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*  Quisqualic acid
... and group I metabotropic glutamate receptors. It is one of the most potent AMPA receptor agonists known. It causes ... Ion dependence of ligand binding to metabotropic glutamate receptors. Biochemical and Biophysical Research Communications. 2006 ... Insect glutamate receptors. Advances in Insect Biochemistry and Physiology. 24: 309-341.. ... The relationship between agonist potency and AMPA receptor kinetics. Biophysical Journal. 2006 Aug 15;91(4):1336-46. PMID ...
*  Glutamate receptor
... aspartic acid Glutamate transporter Metabotropic glutamate receptor Synaptic plasticity Neurodegeneration Glutamate receptor- ... Glutamate Receptors at the US National Library of Medicine Medical Subject Headings (MeSH) "Metabotropic Glutamate Receptors". ... Mammalian ionotropic glutamate receptor subunits and their genes: Mammalian metabotropic glutamate receptors are all named ... Excessive glutamate, or excitotoxins acting on the same glutamate receptors, overactivate glutamate receptors (specifically ...
*  Metabotropic glutamate receptor
The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect ... Metabotropic glutamate receptors are known to act as modulators of (affect the activity of) other receptors. For example, group ... Unlike ionotropic receptors, metabotropic glutamate receptors are not ion channels. Instead, they activate biochemical cascades ... Metabotropic glutamate receptors are also thought to affect dopaminergic and adrenergic neurotransmission. Like other glutamate ...
*  Metabotropic glutamate receptor 6
Glutamate receptor, metabotropic 6, also known as GRM6, is a protein which in humans is encoded by the GRM6 gene. L-glutamate ... The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the ... Metabotropic glutamate receptor GRCh38: Ensembl release 89: ENSG00000113262 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... 2001). "Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human ...
*  Metabotropic glutamate receptor 1
The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 ... The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the ... "Metabotropic Glutamate Receptors: mGlu1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... metabotropic 1". Stephan D, Bon C, Holzwarth JA, Galvan M, Pruss RM (1996). "Human metabotropic glutamate receptor 1: mRNA ...
*  Metabotropic glutamate receptor 7
"Entrez Gene: GRM7 glutamate receptor, metabotropic 7". Li X, Gardner EL, Xi ZX (2008). "The Metabotropic Glutamate Receptor 7 ( ... Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene. L-glutamate is the major excitatory ... The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the ... Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (1997). "Localization of two metabotropic glutamate receptor genes ...
*  Metabotropic glutamate receptor 4
GRM4 glutamate receptor, metabotropic 4". Chaudhari N, Landin AM, Roper SD (Feb 2000). "A metabotropic glutamate receptor ... Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor family. Group III receptors ... "Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2)". Molecular ... Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. ...
*  Metabotropic glutamate receptor 8
... is a protein that in humans is encoded by the GRM8 gene. L-glutamate is the major excitatory ... The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the ... a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the ... a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the ...
*  Metabotropic glutamate receptor 3
... has been shown to interact with: GRIP1, PICK1, and PPM1A. Metabotropic glutamate receptor ... Metabotropic glutamate receptor 3 is a protein that in humans is encoded by the GRM3 gene. L-glutamate is the major excitatory ... The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the ... "Metabotropic Glutamate Receptors: mGlu3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ...
*  Metabotropic glutamate receptor 2
Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor ... The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the ... "Metabotropic Glutamate Receptors: mGlu2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... "Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in ...
*  Metabotropic glutamate receptor 5
... is a G protein-coupled receptor that in humans is encoded by the GRM5 gene. The amino acid L- ... The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the ... "Metabotropic Glutamate Receptors: mGlu5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... "Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation". The Journal of Biological ...
*  CECXG
doi:10.1016/S0968-0896(02)00387-5. Ure, J.; Baudry, M.; Perassolo, M. (2006). "Metabotropic glutamate receptors and epilepsy". ... is a research drug which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3 ... glycines as High-Affinity Group II Metabotropic Glutamate Receptor Ligands". Bioorganic & Medicinal Chemistry. 11: 197-205. ... glycines as potent and selective antagonists of metabotropic glutamate receptors". Bioorganic & Medicinal Chemistry Letters. 8 ...
*  Neuron
... they lack the typical ionotropic glutamate receptors and instead express a class of inhibitory metabotropic glutamate receptors ... Metabotropic receptors, GPCRs modulate synaptic transmission and postsynaptic excitability. Glutamate can cause excitotoxicity ... Glutamate acts on several different types of receptors, and have effects that are excitatory at ionotropic receptors and a ... ISBN 978-971-23-4807-5. Gerber U (2003). "Metabotropic glutamate receptors in vertebrate retina". Doc Ophthalmol. 106 (1): 83- ...
*  FMR1
"Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at ... Group 1 metabotropic glutamate receptor (mGluR) signaling has been implicated in playing an important role in FMRP-dependent ... Vanderklish PW, Edelman GM (2002). "Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in ... Weiler IJ, Greenough WT (1993). "Metabotropic glutamate receptors trigger postsynaptic protein synthesis". Proceedings of the ...
*  GRIA1
"Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, ... Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene. Glutamate receptors are the predominant ... a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284-8. doi:10.1038/386284a0. PMID ... "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): 27-37. ...
*  HOMER1
"Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): ... This sequence motif exists in group 1 metabotrophic glutamate receptor (mGluR1 and mGluR5), IP3 receptors (IP3R), Shank, ... "Homer 1b regulates the trafficking of group I metabotropic glutamate receptors". J. Biol. Chem. 274 (36): 25953-7. doi:10.1074/ ... "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, ...
*  Alpha-tubulin 3C
Saugstad JA, Yang S, Pohl J, Hall RA, Conn PJ (Mar 2002). "Interaction between metabotropic glutamate receptor 7 and alpha ...
*  PDZ domain
... which mediates interactions between HOMER and type 5 metabotropic glutamate receptor (mGluR5). The single GLGF repeat on HOMER ... Glutamate receptor interacting protein (GRIP) is a post-synaptic protein with that interacts with AMPA receptors in a fashion ... a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284-288. doi:10.1038/386284a0. ISSN ... Instead of mediating receptors near ion channels, as is the case with GRIP and PSD-95, HOMER is involved in metabotropic ...
*  Long-term depression
When glutamate binds to the AMPA receptor, the membrane depolarizes. Glutamate binding to the metabotropic receptor activates ... In one pathway, parallel fiber terminals release glutamate to activate AMPA and metabotropic glutamate receptors in the ... Hippocampal/cortical LTD can be dependent on NMDA receptors, metabotropic glutamate receptors (mGluR), or endocannabinoids. The ... Activation of NMDA-type glutamate receptors, which belong to a class of ionotropic glutamate receptors (iGluRs), is required ...
*  HOMER3
"Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): ... "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, ... a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284-8. doi:10.1038/386284a0. PMID ... Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell ...
*  DCPG
Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology. 2003 Aug 22;476(1-2 ... which acts as a potent and subtype-selective agonist for the metabotropic glutamate receptor mGluR8. It has anticonvulsant ... an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 Feb;52(2):253-62. PMID ...
*  GRIK1
Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 ( ... 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related ... 1997). "Homer: a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284-8. doi:10.1038/ ... 2001). "Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer". Nature. 411 ( ...
*  TUBA8
2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". J. Neurochem. 80 (6): 980-8. doi:10.1046/j. ...
*  Fenobam
Marino, MJ; Conn, PJ (2006). "Glutamate-based therapeutic approaches: Allosteric modulators of metabotropic glutamate receptors ... Palucha, A; Pilc, A (2007). "Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs". ... Carroll, FI (2008). "Antagonists at metabotropic glutamate receptor subtype 5: Structure activity relationships and therapeutic ... "Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam". ACS Medicinal Chemistry ...
*  LY-487,379
Marino; Conn, P. (2006). "Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors". ... Hermes, M. L. H. J.; Renaud, L. P. (2010). "Postsynaptic and Presynaptic Group II Metabotropic Glutamate Receptor Activation ... Harich; Gross, G.; Bespalov, A. (2007). "Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty ... "Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus". Neuropharmacology. 49 ...
*  Pre-Bötzinger complex
Metabotropic glutamate 1/5 receptors appear to be important for the increase in intracellular calcium that activate ICAN. The ... Since many of these neurons express GABA, glutamate, serotonin and adenosine receptors, chemicals custom tailored to bind at ... Eupneic activity is generated using the excitatory mechanism through the NMDA glutamate receptor. Sighs have a differential ... Adenosine modulates the preBötC output via activation of the A1 and A2A receptor subtypes. An adenosine A1 receptor agonist has ...
*  Heteroreceptor
Semyanov, A; Kullmann, D. M. (2000). "Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors ... "Control of Cannabinoid CB1 Receptor Function on Glutamate Axon Terminals by Endogenous Adenosine Acting at A1 Receptors". ... Glutamate released from an excitatory neuron escapes from the synaptic cleft and preferentially affects mGluR III receptors on ... "Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: ...