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*  Dopamine receptor D1
"Entrez Gene: DRD1 dopamine receptor D1". Zhang J, Xiong B, Zhen X, Zhang A (2009). "Dopamine D1 receptor ligands: where are we ... The D1 receptor forms heteromers with the following receptors: dopamine D2, D3, histamine H3, μ opioid. D1-D2 D1−H3−NMDA ... The D1 subtype of the dopamine receptor is the most abundant dopamine receptor in the central nervous system. This G-protein ... "Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the ...
*  D1-D2 dopamine receptor heteromer
The D1-D2 dopamine receptor heteromer is a receptor heteromer consisting of D1 and D2 protomers. D1 and D2 receptors interact ... Hasbi A, O'Dowd BF, George SR (Feb 2010). "Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates ... The D1-D2 receptor is upregulated in individuals suffering from major depression, and especially the ratio D1-D2 to D1 receptor ... "Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal ...
*  DRD1IP
The encoded protein interacts with dopamine receptor D1 and may interact with other DA receptor subtypes and/or GPCRs. GRCh38: ... "Entrez Gene: DRD1IP dopamine receptor D1 interacting protein". Milligan G, White JH (2001). "Protein-protein interactions at G- ... a D1 dopamine receptor interacting protein". Science. 287 (5458): 1660-4. doi:10.1126/science.287.5458.1660. PMID 10698743. ( ... Ali MK, Bergson C (2004). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein ...
*  DNAJC14
... has been shown to interact with Dopamine receptor D1. GRCh38: Ensembl release 89: ENSG00000135392 - Ensembl, May 2017 ... "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein". Nat Cell Biol. 3 (5): 492-8. doi: ... like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking ... "Accessory proteins in the biogenesis of G protein-coupled receptors". Mol. Interv. 1 (5): 282-7. PMID 14993367. Leclerc PC, ...
*  Addiction-related structural neuroplasticity
Cameron, DL (1993). "Dopamine D1 receptors facilitate transmitter release". Nature. 366 (6453): 344-47. doi:10.1038/366344a0. ... For LTP to occur, NMDA receptors on the dendritic spine send intracellular signals to increase the number of AMPA receptors on ... GABAergic neurons in the VTA also synapse on local dopamine cells. In non-drug models, the VTA dopamine neurons are stimulated ... These drugs induce an increase in synaptic dopamine by inhibiting the reuptake of dopamine from the synaptic cleft, effectively ...
*  EHD3
To recycle the D1 dopamine receptor. The gene that encodes the human EHD3 protein is located in chromosome number 2, most ... This family of four paralogs (EHD1-EHD4) has been implicated in receptor intracellular trafficking, particularly in ...
*  Dihydrexidine
... is a moderately selective full agonist at the dopamine D1 and D5 receptors. It has approximately 10-fold selectivity for D1 and ... Zhang J, Xiong B, Zhen X, Zhang A (2009). "Dopamine D1 receptor ligands: where are we now and where are we going". Med Res Rev ... Salmi P, Isacson R, Kull B (2004). "Dihydrexidine--the first full dopamine D1 receptor agonist". CNS Drug Rev. 10 (3): 230-242 ... Mottola DM, Brewster WK, Cook LL, Nichols DE, Mailman RB (1992). "Dihydrexidine, a novel full efficacy D1 dopamine receptor ...
*  COPG2
... has been shown to interact with Dopamine receptor D1 and COPB1. GRCh38: Ensembl release 89: ENSG00000158623 - Ensembl, ... Bermak JC, Li M, Bullock C, Weingarten P, Zhou QY (2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C ... "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2): 77-85. doi:10.1078/ ...
*  Dehydrocorybulbine
... binds to the dopamine D1 receptor. Research has indicated that DHCB can be helpful in reducing neuropathic ... "Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor". Molecules ( ...
*  COPG
... has been shown to interact with Dopamine receptor D1, COPZ1 and COPB1. GRCh38: Ensembl release 89: ENSG00000181789 - ... 2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2): 77-85. doi: ... "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. Germany. 81 (2): 77-85. doi: ...
*  A-77636
"Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors". Neuropharmacology. ... "Persistent activation of the dopamine D1 receptor contributes to prolonged receptor desensitization: studies with A-77636". The ... Ruskin DN, Rawji SS, Walters JR (July 1998). "Effects of full D1 dopamine receptor agonists on firing rates in the globus ... Graham DL, Hoppenot R, Hendryx A, Self DW (April 2007). "Differential ability of D1 and D2 dopamine receptor agonists to induce ...
*  AL-LAD
Pharmacological evaluation at D1 dopamine receptors". Psychopharmacology. 118 (4): 401-9. doi:10.1007/BF02245940. PMID 7568626 ...
*  CY-208,243
D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). "Dopamine D1 receptor agonists induce penile erections in rats ... Beninger RJ, Rolfe NG (December 1995). "Dopamine D1-like receptor agonists impair responding for conditioned reward in rats". ... CY-208,243 is a drug which acts as a dopamine agonist selective for the D1 subtype. Unlike most D1-selective agonists, it shows ... "Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys". Advances in ...
*  A-86929
Zhang J, Xiong B, Zhen X, Zhang A (March 2009). "Dopamine D1 receptor ligands: where are we now and where are we going". ... A-86929 is a synthetic compound that acts as a selective dopamine receptor D1 agonist. It was developed as a possible treatment ... Giardina WJ, Williams M (2001). "Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: ... "Induction by dopamine D1 receptor agonist ABT-431 of dyskinesia similar to levodopa in patients with Parkinson disease". ...
*  Dopexamine
It works by stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also ... Dopexamine stimulates beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also ... Effects of depexamine may be suppressed by concomitant use with ß2-adrenergic and dopamine receptor antagonists requires ... a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors". British Journal of Pharmacology. 85 (3): 599-608. ...
*  A-68930
... is a synthetic compound that acts as a selective dopamine receptor D1 agonist. It is orally active and has ... Trampus M, Ferri N, Adami M, Ongini E (April 1993). "The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal ... AI-Naser HA, Cooper SJ (April 1994). "A-68930, a novel, potent dopamine D1 receptor agonist: a microstructural analysis of its ... Salmi P, Ahlenius S (April 2000). "Sedative effects of the dopamine D1 receptor agonist A 68930 on rat open-field behavior". ...
*  Aging brain
Significant age-related decreases in dopamine receptors D1, D2, and D3 have also been highly reported. A general decrease in D1 ... A general decrease in D1 receptor density has also been shown to occur with age. Significant age-related declines in dopamine ... Iyo, M.; Yamasaki, T. (1993). "The detection of age-related decrease of dopamine, D1, D2 and serotonin 5-HT2 receptors in ... September 1998). "Age-dependent decline of dopamine D1 receptors in human brain: a PET study". Synapse. 30 (1): 56-61. doi: ...
*  Epigenetics of cocaine addiction
... suggesting functional dopamine D1 receptor is necessary for their induction. This receptor had been seen to modulate the ... They had observed previous cocaine injections led to a direct increase in D1 receptor sensitivity. Through lines of D1 receptor ... Also involved in the CREB-Fos protein pathways is the dopamine D1 receptor (DRD1), expressed in neurons in the nucleus ... response to D1/D2 receptor stimulation it could be involved in alterations of the signal transduction pathway after D1 receptor ...
*  Dinapsoline
Gleason SD, Witkin JM (May 2006). "Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine". ... that acts as a selective full agonist at the dopamine D1 receptor. Gulwadi AG, Korpinen CD, Mailman RB, Nichols DE, Sit SY, ... characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease". The Journal of Pharmacology and ... a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore". Journal of Medicinal Chemistry. 39 (2 ...
*  6-Br-APB
Neumeyer JL, Kula NS, Baldessarini RJ, Baindur N (April 1992). "Stereoisomeric probes for the D1 dopamine receptor: synthesis ... Weed MR, Woolverton WL (December 1995). "The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys". The ... a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship". Journal of Medicinal Chemistry ... Barrett AC, Miller JR, Dohrmann JM, Caine SB (2004). "Effects of dopamine indirect agonists and selective D1-like and D2-like ...
*  SKF-82,958
CS1 maint: Multiple names: authors list (link) Wang JQ, McGinty JF (May 1997). "The full D1 dopamine receptor agonist SKF-82958 ... Terry P, Katz JL (1992). "Differential antagonism of the effects of dopamine D1-receptor agonists on feeding behavior in the ... Weed MR, Woolverton WL (December 1995). "The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys". The ... Abrahams BS, Rutherford JD, Mallet PE, Beninger RJ (February 1998). "Place conditioning with the dopamine D1-like receptor ...
*  Working memory training
... claimed that adaptive span training had led to changes in dopamine D1 and D2 receptors. In the same study, tests of "far ... "Changes in cortical dopamine D1 receptor binding associated with cognitive training". Science. 323 (5915): 800-802. doi:10.1126 ...
*  Working memory
February 2009). "Changes in cortical dopamine D1 receptor binding associated with cognitive training". Science. 323 (5915): 800 ... It has been shown in one study that working memory training increases the density of prefrontal and parietal dopamine receptors ... Mood states (positive or negative) can have an influence on the neurotransmitter dopamine, which in turn can affect problem ... Several neurotransmitters, such as dopamine and glutamate may be both involved in ADHD and working memory. Both are associated ...
*  Dopamine receptor D5
It belongs to the D1-like receptor family along with the D1 receptor subtype. D5 receptor is a subtype of the dopamine receptor ... dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor ... "Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors". British Journal of ... D5 receptor is expressed more widely in the CNS than its close structural homolog dopamine receptor D1. It is found in neurons ...
*  Perlapine
However, it retains higher affinity for the dopamine D1 receptor (IC50 = 198 nM). Its IC50 values are 19 nM for the α1- ... The drug has relatively weak affinity for the dopamine D2 receptor (IC50 = 1,803 nM) and, in accordance, is said to be ... adrenergic receptor, 4,945 nM for the α2-adrenergic recpetor, and 70 nM for the serotonin 5-HT2A receptor. Perlapine is closely ...
*  Dinoxyline
"Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists". Molecular ... Zhang J, Xiong B, Zhen X, Zhang A (March 2009). "Dopamine D1 receptor ligands: where are we now and where are we going". ... which acts as a potent full agonist at all five dopamine receptor subtypes. Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen ... a high affinity and potent agonist at all dopamine receptor isoforms". Bioorganic & Medicinal Chemistry. 12 (6): 1403-12. doi: ...