*Food allergy

... a kind of Fc receptor called FcεRI) on the surface of other kinds of immune cells called mast cells and basophils, which are ... 1 - antigen. 2 - IgE antibody. 3 - FcεRI receptor. 4 - preformed mediators (histamine, proteases, chemokines, heparin). 5 - ... Cross-linking of the IgE and Fc receptors occurs when more than one IgE-receptor complex interacts with the same allergenic ... causes a response in a type of immune cell called a TH2 lymphocyte, which belongs to a subset of T cells that produce a ...

*Immunoglobulin E

IgE can upregulate the expression of both types of Fcε receptors. FcεRI is expressed on mast cells, basophils, and the antigen- ... Receptors[edit]. IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells ... receptor FcεRII, or CD23.[23] CD23 may also allow facilitated antigen presentation, an IgE-dependent mechanism whereby B cells ... presenting dendritic cells in both mice and humans. Binding of antigens to IgE already bound by the FcεRI on mast cells causes ...

*Human genetic resistance to malaria

Non-expression of Duffy antigen on red cells Miller, et al. 1976 P. vivax Non-expression of Duffy antigen on red cells Miller ... Gerbich antigen receptor negativity[edit]. Main article: Gerbich antigen system. The Gerbich antigen system is an integral ... Sickle-cell[edit]. Main article: Sickle-cell anemia. See also: Sickle-cell trait and Evolutionary_baggage § Sickle-Cell and ... Duffy antigen receptor negativity[edit]. Main article: Duffy antigen system. Plasmodium vivax has a wide distribution in ...

*HLA-DQ

As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft versus ... class II receptor/antigens to a great many T-cells, each with unique T-cell receptor (TCR) variants. A few TCR variants that ... HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an αβ heterodimer of type MHC class II ... HLA DQ functions as a cell surface receptor for foreign or self antigens. The immune system surveys antigens for foreign ...

*Immunosuppressive drug

... that prevents T-cell activation and proliferation by binding the T-cell receptor complex present on all differentiated T cells ... The IL-2a (CD25, T-cell activation antigen, TAC) is expressed only by the already-activated T lymphocytes. Therefore, it is of ... causing B cells to express smaller amounts of IL-2 and IL-2 receptors. This diminishes both B cell clone expansion and antibody ... T-cell receptor directed antibodies[edit]. Muromonab-CD3 is a murine anti-CD3 monoclonal antibody of the IgG2a type ...

*MALT1

Ruland J, Duncan GS, Wakeham A, Mak TW (2003). "Differential requirement for Malt1 in T and B cell antigen receptor signaling ... Fc-epsilon receptor signaling pathway. • T cell proliferation. • B cell activation. • response to fungus. • positive regulation ... "T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20". Nature ... helper T cells regulates immune activation". Cell. 153 (5): 1036-49. doi:10.1016/j.cell.2013.04.034. PMID 23706741.. ...

*IGHG1

"Association of SWAP-70 with the B cell antigen receptor complex". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2180-4. doi:10.1073/ ... 1992). "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells". J. Mol. Biol. 227 (1): 253-64. doi: ... 1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family". Cell. 29 (2): 671-9. doi: ...

*Rituximab

It downregulates the B cell receptor.. *It induces apoptosis of CD20+ cells. ... It increases MHC II and adhesion molecules LFA-1 and LFA-3 (lymphocyte function-associated antigen). ... cells in destroying these B cells. When an NK cell latched onto the cap, it had an 80% success rate at killing the cell. In ... The antibody binds to the cell surface protein CD20. CD20 is widely expressed on B cells, from early pre-B cells to later in ...

*MHC class I

The α3-CD8 interaction holds the MHC I molecule in place while the T cell receptor (TCR) on the surface of the cytotoxic T cell ... It is in this way, the MHC class I-dependent pathway of antigen presentation, that the virus infected cells signal T-cells that ... Paired-immunoglobulin-like receptor B (PirB), an MHCI-binding receptor, is involved in the regulation of visual plasticity.[5] ... The α3 domain is plasma membrane-spanning and interacts with the CD8 co-receptor of T-cells. ...

*Mark M. Davis

Davis, Mark M.; Bjorkman, Pamela J. (1988). "T-cell antigen receptor genes and T-cell recognition". Nature. 334 (6181): 395-402 ... Davis well known for identifying the first T-cell receptor genes, which are responsible for T lymphocytes ability to "see" ... the demonstration that T cells are able to detect and respond to even a single molecule of their ligand-fragments of antigens ... Grakoui, A. (1999). "The Immunological Synapse: A Molecular Machine Controlling T Cell Activation". Science. 285 (5425): 221- ...

*MAM domain

A5 antigen (a developmentally-regulated cell surface protein); and receptor-like tyrosine protein phosphatase. The MAM domain ... It is an extracellular domain found in many receptors. A 170 amino acid domain, the so-called MAM domain, has been recognised ... Takagi S, Hirata T, Agata K, Eguchi G, Fujisawa H, Mochii M (1991). "The A5 antigen, a candidate for the neuronal recognition ... These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a ...

*DC-SIGN

McGreal E, Miller J, Gordon S (2005). "Ligand recognition by antigen-presenting cell C-type lectin receptors". Curr Opin ... a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells". Cell. 100 (5): 587-97. doi:10.1016/ ... DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages ... Cambi A, Figdor CG (2004). "Dual function of C-type lectin-like receptors in the immune system". Curr. Opin. Cell Biol. 15 (5 ...

*CD97

cell-cell signaling. • G-protein coupled receptor signaling pathway. • cell surface receptor signaling pathway. • movement of ... Eichler W, Hamann J, Aust G (Nov 1997). "Expression characteristics of the human CD97 antigen". Tissue Antigens. 50 (5): 429-38 ... immune cells, epithelial cells, muscle cells as well as their malignant counterparts.[12][13][14][15][16][17] In the case of ... G-protein coupled receptor activity. • protein binding. • transmembrane signaling receptor activity. • signal transducer ...

*Immunoglobulin G

2001). "Ch3 Antigen Recognition by B-Cell and T-cell Receptors". Immunobiology: The Immune System in Health and Disease (5th ed ... antigens can cause systemic anaphylaxis in mice through classic pathway by cross-linking IgE bound to the mast cell receptor Fc ... IgG molecules are created and released by plasma B cells. Each IgG has two antigen binding sites. Antibodies are major ... IgG antibodies can prevent IgE mediated anaphylaxis by intercepting a specific antigen before it binds to mast cell-associated ...

*TINAG

1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen". Kidney Int. 49 (1): 153-7. ... Tubulointerstitial nephritis antigen is a protein that in humans is encoded by the TINAG gene. TINAG is a basement membrane ... 1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron". ... Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405-12. ...

*STAP1

Kurosaki T (1999). "Genetic analysis of B cell antigen receptor signaling". Annu. Rev. Immunol. 17 (1): 555-92. doi:10.1146/ ... protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor ... A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. STAP1 has been shown to interact ... the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun. 268 (3): 697-703. doi: ...

*Dermatitis herpetiformis

The B cell endocytoses the complex and presents the modified gliadin to the activated Th1 cell's T cell receptor (TCR) via pMHC ... Thus, the B cell presents the foreign peptide (modified gliadin) but produces antibodies specific for the self-antigen (tTG). ... These T cells become activated and polarised into type I helper T (Th1) cells. Th1 cells reactive towards gliadin have been ... Classical dendritic cells (cDCs) endocytose the immunogenic peptide and if their pattern recognition receptors (PRRs) are ...

*Antibody

Functions mainly as an antigen receptor on B cells that have not been exposed to antigens.[16] It has been shown to activate ... It is part of the B cell receptor (BCR), which allows a B cell to detect when a specific antigen is present in the body and ... is an antigen found on red blood cells; individuals that are Rh-positive (Rh+) have this antigen on their red blood cells and ... B cell activation follows engagement of the cell-bound antibody molecule with an antigen, causing the cell to divide and ...

*Anthrax toxin

... is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema ... Once the receptor and PA returns to the lipid raft, E3 ubiquitin ligase Cb1 ubiquitinates the cytoplasmic tail of the receptor ... namely cellular signaling and cell migration. The toxin may even induce cell lysis, as is observed for macrophage cells. ... The cell then endocytoses these assembled complexes and carries them to an acidic compartment in the cell. The low pH ...

*Concanavalina A, a enciclopedia libre

OFEK I, MIRELMAN D, SHARON N (1977). "Adherence of Escherichia coli to human mucosal cells mediated by mannose receptors". ... and theta antigen of the lymphocyte surface. Interactions with concanavalin A and with Cytoplasmic structures". J Cell Biol 65 ... a model for a quantitative study of cell adhesion". J Cell Sci 56: 21-48. PMID 7166565.. ... "J Cell Biol 59 (1): 134-142. PMC 2110924. PMID 4201706. doi:10.1083/jcb.59.1.134.. ...

*Link domain

CD44 antigen, the main cell surface receptor for HA. Hyaladherin "Link domain signature and profile". PROSITE. December 2004. ... which may be involved in cell-cell and cell-matrix interactions during inflammation and tumourigenesis; ... a hyaluronan-binding domain involved in extracellular matrix stability and cell migration". Cell. 86 (5): 767-75. doi:10.1016/ ... It is important in blood cell migration and apoptosis. The link domain is found in some extracellular proteins in vertebrates ...

*Immunotherapy

... gene that is specialised to recognise tumour antigens. The virus integrates the receptor into the T cells' genome. The cells ... these activated cells present the antigen to the effector lymphocytes (CD4+ helper T cells, cytotoxic CD8+ T cells and B cells ... Dendritic cells can be stimulated to activate a cytotoxic response towards an antigen. Dendritic cells, a type of antigen ... Immune effector cells such as lymphocytes, macrophages, dendritic cells, natural killer cells (NK Cell), cytotoxic T ...

*Anaphylaxis

Antigen-bound IgE then activates FcεRI receptors on mast cells and basophils. This leads to the release of inflammatory ... The coronary spasm is related to the presence of histamine-releasing cells in the heart. While a fast heart rate caused by low ... It is due to the release of inflammatory mediators and cytokines from mast cells and basophils, typically due to an immunologic ... The mechanism involves the release of mediators from certain types of white blood cells triggered by either immunologic or non- ...

*Chronic lymphocytic leukemia

Porter DL, Levine BL, Kalos M, Bagg A, June CH (2011). "Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia ... The T cells had been modified to express genes that would allow the cells to proliferate in the body and destroy B cells ... One week after the T cells were injected, the leukemia cells in his blood had disappeared. The T cells were still found in the ... "T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced ...

*Ketan J. Patel

Patel, K.J.; Neuberger, M.S. (1993). "Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs ... Patel, Ketan Jayakrishna (1994). Antigen presentation by the B cell antigen receptor (PhD thesis). University of Cambridge. ... Such crosslinks are lethal to cells since they would prevent DNA from being copied (DNA replication) or for the genes it ... Patel's research on the Fanconi pathway has provided key molecular insights into how cells remove DNA crosslinks and, most ...

*IGHE

"The B-cell antigen receptor of the five immunoglobulin classes". Nature. 352 (6338): 777-81. doi:10.1038/352777a0. PMID 1881434 ... Cell. 29 (2): 691-9. doi:10.1016/0092-8674(82)90185-4. PMID 6288268. Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence ... Cell. 36 (3): 681-8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489. Ellison J, Hood L (Mar 1982). "Linkage and sequence ... "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". ...

*Plasma cell

... and internalizes offending antigens, which are taken up by the B cell through receptor-mediated endocytosis and processed. ... Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete ... In humans, CD27 is a good marker for plasma cells, naive B cells are CD27-, memory B-cells are CD27+ and plasma cells are ... Germinal center B cells may differentiate into memory B cells or plasma cells. Most of these B cells will become plasmablasts ( ...

*NK-92

... cells can be genetically engineered to recognize and kill human cancer cells. Chimeric Antigen Receptor (CAR) engineered ... Blood NK cells, unlike NK-92 cells, recognize "invaders" or foreign cells only if those cells do not express self MHC molecules ... Porter DL, Levine BL, Kalos M, Bagg A, June CH (August 2011). "Chimeric antigen receptor-modified T cells in chronic lymphoid ... NK-92 cells are a very close match with blood NK cells: they express on their surface the characteristic CD56 antigen and are ...