... a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain". Cell. 58 (4): 623-9. doi:10.1016 ... Tran H, VanDusen WJ, Argraves WS (Sep 1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium- ... Tran H, VanDusen WJ, Argraves WS (Sep 1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium- ... Fibulin-1 is a secreted glycoprotein that is found in association with extracellular matrix structures including fibronectin- ...

"Entrez Gene: FLRT3 fibronectin leucine rich transmembrane protein 3". Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal ... They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich ... FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. ...

The interaction between fibronectin and the integrin receptor causes a conformational change in the fibronectin. Additional ... Fibronectin a glycoprotein that binds to receptor proteins known as integrins within the cytoskeleton is a key player in the ... receptors bind to fibronectin bringing in type I collagen, procollagen I and collagen V. These molecules interact with ... Kader, Karl (2008). "Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators". ...

August 2003). "Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator". ... In addition, this protein binds with high affinity to fibronectin. Plasma gelsolin and cytoplasmic gelsolin are derived from a ... Gelsolin has been shown to interact with: Amyloid precursor protein, Androgen receptor, PTK2B, and VDAC1. Plasma gelsolin ...

This fold consist of two related β-sandwich subdomains with a fibronectin type III domain topology. The two domains are joined ... 2006). "An Essential Role for SNX1 in Lysosomal Sorting of Protease-activated Receptor-1: Evidence for Retromer-, Hrs-, and ... Gurevich VV, Gurevich EV (June 2006). "The structural basis of arrestin-mediated regulation of G-protein-coupled receptors". ... Arrestins are regulatory proteins known for connecting G-protein coupled receptors (GPCRs) to clathrin during endocytosis. They ...

Rosemblatt M, Vuillet-Gaugler MH, Leroy C, Coulombel L (1991). "Coexpression of two fibronectin receptors, VLA-4 and VLA-5, by ... It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family of ... "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". Hadari YR, Arbel-Goren R, Levy Y, ... Humphries MJ, Sheridan J, Mould AP, Newham P (1995). "Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: ...

The mannose receptor is the only member of the family in which this domain is functional. The fibronectin type II repeat domain ... The mannose receptor on liver sinusoidal endothelial cell is a rapidly recycling receptor, with a Ke (endocytotic rate constant ... In this way, the mannose receptor acts as a pattern recognition receptor. The presence of a di-aromatic FENTLY (Phe-Glu-Asn-Thr ... As opposed to macrophages that use the mannose receptors for phagocytosis of particulate matter >200 nm, the mannose receptor ...

... L degrades fibronectin, insulin receptor (IR), and insulin-like growth factor 1 receptor (IGF-1R). Cathepsin L- ... Cathepsin D (an aspartyl protease) appears to cleave a variety of substrates such as fibronectin and laminin. Unlike some of ... and more fibronectin than wild type controls. Five cyclic peptides show inhibitory activity towards human cathepsins L, B, H, ... deficient mice were shown to have less adipose tissue, lower serum glucose and insulin levels, more insulin receptor subunits, ...

"Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis". The ... OPN binds to several integrin receptors including α4β1, α9β1, and α9β4 expressed by leukocytes. These receptors have been well- ... These integrin receptors are present on a number of immune cells such as mast cells, neutrophils, and T cells. It is also ... Upon binding these receptors, cells use several signal transduction pathways to elicit immune responses in these cells. OPN-R ...

CDON (MIM 608707) and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) ...

"Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor". Cell. ... in much the same way as cells with surface receptors. The discovered receptors were later named integrins. The RGD motif is ... CEND-1, also known as iRGD, is a cyclic peptide that homes to tumors via binding to integrin alpha V receptors. It also binds ... To do this, the authors synthesized various peptides based on the hypothesized cell attachment site of fibronectin. They then ...

1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin". J. Biol. Chem. ... 1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor ...

1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin". J. Biol. Chem. ... TN-C also interacts with one or more TN-C receptors on cells which activate and repress the same signal transduction pathway. ... 1994). "The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of ... This results in a multitude of TN-C subunits differing in the number and identity of fibronectin type III domain repeats. ...

Collagen, laminin, and fibronectin are major ECM molecules that are secreted and assembled into sheets, fibers, and gels. ... Multisubunit transmembrane receptors called integrins are used to bind to the ECM. Integrins bind extracellularly to ... Integrins also serve as receptors to trigger signal transduction cascades when binding to the ECM. A well-studied example of ... Morphogens typically act through binding to specific protein receptors. An important class of molecules involved in ...

They bind to TGF-β type II receptor (TGFBRII). TGF-β1 stimulates the synthesis of collagen and fibronectin and inhibits the ... There are five kinds of type II receptors and seven types of type I receptors in humans and other mammals. These receptors are ... Binds to Activin A Type 2B receptor Forms receptor complex with Activin A Type 1B receptor or with Activin A Type 1C receptor. ... The Kit receptor and related tyrosine kinase receptors actually are inhibitory and effectively suppresses receptor firing. ...

... is part of the extracellular portions of EphA2 receptor proteins. FN2 domain on EphA2 receptors ... mannose receptor of macrophages; 180 Kd secretory phospholipase A2 receptor; DEC-205 receptor; 72 Kd and 92 Kd type IV ... Fibronectin type II domain is a collagen-binding protein domain. Fibronectin is a multi-domain glycoprotein, found in a soluble ... Fibronectin type-II collagen-binding domain in PROSITE v t e (Protein domains, Peripheral membrane proteins, All stub articles ...

... which naturally binds weakly to the receptor. Fibronectin domain 10 contains the RGD motif that αVβ3 recognizes. A high- ... αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin ... Furthermore, it is a receptor for phagocytosis on macrophages or dendritic cells. Integrin αVβ3 is a potential drug target ... "The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by ...

This actin regulatory protein binds to fibronectin receptors and aids in the haptotactic and chemotactic processes of tumor ... Fibronectin and laminin both play a role in adrenocyte mutation into distinctive distribution in the adrenal gland. The ... Taniuchi, M.; Clark, H. B.; Johnson, E. M. (1986). "Induction of nerve growth factor receptor in Schwann cells after axotomy". ... The haptotaxis is mediated by fibronectin, vitronectin, and type I collagen. A recent study has tentatively proposed the idea ...

The giant 30,000 residue muscle protein titin comprises about 120 fibronectin-III-type and Ig-type domains. In the serine ... cell surface adhesion molecules and cytokine receptors. Four concrete examples of widespread protein modules are the following ... domains: SH2, immunoglobulin, fibronectin type 3 and the kringle. Molecular evolution gives rise to families of related ...

... and fibronectin. It is important that these outer-membrane adhesins make physical contact with the receptors found on the host ... "Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor ... Function: The function of this protein domain is to bind to the extracellular matrix of the host, most notably fibronectin, ... fibronectin, etc. Most TAAs have a similar protein structure. When observed with electron microscopy, the structure has been ...

Extracellular tTG has been linked to cell adhesion, ECM stabilization, wound healing, receptor signaling, cellular ... identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix". The Journal of ... "Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin". The Journal of Cell Biology. 148 (4): 825- ...

Lee, JH; Park, JW; Kim, SW; Park, J; Park, TS (15 December 2017). "C-X-C chemokine receptor type 4 (CXCR4) is a key receptor ... the PGCs migrate along the mesentery to the gonadal mesoderm facilitated by orientated extracellular matrix with fibronectin. ... the PGCs express two CXCR4 transmembrane receptor proteins. The signaling system involving this protein and its ligand, Sdf1, ...

Components of the extracellular matrix such as fibronectin and hyaluronan can also bind to such receptors (integrins and CD44, ... The binding of a signaling molecule with a receptor causes a change in the conformation of the receptor, known as receptor ... Certain intracellular receptors of the immune system are cytoplasmic receptors; recently identified NOD-like receptors (NLRs) ... Receptors can be roughly divided into two major classes: intracellular and extracellular receptors. Extracellular receptors are ...

"Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet ... "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)". Hermann P, Armant M, Brown E, ... Porter JC, Hogg N (October 1998). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends ... Horton MA (May 1997). "The alpha v beta 3 integrin "vitronectin receptor"". The International Journal of Biochemistry & Cell ...

August 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for ...

It is known that fetal skin contains more HA than adult skin due to the expression of more HA receptors. The expression of HA ... This is due to the early up regulation of cell adhesion proteins such as fibronectin and tenascin in the fetus. During early ... It is this ability of the fetal fibroblast to quickly express and deposit fibronectin and tenascin, which ultimately allows ... Proteins and cell surface receptors found in the ECM differ in fetal and adult wound healing. ...

... a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains". J. Exp. Med. 172 (6): 1559-70. doi: ... The G-CSF receptors belong to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony ... The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and ... The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein ...

Fibronectin domains of L1 protein are also capable of binding cell surface integrins. They interact with fibroblast growth ... And also heterophilic interactions, where an adhesion molecule on one cell works as a receptor that connects with a different ... They are also important in the formation of heterophilic interactions with NCAM, TAG-1, F11 and receptor tyrosine kinases ( ... The extracellular portion is formed of six immunoglobulin domains followed by five fibronectin type III domains which are ...

Fibronectin and other ECM proteins bind to cell surface receptor proteins called integrins that are built into the plasma ... Current research on fibronectin, other ECM molecules, and integrins is revealing the influential role of the ECM in the lives ... Mechanical signaling involves fibronectin, integrins, and microfilaments of the cytoskeleton. Changes in the cytoskeleton may ... Some cells are attached to the ECM by still other ECM glycoproteins such as fibronectin. ...

As these receptors interact and are pulled or pushed, tension can be created, leading to a change in the conformation of alpha- ... which can bind to a major ECM component called fibronectin. This leads to an accumulation of integrins in the area of contact ... Different cellular receptors are important in cellular mechanotransduction involved in contact with a substrate such as the ...

... receptors. The net result is the shunting of LDL particles to these scavenger receptors. Scavenger receptors typically are ... Interaction of ApoB with proteoglycans, collagen, and fibronectin is believed to cause atherosclerosis. Click on genes, ... lead to competition at the ApoB100 receptor (i.e. LDL receptor) of peripheral cells. Since such competition will prolong the ... What is also clear is that the ApoB on the LDL particle acts as a ligand for LDL receptors in various cells throughout the body ...

... and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII) repeat family involved in ... encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors". American ... and anchorage-regulated member of the Ig/fibronectin type III repeat family". The Journal of Cell Biology. 138 (1): 203-13. doi ...