Loading...
*  Proglumide
It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of ... "Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: Synergism with pharmacological levels of ... McCleane, GJ (1998). "The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with ... McCleane, GJ (2003). "The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine". The Clinical ...
*  Secretin
Chu JY, Chung SC, Lam AK, Tam S, Chung SK, Chow BK (2007). "Phenotypes developed in secretin receptor-null mice indicated a ... Meanwhile, in concert with secretin's actions, the other main hormone simultaneously issued by the duodenum, cholecystokinin, ... In the absence of secretin or its receptor in the gene knockout animals, central injection of angiotensin II was unable to ... As secretin binds to these receptors, it stimulates adenylate cyclase activity and converts ATP to cyclic AMP. Cyclic AMP acts ...
*  Cholecystokinin B receptor
Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene ... The cholecystokinin B receptor is stimulated by CCK and gastrin in the stomach during digestion. The cholecystokinin B receptor ... "Entrez Gene: CCKBR cholecystokinin B receptor". Altar CA, Boyar WC (Apr 1989). "Brain CCK-B receptors mediate the suppression ... "Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin". The ...
*  Cholecystokinin receptor
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones ... Cholecystokinin Receptors at the US National Library of Medicine Medical Subject Headings (MeSH). ... Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805-47. doi:10.1152/physrev ... Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews. 51 (4): 745-81. PMID 10581329. ...
*  Cholecystokinin A receptor
Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene ... "Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor ... "Cholecystokinin Receptors: CCK1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... It is required for interaction of the cholecystokinin A receptor with its corresponding hormonal ligand. Cholecystokinin ...
*  Parasympathetic nervous system
ISBN 978-0-7817-5940-3. Wank, SA (Nov 1995). "Cholecystokinin receptors". The American Journal of Physiology. 269 (5 Pt 1): ... The five main types of muscarinic receptors: The M1 muscarinic receptors (CHRM1) are located in the neural system. The M2 ... The M4 muscarinic receptors: Postganglionic cholinergic nerves, possible CNS effects The M5 muscarinic receptors: Possible ... The ACh acts on two types of receptors, the muscarinic and nicotinic cholinergic receptors. Most transmissions occur in two ...
*  Lorglumide
Berna, M. J.; Tapia, J. A.; Sancho, V; Jensen, R. T. (2007). "Progress in developing cholecystokinin (CCK)/gastrin receptor ... De Tullio, P; Delarge, J; Pirotte, B (1999). "Recent advances in the chemistry of cholecystokinin receptor ligands (agonists ... De Tullio, P; Delarge, J; Pirotte, B (2000). "Therapeutic and chemical developments of cholecystokinin receptor ligands". ... Herranz, R (2003). "Cholecystokinin antagonists: Pharmacological and therapeutic potential". Medicinal Research Reviews. 23 (5 ...
*  Asperlicin
It acts as a selective antagonist for the cholecystokinin receptor CCKA, and has been used as a lead compound for the ... Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists. Journal of Medicinal Chemistry. 1987 Jul;30( ... Molecular modelling of asperlicin derived cholecystokinin A receptor antagonists. European Journal of Pharmacology. 1992 Aug 3; ... Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility. Journal of Medicinal ...
*  Nocebo
... hyperalgesia is believed to involve the activation of cholecystokinin receptors. In a paper, Stewart-Williams and Podd ... For example, an expectation of pain may induce anxiety, which in turn causes the release of cholecystokinin, which facilitates ...
*  Insulin
"Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor". British Journal of Pharmacology. 159 (5 ... The effects of insulin are initiated by its binding to a receptor present in the cell membrane. The receptor molecule contains ... because insulin release is inhibited by α2-adrenergic receptors and stimulated by β2-adrenergic receptors. The net effect of ... Jang WG, Kim EJ, Park KG, Park YB, Choi HS, Kim HJ, Kim YD, Kim KS, Lee KU, Lee IK (January 2007). "Glucocorticoid receptor ...
*  Rostral ventromedial medulla
"Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors". Brain. 132 (3): 778- ... NK1 agonism induced hypersensitivity is dependent on 5-HT3 receptors, and modulated by GABAA and NMDA receptors as well. ... Serotonin receptors have been hypothesized to play a bidirectional role in the modulation of pain. Based on previous ... To find out more about the role of NMDA receptors in RVM pain facilitation, intrathecal MK-801 was administered before a RVM SP ...
*  CCK-4
"Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor". Journal of Medicinal ... Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH2) is a peptide fragment derived from the larger peptide hormone ... Léna I, Dh tel H, Garbay C, Daugé V (January 2001). "Involvement of D2 dopamine receptors in the opposing effects of two CCK-B ... Kalindjian SB, McDonald IM (2007). "Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand". ...
*  Devazepide
Cooper, SJ; Dourish, CT (Dec 1990). "Multiple cholecystokinin (CCK) receptors and CCK-monoamine interactions are instrumental ... "Differentiation of central cholecystokinin receptor binding sites using the non-peptide antagonists MK-329 and L-365,260". ... lacking affinity for GABAA receptors and instead acting as an CCKA receptor antagonist. It increases appetite and accelerates ... It is also widely used in scientific research into the CCKA receptor. Devazepide is synthesised in a similar manner to other ...
*  Patri Vergara
Rodríguez-Membrilla A, Martínez V, Vergara P. Peripheral and central cholecystokinin receptors regulate postprandial intestinal ...
*  Orexin
... adenosine A1 receptors, muscarinic M3 receptors, serotonin 5-HT1A receptors, neuropeptide Y receptors, cholecystokinin A ... CB1 receptors formed homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors ... "Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... As orexin receptors efficiently signal via endocannabinoid production to CB1 receptors, dimerization could be an effective way ...
*  Cholecystokinin
... shown to interact with the Cholecystokinin A receptor located mainly on pancreatic acinar cells and Cholecystokinin B receptor ... "Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... This modification is crucial for the ability of CCK to activate the cholecystokinin A receptor. Nonsulfated CCK peptides also ... Media related to Cholecystokinin at Wikimedia Commons Cholecystokinin at the US National Library of Medicine Medical Subject ...
*  Pentagastrin
... binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors ...
*  CI-988
The cholecystokinin-B receptor antagonist CI-988 failed to affect CCK-4 induced symptoms in panic disorder patients. ... Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proceedings ... a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically ... CI-988 (PD-134,308) is a drug which acts as a cholecystokinin antagonist, selective for the CCKB subtype. In animal studies it ...
*  Index of biochemistry articles
... cholecystokinin receptor - cholesterine - cholinergic receptor - chorionic gonadotropin - chromatid - chromatin - ciclosporin ... interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 receptor - intermediate ... G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc fusion protein - galanin - gamete - gamma- ... IgE receptor - IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - ...
*  PRKD2
This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric ... 2002). "Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor". J. Biol. Chem. 277 (33): 29431-6. ... 2005). "Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation". J. Biol. Chem ... "Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonists". Biochem. Biophys. Res. ...
*  Miodrag Radulovacki
"Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag ... "Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag ... Snyder, S. H.; Katims, J. J.; Annau, Z.; Bruns, R. F.; Daly, J. W. (May 1981). "Adenosine receptors and behavioral actions of ... Radulovacki, M; Trbovic, SM; Carley, DW (1998). "Serotonin 5-HT3-receptor antagonist GR 38032F suppresses sleep apneas in rats ...
*  Veterinary acupuncture
... glutamate and NMDA receptors, serotonin and cholecystokinins. The autonomic neuromodulatory signaling of tissue cytokines ... A diverse array of neurotransmitters and receptors contribute to acupuncture analgesia including opioids, ...
*  Cancer and nausea
... and cholecystokinin-1 receptors. Various local mediators located in enterochromaffin cells of the gut mucosa play a role in ... NK1 receptor antagonists: such as Aprepitant block the NK1 receptor in the brainstem and gastrointestinal tract. Their ... This structure contains receptors which form a chemoreceptor trigger zone. Some of the receptors and neurotransmitters involved ... muscarinic receptors type 1 to 5, M1-5). Some other receptors such as substance P, cannabinoid type 1 (CB1) and the endogenous ...
*  Enterogastrone
"Somatostatin is released in response to cholecystokinin by activation of type A CCK receptors". Peptides. 15 (2): 223-7. doi: ... Examples include: Secretin Cholecystokinin You C, Chey W (1987). "Secretin is an enterogastrone in humans". Dig Dis Sci. 32 (5 ...
*  Histamine H3 receptor
Attoub S, Moizo L, Sobhani I, Laigneau JP, Lewin MJ, Bado A (Jun 2001). "The H3 receptor is involved in cholecystokinin ... 1997 H3 receptors shown to modulate ischemic norepinephrine release in animals. 1999 H3 receptor cloned 2000 H3 receptors ... the H3 receptor is a G-protein coupled receptor. The H3 receptor is coupled to the Gi G-protein, so it leads to inhibition of ... H3 receptors are thought to play a part in the control of satiety. There are at least six H3 receptor isoforms in the human, ...
*  Tyrosylprotein sulfotransferase
... follicle-stimulating hormone receptor (FSHR), and other chemokine and G-protein coupled receptors. A full, up-to-date list can ... Beyond these two proteins, other notable protein substrates include Cholecystokinin (CCK), Factor V and Factor VIII, gastrin, ... Another substrate for TPST, CC-chemokine Receptor 5 (CCR5), has generated interest because of its role as the target protein ... been extensively studied as a substrate for TPST and the importance of sulfation in PSGL-1 and its ability to bind its receptor ...
*  Cholecystokinin antagonist
A cholecystokinin antagonist is a specific type of receptor antagonist which blocks the receptor sites for the peptide hormone ... cholecystokinin (CCK). There are two subtypes of this receptor known at present, defined as CCKA and CCKB (also called CCK-1 ... CCKA receptors are also expressed in the brain to some extent, and interestingly IQM-95333, an antagonist selective for this ... Antagonists for the CCK receptors can thus have multiple functions in both the gut and brain. The best known CCK antagonist is ...