... derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors". Journal of Natural ... where compounds 4-6 show good binding affinity for the human opioid receptors. These findings have important implications for ...
... is an analgesic drug that is a cannabinoid agonist. It is a highly selective agonist for the CB2 receptor, with ... "Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630". British Journal ... Cannabinoids, Benzochromenes, Phenol ethers, Vinylidene compounds, All stub articles, Cannabinoid stubs). ... It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or ...
... is a full agonist at the CB1 cannabinoid receptor (Ki = 1.9 nM) and has much higher affinity than THC (Ki = 41 nM ... WIN 55,212-2 is a potent cannabinoid receptor agonist that has been found to be a potent analgesic in a rat model of ... WIN 55,212-2 is also a CB2 receptor agonist and thereby, like other cannabinoid CB2 agonists, found to significantly improve ... Ferraro L, Tomasini MC, Gessa GL, Bebe BW, Tanganelli S, Antonelli T (August 2001). "The cannabinoid receptor agonist WIN ...
The mechanisms that create this tolerance to THC are thought to involve changes in cannabinoid receptor function. One study has ... June 2012). "Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis ... The CB1 receptor antagonist rimonabant has shown efficacy in reducing the effects of cannabis in users, but with a risk for ... Zolpidem, a GABAA receptor agonist and "Z-hypnotic" medication, has shown some efficacy in treating insomnia due to cannabis ...
"Discovery of High-Affinity Cannabinoid Receptors Ligands through a 3D-QSAR Ushered by Scaffold-Hopping Analysis". Molecules. 23 ... To combat the illicit synthetic cannabinoid industry many jurisdictions have created a system to control these cannabinoids ... "Further consideration of the synthetic cannabinoids. ACMD, 2012" (PDF). "Third generation synthetic cannabinoids. ACMD, 2014" ( ... Part I. Synthetic cannabinoids (IUPAC Technical Report). Pure and Applied Chemistry 2018; 90(8):1256-1279. doi:10.1515/pac-2017 ...
... is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 26.0 nM ... JWH cannabinoids, 1-Naphthyl compounds, Indenes, Polycyclic aromatic hydrocarbons, CB1 receptor agonists). ... Cannabinoids. Handbook of Experimental Pharmacology. Vol. 168. Springer. p. 269. ISBN 3-540-22565-X. Huffman JW, Padgett LW (10 ... In the United States, CB1 receptor agonists of the 1-(1-naphthylmethylene)indene class such as JWH-176 and JWH-171 are Schedule ...
... (SP-175) is a synthetic cannabinoid receptor agonist, which has anticonvulsant properties. Morton IK, Hall JM (1999 ... Cannabinoids, Benzochromenes, Azepanes, Carboxylate esters, Anticonvulsants, All stub articles, Cannabinoid stubs). ...
"Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity". The Journal of Clinical ... "A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not ... a peripherally selective mu opioid receptor antagonist TM-38837 - another peripherally selective cannabinoid antagonist Tam J, ... AM cannabinoids, CB1 receptor antagonists, Peripherally selective drugs). ...
... that appear to be related to the cannabinoid receptors. O-1918 is used in the study of these receptors, which have been found ... June 2010). "A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in ... March 2003). "Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor". Molecular ... October 2011). "Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid ...
... suggesting a novel non-cannabinoid receptor mediated approach to alleviate inflammatory pain. NaGly was shown to be endogenous ... Recently, NAGly has been found to bind to G-protein coupled receptor 18 (GPR18), the putative abnormal cannabidiol receptor. ... "Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor". Journal of Medicinal ... acid-amino acid conjugates did not have the same effects and the actions of NaGly were not affected by cannabinoid receptor ...
"Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not ... April 2010). "A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss". Life Sciences. 86 (17-18): ... February 2005). "CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous ... Kim K, Moore DH, Makriyannis A, Abood ME (August 2006). "AM1241, a cannabinoid CB2 receptor selective compound, delays disease ...
... is a selective ligand for the suggested novel cannabinoid receptor GPR119. AR-231,453 PSN-632,408 Overton HA, Babbs ... "Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule ...
Cannabinoid receptor antagonist O-1269 Rinaldi-Carmona M, Barth F, Congy C, Martinez S, Oustric D, Pério A, et al. (September ... Tonstad S, Aubin HJ (July 2012). "Efficacy of a dose range of surinabant, a cannabinoid receptor blocker, for smoking cessation ... Surinabant (SR147778) is a cannabinoid receptor type 1 antagonist developed by Sanofi-Aventis. It is being investigated as a ... Gessa GL, Serra S, Vacca G, Carai MA, Colombo G (2005). "Suppressing effect of the cannabinoid CB1 receptor antagonist, ...
Pertwee RG (2012). "Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and ... Cannabinoid medication might be useful in the treatment of the symptoms in patients with TS, but the 2009 review found that the ... Cannabinoids have been proposed for the treatment of primary anorexia nervosa, but have no measurable beneficial effect. The ... "Cannabis and Cannabinoids (PDQ®)". National Cancer Institute at the National Institutes of Health. National Cancer Institute. 2 ...
Choloylglycine hydrolase family Ethanolamine Macrophage Lactone Cannabinoid Cannabinoid receptor ASAH1 "NAAA Gene - GeneCards ...
WO application 2006069196, Pace JM, Tietje K, Dart MJ, Meyer MD, "3-Cycloalkylcarbonyl indoles as cannabinoid receptor ligands ... UR-144 has high affinity for the CB2 receptor with a Ki of 1.8 nM but 83x lower affinity for the CB1 receptor with a Ki of 150 ... March 2008). "Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor ... UR-144 was found to possess an EC50 of 421 nM for human CB1 receptors, and 72 nM for human CB2 receptors. UR-144 produces ...
... is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a binding affinity of ... AB-FUBINACA ADB-FUBINACA Banister SD, Connor M (2018). "The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor ... Cannabinoids, Designer drugs, Indazolecarboxamides, Fluoroarenes, All stub articles, Cannabinoid stubs). ... Cannabinoids are proposed to be classified as hazardous to health] (in Swedish). Folkhälsomyndigheten (The Swedish Public ...
Banister SD, Connor M (August 2018). "The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive ... June 2020). "In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018". ... CB1 receptor agonists, All stub articles, Cannabinoid stubs). ... It acts as a partial agonist of the CB1 and CB2 receptor, with ... Diao X, Carlier J, Zhu M, Huestis MA (July 2018). "Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by ...
"Competitive inhibition of delta8-tetrahydrocannabinol and its active metabolites for cannabinoid receptor binding". Biological ... It was the first cannabinoid metabolite discovered in 1970. It retains psychoactive effects in animal studies with higher ... Järbe TU, Mathis DA (1991). "Discriminative stimulus functions of cannabinoids/cannabimimetics". Drug Discrimination: ... a psychoactive cannabinoid found in small amounts in cannabis. It is an isomer of 11-OH-Δ9-THC, and is produced via the same ...
... is a drug which acts as both a non-selective agonist of the CB1 and CB2 cannabinoid receptors, and also as a blocker of T ... "Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands". Molecular Pain. 7: ... Cannabinoids, Carbazoles, All stub articles, Cannabinoid stubs). ...
It is found that the anti-inflammatory lipid lipoxin A4 is an endogenous allosteric enhancer of the CB1 cannabinoid receptor. ... FPR2, which is now termed the ALX, ALX/FPR, or ALX/FPR2 receptor, is a G protein coupled receptor initially identified as a ... LXA4 and 15-epi-LXA4 are high affinity receptor ligands for and activators of the FPR2 receptor. ... "Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor". Proceedings of the National ...
"Fourth generation of synthetic cannabinoid receptor agonists: a summary on the latest insights". Acta Bio-Medica. 92 (6): ... Cumyl-BC-HpMeGaClone-221 (Cumyl-BC[2.2.1]HpMeGaClone, SGT-271) is a gamma-carboline derivative which is a synthetic cannabinoid ... Cannabinoids, Designer drugs, Gamma-Carbolines, Nitrogen heterocycles, Heterocyclic compounds with 2 rings, All stub articles, ...
... is a selective cannabinoid receptor agonist invented by Japan Tobacco. It is a reasonably highly selective CB2 agonist ... Cannabinoids, Japan Tobacco, All stub articles, Cannabinoid stubs). ... structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor". ...
Cannabinoids, CB1 receptor antagonists, Phenols, Sulfonamides, All stub articles, Cannabinoid stubs). ... O-2050 is a drug that is a classical cannabinoid derivative, which acts as an antagonist for the CB1 receptor. This gives it an ... 2010). "The cannabinoid 1-receptor silent antagonist O-2050 attenuates preference for high-fat diet and activated astrocytes in ... January 2011). "Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist". ...
... is a selective ligand for the suggested novel cannabinoid receptor GPR119. AR-231,453 PSN-375,963 Overton HA, Babbs ... "Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule ...
... is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 ... Poso A, Huffman JW (January 2008). "Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 ... March 2008). "Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor ... January 2008). "Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI". ...
"Culture and cannabinoid receptor gene polymorphism interact to influence the perception of happiness". PLOS ONE. 13 (12): ... 2018), certain gene receptors have been found to play a role in the perception of one's happiness as they directly impact ...
JWH cannabinoids, Designer drugs, CB1 receptor agonists, CB2 receptor agonists). ... Ashton JC, Wright JL, McPartland JM, Tyndall JD (2008). "Cannabinoid CB1 and CB2 receptor ligand specificity and the ... Poso A, Huffman JW (January 2008). "Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 ... is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors. ...
Wise ML, Soderstrom K, Murray TF, Gerwick WH (1996). "Synthesis and cannabinoid receptor binding activity of conjugated triene ...
... cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB( ... Saroz Y, Kho DT, Glass M, Graham ES, Grimsey NL (2019-10-19). "Cannabinoid Receptor 2 (CB 2 ) Signals via G-alpha-s and Induces ... Lay L, Angus JA, Wright CE (March 2000). "Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse ... February 1998). "SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor". The Journal of ...