... were discovered to exist in the brain and have specific receptors in it, by investigations on the mechanism of action of ... Endorphins Dynorphin Bradykinin Prostaglandins Angiotensin Secretin Gastrin Cholecystokinin Histamine Cannabinoids Substance P ... The main scientific criterion for an autopharmacological agent is the discovery of specific membrane receptors for it and, ...

... shown to interact with the Cholecystokinin A receptor located mainly on pancreatic acinar cells and Cholecystokinin B receptor ... "Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... Cholecystokinin is a member of the gastrin/cholecystokinin family of peptide hormones and is very similar in structure to ... Media related to Cholecystokinin at Wikimedia Commons Cholecystokinin at the U.S. National Library of Medicine Medical Subject ...

... follicle-stimulating hormone receptor (FSHR), and other chemokine and G-protein coupled receptors. A full, up-to-date list can ... Beyond these two proteins, other notable protein substrates include Cholecystokinin (CCK), Factor V and Factor VIII, gastrin, ... Another substrate for TPST, CC-chemokine Receptor 5 (CCR5), has generated interest because of its role as the target protein ... been extensively studied as a substrate for TPST and the importance of sulfation in PSGL-1 and its ability to bind its receptor ...

... cholecystokinin receptor - cholesterine - cholinergic receptor - chorionic gonadotropin - chromatid - chromatin - ciclosporin ... interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 receptor - intermediate ... G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc fusion protein - galanin - gamete - gamma- ... IgE receptor - IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - ...

... the mu opioid receptor to some extent through a delta-opioid receptor mediated interaction with another peptide cholecystokinin ... are enhanced by a cholecystokinin type B receptor antagonist, as revealed by noxiously evoked spinal c-Fos expression in rats ... The antidepressant and anxiolytic actions are thought to be mediated through the delta opioid receptor, while the analgesic ... This causes RB-101 to be strongly synergistic with cholecystokinin antagonists, such as proglumide. Unlike the more commonly ...

Acetylcholine binds to both metabotropic muscarinic receptors (mAChR) and the ionotropic nicotinic receptors (nAChR). The ... Endorphins Enkephalins Dynorphins Vasopressin Oxytocin Gastrin Cholecystokinins Somatostatin Cortistatins RF-amides ... 5-HT2c receptor agonist Natural neuroactive substance DeRiemer, S. A.; Strong, J. A.; Albert, K. A.; Greengard, P.; Kaczmarek, ... It acts on dopamine receptors. Parkinson's disease is at least in part related to dropping out of dopaminergic cells in deep- ...

... is a drug developed by Merck which acts as an orally active, non-peptide, selective antagonist for the NK1 receptor, ... Loonam TM, Noailles PA, Yu J, Zhu JP, Angulo JA (June 2003). "Substance P and cholecystokinin regulate neurochemical responses ... Bang R, Sass G, Kiemer AK, Vollmar AM, Neuhuber WL, Tiegs G (April 2003). "Neurokinin-1 receptor antagonists CP-96,345 and L- ... Rosso M, Robles-Frías MJ, Coveñas R, Salinas-Martín MV, Muñoz M (2008). "The NK-1 receptor is expressed in human primary ...

Major receptors of neurotransmitters include AMPA receptors, NMDA receptors, and Kainate Receptors. Changes in the homeostatic ... Neuropeptides include bradykinin, cholecystokinin, corticotropin-releasing factor (CRF), galanin, MCH, MSH, Neuropeptide Y (NPY ... For example, morphine is an agonist of the opioid receptor family. Conversely, antagonists bind to a receptor and elicit no ... One assay to determine the extent at which a ligand binds to its receptor is the radioligand binding assay (RBA), in which ...

The GABAA receptor negative allosteric modulator flumazenil can cause panic attacks in people with panic disorder. Anxiolytic ... and cholecystokinin (CCK) (especially the tetrapeptide and octapeptide fragments CCK-4 and CCK-8). Sodium lactate given ...

Thompson, J. (2012). Gastrointestinal Endocrinology: Receptors and Post-Receptor Mechanisms. Elsevier Science. p. 300. ISBN 978 ... specifically the release of cholecystokinin (CCK). One of the primary functions of monitor peptide is to stimulate the release ... "Characteristic and Localization of the Monitor Peptide Receptor". Bioscience, Biotechnology, and Biochemistry. Informa UK ... Effect of Monitor Peptide and Human Pancreatic Secretory Trypsin Inhibitor on Pancreatic Secretion and Cholecystokinin Release ...

The ghrelin receptor GHS-R1a (a splice-variant of the growth hormone secretagogue receptor, with the GHS-R1b splice being ... ghrelin and cholecystokinin take the central stage". Current Protein & Peptide Science. 12 (4): 293-304. doi:10.2174/ ... Ghrelin was discovered after the ghrelin receptor (called growth hormone secretagogue type 1A receptor or GHS-R) was determined ... Ghrelin stimulates brain structures having a specific receptor - the growth hormone secretagogue receptor 1A (GHSR-1A). Ghrelin ...

... receptor, cholecystokinin a MeSH D12.776.543.750.100.170.200 - receptor, cholecystokinin b MeSH D12.776.543.750.100.200.450 - ... receptor, cholecystokinin a MeSH D12.776.543.750.720.600.270.200 - receptor, cholecystokinin b MeSH D12.776.543.750.720.600.285 ... receptor, cholecystokinin a MeSH D12.776.543.750.750.360.200.200 - receptor, cholecystokinin b MeSH D12.776.543.750.750.360.300 ... receptor, cholecystokinin a MeSH D12.776.543.750.750.555.270.200 - receptor, cholecystokinin b MeSH D12.776.543.750.750.555.285 ...

Another receptor of clinical importance is the opioid-receptor-like receptor 1 (ORL1), which is involved in pain responses as ... cholecystokinin antagonists, such as proglumide Newer agents such as the phosphodiesterase inhibitor ibudilast have also been ... including the nociceptin receptor, sigma receptor and Toll-like receptor 4, and can be counteracted in animal models by ... receptors. Conversely, σ (Sigma) receptors are no longer considered to be opioid receptors because their activation is not ...

"Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor". ... 2001). "Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and ... 2006). "Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the ... Cholecystokinin octapeptide (CCK-8) Dehydroepiandroserone-3-sulfate (DHEAS) Deltorphin II Demethylphalloin Digoxin Docetaxel [D ...

Hofland LJ, Lamberts SW (January 1996). "Somatostatin receptors and disease: role of receptor subtypes". Baillière's Clinical ... cholecystokinin, glucagon, growth hormone, insulin, secretin, pancreatic polypeptide, TSH, and vasoactive intestinal peptide, ... It has also been shown to produce analgesic effects, most probably acting as a partial agonist at the mu opioid receptor. ... It was first synthesized in 1979 by the chemist Wilfried Bauer, and binds predominantly to the somatostatin receptors SSTR2 and ...

However, other studies show that proglumide has low affinity to the μ-opioid receptor (MOR) and the κ-opioid receptor (KOR) (13 ... It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of ... Proglumide has also been shown to act as a δ-opioid receptor (DOR) agonist, which may contribute to its analgesic effects. ... Gaudreau P, Lavigne GJ, Quirion R (May 1990). "Cholecystokinin antagonists proglumide, lorglumide and benzotript, but not L- ...

... steatorrhoea by inhibiting cholecystokinin and secretin, gall stones by inhibiting cholecystokinin which normally induce ... Fasting plasma somatostatin greater than 30 pg/mL.[citation needed] SRS (Somatostatin Receptor Scintigraphy) - It is a radio- ... due to inhibition of cholecystokinin release), and achlorhydria (due to inhibition of gastrin release). Somatostatinomas are ... Somatostatin suppresses the release of gastrointestinal hormones Gastrin Cholecystokinin (CCK) Secretin Motilin Vasoactive ...

Cavallaro S, Pani L, Guidotti A, Costa E (1993). "ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor ... binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin ... "Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)". Papadopoulos V, Brown ... 1987). "Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand". DNA. 6 (1): 71-79. doi:10.1089/dna ...

He developed the first selective ligands of the D3 receptor and used them to demonstrate the involvement of this receptor in ... Characterization and inhibition of a cholecystokinin-inactivating serine peptidase», Nature, 1996, 380, p. 403-409 Roques B.P ... He developed pitolisant, the first clinically approved antagonist for H3 receptors. Jean-Charles Schwartz holds a doctorate in ... He discovered the H3 receptor, demonstrated the role of its strong constitutive activity in controlling the activity of ...

motilin: This substance increases gastro-intestinal motility via specialized receptors called "motilin receptors". somatostatin ... Cholecystokinin (CCK) is a unique peptide released by the duodenal "I cells" in response to chyme containing high fat or ... Cholecystokinin (CCK) is a unique peptide released by the duodenal "I cells" in response to chyme containing high fat or ... Acinar cells are stimulated by cholecystokinin (CCK), which is a hormone/neurotransmitter produced by the intestinal cells (I ...

Almost a third of drugs work through these G protein-coupled receptors. She was the first to identify and describe the cloning ... Marshall, Fiona Hamilton (1990). Cholecystokinin/dopamine interactions in the rat basal ganglia. cam.ac.uk (PhD thesis). ... Here she investigated the receptors that are activated by neurotransmitters and microbial metabolites. After only nine years, ... Fiona H Marshall; Kenneth A Jones; Klemens Kaupmann; Bernhard Bettler (1 October 1999). "GABAB receptors - the first 7TM ...

Oxytocin neurons themselves express oxytocin receptors, and vasopressin neurons express vasopressin receptors, so dendritically ... Oxytocin neurons also make large amounts of cholecystokinin as well as the cocaine and amphetamine regulatory transcript (CART ... Oxytocin and vasopressin receptors are present in many other brain regions, including the amygdala, brainstem, and septum, as ... as blocking oxytocin receptors in this region blocks social recognition. Vasopressin neurons and oxytocin neurons make many ...

... a seven-transmembrane receptor related to angiotensin type 1 receptor in blood pressure in vivo". J. Biol. Chem. 279 (25): ... and stimulation of gastric cell proliferation and of cholecystokinin secretion". Endocrinology. 145 (3): 1342-8. doi:10.1210/en ... The apelin receptor is expressed early during the embryonic development of the heart, where it regulates the migration of cell ... Apelin receptor is also expressed in the neurons of brain areas involved in regulating water and food intake. Apelin injection ...

August 1996). "The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors". ... interactions with cholecystokinin, neuropeptide Y and orexin A, and modulation by fasting". Brain Research. 972 (1-2): 90-109. ... "Genomic characterization and tissue distribution of leptin receptor and leptin receptor overlapping transcript genes in the ... Liu Q, Chen Y, Copeland D, Ball H, Duff RJ, Rockich B, Londraville RL (April 2010). "Expression of leptin receptor gene in ...

... is a drug which acts as a cholecystokinin antagonist, selective for the CCKA subtype. It inhibits ... Maselli MA, Mennuni L (September 2003). "CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. ... "Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract ...

Additionally, gastrin, insulin, cholecystokinin, glucagon, and secretin have been reported to disrupt the MMC. Eating ... Lördal M, Hellström PM (1998-04-15). "Serotonin induces phase III of the MMC, VIA 5-HT3-receptors dependent on cholinergic ... Serotonin induces phase III of the MMC, and so serotonin receptor agonists are commonly administered as prokinetics. Motilin ...

These are motility stimulants that work through activation of 5-HT4 receptors of the enteric nervous system in the ... Magnesium-containing agents also cause the release of cholecystokinin, which increases intestinal motility and fluid secretion ...

... cholecystokinin MeSH D06.472.317.152.700 - sincalide MeSH D06.472.317.350 - epidermal growth factor MeSH D06.472.317.400 - ... selective estrogen receptor modulators MeSH D06.472.040.502 - 17-ketosteroids MeSH D06.472.040.502.112 - androstenedione MeSH ...

... reduced cholecystokinin tetrapeptide-induced symptoms of panic disorder, in addition to elevated cortisol and ACTH ... but does not bind to GABA receptors. In Canada, vigabatrin is approved for use as an adjunctive treatment (with other drugs) in ... "Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers". Neuropsychopharmacology. 25 (5 ...

Cain BM, Wang W, Beinfeld MC (September 1997). "Cholecystokinin (CCK) levels are greatly reduced in the brains but not the ... "Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe( ... "Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe( ...