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*  Tachykinin receptor 2
"Crosstalk between neurokinin receptors is relevant to hematopoietic regulation: cloning and characterization of neurokinin-2 ... Gerard NP, Eddy RL, Shows TB, Gerard C (Jan 1991). "The human neurokinin A (substance K) receptor. Molecular cloning of the ... Gerard NP, Eddy RL, Shows TB, Gerard C (Nov 1990). "The human neurokinin A (substance K) receptor. Molecular cloning of the ... This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. Several selective ...
*  Trefoil factor 2
Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. ... Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in ... Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. ... "The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough ...
*  TAC3
Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia ... Neurokinin B Tachykinin receptor 3 GRCh38: Ensembl release 89: ENSG00000166863 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... 1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds 3Hsenktide and 125I-MePhe7neurokinin B ... Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. ...
*  Neurokinin A
Modified from: Sun J, Ramnath RD, Tamizhselvi R, Bhatia M."Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB- ... Sun, J; Ramnath, RD; Tamizhselvi, R; Bhatia, M (Sep 2008). "Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB- ... Neurokinin A has an inhibitory effect on the formation of myeloid cells, and appear to be involved in one specific receptor ... most notably through the receptor NK2, though regulation of NK2 receptors seems to be mediated by the activity of NK1 receptors ...
*  Tachykinin peptides
Antagonists of neurokinin-1 (NK1) receptors (NK1 receptor antagonists), through which substance P acts, have been proposed to ... NK1, NK2 and NK3 selectively bind to substance P, neurokinin A, and neurokinin B, respectively. Whilst the receptors are not ... neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior". Physiol. Behav. 54 (2): 249- ... TAC3 encodes neurokinin B. The most notable tachykinin is Substance P. There are three known mammalian tachykinin receptors ...
*  Meclinertant
... (SR-48692) is a drug which acts as a selective, non-peptide antagonist at the neurotensin receptor NTS1, and was ... Griebel G, Moindrot N, Aliaga C, Simiand J, Soubrié P (December 2001). "Characterization of the profile of neurokinin-2 and ... Felszeghy K, Espinosa JM, Scarna H, Bérod A, Rostène W, Pélaprat D (December 2007). "Neurotensin receptor antagonist ... possible role of NTR1 receptors in neuropsychiatric disorders". Neurochemistry International. 53 (6-8): 355-61. doi:10.1016/j. ...
*  Tachykinin receptor 3
Neurokinin B - endogenous peptide ligand, also interacts with other neurokinin receptors but has highest affinity for NK3 ... This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. A number of selective ligands ... "Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and ... Page NM, Dakour J, Morrish DW (Jul 2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre- ...
*  Tachykinin receptor 1
The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein ... NK1 receptor antagonist Tachykinin receptor Discovery and development of neurokinin 1 receptor antagonists GRCh38: Ensembl ... SP binds to all three of the tachykinin receptors, but it binds most strongly to the NK1 receptor. Tachykinin NK1 receptor ... IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Receptors, Neurokinin-1 ...
*  Substance P
The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). It belongs to the tachykinin receptor ... Other neurokinin subtypes and neurokinin receptors that interact with SP have been reported as well. Amino acid residues that ... "Absence of the SP/SP receptor circuitry in the substance P-precursor knockout mice or SP receptor, neurokinin (NK)1 knockout ... Its receptor - the neurokinin type 1 - is distributed over cytoplasmic and nuclear membranes of many cell types (neurons, glia ...
*  L-733,060
Bang R, Sass G, Kiemer AK, Vollmar AM, Neuhuber WL, Tiegs G (2003). "Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 ... Rittner HL, Lux C, Labuz D, Mousa SA, Schäfer M, Stein C, Brack A (2007). "Neurokinin-1 receptor antagonists inhibit the ... Bang R, Biburger M, Neuhuber WL, Tiegs G (2004). "Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis ... Muñoz M, Rosso M, Coveñas R, Montero I, González-Moles MA, Robles MJ (2007). "Neurokinin-1 receptors located in human ...
*  Tradipitant
2008). "Neurokinin 1 receptor antagonism as a possible therapy for alcoholism". Science. 6: 1536-1539. doi:10.2147/SAR.S70350. ... 2010). "Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder". European ... Tradipitant (VLY-686 or LY686017) is an experimental drug that is a neurokinin 1 antagonist. It works by blocking substance P, ...
*  Serlopitant
Payton, S (August 2010). "Urinary Incontinence: Neurokinin Receptor Antagonist Inferior to Tolterodine for OAB". Nature Reviews ... Placebo Controlled Trial of a Neurokinin-1 Receptor Antagonist for Overactive Bladder". The Journal of Urology. 184 (2): 616-22 ... Serlopitant (INN, codenamed VPD-737) is a drug which acts as an NK1 receptor antagonist. It was assessed in clinical trials for ... Serlopitant is now undergoing clinical trials for the treatment of chronic pruritus (itch) NK1 receptor antagonist " ...
*  Lanepitant
Pharmacological characterization of LY303870: a novel, potent and selective nonpeptide substance P (neurokinin-1) receptor ... Lanepitant (INN, code name LY303870) is a drug developed by Eli Lilly which acts as a selective antagonist for the NK1 receptor ... PMID 11290877 Bignami F, Giacomini C, Lorusso A, Aramini A, Rama P, Ferrari G. NK1 receptor antagonists as a new treatment for ... 2001 Mar;21(2):102-6. PMID 11422091 Goldstein DJ, Wang O, Todd LE, Gitter BD, DeBrota DJ, Iyengar S. Study of the analgesic ...
*  NK1 receptor antagonist
The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting ... SP binds to all three of the tachykinin receptors, but it binds most strongly to the NK1 receptor. Tachykinin NK1 receptor, ... In 1984, it was decided that the tachykinin receptors should be called tachykinin NK1 receptor, tachykinin NK2 receptor and ... NK1 receptor consists of 407 amino acid residues, and it has a molecular weight of 58.000. NK1 receptor, as well as the other ...
*  Rhodopsin-like receptors
Melatonin receptor InterPro: IPR000025 Melatonin receptor 1A (MTNR1A, ML1A) Melatonin receptor 1B (MTNR1B, ML1B) Neurokinin ... chemokine receptor (DARC, DUFF) G Protein-coupled Receptor 30 (GPER, CML2, GPCR estrogen receptor) Angiotensin II receptor ... Opioid receptor InterPro: IPR001418 delta Opioid receptor (OPRD1, OPRD) kappa Opioid receptor (OPRK1, OPRK) mu Opioid receptor ... Motilin receptor (MLNR, GPR38) Anaphylatoxin receptors InterPro: IPR002234 C3a receptor (C3AR1, C3AR) C5a receptor (C5AR1, C5AR ...
*  5-HT1A receptor
5-HT1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit ... The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the ... The serotonin 1A receptor is encoded by the HTR1A gene. The 5-HT1A receptor is the most widespread of all the 5-HT receptors. ... Gobbi G, Cassano T, Radja F, Morgese MG, Cuomo V, Santarelli L, Hen R, Blier P (April 2007). "Neurokinin 1 receptor antagonism ...
*  Vofopitant
A selective neurokinin-1 receptor antagonist in chronic PTSD: a randomized, double-blind, placebo-controlled, proof-of-concept ... Anxiolytic-like effects of the neurokinin 1 receptor antagonist GR-205171 in the elevated plus maze and contextual fear- ... NK1 receptor antagonist Gardner CJ, Armour DR, Beattie DT, Gale JD, Hawcock AB, Kilpatrick GJ, Twissell DJ, Ward P. GR205171: a ... Vofopitant (GR-205,171) is a drug which acts as an NK1 receptor antagonist. It has antiemetic effects as with other NK1 ...
*  List of MeSH codes (D12.776.543)
... receptors, neurokinin-1 MeSH D12.776.543.750.720.600.830.540 -- receptors, neurokinin-2 MeSH D12.776.543.750.720.600.830.580 ... receptors, neurokinin-1 MeSH D12.776.543.750.750.555.830.540 -- receptors, neurokinin-2 MeSH D12.776.543.750.750.555.830.580 ... receptors, neurokinin-3 MeSH D12.776.543.750.720.600.850 -- receptors, thyrotropin MeSH D12.776.543.750.720.600.860 -- ... receptors, neurokinin-3 MeSH D12.776.543.750.750.555.850 -- receptors, thyrotropin MeSH D12.776.543.750.750.555.860 -- ...
*  Ezlopitant
Giardina GA, Gagliardi S, Martinelli M (August 2003). "Antagonists at the neurokinin receptors--recent patent literature". ... Ezlopitant (INN, code name CJ-11,974) is an NK1 receptor antagonist. It has antiemetic and antinociceptive effects. Pfizer was ... NK1 receptor antagonist Maropitant (tert-butyl instead of isopropyl) "International Nonproprietary Names for Pharmaceutical ... Tsuchiya M, Sakakibara A, Yamamoto M (January 2005). "A tachykinin NK1 receptor antagonist attenuates the 4 beta-phorbol-12- ...
*  Burapitant
... a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pharmacological ... a centrally active nonpeptide antagonist of the tachykinin neurokinin 1 receptor: II. Neurochemical and behavioral ... implication of new neurokinine 1-sensitive receptor binding site and interaction with enkephalin/mu opioid receptor ... which was one of the first compounds developed that acts as a potent and selective antagonist for the NK1 receptor. While ...
*  Sean Ekins
... and identification of the cytochrome P-450 inhibitory potency of neurokinin-1 receptor antagonists."[5] U.S. Patent no 6489094 ... J Pharmacol Exp Ther 301, 427-434 Ekins, S.; Erickson, J.A. (2002). "A pharmacophore for human pregnane-X-receptor ligands". ... 2005). "A Novel Method for Visualizing Nuclear Hormone Receptor Networks Relevant to Drug Metabolism". Drug Metab Dispos. 33: ... models for studying nuclear receptor-ligand co-evolution, computational models for PXR agonists and antagonists as well as ...
*  Preprotachykinin
... which produces substance P and neurokinin A (also called "substance K"), and the derived neuropeptide K and neurokinin gamma. ... receptors, and regulatory mechanisms". FASEB Journal. 4: 1606-15. PMID 1969374. ... which produces neurokinin B. Helke CJ, Krause JE, Mantyh PW, Couture R, Bannon MJ (1 April 1990). "Diversity in mammalian ... preprotachykinin-2 (also PPT-2, PPT-II, or PPT-B), ...
*  5-HT3 antagonist
... are a class of drugs that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals ... on responses to injection of a neurokinin agonist into the ventral tegmental area of the rat brain". Eur. J. Pharmacol. 138 (2 ... The 5-HT3 receptor was later found to correspond to the M receptor. In the 1970s, John Fozard found that metoclopramide and ... The 5-HT3 receptor antagonists suppress vomiting and nausea by inhibiting serotonin binding to the 5-HT3 receptors. The highest ...
*  Fezolinetant
... the genes respectively encoding neurokinin B and its receptor, the NK3 receptor, have been found in patients with idiopathic ... "Optimization of Novel Antagonists to the Neurokinin‑3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)". ACS ... NK3 receptor antagonists are anticipated as a useful clinical alternative to estrogens for management of hot flashes, but with ... In accordance, NK3 receptor antagonists like fezolinetant have been found to dose-dependently suppress luteinizing hormone (LH ...
*  MLE-4901
... selective neurokinin-3 (NK3) receptor antagonist which is under development by AstraZeneca and Millendo Therapeutics for the ... "Tachykinin neurokinin 3 receptor antagonists: a patent review (2005 - 2010)". Expert Opin Ther Pat. 21 (5): 637-55. doi:10.1517 ... Litman RE, Smith MA, Desai DG, Simpson T, Sweitzer D, Kanes SJ (2014). "The selective neurokinin 3 antagonist AZD2624 does not ... Tachykinin receptor 3 § Agonists List of investigational hormonal agents § GnRH/gonadotropins http://adisinsight.springer.com/ ...
*  R-type calcium channel
Meza U, Thapliyal A, Bannister RA, Adams BA (2007). "Neurokinin 1 receptors trigger overlapping stimulation and inhibition of ... 184 (2): 143-59. doi:10.1007/s00232-001-0083-4. PMID 11719851. Pereverzev A, Leroy J, Krieger A, et al. (2002). "Alternate ... 21 (2): 352-65. doi:10.1006/mcne.2002.1179. PMID 12401453. Fernandez F, Curtain RP, Colson NJ, et al. (2007). "Association ... doi:10.1007/s00125-007-0846-2. PMID 17934712. Nyholt DR, LaForge KS, Kallela M, et al. (2008). "A high-density association ...