... inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism, ACS Chem. Biol. 2015; 10: 1555- ... These complexes are a subset of macrocyclic molecular receptors and their structure is that the two "arms" that bind the guest ... islet amyloid polypeptide (amylin), which kills pancreatic β-cells in type-2 diabetes; transthyretin (TTR), which causes ... Amyloid β-protein Assembly: The Effect of Molecular Tweezer CLR01 and CLR03. J. Phys. Chem. B, 2015; 119: 4831-4841. S ...

2001). "The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal ... 2000). "Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor". Endocrinology. 141 (9): ...

Amylin, also known as islet amyloid polypeptide (IAPP). The function of amylin is to slow the rate of glucose entering the ... Gastric inhibitory polypeptide receptor List of terms associated with diabetes Guangxitoxin Alpha cell Pancreatic development ... It is believed to be due to the decline of specific receptors on the surface of the liver, adipose, and muscle cells which lose ... Beta cells make up 50-70% of the cells in human islets. In patients with Type 1 diabetes, beta-cell mass and function are ...

Amyloid deposits deriving from islet amyloid polypeptide (IAPP, or amylin) are commonly found in pancreatic islets of patients ... All three complexes contain the calcitonin receptor at the core, plus one of three receptor activity-modifying proteins, RAMP1 ... "Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid ... "Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic ...

Nishi, M.; Steiner, D. (2003). "Cloning of complementary DNA's encoding islet amyloid polypeptide, insulin, and glucagon ... separation-induced receptor changes in the prefrontal cortex of Octodon degus", Neuroscience, 119 (2): 433-441, doi:10.1016/ ... 2004), "Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degus", Neurobiol. ...

Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC (May 2007). "Toxic human islet amyloid polypeptide (h-IAPP ... protein receptors, soluble proteins, RNAs, small metabolites, etc. In the clinical setting, amyloid diseases are typically ... There are multiple classes of amyloid-forming polypeptide sequences. Glutamine-rich polypeptides are important in the ... Wikimedia Commons has media related to Amyloid. Bacterial Inclusion Bodies Contain Amyloid-Like Structure at SciVee Amyloid ...

The CALC1 gene belongs to a superfamily of related protein hormone precursors including islet amyloid precursor protein, ... The calcitonin receptor is a G protein-coupled receptor localized to osteoclasts as well kidney and brain cells. It is coupled ... Calcitonin is a polypeptide hormone of 32 amino acids, with a molecular weight of 3454.93 daltons. Its structure comprises a ... Osteoblasts do not have calcitonin receptors and are therefore not directly affected by calcitonin levels. However, since bone ...

"GPR40 receptor agonist TAK-875 improves cognitive deficits and reduces β-amyloid production in APPswe/PS1dE9 mice". ... 5) Ffar1 gene knockout mice had impaired secretion of glucagon-like peptide-1 and gastric inhibitory polypeptide into the ... and pancreatic islets isolated from humans. These fatty acid activators did not have this action in the absence of concurrent ... Free fatty acid receptor 1 (FFAR1), also known as G-protein coupled receptor 40 (GPR40), is a rhodopsin-like G-protein coupled ...