic receptor is a type of nicotinic acetylcholine receptor, consisting of the subunit combination (α1)2 ... Carbachol Suxamethonium α-Bungarotoxin α-Conotoxin Hexamethonium Pancuronium Tubocurarine Ganglion type nicotinic receptor ...

*Alpha-7 nicotinic receptor

... α7 subtype preferring blocker α3β2-Nicotinic receptor α3β4-Nicotinic receptor α4β2-Nicotinic receptor RIC3, a chaperone protein ... The alpha-7 nicotinic receptor, also known as the α7 receptor, is a type of nicotinic acetylcholine receptor implicated in long ... As with other nicotinic acetylcholine receptors, functional α7 receptors are pentameric [i.e., (α7)5 stoichiometry]. It is ... 2007). "Nootropic α7 nicotinic receptor allosteric modulator derived from GABA A receptor modulators". PNAS. 104 (19): 8059- ...

*Alpha-3 beta-2 nicotinic receptor

The alpha-3 beta-2 nicotinic receptor, also known as the α3β2 receptor, is a type of nicotinic acetylcholine receptor, ... βE Mecamylamine Memantine Methyllycaconitine Tubocurarine α3β4-Nicotinic receptor α4β2-Nicotinic receptor α7-Nicotinic receptor ... Crooks PA, Bardo MT, Dwoskin LP (2014). "Nicotinic receptor antagonists as treatments for nicotine abuse". Adv. Pharmacol. 69: ... October 2000). "Characterization of the recombinant human neuronal nicotinic acetylcholine receptors alpha3beta2 and ...

*Alpha-4 beta-2 nicotinic receptor

Oxantel α3β2-Nicotinic receptor α3β4-Nicotinic receptor α6β2-Nicotinic receptor α7-Nicotinic receptor Cordero-Erausquin, M; ... The alpha-4 beta-2 nicotinic receptor, also known as the α4β2 receptor, is a type of nicotinic acetylcholine receptor ... among the nicotinic receptor subtypes, nicotine has the highest binding affinity at the α4β2 receptor (ki=1 nM), which is also ... HS receptors) (α4)3(β2)2 receptors have low sensitivity to nicotine and high Ca2+ permeability (LS receptors) The x-ray ...

*Alpha-3 beta-4 nicotinic receptor

AT-1001 Choline α3β2-Nicotinic receptor α4β2-Nicotinic receptor α7-Nicotinic receptor Muscle-type nicotinic receptor ... The alpha-3 beta-4 nicotinic receptor, also known as the α3β4 receptor and the ganglion-type nicotinic receptor, is a type of ... As with other nicotinic acetylcholine receptors, the α3β4 receptor is pentameric [(α3)m(β4)n where m + n = 5]. The exact ... Poth K, Nutter TJ, Cuevas J, Parker MJ, Adams DJ, Luetje CW (January 1997). "Heterogeneity of nicotinic receptor class and ...

*Nicotinic acetylcholine receptor

Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Since nicotinic receptors help transmit ... The nicotinic receptors are considered cholinergic receptors, since they respond to acetylcholine. Nicotinic receptors get ... muscle-type nicotinic receptors and neuronal-type nicotinic receptors. In the muscle-type receptors, found at the neuromuscular ... Nicotinic receptors also respond to drugs, including the nicotinic receptor agonist nicotine. They are found in the central and ...

*Dehydronorketamine

DHNK is inactive at the α3β4-nicotinic acetylcholine receptor (IC50 > 100 μM) and is only very weakly active at the NMDA ... Robin A.J. Lester (11 November 2014). Nicotinic Receptors. Springer. pp. 445-. ISBN 978-1-4939-1167-7. Paul, Rajib K.; Singh, ... DHNK has been found to act as a potent and selective negative allosteric modulator of the α7-nicotinic acetylcholine receptor ( ... ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors". European Journal of ...

*Norketamine

Relative to ketamine, norketamine is much more potent as an antagonist of the α7-nicotinic acetylcholine receptor, and produces ... Robin A.J. Lester (11 November 2014). Nicotinic Receptors. Springer. pp. 445-. ISBN 978-1-4939-1167-7. ... as NMDA receptor antagonists in comparison but retain activity as potent antagonists of the α7-nicotinic acetylcholine receptor ... ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors". European Journal of ...

*Muscarinic antagonist

Anticholinergic Muscarinic agonist Nicotinic acetylcholine receptor Nicotinic agonist Nicotinic antagonist Parasympatholytic ... Acetylcholine receptors are classified into two groups based on this: muscarinic, which respond to muscarine nicotinic, which ... A muscarinic receptor antagonist (MRA) is a type of anticholinergic agent that blocks the activity of the muscarinic ... This is because by i.m/s.c it acts on presynaptic M1 receptors (autoreceptors). Intake of acetylcholine in axoplasm is ...

*CHRNB2

2000). "The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy". Nat. Genet. 26 (3): 275-6. doi: ... Bracci L, Lozzi L, Rustici M, Neri P (1992). "Binding of HIV-1 gp120 to the nicotinic receptor". FEBS Lett. 311 (2): 115-8. doi ... 2002). "Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's ... Anand R, Lindstrom J (1990). "Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene". Nucleic ...

*Sensory gating

... and Nicotinic Receptors. Schizophrenia Bulletin, 24(2):189-202.. ... Information from sensory receptors make their way to the brain ...

*Memantine

... nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons". J Pharmacol ... It has been shown that the number of nicotinic receptors in the brain are reduced in Alzheimer's disease, even in the absence ... Buisson B, Bertrand D (1 March 1998). "Open-channel blockers at the human alpha4beta2 neuronal nicotinic acetylcholine receptor ... Memantine acts as a non-competitive antagonist at different neuronal nicotinic acetylcholine receptors (nAChRs) at potencies ...

*CHRND

... has been shown to interact with Cholinergic receptor, nicotinic, alpha 1. Nicotinic acetylcholine receptor GRCh38: ... Beeson D, Jeremiah S, West LF, Povey S, Newsom-Davis J (1990). "Assignment of the human nicotinic acetylcholine receptor genes ... Wang ZZ, Hardy SF, Hall ZW (November 1996). "Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains ... Wang ZZ, Hardy SF, Hall ZW (1996). "Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of ...

*Epiboxidine

... is a chemical compound which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both ... Cheng, J.; Izenwasser, S.; Zhang, C.; Zhang, S.; Wade, D.; Trudell, M. (2004). "Synthesis and nicotinic acetylcholine receptor ... Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors". Chirality. 24 (7 ... further potent agonists for nicotinic receptors". Bioorganic & Medicinal Chemistry. 12 (1): 179-190. doi:10.1016/j.bmc.2003.10. ...

*Adiphenine

... is an inhibitor of nicotinic receptors. Dicycloverine Spitzmaul, G; Gumilar, F; Dilger, JP; Bouzat, C (2009). "The ... local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms". British Journal of ...

*Nicotinic antagonist

Nicotinic acetylcholine receptor Nicotinic agonist Muscarinic acetylcholine receptor Muscarinic agonist Muscarinic antagonist P ... A nicotinic antagonist is a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic ... and 18-methoxycoronaridine block nicotinic acetylcholine receptors in the brain and have been proposed for treating nicotine ... ISBN 0-443-07145-4. Page 149 Nicotinic antagonists at the US National Library of Medicine Medical Subject Headings (MeSH). ...

*Tebanicline

"Neuronal nicotinic receptors: A perspective on two decades of drug discovery research". Biochemical Pharmacology. Nicotinic ... Neuronal nicotinic receptors as analgesic targets: it's a winding road. Biochem Pharmacol. 2013 Oct 15;86(8):1208-14. doi: ... It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. ... Meyer, Michael D. (1 April 2006). "Neuronal nicotinic acetylcholine receptors as a target for the treatment of neuropathic pain ...

*Heteromer

Ligand-gated ion channels such as the nicotinic acetylcholine receptor and GABAA receptor are composed of five subunits ... Sometimes the channel can be made from only one type of subunit, such as the α7 nicotinic receptor, which is made up from five ... "Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology". Brain Research Reviews. 58 (2): 415 ... Graham AJ, Martin-Ruiz CM, Teaktong T, Ray MA, Court JA (August 2002). "Human brain nicotinic receptors, their distribution and ...

*CHRNE

Lobos EA (1993). "Five subunit genes of the human muscle nicotinic acetylcholine receptor are mapped to two linkage groups on ... Nicotinic acetylcholine receptor GRCh38: Ensembl release 89: ENSG00000108556 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Entrez Gene: CHRNE cholinergic receptor, nicotinic, epsilon". Cossins, J.; Burke, G.; Maxwell, S.; Spearman, H.; Man, S.; Kuks ... Acetylcholine receptor subunit epsilon is a protein that in humans is encoded by the CHRNE gene. Acetylcholine receptors at ...

*Lobeline

Damaj, M. I.; Patrick, G. S.; Creasy, K. R.; Martin, B. R. (1997). "Pharmacology of lobeline, a nicotinic receptor ligand". The ... and acts as a mixed agonist-antagonist at nicotinic acetylcholine receptors to which it binds at the subunit interfaces of the ... binds to mu opioid receptors and diminishes the effects of opioid receptor agonists". Drug and Alcohol Dependence. 89 (2-3): ... It is also an antagonist at μ-opioid receptors. It seems to be a P-glycoprotein inhibitor, according to at least one study. It ...

*A-366,833

... is a drug developed by Abbott, which acts as an agonist at neural nicotinic acetylcholine receptors selective for the ... heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in ... "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem. 2 (6): 746-767. doi:10.1002 ... heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists". Journal of Medicinal Chemistry. 50 (22): 5493-5508 ...

*Hirsuteine

... is an in vitro antagonist of nicotinic receptors. Watano, T; Nakazawa, K; Obama, T; Mori, M; Inoue, K; Fujimori, K; ... Takanaka, A (1993). "Non-competitive antagonism by hirsuteine of nicotinic receptor-mediated dopamine release from rat ...

*TC-1698

Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). "Central nicotinic receptors: ... a Class of Potent Nicotinic Acetylcholine Receptor-Ligands". The Journal of Organic Chemistry. 73 (9): 3497-507. doi:10.1021/ ... is a drug developed by Targacept which acts as a partial agonist for the α7 subtype of neural nicotinic acetylcholine receptors ...

*TC-2216

... is a drug developed by Targacept which acts as a partial agonist at neural nicotinic acetylcholine receptors and is ... Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). "Central nicotinic receptors: ...

*Nigel Unwin

"Refined structure of the nicotinic acetylcholine receptor at 4Å resolution", Journal of Molecular Biology 346:967-989 Miyazawa ... A, Fujiyoshi Y, Unwin N (2003), "Structure and gating mechanism of the acetylcholine receptor pore" Nature 423:949-955 Unwin ...

*ABT-202

... is a drug developed by Abbott, which acts as an agonist at neural nicotinic acetylcholine receptors and has been ... Jain, K. K. (2004). "Modulators of nicotinic acetylcholine receptors as analgesics". Current Opinion in Investigational Drugs. ... Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). "Central nicotinic receptors: ...