*Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-receptor complexes in the cell ... Location of M5 receptors is not well known. Like the M1 and M3 muscarinic receptor, M5 receptors are coupled with G proteins of ... M2 muscarinic receptors act via a Gi type receptor, which causes a decrease in cAMP in the cell, inhibition of voltage-gated ... Muscarinic receptors vary in the G protein to which they are bound, with some correlation according to receptor type. G ...

*Muscarinic acetylcholine receptor M5

The human muscarinic acetylcholine receptor M5, encoded by the CHRM5 gene, is a member of the G protein-coupled receptor ... 1996). "Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein ... "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor ... Muscarinic receptors mediate many of the effects of acetylcholine in the central and peripheral nervous system. The clinical ...

*Muscarinic acetylcholine receptor M1

The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that ... "Acetylcholine receptors (muscarinic): M1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... "Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice" ( ... Goyal RK (1989). "Muscarinic receptor subtypes. Physiology and clinical implications". N. Engl. J. Med. 321 (15): 1022-9. doi: ...

*Muscarinic acetylcholine receptor M3

... or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3. The M3 muscarinic receptors are ... Like the M1 muscarinic receptor, M3 receptors are coupled to G proteins of class Gq, which upregulate phospholipase C and, ... "Acetylcholine receptors (muscarinic): M3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, ...

*Muscarinic acetylcholine receptor M4

The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in ... Muscarinic acetylcholine receptors possess a regulatory effect on dopaminergic neurotransmission. Activation of M4 receptors in ... "Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C". J ... "Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice". ...

*Muscarinic acetylcholine receptor M2

The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine ... "Acetylcholine receptors (muscarinic): M2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... M2 muscarinic receptors act via a Gi type receptor, which causes a decrease in cAMP in the cell, generally leading to ... "Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor. Analysis of the role of N-glycosylation in receptor ...

*Milameline

... (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition- ... Broadley, Kenneth J.; Kelly, David R. (2001). "Muscarinic Receptor Agonists and Antagonists". Molecules. 6 (3): 142-193. doi: ... a novel muscarinic agonist for the treatment of Alzheimer's disease". Life Sciences. 56 (11-12): 877-82. doi:10.1016/0024-3205( ...

*Benign prostatic hyperplasia

Abrams, P; Andersson, KE (November 2007). "Muscarinic receptor antagonists for overactive bladder". BJU international. 100 (5 ... Tamsulosin and silodosin are selective α1 receptor blockers that preferentially bind to the α1A receptor in the prostate ... Less-selective α1 receptor blockers such as terazosin and doxazosin may lower blood pressure. The older, less selective α1- ... In both of these cell types, DHT binds to nuclear androgen receptors and signals the transcription of growth factors that are ...

*Nicotinic antagonist

Nicotinic acetylcholine receptor Nicotinic agonist Muscarinic acetylcholine receptor Muscarinic agonist Muscarinic antagonist P ... at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, the classical ... and 18-methoxycoronaridine block nicotinic acetylcholine receptors in the brain and have been proposed for treating nicotine ...

*G beta-gamma complex

Brodde OE, Michel MC (December 1999). "Adrenergic and muscarinic receptors in the human heart". Pharmacological Reviews. 51 (4 ... G protein-coupled receptor kinase 2 (GRK2), which phosphorylates and deactivates certain G protein coupled receptors . When the ... "Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors". ... Studies have shown that it is the Gβγ dimer that demonstrates specificity for the appropriate receptor and that the Gγ subunit ...

*Muscarine

Muscarinic agonists activate muscarinic receptors while nicotinic agonists activate nicotine receptors. Both are direct-acting ... These receptors were named after muscarine. There are 5 different types of muscarinic receptors; M1 - M5, and most tissues ... Atropine is also an alkaloid and inhibits acetylcholine and thus muscarine by binding to muscarinic receptors. Other muscarinic ... Cardiac ventricles contain muscarinic receptors that mediate a decrease in the force of contractions leading to a lower blood ...

*Glycopyrronium bromide

Glycopyrronium blocks muscarinic receptors, thus inhibiting cholinergic transmission. Glycopyrronium bromide affects the ... "Pharmacological characterization of the muscarinic receptor antagonist, glycopyrrolate, in human and guinea-pig airways". Br. J ... Glycopyrronium bromide is a medication of the muscarinic anticholinergic group. It does not cross the blood-brain barrier and ... It is also used in conjunction with neostigmine, a neuromuscular blocking reversal agent, to prevent neostigmine's muscarinic ...

*ANAVEX2-73

This is via competitive inhibition of muscarinic receptors. Muscarinic receptors are involved in the formation of both short ... ANAVEX2-73 acts as a muscarinic receptor and a moderate sigma1 receptor agonist. ANAVEX2-73 may function as a pro-drug for ... a NMDA receptor antagonist. "Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma" (PDF). Journal ... Malviya, M; Kumar, YC; Asha, D; Chandra, JN; Subhash, MN; Rangappa, KS (2008). "Muscarinic receptor 1 agonist activity of novel ...

*Oxomemazine

Lee, S. W.; Woo, C. W.; Kim, J. G. (1994). "Selectivity of oxomemazine for the M1 muscarinic receptors". Archives of pharmacal ...

*Cycloplegia

Cycloplegic drugs are generally muscarinic receptor blockers. These include atropine, cyclopentolate, homatropine, scopolamine ... Cycloplegia with accompanying mydriasis (dilation of pupil) is usually due to topical application of muscarinic antagonists ...

*Protein kinase C

ISBN 0-07-142280-3. "Entrez Gene: CHRM1 cholinergic receptor, muscarinic 1". Walter F. Boron (2005). Medical Physiology: A ... "Excitatory alpha1-adrenergic receptors predominate over inhibitory beta-receptors in rabbit dorsal detrusor". The Journal of ... Their substrates are, e.g., MARCKS proteins, MAP kinase, transcription factor inhibitor IκB, the vitamin D3 receptor VDR, Raf ... Upon activation, protein kinase C enzymes are translocated to the plasma membrane by RACK proteins (membrane-bound receptor for ...

*Methoctramine

Gallamine triethiodide M2 receptor Muscarinic receptor Acetylcholine Jakubik, Jan; Zimcik, Pavel; Randakova, Alena; Fuksova, ... Watson, N.; Barnes, P.J.; Maclagan, J. (1992). "Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic ... ISBN 978-3-8055-6537-0 Gómez-Martínez, LE1; Cueva-Rolón, R. (Nov 5, 2009). "Muscarinic receptor antagonism at the spinal cord ... It preferently binds to the pre-synaptic receptor M2, a muscarinic acetylcholine ganglionic protein complex present basically ...

*Parasympathomimetic drug

M3 receptors) Carbachol (all muscarinic receptors and some nicotinic receptors) Methacholine (all muscarinic receptors) Plant ... These act by stimulating the nicotinic or muscarinic receptors. Choline esters Acetylcholine (all acetylcholine receptors) ... Chemicals in this family can act either directly by stimulating the nicotinic or muscarinic receptors (thus mimicking ... via blockade of the α adrenergic receptors Anti-adrenergics See also: alpha blocker and beta blocker clonidine (α-receptor ...

*Atrioventricular block

The cholinergic receptor types affected are the muscarinic receptors. There are three types: First-degree atrioventricular ...

*Enterochromaffin-like cell

"Muscarinic receptor subtypes in the alimentary tract" (PDF). Journal of Physiology and Pharmacology. 60 (1): 3-21. PMID ... However, ECL cells are activated directly by ACh on M1 receptors from direct vagal innervation leading to histamine release. ...

*Urinary bladder

Stretch receptors in the bladder signal the parasympathetic nervous system to stimulate the muscarinic receptors in the ... The main receptor activated is the M3 receptor, although M2 receptors are also involved and whilst outnumbering the M3 ... Giglio, D; Tobin, G (2009). "Muscarinic receptor subtypes in the lower urinary tract". Pharmacology. 83 (5): 259-69. doi: ... Uchiyama, T; Chess-Williams, R (December 2004). "Muscarinic receptor subtypes of the bladder and gastrointestinal tract". ...

*Otilonium bromide

Otilinium binds to both muscarinic receptors and tachykinin NK2 receptors. It has been shown to inhibit L-type and T-type ...

*KCNQ5

They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct ...

*Oxybutynin

"Muscarinic receptor antagonists in the treatment of overactive bladder". Urology (55)5, Supp. 1:33-46, 2000. Tupker RA, Harmsze ... It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct ... 2006). "Advantages for Transdermal over Oral Oxybutynin to Treat Overactive Bladder: Muscarinic Receptor Binding, Plasma Drug ... M2 and M3 muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea ...

*Mushroom poisoning

Muscarine: Muscarine stimulates the muscarinic receptors of the nerves and muscles. Symptoms include sweating, salivation, ...

*Pre-Bötzinger complex

The suppression of muscarinic receptors and the activation of nicotinic receptors due to prenatal exposure to nicotine have ... Activation of M3 muscarinic receptors by acetylcholine and NK1 by Substance P significantly increases NALCN currents, while ... Acetylcholine plays an important modulatory role on the respiratory system by altering nicotinic and muscarinic receptors. ... Adenosine modulates the preBötC output via activation of the A1 and A2A receptor subtypes. An adenosine A1 receptor agonist has ...