The antigen sensitivity is higher in antigen-experienced T cells than in naive T cells. Naive T cells pass through the process ... T cells expressing this receptor are referred to as α:β (or αβ) T cells, though a minority of T cells express an alternate ... T cells move on quickly from antigens that do not trigger responses, rapidly scanning pMHC on an antigen-presenting cell (APC) ... UMich Orientation of Proteins in Membranes protein/pdbid-2hac - Zeta-zeta dimer of T-cell receptor T-Cell+Receptor at the U.S. ...
"Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling". Cell Host ... PRRs also mediate the initiation of antigen-specific adaptive immune response and release of inflammatory cytokines. The ... The mannose receptor (MR) is a PRR primarily present on the surface of macrophages and dendritic cells. It belongs into the ... and C-type lectin receptors (CLRs). Cytoplasmic PRRs include NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). PRRs ...
Targeting of TNRF2 in tumor cells is associated with increased tumor cell death and decreased progression of tumor cell growth ... CD120b+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e v t e (Articles with short ... April 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell. 61 (2): 361-370. doi: ... Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and ...
A B cell is activated by its first encounter with an antigen (its "cognate antigen") that binds to its receptor, resulting in ... The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor is composed of a membrane- ... B cells are able to gather and grab antigens by engaging biochemical modules for receptor clustering, cell spreading, ... Corcos D (1990). "Oncogenic potential of the B cell antigen receptor and its relevance to heavy chain diseases and other B-cell ...
When antigen binds to T-cell receptor, Lck becomes autophosphorylated and phosphorylates the zeta chain of the T-cell receptor ... Signaling by many receptors is dependent on nRTKs including T-cell receptors (TCR), B-cell receptors (BCR), IL-2 receptors (IL- ... Thirty-two non-receptor tyrosine kinases have been identified in human cells (EC 2.7.10.2). Non-receptor tyrosine kinases ... Another Src family member Lyn is involved in signaling mediated by B-cell receptor. Lyn is activated by stimulation of B-cell ...
Weiss A, Littman DR (January 1994). "Signal transduction by lymphocyte antigen receptors". Cell. 76 (2): 263-74. doi:10.1016/ ... These immune cells include T cells, B cells, NK cells, dendritic cells, macrophages and mast cells. ITIMs have similar ... the activating NK cell receptor NKp44 contains an ITIM, but this seems to be non-functional. Some of the important receptors ... containing receptors, resulting in an innate inhibition mechanism within cells. ITIM bearing receptors have important role in ...
Dual-antigen receptor: CAR T cells are engineered to express two tumor-associated antigen receptors at the same time, reducing ... chimeric T cell receptors or artificial T cell receptors-are receptor proteins that have been engineered to give T cells the ... The intracellular T cell signaling domain lies in the receptor's endodomain, inside the cell. After an antigen is bound to the ... The receptors are chimeric in that they combine both antigen-binding and T cell activating functions into a single receptor. ...
Chimeric antigen receptor T-cells (CAR-T) are predominantly used in cancer immunotherapy. T-cells are harvested from patients' ... Main articles: Cytokine release syndrome; chimeric antigen receptor T cell. IgE-mediated anaphylactic reaction CAR derived from ... These tumors often express chemokine receptors and combine with the tumor-specific T-cell receptors presented on them. This ... CAR-T kill tumor cells specifically by targeting the tumor-associated antigens to keep the damage to healthy tissue at a ...
"Antigen Recognition by B-cell and T-cell Receptors". Garland Science. {{cite journal}}: Cite journal requires ,journal= (help) ... T-cells will recognize foreign peptides through T-cell receptors (TCRs) on the surface of the T cells, and then perform ... The selection model suggests that not all T cell receptors show MHC restriction, however only the T cell receptors with MHC ... In contrast with T cell receptors which recognize linear peptide epitopes, B cell receptors recognize a variety of ...
A5 antigen (a developmentally-regulated cell surface protein; Xenopus nrp1; P28824); and receptor-like tyrosine protein ... It is an extracellular domain found in many receptors. A 170 amino acid domain, the so-called MAM (meprin, A-5 protein, and ... Takagi S, Hirata T, Agata K, Eguchi G, Fujisawa H, Mochii M (1991). "The A5 antigen, a candidate for the neuronal recognition ... These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a ...
McGreal E, Miller J, Gordon S (2005). "Ligand recognition by antigen-presenting cell C-type lectin receptors". Curr Opin ... a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells". Cell. 100 (5): 587-97. doi:10.1016/ ... DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages ... Cambi A, Figdor CG (2004). "Dual function of C-type lectin-like receptors in the immune system". Curr. Opin. Cell Biol. 15 (5 ...
2001). "Ch3 Antigen Recognition by B-Cell and T-cell Receptors". Immunobiology: The Immune System in Health and Disease (5th ed ... antigens can cause systemic anaphylaxis in mice through classic pathway by cross-linking IgE bound to the mast cell receptor Fc ... IgG antibodies can prevent IgE mediated anaphylaxis by intercepting a specific antigen before it binds to mast cell-associated ... IgG affinity to Fc receptors on phagocytic cells is specific to individual species from which the antibody comes as well as the ...
There is recognition of the peptide antigen by T-cell receptors. With the involvement of cytokines and B cells, a humoral ... Conjugated immunogens are injected to deliver the vaccine, which activates B and T cells in a T cell-dependent manner to create ... The conjugated vaccine is exposed to lymphocytes by antigen-presenting cells. ... Plasmatic cells produce immunoglobulins, the anti-nicotine antibodies that bind to nicotine. The nicotine and nicotine-specific ...
1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen". Kidney Int. 49 (1): 153-7. ... Tubulointerstitial nephritis antigen is a protein that in humans is encoded by the TINAG gene. TINAG is a basement membrane ... 1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron". ... Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405-12. ...
This creates an enormous diversity of T cells bearing antigen receptors. Afterward some T cells leave the thymus to migrate to ... B cells Large Pre-B cells => Small Pre-B cells Immature B cells B Cells => (B1 cells; B2 cells) Plasma cells Pro-T cells T- ... T cells, B cells and NK cells (and all other Innate lymphoid cells) are unique to the lymphocyte family, but dendritic cells ... NK cells Dendritic cells (lymphoid lineage; DC2 ) Progenitor B cells Pro-B cells => Early Pro (or pre-pre)-B cells => Late Pro ...
PHA and ConA bind and cross-link components of the T cell receptor, and their ability to activate T cells is dependent on ... de Petris S (April 1975). "Concanavalin A receptors, immunoglobulins, and theta antigen of the lymphocyte surface. Interactions ... It was demonstrated that transformed cells and trypsin-treated normal cells do not agglutinate at 4 °C, thereby suggesting that ... Similar to phytohemagglutinin (PHA), it is a selective T cell mitogen relative to its effects on B cells. ...
Kurosaki T (1999). "Genetic analysis of B cell antigen receptor signaling". Annu. Rev. Immunol. 17 (1): 555-92. doi:10.1146/ ... protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor ... A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. STAP1 has been shown to interact ... the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun. 268 (3): 697-703. doi: ...
Another method combines iPSC and chimeric antigen receptor (CAR) technologies to generate human T cells targeted to CD19, an ... May 2013). "TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen- ... "Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells". Cell Stem Cell. 12 (1): 31 ... June 2014). "Human somatic cell nuclear transfer using adult cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03 ...
Brady BL, Steinel NC, Bassing CH (October 2010). "Antigen receptor allelic exclusion: an update and reappraisal". Journal of ... Chess A, Simon I, Cedar H, Axel R (September 1994). "Allelic inactivation regulates olfactory receptor gene expression". Cell. ... Studies that distinguish fixed and dynamic aRME require single-cell analyses of clonally related cells. Allelic exclusion is a ... depending whether or not the allele-specific expression is conserved in daughter cells after mitotic cell division. Fixed aRME ...
"The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle ... B-cell linker (BLNK) protein is expressed in B cells and macrophages and plays a large role in B cell receptor signaling. Like ... "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates ... Signaling through the B cell antigen receptor". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1793 (7): 1115- ...
June 2010). "Constitutively active Lck kinase in T cells drives antigen receptor signal transduction". Immunity. 32 (6): 766-77 ... "What controls T cell receptor phosphorylation?". Cell. 142 (5): 668-9. doi:10.1016/j.cell.2010.08.018. PMID 20813251. Davis SJ ... A prominent member of this receptor family is the T-cell receptor. Members of the Non-catalytic tyrosine-phosphorylated ... Similar findings have been reported for NK cell receptors, CD28 family receptors, Dectin-1. Phosphorylated tyrosine residues in ...
March 2017). "Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy". The Journal of Clinical ... Finally, inhibition of A2AR, either through pharmacologic or genetic targeting, in chimeric antigen receptor (CAR) T-cells ... In addition, A2A receptor can suppress immune cells, thereby protecting tissue from inflammation. The A2A receptor is also ... As a result, Adenosine receptor A2A decreases activity in the Dopamine D2 receptors. The adenosine A2A receptor has also been ...
Antigens are recognized by antigen receptors, including antibodies and T-cell receptors. Diverse antigen receptors are made by ... An antigen binds the highly variable immunoreceptor products (B-cell receptor or T-cell receptor) once these have been ... T-independent antigen - Antigens that stimulate B cells directly. Immunodominant antigens - Antigens that dominate (over all ... A native antigen is an antigen that is not yet processed by an APC to smaller parts. T cells cannot bind native antigens, but ...
B cells can internalize antigen that binds to their B cell receptor and present it to helper T cells. Unlike T cells, B cells ... B cells and dendritic cells, present foreign antigens to helper T cells, while virus-infected cells (or cancer cells) can ... T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present them to T-cells. ... An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen bound by major histocompatibility complex ( ...
Her clinical trials focus on exploring and optimizing chimeric antigen receptor T cell (CAR-T cell) based strategies and other ... "T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 ... "Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia". Blood. 121 (7): 1165-1174. doi: ... "Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation". Blood. ...
Davis, Mark M.; Bjorkman, Pamela J. (1988). "T-cell antigen receptor genes and T-cell recognition". Nature. 334 (6181): 395-402 ... Davis is well known for identifying the first T-cell receptor genes, which are responsible for T lymphocytes ability to "see" ... "2021 Szent-Györgyi Prize Awarded to Pioneering Research Duo Who Have Paved the Path to Life-Saving T-Cell Receptor-Based Cancer ... the demonstration that T cells are able to detect and respond to even a single molecule of their ligand-fragments of antigens ...
Kit (CD117) is the receptor of Stem Cell Factor. Sca-1 is a murine hematopoietic stem cell antigen. Lin is a series of lineage ... KSL cells in cell biology are an early form of mouse/murine hematopoietic stem cells. Characteristics are Kit (+), Sca-1 (+) ... Biology portal Science portal Cell biophysics Cell disruption Cell physiology Cellular adaptation Cellular microbiology Outline ... Hematopoitic stem cells are of interest because of their ability to self-renew and differentiate into every types of blood cell ...
"Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell". Nature ... Because CAR-T cells attack cancerous cells at a surface level, this leaves the CAR-T cells vulnerable to cancerous cell ... Engineered chimeric antigen receptor (CAR)-T cell delivery is the methodology by which clinicians introduce the cancer- ... Sridhar, Praveen; Petrocca, Fabio (Jul 2017). "Regional Delivery of Chimeric Antigen Receptor (CAR) T-Cells for Cancer Therapy ...
CD44 antigen, the main cell surface receptor for HA. Hyaladherin "Link domain signature and profile". PROSITE. December 2004. ... which may be involved in cell-cell and cell-matrix interactions during inflammation and tumourigenesis; ... a hyaluronan-binding domain involved in extracellular matrix stability and cell migration". Cell. 86 (5): 767-75. doi:10.1016/ ... It is important in blood cell migration and apoptosis. The link domain is found in some extracellular proteins in vertebrates ...
... a monoclonal antibody that targets the CD20 receptor on the surface of B cells, thus destroying the self-reactive B cells. ... The recruitment of the complement cascade via the classical pathway (antibody-antigen interaction). Membrane attack complex ( ... These can be produced by cross reactivity with NMDA receptors in teratomas, which contain many cell types, including brain ... The cell subsequently lyses. Notably, this mechanism is unlikely as it causes the cell to die, which is inconsistent with ...
Yang, Jianying; Reth, Michael (September 2010). "Oligomeric organization of the B-cell antigen receptor on resting cells". ... thus forming the B-cell antigen receptor (BCR). This occurs in a similar manner to the association of CD3 with the T-cell ... Engels N, Wollscheid B, Wienands J (Jul 2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM ... Flaswinkel H, Reth M (1992). "Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex". ...
Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors ... The process as a whole result in an effector cell, typically a T-cell, that can recognize a tumor cell antigen in a manner that ... T cells purified from each person are modified by a virus that inserts genes that encode a chimaeric antigen receptor into ... April 2013). "Chimeric antigen receptor-modified T cells for acute lymphoid leukemia". The New England Journal of Medicine. 368 ...
Patel, K.J.; Neuberger, M.S. (1993). "Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs ... Patel, Ketan Jayakrishna (1994). Antigen presentation by the B cell antigen receptor (PhD thesis). University of Cambridge. ... Such crosslinks are lethal to cells since they would prevent DNA from being copied (DNA replication) or for the genes it ... Patel's research is mainly concerned with how living cells repair DNA crosslinks. These lesions cause the two opposing strands ...
"The B-cell antigen receptor of the five immunoglobulin classes". Nature. 352 (6338): 777-81. Bibcode:1991Natur.352..777V. doi: ... Cell. 36 (3): 681-8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489. S2CID 54312675. Ellison J, Hood L (Mar 1982). "Linkage and ... Cell. 29 (2): 691-9. doi:10.1016/0092-8674(82)90185-4. PMID 6288268. S2CID 54345379. Ellison J, Buxbaum J, Hood L (1983). " ... "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". ...
"Actin restricts FcɛRI diffusion and facilitates antigen-induced receptor immobilization". Nature Cell Biology. 10 (8): 955-963 ... Meanwhile, the formation of engaged receptor clusters might lead to de novo polymerization of actin filaments at the receptor ... Kusumi A, Sako Y (August 1996). "Cell surface organization by the membrane skeleton". Current Opinion in Cell Biology. 8 (4): ... Receptor monomers can hop across the inter-compartment boundaries quite readily, but when they form oligomers, their size ...
"Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor". Cell. 68 (4): 625-634. doi: ... "Antigen analogs/MHC complexes as specific T cell receptor antagonists". Annual Review of Immunology. 12: 413-431. doi:10.1146/ ... function is to bind antigenic peptides and present them to the T cell receptor, which triggers a T cell response. Follow-up ... "Isolation and characterization of antigen-Ia complexes involved in T cell recognition". Cell. 47 (6): 1071-1077. doi:10.1016/ ...
"Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia". New England Journal of Medicine. 365 (8): 725-733. ... American cell phone service provider Sprint Nextel reportedly pays $20 billion for rights to Apple's next mobile phone. October ... January 20 - In a landmark study that will ultimately see the cure for AIDS, a new technique renders T-Cells resistant to HIV. ... The United States Department of Justice files a lawsuit in an attempt to stop the $39 billion merger between cell phone giants ...
Discovery of the T cell antigen receptor TCR (Ellis Reinherz) (Philippa Marrack) and (John Kappler) (James Allison) 1983 - ... "The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody". The ... Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow- ... Allman, DM; Ferguson, SE; Cancro, MP (15 October 1992). "Peripheral B cell maturation. I. Immature peripheral B cells in adults ...
... and KIR2DL4 in antigen presenting cells, NK cells, and T cells". FASEB Journal. 19 (6): 662-4. doi:10.1096/fj.04-1617fje. PMID ... March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nature ... "Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor ... The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and ...