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*  Sedative
Yi PL; Tsai CH; Chen YC; Chang FC (March 2007). "Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional ... In spite of the fact that each sedative acts in its own way, they produce beneficial relaxing effect by increasing GABA ... Advances in pharmacology have permitted more specific targeting of receptors, and greater selectivity of agents, which ... GABA), which are brain chemicals performing communication between brain cells. ...
*  Translocator protein
Bormann J, Ferrero P, Guidotti A, Costa E (1985). "Neuropeptide modulation of GABA receptor C1- channels". Regulatory Peptides ... benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA". DNA Cell Biol ... "Peripheral" benzodiazepine receptors are also found in the brain, although only at around a quarter the expression levels of ... YL-IPA08 Ro5-4864 - original ligand with which TSPO receptor was characterised, now less used due to inter-species differences ...
*  Gamma-aminobutyric acid receptor subunit alpha-1
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated ... At least 16 distinct subunits of GABA-A receptors have been identified. The GABRA1 receptor is the specific target of the z- ... 1999). "Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders ... Sarto I, Wabnegger L, Dögl E, Sieghart W (2002). "Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits ...
*  GABA receptor
Although the term "GABAС receptor" is frequently used, GABAС may be viewed as a variant within the GABAA receptor family. ... The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief ... GABA receptors influence neural function by coordinating with glutamatergic processes. A subclass of ionotropic GABA receptors ... Over-excitation of this receptor induces receptor remodeling and the eventual invagination of the GABA receptor. As a result, ...
*  GABA receptor antagonist
... s are drugs that inhibit the action of GABA. In general these drugs produce stimulant and convulsant ... Also thujone, ginkgo biloba, kudzu and muira puama[citation needed] may have properties of GABAA receptor antagonism. GABA ... Examples include bicuculline, securinine and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. ...
*  Ionotropic GABA receptor
Ionotropic GABA receptors (iGABARs) are ligand-gated ion channel GABA receptors and include: GABAA receptor GABAA-ρ receptor ... The GABAB receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor.. ...
*  GABA receptor agonist
GABA-α and GABAreceptors produce sedative and hypnotic effects and have anti-convulsion properties. GABAreceptors too ... A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative ... There are three receptors of the gamma-aminobutyric acid. The two receptors GABA-α and GABA-ρ are ion channels that signal ... Alcohol is believed to mimic GABA's effect in the brain, binding to GABA receptors and inhibiting neuronal signaling. GABA ...
*  Gaba type a receptor associated protein like 1
... is a protein that in humans is encoded by the GABARAPL1 gene. GRCh38: Ensembl ... GABA type A receptor associated protein like 1". Retrieved 2017-12-21. Nemos C, Mansuy V, Vernier-Magnin S, Fraichard A, ... "GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor". J. Biol. Chem. 281 (12): 7983-93. doi: ... Chen Y, Chen C, Kotsikorou E, Lynch DL, Reggio PH, Liu-Chen LY (2009). "GEC1-kappa opioid receptor binding involves hydrophobic ...
*  Clobazam
... is a GABA-A receptor agonist action and may affect sodium channels and voltage-sensitive calcium channels. Like other ... GABA Receptor Agonists". Drugs and Diseases. Medccape. Retrieved 10 July 2005. Ralvenius WT, Acuña MA, Benke D, Matthey A, ... 2000). "Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype". Nature ... work by enhancing GABA-activated chloride currents at GABAA-receptor-coupled Cl− channels. It was also reported that these ...
*  Picrotoxin
However, due to its antagonist effect on GABA receptors, it has been used as a central nervous system stimulant. It was also ... Newland, C F; Cull-Candy, S G (February 1992). "On the mechanism of action of picrotoxin on GABA receptor channels in ... Olsen, R. W.; DeLorey, T. M. (1999). "GABA Receptor Physiology and Pharmacology". In Siegel G. J.; Agranoff, B. W.; Albers, R. ... Other research suggests that the toxin acts instead as a non-competitive antagonist, or inhibitor, for GABA receptors. A study ...
*  Pitrazepin
"Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors". European Journal of ... Sattelle DB, Pinnock RD, Wafford KA, David JA (January 1988). "GABA receptors on the cell-body membrane of an identified insect ... Murphy VF, Wann KT (November 1988). "The action of GABA receptor agonists and antagonists on muscle membrane conductance in ... Anthony NM, Harrison JB, Sattelle DB (1993). "GABA receptor molecules of insects". Exs. 63: 172-209. doi:10.1007/978-3-0348- ...
*  Effects of alcohol on memory
Alcohol acts as a positive allosteric modulator of GABA receptors, specifically type GABAA. Upon activation, these GABA ... Schummers, J.; Browning, M. D. (2001). "Evidence for a role for GABA(A) and NMDA receptors in ethanol inhibition of long-term ... Hodge, C. W.; Cox, A. A. (1998). "The discriminative stimulus effects of ethanol are mediated by NMDA and GABA(A) receptors in ... Alcohol Research & Health, 27(2),186-196 Paul, S. (2006). Alcohol-sensitive GABA receptors and alcohol antagonists. Published ...
*  Bamaluzole
... is a GABA receptor agonist. It was patented as an anticonvulsant by Merck but was never marketed. Imidazopyridine ...
*  Eszopiclone
It works by interacting with the GABA receptors. Eszopiclone is slightly effective in the treatment of insomnia where ... In terms of benzodiazepine receptor binding and relevant potency, 3 mg of eszopiclone is equivalent to 10 mg of diazepam. In a ... It was found that newer agents with novel mechanisms of action and improved safety profiles, such as the melatonin receptor ...
*  GABRR2
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated ... receptor, rho 2". Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 ... 1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C ... Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3-5): 237- ...
*  Iomazenil
30 (2): 325-8. Ahn, Kyungheup; Gil R; Seibyl J; Sewell RA; D'Souza DC (February 2011). "Probing GABA receptor function in ... The effect of iomazenil of reducing levels of GABA in the brain was used by researchers to exacerbate symptoms in patients with ... Goethals, I; Van de Wiele C; Boon P; Dierckx R (February 2003). "Is central benzodiazepine receptor imaging useful for the ... Höll, K; Deisenhammer E; Dauth J; Carmann H; Schubiger PA (1989). "Imaging benzodiazepine receptors in the human brain by ...
*  North West England
... it works by binding to the GABA receptor. Sir John Charnley of Bury invented the hip replacement in 1962 at Wrightington, ...
*  Muscimol
GABA. Muscimol binds to the same site on the GABAA receptor complex as GABA itself, as opposed to other GABAergic drugs such as ... CS1 maint: Multiple names: authors list (link) S. R. Snodgrass (1978). "Use of 3H-muscimol for GABA receptor studies". Nature. ... Frølund, B; Ebert, B; Kristiansen, U; Liljefors, T; Krogsgaard-Larsen, P (2002). "GABA-A receptor ligands and their therapeutic ... association with synaptic GABA receptors". Brain Res. 148 (1): 153-62. doi:10.1016/0006-8993(78)90385-2. PMID 207386. ...
*  CGS-13767
... is an anxiolytic GABA receptor ligand. DeSimone, Robert W.; Charles A. Blum (2000). "Substituted 3-(2-benzoxazyl)- ... benzimidazol-2-(1H)-ones: A new class of GABAA brain receptor ligands". Bioorganic & Medicinal Chemistry Letters. 10 (24): 2723 ...
*  Developmental plasticity
Hebbian theory Long-term potentiation Long-term depression NMDA receptor GABA receptor Cultured neuronal network Foehring, RC; ... effects such as severe physical and cognitive deficits as a result of impeding the normal activation of acetylcholine receptors ...
*  Homoquinolinic acid
Jan Egebjerg; Arne Schousboe; Povl Krogsgaard-Larsen (4 October 2001). Glutamate and GABA Receptors and Transporters: Structure ... It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor ... HQA has also been found to label a novel, yet uncharacterized binding site, which can be distinguished from the NMDA receptor ... and a partial agonist of the main/glutamate site of the NMDA receptor, with some selectivity for NR2B subunit-containing ...
*  Paroxysmal sympathetic hyperactivity
Benzodiazepines bind to GABA receptors and work as muscle relaxants. Benzodiazepines also combat high blood pressure and ... Baclofen is a GABA agonist that helps control muscle spasms, proving to be helpful in treating dystonia. ... Clonidine is an alpha receptor agonist that helps reduces sympathetic activity leaving the hypothalamus and reduces circulating ... Hinson, HE; Takahashi, C; Altowaijri, G; Baguley, I; Bourdette, D (April 2013). "Anti-NMDA receptor encephalitis with ...
*  Benzodiazepine use disorder
Tolerance leads to a reduction in GABA receptors and function; when benzodiazepines are reduced or stopped this leads to an ... working on the GABAA receptor complex and are cross tolerant with each other and also have abuse potential. Use of prescription ...
*  Epipregnanolone
6-. ISBN 978-1-4020-6854-6. Jan Egebjerg; Arne Schousboe; Povl Krogsgaard-Larsen (4 October 2001). Glutamate and GABA Receptors ... It acts as a negative allosteric modulator of the GABAA receptor and reverses the effects of potentiators like allopregnanolone ... The sulfate of epipreganolone, epipregnanolone sulfate, is a negative allosteric modulator of the NMDA and GABAA receptors and ... Norman G. Bowery (19 June 2006). Allosteric Receptor Modulation in Drug Targeting. CRC Press. pp. 112-. ISBN 978-1-4200-1618-5 ...
*  CECXG
Glutamate and gaba receptors and transporters: structure, function and pharmacology. pp 171-173. Taylor & Francis, 2002. ISBN 0 ... doi:10.1016/S0968-0896(02)00387-5. Ure, J.; Baudry, M.; Perassolo, M. (2006). "Metabotropic glutamate receptors and epilepsy". ... is a research drug which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3 ... making it one of the few ligands available that is able to distinguish between these two closely related receptor subtypes. ...
*  List of investigational anxiolytics
"GABA modulator" / undefined mechanism of action[22] JNJ-42165279 - FAAH inhibitor[23] MP-20X - CB1 and 5-HT1A receptor ... 5-HT1A receptor agonist, 5-HT2A receptor antagonist [4] Vilazodone (EMD-68843, SB-659746A; Viibryd) - 5-HT1A receptor partial ... 5-HT1A receptor agonist, 5-HT2A receptor antagonist [18] Verucerfont (GSK-561679, NBI-77860) - CRF1 receptor antagonist [19] ... Agomelatine (AGO-178; Valdoxan) - melatonin MT1 and MT2 receptor agonist, 5-HT2C receptor antagonist[1] Riluzole sublingual ( ...
*  GABRA2
... excitatory receptors. In GABA receptors, alcohol substrates binds allosterically, which allows the GABA receptors to increase ... "Entrez Gene: GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2". Hanns S, Möhler H (2007). The GABA Receptor. New York ... that bind to the GABA-A receptor. GABA-A receptors are composed of two alpha, two beta, and one gamma subunits. They have at ... GABRA2 is one of the 16 distinct alpha subunits found for the GABA receptor. GABA-A has a pentametric form, with two alpha, two ...