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*  MS4A2
Hill MR, Cookson WO (1997). "A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon ... 1995). "Different roles for the Fc epsilon RI gamma chain as a function of the receptor context". J. Exp. Med. 181 (1): 247-55 ... "Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta ... 1993). "Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q". Lancet. 341 ( ...
*  Fc receptor
FcγR), those that bind IgA are called Fc-alpha receptors (FcαR) and those that bind IgE are called Fc-epsilon receptors (FcεR ... Only one Fc receptor belongs to the FcαR subgroup, which is called FcαRI (or CD89). FcαRI is found on the surface of ... All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing ... This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which ...
*  Neonatal Fc receptor
The neonatal Fc receptor is an Fc receptor which is similar in structure to the MHC class I molecule and also associates with ... The neonatal Fc receptor (FcRn), also known as the Brambell receptor, is a protein that in humans is encoded by the FCGRT gene ... Further studies revealed a similar receptor in humans, leading to the naming as a neonatal Fc receptor. In humans, however, it ... Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine, TNF-α, and down-regulated by IFN-γ. FcRn helps ...
*  Fc receptor-like molecule
... s (FCRLs) are a class of proteins that resemble Fc receptors. They have been characterized in a number ... FCRLB Fc receptor Davis RS (2007). "Fc receptor-like molecules". Annual Review of Immunology. 25: 525-60. doi:10.1146/annurev. ... Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of antibodies. ... "Immunoregulatory Roles for Fc Receptor-Like Molecules". In Ahmed R, Honjo T. Negative Co-Receptors and Ligands. Current Topics ...
*  Fc fragment of igg receptor iic (gene/pseudogene)
... is a protein that in humans is encoded by the FCGR2C gene. This gene encodes ... Chai L, Song YQ, Zee KY, Leung WK (2010). "SNPs of Fc-gamma receptor genes and chronic periodontitis". J. Dent. Res. 89 (7): ... Fc fragment of IgG receptor IIc (gene/pseudogene)". Retrieved 2017-05-24. Breunis WB, van Mirre E, Bruin M, Geissler J, de Boer ... Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, ...
*  Antibody
Each Fc region of a particular antibody isotype is able to bind to its specific Fc Receptor (except for IgD, which is ... IgE's Fab paratope binds to allergic antigen, for example house dust mite particles, while its Fc region binds to Fc receptor ε ... Those cells that recognize coated pathogens have Fc receptors, which, as the name suggests, interact with the Fc region of IgA ... and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions". J Biol Chem. 273 (4): 2260-2272. doi:10.1074 ...
*  CD16
... has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG ... CD16 is a low affinity Fc receptor. It is a cluster of differentiation molecule found on the surface of natural killer cells, ...
*  Clark L. Anderson
The Fcγ Receptor (FcγR) family of molecules. Anderson's early work on identifying and characterizing the high affinity FcγRI ... antibodies mediate their cell biological effects through the family of Fcγ receptors (a class of Fc receptors that are members ... The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy. Adv drug Deliv Rev 91: 109-124. Chaudhury, C., S. ... Human IgG Fc receptors. Clin. Immunol. Immunopathol. 1989 Nov;53(2 Pt 2):S63-71. Review. PMID 2529071 Anderson CL, Guyre PM, ...
*  LYN
"Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI". Seminars in Immunology. 7 (1 ... In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor ... Müller G, Wied S, Frick W (Jul 2000). "Cross talk of pp125(FAK) and pp59(Lyn) non-receptor tyrosine kinases to insulin-mimetic ... Müller G, Wied S, Frick W (Jul 2000). "Cross talk of pp125(FAK) and pp59(Lyn) non-receptor tyrosine kinases to insulin-mimetic ...
*  Antibody-dependent cell-mediated cytotoxicity
The most common Fc receptor on the surface of an NK cell is called CD16 or FcγRIII. Once the Fc receptor binds to the Fc region ... A NK cell expresses Fc receptors, mostly CD16. These receptors recognize, and bind to, the Fc portion of an antibody, such as ... the Fc receptor (FceRI) of an eosinophil will then recognize IgE. Subsequently, interaction between FceRI and the Fc portion of ... Next, the NK cells which have Fc Receptors will bind to that antibody, inducing the NK cell to release proteins such as ...
*  FCER1A
2000). "Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha". Nature. 406 (6793): ... 1996). "Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI ... Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is ... "Entrez Gene: FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide". Gounni AS (2006). "The high-affinity ...
*  FCRL1
"Entrez Gene: FCRL1 Fc receptor-like 1". Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor ... Fc receptor-like protein 1 is a protein that in humans is encoded by the FCRL1 gene. GRCh38: Ensembl release 89: ... "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): ... a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662-2669. doi:10.1182/blood. ...
*  FCRL5
Fc receptor-like protein 5 is a protein that in humans is encoded by the FCRL5 gene. FCRL5 has also been designated as CD307 ( ... "Entrez Gene: FCRL5 Fc receptor-like 5". Nakayama Y, Weissman SM, Bothwell AL (2001). "BXMAS1 identifies a cluster of homologous ... Davis RS, Wang YH, Kubagawa H, Cooper MD (2001). "Identification of a family of Fc receptor homologs with preferential B cell ... Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of ...
*  FCRL4
"Entrez Gene: FCRL4 Fc receptor-like 4". Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor ... Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed ... Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B ... 2004). "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa- ...
*  FCRL2
... Fc receptor-like 2". Davis RS, Wang YH, Kubagawa H, Cooper MD (2001). "Identification of a family of Fc receptor homologs ... Fc receptor-like protein 2 is a protein that in humans is encoded by the FCRL2 gene. GRCh38: Ensembl release 89: ... Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of ... 2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662-9. doi: ...
*  FCRL3
Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". Curr ... This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins ... "Entrez Gene: FCRL3 Fc receptor-like 3". Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig ... Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene. ...
*  Lymph node stromal cell
They also express the Fc receptors, CD16, CD23 and CD32; the complement receptors CD21 and CD35 and complement components. The ... Lymphocytes have receptors for such chemokines. For example, Naive T cells express the CCR7 receptor for the chemokine CCL21. ... and dendritic cells express a surface CCR7 receptor. This type of receptor interacts with the chemokine CCL21, produced by ... FRCs express chemokines such as CCL21 and CCL19 which assist the movement of T cells and dentritic cells with CCR7 receptors. ...
*  FCER1G
... receptor for; gamma polypeptide". Tsuji M, Ezumi Y, Arai M, Takayama H (September 1997). "A novel association of Fc receptor ... LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets". European ... Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is a protein that in humans is encoded by the FCER1G gene ... Takahashi K, Hayashi N, Shimokawa T, Umehara N, Kaminogawa S, Ra C (May 2008). "Cooperative regulation of Fc receptor gamma- ...
*  Trastuzumab
Clynes, RA; Towers, TL; Presta, LG; Ravetch, JV (2000). "Inhibitory Fc receptors modulate in vivo cytoxicity against tumor ... The HER receptors are proteins that are embedded in the cell membrane and communicate molecular signals from outside the cell ( ... The EGF pathway includes the receptors HER1 (EGFR), HER2, HER3, and HER4; the binding of EGF to HER is required to activate the ... Specifically it is used for breast cancer that is HER2 receptor positive. It may be used by itself or together with other ...
*  TREM2
Fc receptors, CD14 and Toll-like receptors (e.g., TLR4), and cytokine receptors (e.g., IFNGR1). Engagement of these receptors ... Triggering receptor expressed on myeloid cells 2 also known as TREM-2 is a protein that in humans is encoded by the TREM2 gene ... Myeloid cells express receptors belonging to the Immunoglobulin (Ig) superfamily, such as TREM2, or to the C-type lectin ... "Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2". Guerreiro RJ, Lohmann E, Brás JM, Gibbs JR, Rohrer JD, ...
*  Immunoglobulin heavy chain
"Human antibody-Fc receptor interactions illuminated by crystal structures". Nature Reviews Immunology. 4 (2): 89-99. doi: ... The resulting antibodies are designated IgW (also called IgX or IgNARC) and IgNAR ('immunoglobulin new antigen receptor'). The ... "Role of the surrogate light chain and the pre-B-cell receptor in mouse B-cell development". Immunology. 101 (4): 435-441. doi: ...
*  CD79A
Cambier JC (Oct 1995). "Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation ... "Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization". The ... Engels N, Wollscheid B, Wienands J (Jul 2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM ... Patterson HC, Kraus M, Kim YM, Ploegh H, Rajewsky K (Jul 2006). "The B cell receptor promotes B cell activation and ...
*  Immunoglobulin therapy
By binding to receptors on antigen presenting cells, IVIG can increase the expression of the inhibitory Fc receptor, FcgRIIB ... Once these immune complexes are formed, they can interact with Fc receptors on dendritic cells which then mediate anti- ... Gern JE (August 2002). "Antiinflammatory Activity of IVIG Mediated through the Inhibitory FC Receptor". Pediatrics. 110 (2): ... "Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells". Nat. Med. 12 (6): 688-92. doi ...
*  Opsonin
The Fab region of the antibody binds to the antigen, whereas the Fc region of the antibody binds to an Fc receptor on the ... Phagocytic cells do not have an Fc receptor for immunoglobulin M (IgM), making IgM ineffective in assisting phagocytosis alone ... ISBN 0-8016-0495-8. Zhang, Youxin; Hoppe, Adam D.; Swanson, Joel A. (2010-11-09). "Coordination of Fc receptor signaling ... These antibodies interact with Fc receptors on macrophages and neutrophils resulting in phagocytosis. The C1 complement complex ...
*  Daniel A. Portnoy
At Rockefeller University he worked on macrophage Fc receptors and lysosomal proteases. In 1986 Dr. Portnoy started his ... Russell Vance identified that STING was the host receptor of cyclic-di-nucleotides (CDNs) that leads to the production of type ...
*  Follicular dendritic cells
Follicular DCs have high expression of complement receptors CR1 and CR2 (CD 35 and CD 21 respectively) and Fc-receptor FcγRIIb ... Follicular DCs receptors CR1, CR2 and FcγRIIb trap antigen opsonized by complement or antibodies. To become selected as a ... TNF-a binds on the TNFRI receptor, while LT interacts with LTβ-receptor expressed on FDC precursors. In mice lacking B cells, ... B cells lacking CXCR5, the receptor for CXCL13, still enter the white pulp, but are mislocalized and disorganized. To generate ...