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*  Protein primary structure
Instead of a simple methyl group, the myristoyl group has a tail of 14 hydrophobic carbons, which make it ideal for anchoring ... Similar to phosphorylated tyrosines, sulfated tyrosines are used for specific recognition, e.g., in chemokine receptors on the ... deamidation (succinimide formation) In this modification, an asparagine or aspartate side chain attacks the following peptide ...
*  Excitotoxicity
This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and ... Ischemia is followed by accumulation of glutamate and aspartate in the extracellular fluid, causing cell death, which is ... 2012). "Excitotoxic potential of the cyanotoxin β-methyl-amino-l-alanine (BMAA) in primary human neurons". Toxicon. 60 (6): ... Blood sugars are the primary glutamate removal method from inter-synaptic spaces at the NMDA and AMPA receptor site. Persons in ...
*  Molecular and epigenetic mechanisms of alcoholism
Several receptors directly interact with ethanol to promote a cascade of signaling. N-methyl-D-aspartate (NMDA) receptors are ... Ethanol sensitivity of recombinant human N-methyl-D-aspartate receptors. Neurochem Int. 38, 333-340. Nagy, J. (2004). The NR2B ... Another family of receptors, metabotropic glutamate receptors (mGluR), may also contribute by activating MAPK pathways and ... In chronic ethanol users, ethanol binds to GABA receptors causing the down-regulation of GABA receptors; which are now less ...
*  Felbamate
Kleckner NW, Glazewski JC, Chen CC, Moscrip TD (May 1999). "Subtype-Selective Antagonism of N-Methyl-D-aspartate Receptors by ... Harty TP, Rogawski MA (March 2000). "Felbamate Block of Recombinant N-Methyl-D-aspartate Receptors: Selectivity for the NR2B ... Opposing Effects on N-Methyl-D-aspartate and Gamma-Aminobutyric Acid A Receptors". Annals of Neurology. 35 (2): 229-34. doi: ... "Felbamate Block of the N-Methyl-D-aspartate Receptor". The Journal of Pharmacology and Experimental Therapeutics. 273 (2): 878- ...
*  Actinin alpha 2
"Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors". Neuron. 21 (2): 443-53. doi:10.1016/ ... "Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors". The ... "Competitive binding of alpha-actinin and calmodulin to the NMDA receptor". Nature. 385 (6615): 439-42. doi:10.1038/385439a0. ... "Competitive binding of alpha-actinin and calmodulin to the NMDA receptor". Nature. 385 (6615): 439-42. doi:10.1038/385439a0. ...
*  List of neurosteroids
... hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors". J. Neurosci. 33 (44): 17290-300. doi: ... "Different oxysterols have opposing actions at N-methyl-D-aspartate receptors". Neuropharmacology. 85: 232-42. doi:10.1016/j. ... GABAA receptor positive allosteric modulator Ganaxolone: 3β-methyl-5α-pregnan-3α-ol-20-one - GABAA receptor positive allosteric ... GABAA receptor negative allosteric modulator, NMDA receptor positive allosteric modulator, sigma-1 receptor agonist, TRPM3 ...
*  Martha Constantine-Paton
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes. Cline HT, Debski EA, Constantine-Paton M. Proc Natl ... Using this system, she and her colleagues demonstrated the importance of NMDA receptors in development plasticity. She ...
*  Tyrosine phosphorylation
Lau LF, Huganir RL (1995). "Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits". J Biol Chem. 270 ... The major excitatory neurotransmitter receptors in the central nervous system are the glutamate receptors. These receptors can ... association of growth factor with receptor dimerization of receptor and autophosphorylation of receptor tyrosine kinase (RTK) ... Receptor tyrosine kinases are type I transmembrane proteins possessing an N-terminal extracellular domain, which can bind ...
*  Paraneoplastic syndrome
January 2007). "Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Ovarian Teratoma". Ann. Neurol. ... anti-NMDA receptor encephalitis, and polymyositis. The following diseases manifest by means of mucocutaneous dysfunction: ...
*  Dexanabinol
December 1989). "Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker". Proceedings of the ... Unlike other cannabinoid derivatives, HU-211 does not act as a cannabinoid receptor agonist, but instead has NMDA antagonist ...
*  GRIN2B
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. The NMDA receptor channel has been shown ... Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a ... "Entrez Gene: GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B". Yoshimura Y, Ohmura T, Komatsu Y (July 2003). " ... Adams SL, Foldes RL, Kamboj RK (January 1995). "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and ...
*  GRIN2A
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved ... "Entrez Gene: GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A". Hamza TH, Chen H, Hill-Burns EM, Rhodes SL, ... Foldes RL, Adams SL, Fantaske RP, Kamboj RK (1994). "Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and ... Ma J, Zhang GY (September 2003). "Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its ...
*  Perzinfotel
"Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en- ... a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere". J ... "Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl] ...
*  Niflumic acid
PMID 12920213 Lerma J., Martin d.R. (1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex ... 2003): Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a ...
*  Autoimmune encephalitis
... such as N-methyl D-aspartate receptors and leucine-rich, glioma inactivated protein and contactin-associated protein like, that ... "Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents". Annals of Neurology. 66 (1): 11-18. doi: ... "N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse". Movement Disorders. ... "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma". Annals of Neurology. 61 (1): ...
*  Mechanisms of schizophrenia
"A quantitative review of the postmortem evidence for decreased cortical N-methyl-d-aspartate receptor expression levels in ... "Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia". Molecular Psychiatry. 18 (11): 1185-92. doi ... "Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and ... In particular, the expression of mRNA for the NR1 receptor subunit, as well as the protein itself is reduced in the prefrontal ...
*  Short-term effects of alcohol consumption
April 2007). "Aberrant synaptic activation of N-methyl-D-aspartate receptors underlies ethanol withdrawal hyperexcitability". J ... "Chronic intermittent ethanol treatment selectively alters N-methyl-D-aspartate receptor subunit surface expression in cultured ... Ethanol inhibits the ability of glutamate to open the cation channel associated with the N-methyl-D-aspartate (NMDA) subtype of ... Alteration of NMDA receptor numbers in chronic alcoholics is likely to be responsible for some of the symptoms seen in delirium ...
*  Gacyclidine
... a new neuroprotective agent acting at the N-methyl-D-aspartate receptor". CNS Drug Reviews. 7 (2): 172-98. doi:10.1111/j.1527- ... Gacyclidine (GK-11) is a psychoactive drug which acts as a dissociative via functioning as a non-competitive NMDA receptor ... "The search for TCP analogues binding to the low affinity PCP receptor sites in the rat cerebellum". Eur. J. Med. Chem. 34 (2): ...
*  Ifenprodil
Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with ... "Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects". Steroids. 76 (13): 1409 ... NMDA receptors are multimeric ionotropic glutamate receptors composed of four subunits. GluN1 is obligate for functional ... Ifenprodil is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B ( ...
*  Freeman-Sheldon syndrome
"Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation". Proc. Natl. Acad. Sci. U.S ... Liberzon I, Zubieta JK, Fig LM, Phan KL, Koeppe RA, Taylor SF (May 2002). "mu-Opioid receptors and limbic responses to aversive ...
*  Indantadol
August 2003). "Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride ... a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain ... a putative N-methyl-D-aspartate receptor antagonist". NeuroReport. 13 (16): 2071-4. doi:10.1097/00001756-200211150-00016. PMID ... non-competitive NMDA receptor antagonist. A pilot study of indantadol for chronic cough was initiated in October 2009 and in ...
*  Traxoprodil
... a novel NR2B subunit antagonist of the N-methyl-D-aspartate receptor, on the volume of ischemic brain damage off cytotoxic ... "Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors". Proceedings of the ... an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors". Experimental Neurology. 163 (1): 239-43. doi:10.1006/ ... a potent new neuroprotectant which blocks N-methyl-D-aspartate responses". Journal of Medicinal Chemistry. 38 (16): 3138-45. ...
*  NMDA receptor antagonist
Hara K, Sata T (2006). "Inhibitory effect of gabapentin on N-methyl-D-aspartate receptors expressed in Xenopus oocytes". Acta ... link) "Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical ... November 2013). "Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor ... the N-Methyl-D-aspartate receptor (NMDAR). They are used as anesthetics for animals including humans; the state of anesthesia ...
*  Oligodendrocyte
Damage has also been shown to be mediated by N-methyl-D-aspartate receptors. Oligodendrocyte dysfunction may also be implicated ... "PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells ... Ragheb, Fadi (1999). "The M3 Muscarinic Acetylcholine Receptor Mediates p42mapk Activation and c-fos mRNA Expression in ... Káradóttir, R.; D. Attwell (14 April 2007). "Neurotransmiter receptors in the life and death of oligodendrocytes". Neuroscience ...
*  Pregnenolone
... a positive allosteric modulator at the N-methyl-D-aspartate receptor". Molecular Pharmacology. 40 (3): 333-6. PMID 1654510. ... December 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature ... The 3β-methyl ether of pregnenolone, 3β-methoxypregnenolone (MAP-4343), retains similar activity to pregnenolone in regards to ... It prevents CB1 receptor agonists like tetrahydrocannabinol, the main active constituent in cannabis, from fully activating the ...
*  GRIK5
Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor ... "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult ... 2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): ... Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene. This gene encodes a protein ...
*  CAMK2B
"Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current". Mol. Pharmacol. 59 (5): 960 ... phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor ...