Bunch, Lennart; Krogsgaard‐Larsen, Povl (2009). "Subtype selective kainic acid receptor agonists: Discovery and approaches to ... of AMPA receptors. Like AMPA receptors, kainate receptors are tetrameric, transmembrane, ionotropic glutamate receptors on ... either kainic acid or glutamate, binds to the ligand binding site. However, unlike AMPA receptors, external ions also bind to ... The rise and decay times of postsynaptic potentials is much slower in kainate receptors than AMPA receptors. Kainate receptors ...
... reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity". Journal of Neuroscience ... Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor", later renamed to mitochondrial ... Obame FN, Zini R, Souktani R, Berdeaux A, Morin D (October 2007). "Peripheral benzodiazepine receptor-induced myocardial ... However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine ...
... kainic acid and N-methyl-D-aspartic acid (NMDA) channels. In the synapse, these receptors serve very different purposes. AMPA ... AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) is a compound that is a specific agonist for the AMPA receptor, ... AMPA generates fast excitatory postsynaptic potentials (EPSP). AMPA activates AMPA receptors that are non-selective cationic ... can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing ...
These receptors are most dense in sectors CA3 and CA2 of the hippocampus, where nanomolar (nM) concentrations of kainic acid ... Kainic acid, used to model TLE and related scleroses, affects primarily the mossy fiber synapses in CA3. It is thought that at ... Chronic administration of corticosteroids decreases 5-HT1A receptor binding, 5-HT2 receptor binding, serotonin levels, and ... Mice lacking this receptor possess exuberant dendritic trees. However, pyramidal cells exposed to CRH during the first week of ...
... a genre in Ottoman classical music Kainic acid receptor, ion channels that respond to neurotransmitters Karair, a Finnish ... airline, by ICAO code Killer activation receptor King's African Rifles, British regiment, 1902-1960s ISO 639-5 code for Karenic ...
... receptor agonists AMPA Domoic acid Kainic acid NMDA Quinolinic acid Quisqualic acid Tetrazolylglycine Acetylcholine receptor ... GABAA receptor antagonists, inverse agonists or negative allosteric modulators Bemegride Bicuculline Cicutoxin Cyclothiazide ... Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate ... TBPS Tetramethylenedisulfotetramine Thujone GABA synthesis inhibitors 3-Mercaptopropionic acid Allylglycine Glycine receptor ...
AMPA receptors, kainate receptors, and the metabotropic glutamate receptors. Kainic acid is an agonist for kainate receptors, a ... Kainic acid, or kainate, is an acid that naturally occurs in some seaweed. Kainic acid is a potent neuroexcitatory amino acid ... kainic acid is excitotoxic and epileptogenic. Kainic acid induces seizures via activation of kainate receptors containing the ... Kainic acid is commonly injected into laboratory animal models to study the effects of experimental ablation. Kainic acid is a ...
... administration have shown a neuroprotective effect on hippocampal neurons in seizure models induced by kainic acid. The proper ... Progesterone has been shown to lower the number of estrogen receptors, and thus act as an antagonist to estrogen actions. In ... Estradiol represents the most prolific estrogen ligand receptor in the female body, particularly in non-pregnant females, and ... Woolley CS, McEwen BS (1994). "Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor- ...
Kainate receptors, or kainic acid receptors (KARs), are ionotropic receptors that respond to the neurotransmitter glutamate. ... 5-Iodowillardiine ATPA Domoic acid Glutamic acid (glutamate) - the endogenous agonist Kainic acid - a synthetic agonist after ... The convulsant kainic acid induces seizures, in part, by activation of kainate receptors containing the GluK2 subunit and also ... Unlike AMPA receptors, kainate receptors play only a minor role in signaling at synapses. Kainate receptors have a subtle role ...
AMPA receptors play a key role in the generation and spread of epileptic seizures. Kainic acid, a convulsant that is widely ... The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor ... Decanoic acid and the AMPA receptor antagonist drug perampanel act at separate sites on the AMPA receptor, and so it is ... November 2007). "NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840". The ...
... inhibited seizures evoked by bicuculline, pentylenetetrazole, and kainic acid as well as increasing the latency of ... It has been shown to be a potent nicotinic receptor antagonist in animal models with an IC50 of 6µM at the α7 site and 13 nM ... erythravine prevented death in all the animals tested with the four convulsants except a few of those treated with kainic acid ... "Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells". PLOS ONE. 8 (12 ...
AMPA Glutamic acid Ibotenic acid Kainic acid N-Methyl-D-aspartic acid Quisqualic acid Excitatory amino acid receptor antagonist ... An excitatory amino acid receptor agonist, or glutamate receptor agonist, is a chemical substance which agonizes one or more of ... Excitatory amino acid reuptake inhibitor Excitatory+amino+acid+agonists at the US National Library of Medicine Medical Subject ...
"Lesion of Striatal Neurons with Kainic Acid Provides a Model for Huntington's Chorea." Nature, 246: 244-46. ... Dutertre, S., and R. Lewis (2006) "Toxin Insights into Nicotinic Acetylcholine Receptors." Biochemical Pharmacology, 72 (6): ... Nadler, J. Victor, Bruce W. Perry, and Carl W. Cotman (1978) "Intraventricular Kainic Acid Preferentially Destroys Hippocampal ... Rothman, S., J. Thurston, and R. Hauhart (1987) "Delayed Neurotoxicity of Excitatory Amino Acids In Vitro." Neuroscience, 22 (2 ...
In the opposing postsynaptic cell, glutamate receptors, such as the NMDA receptor or the AMPA receptor, bind glutamate and are ... Ajinomoto Disodium glutamate Disodium inosinate Glutamate flavoring Guanosine monophosphate Inosinic acid Kainic acid ... R2-amino acid A very common α-keto acid is α-ketoglutarate, an intermediate in the citric acid cycle. Transamination of α- ... Glutamic acid (symbol Glu or E; the ionic form is known as glutamate) is an α-amino acid that is used by almost all living ...
... inhibition of the channel by membrane fatty acids such as arachidonic acid and docosahexaenoic acid For Kainate receptors with ... Kainic acid as a tool for the study of temporal lobe epilepsy". Life Sci. 29 (20): 2031-42. doi:10.1016/0024-3205(81)90659-7. ... Ben-Ari Y (February 1985). "Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal ... The receptor is 90% edited in all grey matter structures, while in white matter, the receptor is edited in just 10% of cases. ...
Caramboxin is a new nonpeptide amino acid toxin that stimulate the glutamate receptors in neurons. Caramboxin is an agonist of ... "Lesion of Striatal Neurons with Kainic Acid Provides a Model for Huntington's Chorea". Nature. 246: 244-46. Cruz, Lourdes J.; ... Stimulation of these receptors causes a muscular contraction. The anatoxin-a molecule is shaped so it fits this receptor, and ... Nadler; Victor, J.; Perry, Bruce W.; Cotman, Carl W. (1978). "Intraventricular Kainic Acid Preferentially Destroys Hippocampal ...
The discovery of NMDA receptors was followed by the synthesis and study of N-methyl-D-aspartic acid (NMDA) in the 1960s by Jeff ... The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in ... The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainate receptors. ... Receptor modulation[edit]. The NMDA receptor is a non-specific cation channel that can allow the passage of Ca2+ and Na+ into ...
"Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation". Basic & Clinical Pharmacology & ... on nicotinic receptors in rat cortical synaptosomes". Neuropharmacology. 46 (1): 95-102. doi:10.1016/j.neuropharm.2003.08.005. ... as well as showing direct agonist activity at both nicotinic and muscarinic acetylcholine receptors. In animal studies it has ... huprine X with muscarinic receptors in rat brain". Neuroscience Letters. 325 (2): 103-6. doi:10.1016/s0304-3940(02)00245-8. ...
For example, kainic acid-induced seizures, antidepressant (fluoxetine), neurotransmitters such as GABA and growth factors ( ... The inhibitory ligands bind to growth cone receptors on a damaged neuron, which causes repulsion and collapse of the growth ... Receptor Signaling, and Correlation with Axon Regeneration". Glia. 46 (3): 225-251. doi:10.1002/glia.10315. PMID 15048847. ...
I. Effects of kainic acid-induced lesions". Journal of Neurophysiology. 52 (2): 290-304. doi:10.1152/jn.1984.52.2.290. PMID ... Another treatment, still in an experimental stage, is the administration of nociception FQ peptide (NOP) receptor antagonists. ... "Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with ...
... such as the NMDA receptor and AMPA receptor are overactivated by glutamatergic storm. Excitotoxins like NMDA and kainic acid ... NMDA receptor antagonist. References[edit]. *^ a b Jaiswal MK, Zech WD, Goos M, Leutbecher C, Ferri A, Zippelius A, Carrì MT, ... This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) ... The role of glutamate receptors in the pathophysiology of traumatic CNS injury. Chapter 4 in Head Trauma: Basic, Preclinical, ...
Similar results are obtained after injection of kainic acid, an analog of glutamic acid which causes a severe neurodegenerative ... The transmembrane glycoprotein Basigin (BSG; CD147) was identified as an ApoD receptor. BSG is a membrane glycoprotein receptor ... Tg mice treated with kainic acid show a significant reduction of inflammatory responses and a much stronger protection against ... Other ApoD ligands include E-3-methyl-2-hexenoïc acid, a molecule present in axillary secretions; retinoic acid which is ...
... (DA) is a kainic acid-type neurotoxin that causes amnesic shellfish poisoning (ASP). It is produced by algae and ... but the one of concern is through glutamate receptors. Domoic acid is an excitatory amino acid analogue of glutamate; a ... the influence of domoic acid in Pismo Beach on the Central California coast Domoic acid is a structural analog of kainic acid, ... Domoic acid has a very strong affinity for these receptors, which results in excitotoxicity initiated by an integrative action ...
In certain cases, seizures tend to appear to originate from the claustrum when they are involved in early kainic acid induced ... The claustrum has Kappa Opioid Receptors to which Salvinorin A binds, eliciting this effect. High frequency stimulation (HFS) ...
... receptors, ampa MeSH D12.776.543.750.720.200.450.400 - receptors, kainic acid MeSH D12.776.543.750.720.200.450.500 - receptors ... scavenger receptors, class f MeSH D12.776.543.750.720.200 - receptors, amino acid MeSH D12.776.543.750.720.200.300 - receptors ... receptor, galanin, type 3 MeSH D12.776.543.750.100.420.249 - receptors, lysophosphatidic acid MeSH D12.776.543.750.100.420.500 ... receptor, erbb-2 MeSH D12.776.543.750.060.437 - receptor, erbb-3 MeSH D12.776.543.750.060.468 - receptor, igf type 1 MeSH ...
Junk DNA kainic acid receptor - kallidin - kappa opioid receptor - kappa-chain immunoglobulin - karyoplasm - karyotype - kelvin ... amino acid - amino acid receptor - amino acid sequence - amino acid sequence homology - aminobutyric acid - ammonia - AMPA ... erbB-2 receptor - erythropoietin - erythropoietin receptor - Essential amino acid - Ester - estradiol receptor - estrogen ... glucagon receptor - glucocorticoid receptor - glucose - glutamate - glutamate receptor - Glutamic acid - Glutamine - Glycerine ...
... the use of Kainic acid lesions, which destroy neuronal cell bodies and spare passing fibers, provided evidence for a highly ... They infused the AMPA receptor antagonist CNQX into HVI during acquisition training and found that CNQX-infused rabbits did not ... For example, Krupa (1993) inactivated lobule HVI with the GABAA receptor agonist Muscimol and found significant acquisition ...
... and kainic acid". Mol Cell Biochem, Oct. 4 (151): 49-54.. ... evidence for glutamate receptor-mediated excitotoxicity in ... B. Jakobsen, A. Tasker & J. Zimmer (2002). „Domoic acid neurotoxicity in hippocampal slice cultures". Amino Acids. 23: 37-44. ... Domoic Acid and Amnesiac Shellfish Poisoning" (PDF). Архивирано из оригинала (PDF) на датум 31. 05. 2010. Приступљено 08. 06. ... JS Teitelbaum; RJ Zatorre; S Carpenter; D Gendron; AC Evans; A Gjedde & NR Cashman (1990). „Neurologic sequelae of domoic acid ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... While its exact mechanism of action is not well characterized,[2] it is believed to be an NMDA receptor antagonist,[4][5] but ... Kornhuber J., Herr B., Thome J., Riederer P. (1995). "The antiparkinsonian drug budipine binds to NMDA and sigma receptors in ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... Indirect/downstream NO modulators: ACE inhibitors/AT-II receptor antagonists (e.g., captopril, losartan) ... Some cases of anemia, possibly related to folic acid deficiency, have been described.[18] ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... Mathiesen O, Imbimbo BP, Hilsted KL, Fabbri L, Dahl JB (August 2006). "CHF3381, a N-methyl-D-aspartate receptor antagonist and ... See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake ...
T1R3 umami taste receptor". Amino Acids. 46 (6): 1583-7. doi:10.1007/s00726-014-1713-3. PMID 24633359.. ... Kainic acid. *L-(-)-threo-3-Hydroxyaspartic acid. *L-αAA. *L-CCG-III ((2S,3S,4R)-CCG) ... See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators ... derived from the related proteinogenic L-amino acid glutamic acid. Theanine is an analog of this amino acid, and its primary ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Receptor/signaling modulators. GABA receptor modulators. GABAA receptor positive modulators. Ionotropic glutamate receptor ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol). *Unsorted benzodiazepine site positive ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... 2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-Tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioic acid[2] ... Crocetin is a natural apocarotenoid dicarboxylic acid that is found in the crocus flower and Gardenia jasminoides[3] (fruits). ...
"Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor ... Kainic acid. *L-(-)-threo-3-Hydroxyaspartic acid. *L-αAA. *L-CCG-III ((2S,3S,4R)-CCG) ... Receptor/signaling modulators GABA receptor modulators GABAA receptor positive modulators Glutamate metabolism/transport ... See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators ...
... chemical lesions by kainic acid. Hypothesis after Ewert 1974 and 2004 ...
AMPA receptors play a key role in the generation and spread of epileptic seizures.[68] Kainic acid, a convulsant that is widely ... The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor ... Decanoic acid and the AMPA receptor antagonist drug perampanel act at separate sites on the AMPA receptor, and so it is ... Here, A→I editing alters the uncharged amino acid glutamine (Q) to the positively charged arginine (R) in the receptor's ion ...
"Lesion of Striatal Neurons with Kainic Acid Provides a Model for Huntington's Chorea." Nature, 246: 244-46. ... Dutertre, S., and R. Lewis (2006) "Toxin Insights into Nicotinic Acetylcholine Receptors." Biochemical Pharmacology, 72 (6): ... Nadler, J. Victor, Bruce W. Perry, and Carl W. Cotman (1978) "Intraventricular Kainic Acid Preferentially Destroys Hippocampal ... Rothman, S., J. Thurston, and R. Hauhart (1987) "Delayed Neurotoxicity of Excitatory Amino Acids In Vitro." Neuroscience, 22 (2 ...
... has been found to bind to and activate ionotropic receptors that are different from any other excitatory amino acid receptor, ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators ... Acetylcysteine is the N-acetyl derivative of the amino acid L-cysteine, and is a precursor in the formation of the antioxidant ...
... glutamate receptors, such as the NMDA receptor or the AMPA receptor, bind glutamate and are activated. Because of its role in ... R1-amino acid + R2-α-ketoacid ⇌ R1-α-ketoacid + R2-amino acid. A very common α-keto acid is α-ketoglutarate, an intermediate in ... Kainic acid. *Monopotassium glutamate. *Tien Chu Ve-Tsin. ReferencesEdit. *^ "L-Glutamic acid CAS#: 56-86-0". www.chemicalbook. ... Glutamic acid (symbol Glu or E;[4] the ionic form is known as glutamate) is an α-amino acid that is used by almost all living ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Receptor/signaling modulators. GABA receptor modulators. GABAA receptor positive modulators. Ionotropic glutamate receptor ... Ethanol is mixed with a strong acid, typically sulfuric acid, H2SO4. The acid dissociates in the aqueous environment producing ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ...
Kainic acid. *L-(-)-threo-3-Hydroxyaspartic acid. *L-αAA. *L-CCG-III ((2S,3S,4R)-CCG) ... See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators ... The four amino acids bind to the site by their common atoms, "the main chain" of amino acids.[5] Glutamate is another product ... "Nucleic Acids Research. 46 (19): 10082-10094. doi:10.1093/nar/gky709. PMC 6212724. PMID 30085248.. ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Receptor/signaling modulators. GABA receptor modulators. GABAA receptor positive modulators. Ionotropic glutamate receptor ... With acid chlorides, one obtains the amidocarboxylic acid, such as hippuric acid[23] and acetylglycine.[24] With nitrous acid, ... It is the simplest amino acid (since carbamic acid is unstable), with the chemical formula NH2‐CH2‐COOH. Glycine is one of the ...
... a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor". Neuroscience Letters. 118 (2): 241-4. doi:10.1016/ ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... Each subtype selectively targets different subunits of the receptor. Toxicity[edit]. Some of these peptide effects are age- ... Conantokins act as potent and specific antagonists of the N-methyl-D-aspartate receptor (NMDAR).[1] They are the only naturally ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... Like some related amines, it is used in oil industry for the extraction of acid gas. ...
Inanobe A, Furukawa H, Gouaux E (2005). "Mechanism of partial agonist action at the NR1 subunit of NMDA receptors". Neuron. 47 ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... 1-Aminocyclopropane-1-carboxylic acid (ACC) is a disubstituted cyclic α-amino acid in which a three-membered cyclopropane ring ... "Nucleic Acids Res. 34 (Database issue): D511-6. doi:10.1093/nar/gkj128. PMC 1347490 . PMID 16381923.. ...
Kainic acid. *L-(-)-threo-3-Hydroxyaspartic acid. *L-αAA. *L-CCG-III ((2S,3S,4R)-CCG) ... See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Nicotinic acetylcholine receptor ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... and NMDA receptor antagonist[10] that crosses the blood-brain barrier.[11] Acetylcholinesterase is an enzyme that catalyzes the ...
... glutamate receptors, such as the NMDA receptor or the AMPA receptor, bind glutamate and are activated. Because of its role in ... Not to be confused with Glutamine or Glutaric acid.. Glutamic acid (symbol Glu or E)[4] is an α-amino acid that is used by ... R1-amino acid + R2-α-ketoacid ⇌ R1-α-ketoacid + R2-amino acid. A very common α-keto acid is α-ketoglutarate, an intermediate in ... Kainic acid. *Monosodium glutamate. ReferencesEdit. *^ "L-Glutamic acid CAS#: 56-86-0". www.chemicalbook.com.. .mw-parser- ...
Glutamate receptor agonists. *AMPA. *NMDA. *Kainic acid. *Domoic acid. *Quisqualic acid. *Tetrazolylglycine ... Rindi, G; Ferrari, G (1959). "The γ-Aminobutyric Acid and Glutamic Acid Content of Brains of Rats treated with Toxopyrimidine ...
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... NAAG consists of N-acetylaspartic acid (NAA) and glutamic acid coupled via a peptide bond. ... NAAG activates a specific receptor, the metabotropic glutamate receptor type 3. It is synthesized enzymatically from its two ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ... Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol). *Unsorted benzodiazepine site positive ... See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators ...
Ionotropic glutamate receptor modulators. AMPAR. *Agonists: Main site agonists: 5-Fluorowillardiine. *Acromelic acid ( ... Kainic acid. *LY-339434. *Proline. *Quisqualic acid. *SYM-2081; Positive allosteric modulators: Cyclothiazide ...