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*  Palmitoylethanolamide
PEA cannot strictly be considered a classic endocannabinoid because it lacks affinity for the cannabinoid receptors CB1 and CB2 ... Phan, N. Q.; Siepmann, D.; Gralow, I.; Ständer, S. (2009). "Adjuvant topical therapy with a cannabinoid receptor agonist in ... For instance during β-amyloid-induced neuroinflammation the deregulation of cannabinoid receptors and its endogenous ligands ... O'Sullivan, S. E.; Kendall, D. A. (2010). "Cannabinoid activation of peroxisome proliferator-activated receptors: Potential for ...
*  Hemp juice
Henceforth, cannabinoids are consumed in their natural cannabinoid-acid form as well as in their activated form. Hemp salt ... which are being recognized by special receptors in the human body (endocannabinoid system and signal transduction). Hemp is the ... The ultra-heat-treatment will "activate" the cannabinoids by separating the acid part from the natural cannabinoids. Increasing ... Freezing and freeze-drying stabilize the natural form of the cannabinoids as cannabinoid-acids. Another procedure is ...
*  Cannabinoid receptor type 2
The cannabinoid receptor type 2, abbreviated as CB2, is a G protein-coupled receptor from the cannabinoid receptor family that ... Cannabinoid receptor Cannabinoid receptor type 1 (CB1) GRCh38: Ensembl release 89: ENSG00000188822 - Ensembl, May 2017 GRCm38: ... The receptor was identified among cDNAs based on its similarity in amino-acid sequence to the cannabinoid receptor type 1 (CB1 ... "Cannabinoid Receptors: CB2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
*  Cannabis in pregnancy
... period of cannabinoid receptors, cannabis can hijack endocannabinoid signals to evoke molecular rearrangements, leading to the ... annabis impacts the formation and functions of neuronal circuitries by targeting cannabinoid receptors ... By indiscriminately ... "Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain". NCBI. Future ... said there was "... increasing evidence from animal studies showing that cannabinoid drugs ... induce enduring neurobehavioral ...
*  Cannabinoid receptor
See also: cannabinoid receptor type 1 ligands, cannabinoid receptor type 2 ligands Cannabinoid receptor antagonist ... GPR119 has been suggested as a fifth possible cannabinoid receptor. Cannabinoid receptors are activated by cannabinoids, ... Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of ... Cannabinoid receptor type 1 (CB1) receptors are thought to be one of the most widely expressed Gαi protein-coupled receptors in ...
*  Cannabinoid receptor antagonist
... cannabinoid receptor 1 (CB1) and 2 (CB2). Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit ... A cannabinoid receptor antagonist, also known simply as a cannabinoid antagonist or as an anticannabinoid, is a type of ... The endogenous cannabinoid system includes cannabinoid receptors, their endogenous ligands (endocannabinoids) and enzymes for ... Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body. Cannabinoid ...
*  Cannabinoid receptor type 1
Discovery and development of Cannabinoid Receptor 1 Antagonists Cannabinoid receptor Cannabinoid receptor type 2 (CB2) GRCh38: ... The cannabinoid type 1 receptor, often abbreviated as CB1, is a G protein-coupled cannabinoid receptor located primarily in the ... Selective CB1 agonists may be used to isolate the effects of the receptor from the CB2 receptor, as most cannabinoids and ... "Cannabinoid Receptors: CB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
*  Anandamide
These distinct effects are mediated primarily by CB1 cannabinoid receptors in the central nervous system, and CB2 cannabinoid ... Cannabinoid receptors. Boston: Academic Press. pp. 233-258. ISBN 0-12-551460-3. Wang, J.; Ueda, N. (2009). "Biology of ... Cannabinoid receptors were originally discovered as being sensitive to Δ9-tetrahydrocannabinol (Δ9-THC, commonly called THC), ... Mallet PE, Beninger RJ (1996). "The endogenous cannabinoid receptor agonist anandamide impairs memory in rats". Behavioural ...
*  Lumír Ondřej Hanuš
Cannabinoid receptors. Boston: Academic Press. pp. 233-258. ISBN 0-12-551460-3. "Konopí je jedním z nejbezpečnějších známých ... "Isolation and structure of a brain constituent that binds to the cannabinoid receptor". Science. 258 (5090): 1946-9. doi: ... an endogenous cannabinoid neurotransmitter. Hanuš continues his research in Jerusalem on cannabinoids, endocannabinoids and its ... In April 2010 and September 2011, Hanuš took part in a seminar of Czech Parliament aimed at introduction of cannabinoid ...
*  GPR55
The synthetic cannabinoid CP-55940 is also able to activate the receptor while the structurally unrelated cannabinoid mimic WIN ... "The orphan receptor GPR55 is a novel cannabinoid receptor". British Journal of Pharmacology. 152 (7): 1092-101. doi:10.1038/sj. ... GPR55 G protein-coupled receptor 55". Brown AJ (Nov 2007). "Novel cannabinoid receptors". British Journal of Pharmacology. 152 ... Later it was identified by an in silico screen as a putative cannabinoid receptor because of a similar amino acid sequence in ...
*  JWH-250
The Cannabinoid Receptors. Edited by Patricia H Reggio. Humana Press 2009. ISBN 978-1-58829-712-9 Understanding the 'Spice' ... AM-2201 JWH-073 JWH-200 List of JWH cannabinoids List of AM cannabinoids MEPIRAPIM SDB-001 THJ-2201 Legal article in Latvian ( ... an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors, ... Manera, C; Tuccinardi, T; Martinelli, A (2008). "Indoles and related compounds as cannabinoid ligands". Mini reviews in ...
*  List of AM cannabinoids
AM-6545 - a peripherally selective silent antagonist of CB1 receptors. List of CP cannabinoids List of JWH cannabinoids List of ... 2008). "Ligand-Binding Architecture of Human CB2 Cannabinoid Receptor: Evidence for Receptor Subtype-Specific Binding Motif and ... of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist ... "F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to ...
*  GPR119
... G protein-coupled receptor 119". Brown AJ (Nov 2007). "Novel cannabinoid receptors". British Journal of Pharmacology. ... G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the GPR119 ... GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors. GPR119 is expressed predominantly in ... Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also ...
*  Abnormal cannabidiol
Cannabinoids Cannabinoid receptors Cannabidiol O-1918 Rimonabant Adams, MD; Earnhardt, JT; Martin, BR; Harris, LS; Dewey, WL; ... "The orphan receptor GPR55 is a novel cannabinoid receptor". British Journal of Pharmacology. 152 (7): 1092-1101. doi:10.1038/sj ... Jarai, Z. (1999). "Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors ... Further research suggests there are yet more additional cannabinoid receptors. Research of the effects on abnormal cannabidiol ...
*  List of JWH cannabinoids
JWH-171 - an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 51nM ... List of AM cannabinoids List of CP cannabinoids List of HU cannabinoids List of miscellaneous designer cannabinoids Huffman JW ... which acts as a cannabinoid agonist at both the CB1 receptor and CB2 receptors, with some selectivity for CB2 with a Ki of 2.9 ... which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC ...
*  A-40174
... (SP-1) is an analgesic drug which acts as a potent cannabinoid receptor agonist, and was developed by Abbott ...
*  Oleoylethanolamide
OEA has been demonstrated to bind to the novel cannabinoid receptor GPR119. OEA has been suggested to be the receptor's ... 2007). "Novel cannabinoid receptors". Br J Pharmacol. 152 (5): 567-575. doi:10.1038/sj.bjp.0707481. PMC 2190013 . PMID 17906678 ... Oleoylethanolamine (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist. It is a naturally ... but unlike anandamide it acts independently of the cannabinoid pathway, regulating PPAR-α activity to stimulate lipolysis. OEA ...
*  Otenabant
Cannabinoid receptor antagonist Kim, M.; et al. (2008), "Design, chemical synthesis, and biological evaluation of novel ... a cannabinoid-1 receptor inverse agonist" (PDF), Tetrahedron, 64 (48): 10802-10809, doi:10.1016/j.tet.2008.09.057 Woods SC. The ...
*  O-774
1998 Oct 22;41(22):4400-7. PMID 9784115 The Cannabinoid Receptors. Part I. Cannabinoid Receptor Ligands and Structure-Activity ... O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, with a Ki of 0.6 nM ... at CB1, and very potent cannabinoid effects in animal studies. AM-2232 O-1057 O-1812 Singer M, et al. Potent cyano and ...
*  Striatum
"Adenosine-cannabinoid receptor interactions. Implications for striatal function". Br. J. Pharmacol. 160 (3): 443-453. doi: ... It has been demonstrated that D1 receptors form the hetero-oligomer with D2 receptors, and that the D1-D2 receptor hetero- ... The dopamine receptors are a superfamily of heptahelical G protein-coupled receptors, and are grouped into two categories, D1- ... MSNs that express D2-type receptors and "direct" MSNs that express D1-type receptors. The basal ganglia core is made up of the ...
*  Nucleus accumbens
June 2010). "Adenosine-cannabinoid receptor interactions. Implications for striatal function". Br. J. Pharmacol. 160 (3): 443- ... It has been demonstrated that D1 receptors form the hetero-oligomer with D2 receptors, and that the D1-D2 receptor hetero- ... Glucocorticoids and dopamine: Glucocorticoid receptors are the only corticosteroid receptors in the nucleus accumbens shell. L- ... dopamine receptors. A subpopulation of MSNs contain both D1-type and D2-type receptors, with approximately 40% of striatal MSNs ...
*  Basal ganglia
"Adenosine-cannabinoid receptor interactions. Implications for striatal function". British Journal of Pharmacology. 160 (3): 443 ... This pathway consists of MSNs that express dopamine receptor D2, muscarinic acetylcholine receptor M1, and adenosine receptor ... This pathway consist of medium spiny neurons (MSNs) that express dopamine receptor D1, muscarinic acetylcholine receptor M4, ... This model of direct D1, and indirect D2 pathways explain why selective agonists of each receptor are not rewarding, as ...
*  Medium spiny neuron
"Adenosine-cannabinoid receptor interactions. Implications for striatal function". Br. J. Pharmacol. 160 (3): 443-453. doi: ... Both types express glutamate receptors (NMDAR and AMPAR), cholinergic receptors (M1 and M4) and CB1 receptors are expressed on ... It has been demonstrated that D1 receptors form the hetero-oligomer with D2 receptors, and that the D1-D2 receptor hetero- ... The dopamine receptors are a superfamily of heptahelical G protein-coupled receptors, and are grouped into two categories, D1- ...
*  JWH-051
Klein TW, Newton C, Friedman H (1998). "Cannabinoid receptors and the cytokine network". Advances in experimental medicine and ... 1997). "Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals". European Journal of ... "Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor". ... JWH-051 retains high affinity for the CB1 receptor, but is a much stronger agonist for CB2, with a Ki value of 14nM at CB2 vs ...
*  WIN 54,461
... (6-Bromopravadoline) is a drug that acts as a potent and selective inverse agonist for the cannabinoid receptor CB2 ... "Cannabinoid Receptor Agonists and Antagonists". Current Pharmaceutical Design. 1 (3): 343-352. ...
*  Guineesine
In addition, the analgesic and catatonic effects were reversed by the cannabinoid receptor type 1 (CB1) inverse agonist ... "Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and ... This causes an increase in the activity of the two neurotransmitters which are classified as endogenous cannabinoids. ...
*  Removal of cannabis from Schedule I of the Controlled Substances Act
Herkenham M (1992). "Cannabinoid receptor localization in brain: relationship to motor and reward systems". Ann. N. Y. Acad. ... Herkenham M, Lynn A, Little M, Johnson M, Melvin L, de Costa B, Rice K (1990). "Cannabinoid receptor localization in brain". ... They based their claims on studies of the brain's cannabinoid receptor system conducted by the National Institute of Mental ... Gettman claims that the discovery of the cannabinoid receptor system in the late 1980s revolutionized scientific understanding ...