... is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. In ... The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), ... Lia F, Rajotte D, Clark SC, Hoang T (Nov 1996). "A dominant negative granulocyte-macrophage colony-stimulating factor receptor ... It is associated with Surfactant metabolism dysfunction type 4. The granulocyte-macrophage colony-stimulating factor receptor ...
... of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) receptor complexes ... IL-3 shares the β subunit with IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). This β subunit sharing ... Granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6. IL-3 is secreted by basophils and activated T cells to ... "Granulocyte-Macrophage colony stimulating factor and interleukin 3: Target cells and kinetics of response in vivo". Stem Cells ...
Interleukin-5, granulocyte-macrophage colony stimulating factor, and interleukin-33 enhance anti-Siglec-8 mediated destruction ... Siglec-8 is an inhibitory receptor present on eosinophils and mast cells, with low level expression on basophils. ...
... a granulocyte colony-stimulating factor (G-CSF) analog) Granulocyte-macrophage colony-stimulating factor receptor Lenzilumab ... Root RK, Dale DC (March 1999). "Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: ... Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric ... "Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor". Medical Oncology. 31 (1): 774 ...
Secondary structure analysis has suggested similarity to IL4 and granulocyte-macrophage colony stimulating factor (GMCSF). ... In addition, it acts on some B cells, via receptor-specific binding, as a growth factor and antibody production stimulant. The ... These include granulocyte colony-stimulating factor (GCSF) and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis ... "Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor". Archives of ...
Interleukin-4 (IL-4) and granulocyte-macrophage colony stimulating factor (GMCSF) both upregulate PD-L2 expression in DCs in ... PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). PD-L2 is a cell surface receptor belonging to the ... PD-L2 binds to its receptor PD-1 with dissociation constant Kd of 11.3 nM. Binding to PD-1 can activate pathways inhibiting TCR ... May 2006). "No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell ...
... a human monoclonal igG4 antibody to the alpha chain of granulocyte macrophage colony-stimulating factor (GM-CSF Receptor). In ... "TRAIL Receptor Antibodies - HGS". Hgsi.com. Archived from the original on 16 May 2008. Retrieved 12 May 2010. Pukac, L; ... In addition, the committee voted 18 - 0 in favour of the risk-benefit profile of raxibacumab". Two anti-TRAIL receptor ... These included: Adalimumab (D2E7) - a human monoclonal antibody to tumor necrosis factor-alpha (TNF alpha). This drug went on ...
... and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human ... "JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation ... The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and ... In fact, the β-subunit of the IL-5 receptor is also found in IL-3 and GM-CSF receptors where it is associated with IL-3Rα and ...
... protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor ... G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belong to a ... family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is ... "Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, ...
... in the granulocyte-macrophage colony-stimulating factor receptor or anti-granulocyte-macrophage colony-stimulating factor ... The GATA2 protein is a transcription factor critical for the embryonic development, maintenance, and functionality of blood- ... Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ...
"Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor Inhibits Tumor Necrosis Factor (TNF)-α-induced Osteoclast ... Inhibits Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation by Diverting the Cells to Macrophage Lineage". ... Interleukin 3 Granulocyte Please see Selected bibliography section "Mohan R. Wani Scientist 'F'". nccs.res.in. 20 January 2018 ... Differentiation by Down-regulation of Expression of TNF Receptors 1 and 2". Journal of Biological Chemistry. 280 (12): 11759- ...
... and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in Th2 cells. IL-5 is also ... Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion- ... and granulocyte-macrophage colony-stimulating factor (GM-CSF). Glycosylation of the Asn196 residue of the Rα subunit appears to ... An eosinophil-specific colony-stimulating factor with activity for human cells". J. Exp. Med. 163 (5): 1085-1099. doi:10.1084/ ...
... granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor ... colony stimulating factor receptors and other cytokine receptors Interleukin-1 receptor Interleukin-2 receptor Interleukin-3 ... IL-6 receptor IL-11 receptor IL-12 receptor IL-27 receptor Leukemia inhibitory factor receptor Oncostatin M receptor Type I ... IL-2 receptor IL-4 receptor IL-7 receptor IL-9 receptor IL-13 receptor IL-15 receptor IL-21 receptor The common beta chain ( ...
... site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... Glucocorticoid receptor, HMGA1, HSF1, Nucleolar phosphoprotein p130, RELA, Serum response factor, SMARCA2, Sp1 transcription ... "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid ...
Specifically a "granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-15 (IL-15) 'fusokine' (GIFT15) exerts ... and estrogen receptors(ER): Estrogens have been shown to be anti-inflammatory and neuroprotective in a variety of neurological ... "A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with ... nuclear factor erythroid 2(NF-E2)-related factor 2) transcription factor: Dimethyl fumarate (Tecfidera), Diroximel fumarate ( ...
... that targets colony stimulating factor 2 (CSF2)/granulocyte-macrophage colony stimulating factor (GM-CSF). Pre-clinical ... 2016). "Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice". J. Immunol. 197 (12): 4674-4685. ... 2008). "Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2- ... and its receptor (CCR2). GM-CSF knockout CAR-T cells protect mice from CRS; however, IL-6 knockout mice receiving wild-type CAR ...
The gene is flanked by the genes for granulocyte-macrophage colony-stimulating factor and Colony stimulating factor 1 receptor ... those for granulocyte-macrophage colony-stimulating factor, PDGFRB, and Colony stimulating factor 1 receptor, cause the ... also termed macrophage-colony stimulating factor receptor), all three of which may be lost together by a single deletional ... platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see ...
... is a human monoclonal antibody that inhibits human granulocyte macrophage colony-stimulating factor receptor (GM- ... a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, ...
... and the gene product can also be referred to as granulocyte macrophage colony-stimulating factor receptor. The diagnosis of PAP ... Consequently, a messenger molecule known as granulocyte/macrophage-colony stimulating factor (GM-CSF) is unable to stimulate ... the most common cause of PAP is an autoimmunity to granulocyte-macrophage colony stimulating factor (GM-CSF), a critical factor ... June 1994). "Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but ...
Mavrilimumab is a human monoclonal antibody that inhibits human granulocyte macrophage colony-stimulating factor receptor (GM- ... It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays ... given the significant overlap in the risk factors for severe COVID-19 and vitamin D deficiency. These include obesity, older ... soluble urokinase plasminogen activator receptor) of at least 6 ng per ml." Drugs with immune modulating effects that may prove ...
... colony-stimulating factor-1 receptor (CSF-1R) and granulocyte macrophage colony-stimulating factor (GM-CSF) in preclinical ... December 2010). "Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes ... A similar outcome was achieved by neutralizing macrophage colony-stimulating factor 1, which impaired the intratumoral ... platelet-derived growth factor receptor α (PDGFR-α), platelet-derived growth factor receptor β (PDGFR-β), fibroblast specific ...
... and granulocyte-macrophage colony-stimulating factor in human blood eosinophils". J. Immunol. 160 (9): 4427-32. PMID 9574547. ... This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene ... colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta ... The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for ...
"Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or ... STAT5A has been shown to interact with: CRKL, Epidermal growth factor receptor, ERBB4, Erythropoietin receptor, Janus kinase 1 ... In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and ... "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. 274 (24): ...
... expression in heart muscle is up-regulated by estrogen and down-regulated by granulocyte-macrophage colony-stimulating factor. ... In addition, the receptor is found in macrophages, endothelial cells of capillaries, and in the brain, where it has a very ... Nimpf J, Schneider WJ (December 1998). "The VLDL receptor: an LDL receptor relative with eight ligand binding repeats, LR8". ... The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) ...
... granulocyte colony-stimulating factor receptor, Granulocyte macrophage colony-stimulating factor receptor, Interleukin-3 ... FGFR1 is the gene for the fibroblast growth factor receptor 1, a cell surface receptor that similar to PDGFRA and PDGFRB, is ... It mediates at least in part the cell proliferating signaling stimulated by PDGF receptors as well as by antigen receptors on T ... The PDGFRA gene encodes the platelet-derived growth factor receptor A (PDGFRA) which is a cell surface, RTK class III Receptor ...
... and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation". The Journal of Biological ... Platelet derived growth factor is a major inducer of CCL2 gene. CCR2 and CCR4 are two cell surface receptors that bind CCL2. ... Kim MS, Day CJ, Morrison NA (April 2005). "MCP-1 is induced by receptor activator of nuclear factor-κB ligand, promotes human ... "Permissive factors for HIV-1 infection of macrophages". Journal of Leukocyte Biology. 68 (3): 303-10. doi:10.1189/jlb.68.3.303 ...
Granulocyte colony-stimulating factor Granulocyte colony-stimulating factor receptor Granulocyte macrophage colony-stimulating ... receptor Lysozyme Macrophage Macrophage colony-stimulating factor Macrophage inflammatory protein Macrophage-activating factor ... factor Granulocyte macrophage colony-stimulating factor receptor Granulysin Granzyme Growth factor Gut-associated lymphoid ... CMKLR1 Colony stimulating factor 1 receptor Colony-stimulating factor Common gamma chain Complementarity-determining region ...
"Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by ... "Expression of granulocyte-colony stimulating factor and its receptor is regulated during the development of the human placenta ... Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein ... Metcalf D (July 1985). "The granulocyte-macrophage colony-stimulating factors". Science. 229 (4708): 16-22. Bibcode:1985Sci... ...
Receptor tyrosine kinase Granulocyte-colony stimulating factor (G-CSF) Granulocyte-macrophage colony stimulating factor (GM-CSF ... Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide ... FGF7 and FGF10 (also known as keratinocyte growth factors KGF and KGF2, respectively) stimulate the repair of injured skin and ... Reuss B, von Bohlen und Halbach O (Aug 2003). "Fibroblast growth factors and their receptors in the central nervous system". ...
... macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and neurotactin. " ... The ephrins are a family of neurotrophic factors that signal through eph receptors, a class of receptor tyrosine kinases; the ... The CNTF family of neurotrophic factors includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), ... transforming growth factor alpha (TGFα), and transforming growth factor beta (TGFβ). They signal through receptor tyrosine ...