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*  Serum amyloid A1
These receptors include the G protein-coupled chemoattractant receptor FPR2 (formyl peptide receptor 2), believed to mediate ... The P2X7 purinergic receptor is another receptor used by SAA1 for a number of cellular functions including the activation of ... This effect is believed to be mediated through FPR2, a G protein-coupled chemoattractant receptor. The same receptor also ... Cai L, de Beer MC, de Beer FC, van der Westhuyzen DR (Jan 2005). "Serum amyloid A is a ligand for scavenger receptor class B ...
*  Chemotaxis
... formyl peptides - formyl peptide receptors (FPR), chemokines - chemokine receptors (CCR or CXCR), and leukotrienes - ... The chemotactic factor ligands and receptors related to formyl peptides are summarized in the related article, Formyl peptide ... Formyl peptides are di-, tri-, tetrapeptides of bacterial origin, formylated on the N-terminus of the peptide.[citation needed ... and alter the receptors.[citation needed] The proteins CheW and CheA bind to the receptor. The absence of receptor activation ...
*  Protein primary structure
Peptides can be synthesised chemically via a range of laboratory methods. Chemical methods typically synthesise peptides in the ... The N-terminal methionine usually found after translation has an N-terminus blocked with a formyl group. This formyl group (and ... Similar to phosphorylated tyrosines, sulfated tyrosines are used for specific recognition, e.g., in chemokine receptors on the ... Some organisms can also make short peptides by non-ribosomal peptide synthesis, which often use amino acids other than the ...
*  Formyl peptide receptor 1
... (FPR1, FPR1 receptor, fMet-Leu-Phe receptor 1, FMLP receptor 1, or N-formylmethionyl-leucyl- ... Formyl peptide receptor 1". Migeotte I, Communi D, Parmentier M (Dec 2006). "Formyl peptide receptors: a promiscuous subfamily ... "House dust mite allergen activates human eosinophils via formyl peptide receptor and formyl peptide receptor-like 1". European ... phenylalanine receptor 1) is a cell surface receptor protein that in humans is encoded by the formyl peptide receptor 1 (FPR1) ...
*  Formyl peptide receptor
Further studies defined a receptor for the N-formyl oligopeptides, formyl peptide receptor (FPR), so named based on its ability ... The formyl peptide receptors (FPR) belong to a class of G protein-coupled receptors involved in chemotaxis. In humans, there ... Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to ... Chemotaxis Receptors Migeotte I, Communi D, Parmentier M (Dec 2006). "Formyl peptide receptors: a promiscuous subfamily of G ...
*  Formyl peptide receptor 3
Formyl peptide receptor 1 Formyl peptide receptor 2 N-Formylmethionine-leucyl-phenylalanine GRCh38: Ensembl release 89: ... Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor ... "Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA". Biochemical and ... N-formyl peptide receptor 3 (FPR3) is a receptor protein that in humans is encoded by the FPR3 gene. Confusingly, there are two ...
*  Formyl peptide receptor 2
Eicosanoid receptor Formyl peptide receptor Lipoxin Resolvin Formyl peptide receptor 1 Formyl peptide receptor 3 GRCh38: ... and Formyl peptide receptor 3 (i.e. FPR3). FPR2 and FPR3 are termed formyl peptide receptors base on the similarities of their ... "House dust mite allergen activates human eosinophils via formyl peptide receptor and formyl peptide receptor-like 1". European ... "Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA". Biochemical and ...
*  N-Formylmethionine-leucyl-phenylalanine
Subsequently, Formyl peptide receptor 2 and Formyl peptide receptor 3 were also cloned based on the similarities in their amino ... acid sequence to that of formyl peptide receptor 1. Formyl peptide receptors 2 and 3 have very different abilities to bind and ... to formyl peptide receptor 1 and compared to each other and have very different functions than those of formyl peptide receptor ... The studies cited above lead to the eventual cloning of the human Formyl peptide receptor 1, a G protein coupled receptor that ...
*  Lipoxin
Nomenclature for the formyl peptide receptor (FPR) family". Pharmacological Reviews. 61 (2): 119-61. doi:10.1124/pr.109.001578 ... FPR2, which is now termed the ALX, ALX/FPR, or ALX/FPR2 receptor, is a G protein coupled receptor initially identified as a ... LXA4 and 15-epi-LXA4 are high affinity receptor ligands for and activators of the FPR2 receptor. ... based on its amino acid sequence similarity to the known FMLP receptor, FPR1. At least six homologues of this receptor are ...
*  Humanin
... as well as interaction with the formyl peptide receptor 2 (formylpeptide-like-1 receptor) have been published. Intracellular ... uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor". Journal of Immunology. 172 (11): 7078-85. ... The expressed peptide contains a three-turn α-helix, and has no symmetry. The length of the peptide depends on where it is ... Small humanin-like peptides are a group of peptides found in the mitochondrial 16S rRNA, and also possess retrograde signaling ...
*  HEBP1
... which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis ... the agonist of formyl peptide receptor 3". Journal of Immunology. 187 (3): 1475-85. doi:10.4049/jimmunol.1003545. PMID 21709160 ... the low-affinity N-formylpeptide receptor". Journal of Immunology. 178 (3): 1450-6. doi:10.4049/jimmunol.178.3.1450. PMID ... This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, ...
*  Vomeronasal organ
Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ. Proc Natl Acad Sci U S A. 2009 Jun 16; ... Recent studies proved a new family of formyl peptide receptor like proteins in VNO membranes of mice, which points to a close ... 1997 Aug;19(2):371-9. Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I. Formyl peptide receptor-like proteins are a novel ... Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I; Challet; Fluegge; Spehr; Rodriguez (2009). "Formyl peptide receptor-like ...
*  Spinorphin
... spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor ... Spinorphin is an endogenous, non-classical opioid peptide of the hemorphin family first isolated from the bovine spinal cord ( ... but it has been found to act as an antagonist of the P2X3 receptor, and as a weak partial agonist/antagonist of the FP1 ... a class of enzymes that break down endogenous the enkephalin peptides. It does so by inhibiting the enzymes aminopeptidase N ( ...
*  Cathepsin D
... the agonist of formyl peptide receptor 3". Journal of Immunology. 187 (3): 1475-85. doi:10.4049/jimmunol.1003545. PMID 21709160 ... "Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L ...
*  Annexin
Prossnitz ER, Ye RD (1997). "The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and ... How the annexins are transported out of the cell into the blood is a mystery because they lack a signal peptide necessary for ... In turn, the activation of these receptors functions to send the leukocytes to the site of infection and target the source of ... The expression of annexin A-II on the cell surface is believed to serve as a receptor for plasminogen, which functions to ...
*  Arrestin beta 1
Bennett TA, Maestas DC, Prossnitz ER (2000). "Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated ... Lefkowitz RJ (1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling ... 1998). "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor ... Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated ...
*  Phospholipase D
"A role of p44/42 mitogen-activated protein kinases in formyl-peptide receptor-mediated phospholipase D activity and oxidant ... receptor-mediated endocytosis, exocytosis, and cell migration. Through these processes, it has been further implicated in the ...
*  RASD1
"Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases". The Journal of ... RASD1 is also reported to function with leptin in the activation of TRPC4 transient receptor potential channels and, thus, ... RASD1 could activate G proteins in a receptor-independent manner and inhibit signal transduction through several different G ... apparent disruption of receptor signaling complexes". The Journal of Biological Chemistry. 277 (16): 13827-30. doi:10.1074/jbc. ...
*  Family with sequence similarity 19 member A4, C-C motif chemokine like
"FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of ...
*  Monocyte
... leucyl-phenylalanine and other N-formylated oligopeptides which are made by bacteria and activate the formyl peptide receptor 1 ... There are at least three subclasses of monocytes in human blood based on their phenotypic receptors. Monocytes are amoeboid in ... Sallusto F, Cella M, Danieli C, Lanzavecchia A (1995). "Dendritic cells use macropinocytosis and the mannose receptor to ... 2015). "slan definded subsets of CD16 positive monocytes impact of granulomatous inflammation and M CSF receptor mutation". ...
*  Eicosanoid receptor
... formyl peptide receptor-like 1) - FPR2; receptor for Lipoxin A4 and 15-epi-Lipoxin A4 (or AT-LxA4) eicosanoids but also many ... Nomenclature for the formyl peptide receptor (FPR) family". Pharmacological Reviews. 61 (2): 119-61. doi:10.1124/pr.109.001578 ... The TP receptor is expressed in most human cells types as two alternatively spliced isoforms, TP receptor-α and TP receptor β, ... A final prostanoid receptor, DP2, is structurally related to the chemotaxis class of receptors and unlike the other prostanoid ...
*  Spermatozoon
... formyl peptide receptor (60,000 receptor/cell) as well as the activator ability of its ligand formyl Met-Leu-Phe have been ... "Evidence for the presence of specific receptors for N-formyl chemotactic peptides on human spermatozoa". Journal of Clinical ... common signaling characters of the event is that a prototype of professional chemotaxis receptors, ...
*  Fertilisation
"Evidence for the presence of specific receptors for N-formyl chemotactic peptides on human spermatozoa". J Clin Endocrinol ... In another ligand/receptor interaction, an oligosaccharide component of the egg binds and activates a receptor on the sperm and ... a type of ligand/receptor interaction. Resact is a 14 amino acid peptide purified from the jelly coat of A. punctulata that ... These receptors are unknown in mice but have been identified in guinea pigs. In mammals, the binding of the spermatozoon to the ...
*  Cathelicidin
... utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, ... The cathelicidin family of peptides are classified as antimicrobial peptides (AMPs). The AMP family also includes the defensins ... CAMP cathelicidin antimicrobial peptide". Zanetti M (January 2004). "Cathelicidins, multifunctional peptides of the innate ... and a highly variable cathelicidin peptide domain. Cathelicidin peptides have been isolated from many different species of ...
*  Leukotriene B4 receptor 2
For example, the Formyl peptide receptor 2 (FPL2 receptor) was initially suggested to be a second receptor with ~70% amino acid ... identity to Formyl peptide receptor 1 (FPL1 receptor). Both receptor types bind and are activated by a series of formylated ... Inhibition of BLT2 receptors by LY255283 but not of BLT1 receptors by U75302 and suppression of BLT2 receptors by siRNA ... BLT2 receptors, similar to BLT1 receptors, are G protein coupled receptors that, when ligand-bound, activate G proteins that ...
*  FRP
... a protein found in cyanobacteria Formyl peptide receptor, a class of compound found in many organisms, involved in chemical ...
*  Enfuvirtide
T20 is also an activator of the chemotactic factor receptor, formyl peptide receptor 1 (FPR1), and thereby activates ... phaogocytes and presumably other cells bearing this receptor (See Formyl peptide receptors section on FPR1 receptors). The ... A biomimetic peptide, enfuvirtide was designed to mimic components of the HIV-1 fusion machinery and displace them, preventing ... HIV binds to the host CD4+ cell receptor via the viral protein gp120; gp41, a viral transmembrane protein, then undergoes a ...