CD74 is a surface receptor for MIF. Bacterial antigens stimulate white blood cells to release MIF into the blood stream. The ... revealed by the cloning of its cell surface receptor". Cell Research. 16 (2): 162-8. doi:10.1038/sj.cr.7310022. PMID 16474429. ... Cell injury results in MIF release which then interacts with CD74. MIF-CD74 signaling activates pro-survival and proliferative ... Farr L, Ghosh S, Moonah S (2020). "Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair ...
2001). "Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells ... Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene. This gene was ... "Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1". Nat. Med. 5 (8): ... 2003). "The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens". J. Biol. Chem. ...
DRESS syndrome by interacting with a T cell receptor is limited to those individuals whose T cells express a T cell receptor(s ... An antigen presenting cell (APC) takes up these alter proteins; digests them into small peptides; places the peptides in a ... and presents the MHC-associated peptides to T-cell receptors on CD8+ T cells or CD4+ T cells. Those peptides expressing a drug- ... can bind to a T-cell receptor and thereby stimulate the receptor-bearing parent T cell to initiate attacks on self tissues. ...
B cells express B-cell receptors (BCRs) on their surfaces and antigen binding to these receptors begins a signaling cascade ... or cell death. After B cells are activated, they differentiate into plasma cells and cease to express BCR but continue to ... "Fcγ receptors and toll-like receptor 9 synergize to drive immune complex-induced dendritic cell maturation". Cellular ... B cells also express FcγRIIb, low affinity receptors specific to the constant region of IgG, on their surfaces. IgG immune ...
Although B cell receptors can also recognize MHCs, immune responses seem to only be elicited by T cells. The consequences of an ... CD8+ T cells that are specific for a MiHA can target these antigens when they are expressed specifically on tumor cells, which ... Some of these antigens are ubiquitously expressed in nucleated male cells, and the presence of these antigens has been ... The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA ...
"DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of ... in ATM-mutant cells, an inhibitor of DNA-PKcs causes high levels of apoptotic cell death. In ATM mutant cells, additional loss ... When cancer cells are deficient in ATM the cells are "addicted" to DNA-PKcs, important in the alternative DNA repair pathway ... After ionizing radiation DNA-PKcs was increased in the surviving cells of oral squamous cell carcinoma tissues. The ATM protein ...
Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This ... "Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)". Hynes RO (Apr ... Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including ... LaFlamme SE, Akiyama SK, Yamada KM (Apr 1992). "Regulation of fibronectin receptor distribution". The Journal of Cell Biology. ...
Cyclic AMP has also been found to increase MAGE-A11 expression as well as androgen receptor activity in prostate cancer cell ... Bai S, He B, Wilson EM (2005). "Melanoma Antigen Gene Protein MAGE-11 Regulates Androgen Receptor Function by Modulating the ... Bai, Suxia; He Bin; Wilson Elizabeth M (Feb 2005). "Melanoma Antigen Gene Protein MAGE-11 Regulates Androgen Receptor Function ... MAGE-A11 is part of the androgen receptor signaling pathway in humans. It binds directly to the androgen receptor, promoting ...
Ingham RJ, Krebs DL, Barbazuk SM, Turck CW, Hirai H, Matsuda M, Gold MR (December 1996). "B cell antigen receptor signaling ... "Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: ... in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The ... in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The ...
When a recognized antigen binds to the T cell antigen receptor (TCR) located in the cell membrane of Th0 cells, these cells are ... stem cell memory T cells; Tmp, memory T cells with a naive phenotype), some antigen-naive T cells have lost their naive ... "Vitamin D controls T cell antigen receptor signaling and activation of human T cells" (PDF). Nat. Immunol. 11 (4): 344-9. doi: ... and some T cells are incorporated within the naive T cell phenotype but are a different T cell subset (Treg, regulatory T cells ...
CD49d+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ITGA4 Info with links in the Cell ... "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". Hadari YR, Arbel-Goren R, Levy Y, ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8". J. Cell Biol. 110 (6): ...
CD49c+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ITGA3 Info with links in the Cell ... "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)". Park KR, Inoue T, Ueda M, Hirano T, ... The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2 ... Bosman FT (1993). "Integrins: cell adhesives and modulators of cell function". Histochem. J. 25 (7): 469-77. doi:10.1007/ ...
Gupta N, DeFranco AL (February 2003). "Visualizing lipid raft dynamics and early signaling events during antigen receptor- ... "Directed actin polymerization is the driving force for epithelial cell-cell adhesion". Cell. 100 (2): 209-19. doi:10.1016/S0092 ... "Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission". Nature Cell Biology. 9 (3): 310-5. doi: ... Receptors for signaling proteins are present in motile vesicles in cytonemes, and receptors for different signaling proteins ...
Preparative Regimens Used in Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Therapies". Manual of ... This causes the blood cell and platelet output of bone marrow in the body to decrease quite dramatically, sometimes as low as ... The nadir of this myelosuppression usually occurs 21-28 days after the first treatment, after which the blood cell and platelet ... This decrease in white blood cells (neutropenia) can cause complications, and is sometimes treated with drugs like filgrastim. ...
In T cells, the antigen receptor (TCR) and costimulatory receptors (CD28 and ICOS) are thought to be main receptors responsible ... In immune cells, antigen receptors, cytokine receptors and costimulatory and accessory receptors stimulate tyrosine kinase ... August 2002). "Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice". Science. 297 (5583): ... They also lack to B cell subsets: B1 cells (found in body cavities such as the peritoneum) and marginal zone B cells, found in ...
"Defective antigen receptor mediated proliferation of B and T cells in the absence of Vav." Nature. 374: 467-470. $ joint first ... Webb, L., Vigorito, E., Wymann, M.P,. Hirsch, E and Turner M. (2005) "Cutting Edge: T Cell Development Requires the Combined ... He went on to work on identifying elements of signal transduction pathways that are needed inside cells to promote proper ... Gray, P.W., Barrett, K., Chantry, D., Turner, M., and Feldmann, M. (1990). "Cloning of human tumour necrosis factor receptor ...
... "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells". ... "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation". ... Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without ... "Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and ...
... also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction ... plays a key role in the diversification of T cell signaling pathways following activation of the T-cell antigen receptor (TCR) ... cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells ... cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells ...
NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA ... Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. ... "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of ... "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of ...
The human CD46 antigen is known to be the functional cellular receptor for Measles virus. This type 1 integral membrane ... MV-NIS will attach and fuse to host tumor cell membranes. After fusion, MV-NIS has been observed to kill the tumor cells. Due ... Dörig, R. E.; A. Marcil; A. Chopra; C. D. Richardson (1993-10-22). "The human CD46 molecule is a receptor for measles virus ( ... to the unique properties of iodine uptake in these cells, iodine 123 (I-123) may be used to image MV-NIS-infected tumor cells. ...
"Corneal immunity is mediated by heterogeneous population of antigen‐presenting cells." Journal of Leukocyte Biology 74, no. 2 ( ... "Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision." Proceedings of the National ... "Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells." ... he was the first to discover the presence of and characterize resident antigen-presenting cells in the central cornea. Hamrah ...
"The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells ... The cell surface receptor for insulin-like growth factor 2 also functions as a cation-independent mannose 6-phosphate receptor ... doi:10.1016/j.cell.2004.11.007. PMID 15620351. S2CID 14582599. cation-dependent+mannose-6-phosphate+receptor at the U.S. ... Ghosh P, Dahms NM, Kornfeld S (March 2003). "Mannose 6-phosphate receptors: new twists in the tale". Nat. Rev. Mol. Cell Biol. ...
These receptors are commonly found on natural killer cells and some subpopulations of innate and adaptive cells. They are ... Like ILC2, ILC 3 can express MHC II and be appropriating the function of antigen presenting cells. However, ILCs lack the ... ILC3 cells express several surface receptors for diet-based compounds and microbial products alike, such as SCFA receptors. In ... This is supported by the fact that ILC3 cells mirror the phenotype of Th17 cells, and a subset of ILC3 cells has also been ...
Thus an antigen might bind specifically to a T or B cell receptor, but not induce an adaptive immune response. If the antigen ... antigen presenting cells (APCs), such as a B cell or Dendritic Cell, will present these substances as peptides, which T cells ... Because a T cell's T cell receptor recognizes a specific epitope, only certain T cells are able to respond to a certain peptide ... T cell receptors or antibodies (a.k.a. B cell receptors). Antigenicity was more commonly used in the past to refer to what is ...
Glycoproteins are relevant as cell-surface receptors, cell-adhesion molecules, immunoglobulins, and tumor antigens. Glycolipids ... Therefore, a person with A blood type will have the A antigen and H antigen present on the glycolipids of the red blood cell ... mediate certain cell-cell adhesion processes, including those of leukocytes to endothelial cells. In an immune response, ... A person with B blood type will have the B and H antigen present. A person with AB blood type will have A, B, and H antigens ...
B cells, T cells, or NK cells. Only some of these CD8+ murine cells expressed XCR1 receptors. NK cells release XCL1 along with ... XCR1+ and CD8+cells work together to cross-present antigen and communicate CD8+ activation. Cross presentation of XCR1+ CD8+ ... This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the ... Cross-presenting dendritic cells (DCs) in the spleen develop into XCR1+ DCs in the small intestine, T cell zones of Peyer's ...
"Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population". Tissue Antigens. 65 (6): 556-563 ... Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene. Killer cell ... "Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)". Immunol Rev. 181: ... "Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor ...
T-cell receptor). T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major ... The Vδ2+ T cells recognize small non-peptide antigens, but unlike αβ T cells, these antigens do not need to be processed by ... "Entrez Gene: TRG@ T cell receptor gamma locus". Lefranc MP, Rabbitts TH (Aug 1989). "The human T-cell receptor γ (TRG) genes". ... molecules at the surface of antigen presenting cells (APC) (APC). Each T cell receptor is a dimer consisting of one alpha and ...
Antigen discrimination by T cell receptors - T cells respond to foreign antigens at low concentrations, while ignoring any self ... antigens present at much higher concentration. This ability is known as antigen discrimination. T-cell receptors use kinetic ... "Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation". Science. 281 (5376): 572-5. Bibcode: ... McKeithan TW (May 1995). "Kinetic proofreading in T-cell receptor signal transduction". Proceedings of the National Academy of ...
GRT-R910 is a self-amplifying mRNA delivering spike and T cell epitopes. hAd5-S+N delivers spike and nucleocapsid antigens via ... Another candidate is RBD-scNP, which is a sortase A-conjugated ferritin nanoparticle with receptor-binding domain (RBD) ... May 2022). "A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants ... UB-612 contains SARS-CoV-2 S1-RBD protein and synthetic peptides representing T cell (Th and CTL) epitopes on the nucleocapsid ...
First described by Thomsen as a red blood cell's antigen, later research have determined it to be an oncofetal antigen. it is ... Uhlenbruck, G. (1981). "The Thomsen-Friedenreich (TF) Receptor: An Old History with New Mystery". Immunological Investigations ... "Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice ... Thomsen-Friedenreich antigen (Galβ1-3GalNAcα1-Ser/Thr) is a disaccharide that serves as a core 1 structure in O-linked ...
"Coevolution of paired receptors in Xenopus carcinoembryonic antigen-related cell adhesion molecule families suggests ... In NK cells, ligands for inhibitory receptors are often MHC class I (MHC-I) molecules, while those for activating receptors may ... Paired receptors are highly expressed in the cells of the immune system, especially natural killer (NK) and myeloid cells, and ... Expression of paired receptors is common in many types of leukocytes, especially myeloid cells and natural killer (NK) cells. ...
PI(3)K enzymes are activated by a variety of cell surface receptors including antigen receptors on lymphocytes. Once activated ... overrepresentation of CD10+ transitional B cells, expanded effector (CCR7-) T cells, expanded CD57+ senescent CD8+ T cells, and ... The clinical symptoms are caused by immunological abnormalities (figure 2). These include deficiency in CD27+ B memory cells, ... PASLI stands for "p110 delta activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency." The ...
Mdk is also a tumor antigen able to induce CD8 and CD4 T cell responses (Kerzerho et al. 2010 Journal of Immunology). Midkine ... 1998). "Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine ... cells. Doxorubicin works by putting rampant cancer cells into a senescent state. MK, in WT-MK transfected cells versus WT cells ... non-resistant cell type, the gene for MK was transfected into WT cells to determine if MK was overexpressed in the WT cells ...
DNAM-1 ligands are also expressed in antigen-presenting cells activated by toll-like receptors and CD155 might be activated by ... NK T cell, B cells, dendritic cells, hematopoietic precursor cells, platelets, monocytes and T cells. DNAM-1 gene CD226 is ... Wu MR, Zhang T, Alcon A, Sentman CL (April 2015). "DNAM-1-based chimeric antigen receptors enhance T cell effector function and ... DNAM-1 expression on NK cells can be regulated by cell-cell interaction and by soluble factors. In human, IL-2 and IL-15 up- ...
VIPR2 Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; ... The secretin-receptor family of GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin ... These receptors activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The receptors in this family have 7 ... Secretin receptor family (class B GPCR subfamily) consists of secretin receptors regulated by peptide hormones from the ...