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*  Monoclonal antibody therapy
The heavy and light chains of human IgG proteins are expressed in structural polymorphic (allotypic) forms. Human IgG allotype ... using an antibody fragment against the human transferrin receptor. Tissue-specific gene delivery using immunoliposomes has been ... The four known IgG subclasses are involved in antibody-dependent cellular cytotoxicity. Antibodies are a key component of the ... IgG) antibodies are large heterodimeric molecules, approximately 150 kDa and are composed of two kinds of polypeptide chain, ...
*  Fc fragment of igg receptor iic (gene/pseudogene)
... is a protein that in humans is encoded by the FCGR2C gene. This gene encodes ... Fc fragment of IgG receptor IIc (gene/pseudogene)". Retrieved 2017-05-24. Breunis WB, van Mirre E, Bruin M, Geissler J, de Boer ... "Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles". J. Immunol. 188 (3): 1318-24. doi:10.4049/jimmunol. ... Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, ...
*  Infliximab
... receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity". J. Exp. Med. 174 (6): 1483-9. doi:10.1084/ ... and receptor-bound) TNF-α. Etanercept, a third TNF antagonist, is in a different subclass (receptor-construct fusion protein), ... In rheumatoid arthritis, infliximab seems to work by preventing TNF-α from binding to its receptor in the cell. Infliximab is ... Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that consists of mouse heavy and ...
*  Bruce Beutler
A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity. J.Exp.Med. ... Beutler used TNF production as a phenotypic endpoint to identify the LPS receptor. Identification of the receptor hinged on the ... fusing the binding portion of TNF receptor proteins to the heavy chain of an immunoglobulin molecule to force receptor ... These receptors also mediate severe illness, including shock and systemic inflammation as it occurs in the course of an ...
*  Etanercept
Peppel K, Crawford D, Beutler B (December 1991). "A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a ... First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2, which is a receptor that ... and soluble TNF receptors which are used to deactivate TNF and blunt the immune response. In addition, TNF receptors are found ... Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 ...
*  Anti-NMDA receptor encephalitis
... performance evaluation and laboratory experience with the anti-NMDA-receptor IgG assay". Clin Chim Acta. 421: 1-6. doi:10.1016/ ... Anti-NMDA receptor encephalitis, also known as NMDA receptor antibody encephalitis, is an acute form of brain inflammation that ... A reduction in the density of NMDA receptors on the post synaptic knob, due to receptor internalization once the antibody has ... Anti-glutamate receptor antibodies Dalmau, Josep; Gleichman, Amy J; Hughes, Ethan G; Rossi, Jeffrey E; Peng, Xiaoyu; Lai, ...
*  Antibody
Ravetch J, Bolland S (2001). "IgG Fc receptors". Annu Rev Immunol. 19 (1): 275-290. doi:10.1146/annurev.immunol.19.1.275. PMID ... IgG, and IgE antibodies. The engagement of a particular antibody with the Fc receptor on a particular cell triggers an effector ... In placental mammals there are five antibody isotypes known as IgA, IgD, IgE, IgG, and IgM. They are each named with an "Ig" ... The Fc receptors are isotype-specific, which gives greater flexibility to the immune system, invoking only the appropriate ...
*  FCGR2B
1990). "Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting ... 2001). "The Fc receptor for IgG expressed in the villus endothelium of human placenta is Fc gamma RIIb2". J. Immunol. 166 (6): ... 2001). "The Fc receptor for IgG (Fc gamma RII; CD32) on human neonatal B lymphocytes". Hum. Immunol. 62 (7): 679-85. doi: ... FCGR2B (CD32B) is a "low affinity" receptor for Immunoglobulin G (IgG). Mutation in the gene in humans leads to a lupus ...
*  Adalimumab
... while infliximab is a mouse-human chimeric antibody and etanercept is a TNF receptor-IgG fusion protein. The drug candidate was ... It binds to tumor necrosis factor-alpha (TNFα), which normally binds to TNFα receptors, leading to the inflammatory response of ...
*  FCGR1A
Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (Aug 1992). "Three genes for the human high affinity Fc receptor for IgG (Fc ... van de Winkel JG, Ernst LK, Anderson CL, Chiu IM (Jul 1991). "Gene organization of the human high affinity receptor for IgG, Fc ... "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)". Morton HC, van den Herik-Oudijk IE, Vossebeld P, ... Eizuru Y, Minamishima Y (1989). "Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung ...
*  Clark L. Anderson
2. IgG turnover mediated by the neonatal Fc receptor (FcRn)Anderson, reading the published work of others describing IgG ... The protection receptor for IgG catabolism is the b2- microglobulin-containing neonatal intestinal transport receptor. Proc. ... The protection receptor for IgG catabolism is the 2-microglobulin-containing neonatal intestinal transport receptor. Proc. ... IgG) antibodies mediate their cell biological effects through the family of Fcγ receptors (a class of Fc receptors that are ...
*  FCGRT
IgG receptor FcRn large subunit p51 is a protein that in humans is encoded by the FCGRT gene. FCGRT has been shown to interact ... Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, Walker WA (2003). "Distribution of the IgG Fc receptor, FcRn, in the ... "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha". Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, ... "Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn". J. Immunol. 172 (4): 2021-9. doi: ...
*  Killer activation receptor
Hibbs, ML; Classon, BJ; Walker, ID; McKenzie, IF; Hogarth, PM (1988). "The structure of the murine Fc receptor for IgG. ... Killer Activation Receptor (KAR) and Killer Inhibition Receptors (KIRs). Both type of receptors act together to activate or not ... Killer Activation Receptors) and the NK KIRs (meaning: Killer Inhibitory Receptors). Such receptors have a broad binding ... Each of these receptors has a specific ligand, although some receptors that belong to the same class, such as NCR, recognize ...
*  H2AFZ
2001). "Evidence for a novel polymorphism affecting both N-linked glycosylation and ligand binding of the IgG receptor IIIB ( ...
*  Human serum albumin
"The Major Histocompatibility Complex-related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan". J. Exp. Med. ... through receptors specific for AGE-proteins, and generation of reactive oxygen intermediates. AGEs also react with DNA, thus ...
*  FCGR2A
Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma ... "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)". Chacko, G W; Brandt J T; Coggeshall K M; Anderson C ... 1987). "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)". J. Exp. Med. 166 (6): 1668- ... 1990). "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid". Science. 246 (4937): 1611-3. ...
*  FCGR3A
"Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)". Anderson P, Caligiuri M, O'Brien C, Manley T, ... "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa". Journal ... and identification of the chromosomal locus of two Fc receptors for IgG". Proceedings of the National Academy of Sciences of ... Ritz J, Schlossman SF (March 1990). "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by ...
*  FCGR3B
... (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene ... FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)". Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J ... and identification of the chromosomal locus of two Fc receptors for IgG". Proceedings of the National Academy of Sciences of ... Bharadwaj D, Mold C, Markham E, Du Clos TW (Jun 2001). "Serum amyloid P component binds to Fc gamma receptors and opsonizes ...
*  Fc receptor-like molecule
FCRLA associates with IgM, IgG and IgA. FCRLB Fc receptor Davis RS (2007). "Fc receptor-like molecules". Annual Review of ... Fc receptor-like molecules (FCRLs) are a class of proteins that resemble Fc receptors. They have been characterized in a number ... "Fine specificity of a rabbit antibody interacting with human IgG Fc receptor-like molecules". Immunology Letters. 25 (4): 303- ... Ehrhardt GR, Leu C, Zhang S, Aksu G, Jackson T, Haga C, Hsu JT, Schreeder DM, Davis RS, Cooper MD (2007). "Fc Receptor-like ...
*  Complement component 5a
C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the ... C5a interact with receptor protein C5aR (CD88) on the surface of target cells such as macrophages, neutrophils and endothelial ... C5a binding to the receptor is a two-stage process: an interaction between basic residues in the helical core of C5a and acidic ... C5aR is a member of the G-protein-coupled receptor superfamily of proteins, predicted to have seven transmembrane helical ...
*  CD64 (biology)
Ernst L, van de Winkel J, Chiu I, Anderson C (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI ... It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as ... is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity ... "Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human ...
*  SOS1
Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL (Dec 1999). "High affinity IgG receptor activation of Src family ... Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A (May 2002). "FRS2 alpha attenuates FGF receptor signaling by Grb2- ... Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA (May 2000). "Discoidin domain receptor 1 ... Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB (1995). "Ligation of the T-cell antigen receptor (TCR) induces association of ...
*  CBL (gene)
Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL (December 1999). "High affinity IgG receptor activation of Src family ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ... Mancini A, Koch A, Wilms R, Tamura T (April 2002). "c-Cbl associates directly with the C-terminal tail of the receptor for the ...
*  Raji cell
... and 7S IgG bound to receptors for IgG Fc; however, AHG reacted with C bound to cells only via receptors for C and this binding ... These cells lack membrane-bound immunoglobulin but have receptors for IgG Fc, C3b, C3d, and possibly with other C proteins. ... It expresses certain complement receptors as well as Fc receptors for immunoglobulin G. -Biological source --> Lymph from human ... suggesting that substantial SLE IgG can bind through F(ab')2 regions. Binding of IgG from SLE sera was not directed at ...
*  ABL (gene)
... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... "Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop ... Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J. Biol. Chem. 272 (5): 2659 ... "Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor". J. Neurosci. Res. 59 (3): 356-64. doi: ...
*  Lyme disease
IgM and IgG antibody levels may be elevated for years even after successful treatment with antibiotics. As antibody levels are ... Within the tick midgut, the Borrelia's outer surface protein A (OspA) binds to the tick receptor for OspA, known as TROSPA. ... The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which ... High titers of either immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies to Borrelia antigens indicate disease, but ...
*  NEDD9
... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... that is specifically bound by a retinoid X receptor (RXR)/retinoic acid receptor (RAR) heterodimer. NEDD9 is also induced by ... An effector of the TGFbeta receptor, Smad3, may interact directly with APC subunit APC10 and thus recruit the APC complex. CDH1 ... NEDD9 is involved in chemokine-induced T cell migration and T cell receptor (TCR)-mediated integrin activation. In lymphocytes ...