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*  Monoclonal antibody therapy
... since tumor cells are the patient's own cells. Tumor cells, however are highly abnormal, and many display unusual antigens. ... using an antibody fragment against the human transferrin receptor. Tissue-specific gene delivery using immunoliposomes has been ... can affect T cell functions directly and indirectly via cells such as Treg cells. CD8 cells can be suppressed by B cells ... Some such tumor antigens are inappropriate for the cell type or its environment. Monoclonal antibodies can target tumor cells ...
*  Polymeric immunoglobulin receptor
PIGR polymeric immunoglobulin receptor". Hood L, Kronenberg M, Hunkapiller T (Feb 1985). "T cell antigen receptors and the ... Polymeric immunoglobulin receptor (pIgR) is a protein that in humans is encoded by the PIGR gene. It is a Fc receptor which ... "IL-4 and IFN-gamma increase steady state levels of polymeric Ig receptor mRNA in human airway and intestinal epithelial cells ... "Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31----q41". Cytogenetics and Cell ...
*  Mark M. Davis
Davis, Mark M.; Bjorkman, Pamela J. (1988). "T-cell antigen receptor genes and T-cell recognition". Nature. 334 (6181): 395-402 ... Davis well known for identifying the first T-cell receptor genes, which are responsible for T lymphocytes ability to "see" ... the demonstration that T cells are able to detect and respond to even a single molecule of their ligand-fragments of antigens ... Grakoui, A. (1999). "The Immunological Synapse: A Molecular Machine Controlling T Cell Activation". Science. 285 (5425): 221- ...
*  STAP1
Kurosaki T (1999). "Genetic analysis of B cell antigen receptor signaling". Annu. Rev. Immunol. 17 (1): 555-92. doi:10.1146/ ... protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor ... A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. STAP1 has been shown to interact ... the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun. 268 (3): 697-703. doi: ...
*  Ketan J. Patel
Patel, K.J.; Neuberger, M.S. (1993). "Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs ... Patel, Ketan Jayakrishna (1994). Antigen presentation by the B cell antigen receptor (PhD thesis). University of Cambridge. ... Such crosslinks are lethal to cells since they would prevent DNA from being copied (DNA replication) or for the genes it ... Patel's research on the Fanconi pathway has provided key molecular insights into how cells remove DNA crosslinks and, most ...
*  IGHE
"The B-cell antigen receptor of the five immunoglobulin classes". Nature. 352 (6338): 777-81. doi:10.1038/352777a0. PMID 1881434 ... Cell. 29 (2): 691-9. doi:10.1016/0092-8674(82)90185-4. PMID 6288268. Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence ... Cell. 36 (3): 681-8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489. Ellison J, Hood L (Mar 1982). "Linkage and sequence ... "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". ...
*  SWAP70
"Association of SWAP-70 with the B cell antigen receptor complex". Proc Natl Acad Sci U S A. 97 (5): 2180-4. doi:10.1073/pnas. ... 2004). "SWAP-70 identifies a transitional subset of actin filaments in motile cells". Mol. Biol. Cell. 14 (8): 3242-53. doi: ... Ihara S, Oka T, Fukui Y (2006). "Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling". J. Cell Sci ... Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex". J. Biol. Chem. 273 (27): ...
*  BTLA
1997). "B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation". J. Immunol. ... recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells". J. Immunol. 158 (6): 2663-9. ... Pao LI, Bedzyk WD, Persin C, Cambier JC (1997). "Molecular targets of CD45 in B cell antigen receptor signal transduction". J. ... BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell ...
*  CD79B
1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072-8. doi ... Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated ... 1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812-6. doi:10.1002/eji. ... 1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". J. ...
*  MALT1
Ruland J, Duncan GS, Wakeham A, Mak TW (2003). "Differential requirement for Malt1 in T and B cell antigen receptor signaling ... "T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20". Nature ... helper T cells regulates immune activation". Cell. 153 (5): 1036-49. doi:10.1016/j.cell.2013.04.034. PMID 23706741. Jeltsch KM ... Staal J, Driege Y, Bekaert T, Demeyer A, Muyllaert D, Van Damme P, Gevaert K, Beyaert R (2011). "T-cell receptor-induced JNK ...
*  IGHG1
2000). "Association of SWAP-70 with the B cell antigen receptor complex". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2180-4. doi: ... 1992). "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells". J. Mol. Biol. 227 (1): 253-64. doi: ... 1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family". Cell. 29 (2): 671-9. doi: ...
*  Tyrosine-protein kinase BLK
1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072-8. doi ... c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor". ... Cell. Biol. 13 (9): 5877-87. PMC 360336 . PMID 8395016. Malek SN, Yang CH, Earnshaw WC, et al. (1996). "p150TSP, a conserved ... Cell. Biol. 16 (9): 4735-43. PMC 231474 . PMID 8756631. Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). "Palmitylation of Src ...
*  Protein THEMIS
The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation ... "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nat. Immunol. 10 (8): ... This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. ... a T cell-specific protein important for late thymocyte development". Nat. Immunol. 10 (8): 840-7. doi:10.1038/ni.1768. PMC ...
*  Sandra Saouaf
1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". The Journal of Biological Chemistry. ... Differences in the Activation of Three Classes of Non-Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen Receptor ... After completion of her degree, Saouaf went to work in the cell signaling laboratory of Bristol-Myers Squibb where she ... December 1990). "Mechanisms of Autoimmunity in the Context of T-Cell Tolerance: Insights from Natural and Transgenic Animal ...
*  PTPN7
This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function ... Saxena M, Williams S, Gilman J, Mustelin T (1998). "Negative regulation of T cell antigen receptor signal transduction by ... Swieter M, Berenstein EH, Swaim WD, Siraganian RP (1995). "Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells ... Cell Biol. 1 (5): 305-11. doi:10.1038/13024. PMID 10559944. Pettiford SM, Herbst R (2000). "The MAP-kinase ERK2 is a specific ...
*  HCLS1
1993). "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated ... 1997). "Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis". J. Exp. Med. 185 (7): 1387-92. ... 1994). "Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking". Immunol. ... induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". ...
*  MAPK14
Saxena M, Williams S, Gilman J, Mustelin T (Jun 1998). "Negative regulation of T cell antigen receptor signal transduction by ... "Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases". Nature Immunology. 6 (4): 390-5. doi ... p38α MAPK is ubiquitously expressed in many cell types, in contrast, p38β MAPK is highly expressed in brain and lung, p38γ MAPK ... Wang Y, Huang S, Sah VP, Ross J, Brown JH, Han J, Chien KR (Jan 1998). "Cardiac muscle cell hypertrophy and apoptosis induced ...
*  ZAP70
... by engagement of the T cell receptor with processed antigen fragments presented by professional antigen presenting cells (i.e. ... "Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells". The Journal ... Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB (August 1995). "Ligation of the T-cell antigen receptor (TCR) induces ... It is part of the T cell receptor, and plays a critical role in T-cell signaling. Its molecular weight is 70 kDa, and it is a ...
*  Signal transducing adaptor protein
A good article regarding the role of adaptor proteins involved with the T-cell antigen receptor: Samelson LE (2002). "Signal ... transduction mediated by the T cell antigen receptor: the role of adapter proteins". Annual Review of Immunology. 20 (1): 371- ... Molecular Cell. 5 (4): 649-58. doi:10.1016/S1097-2765(00)80244-0. PMID 10882101. Good article about adaptor proteins involved ... low-density lipoprotein receptor adaptor protein 1 MYD88 - Myeloid differentiation primary response gene 88 NCK1 - NCK adaptor ...
*  B-cell receptor
When a B cell is activated by its first encounter with an antigen that binds to its receptor (its "cognate antigen"), the cell ... The B-cell receptor or BCR is a transmembrane receptor protein located on the outer surface of B cells. The receptor's binding ... Corcos D (1990). "Oncogenic potential of the B-cell antigen receptor and its relevance to heavy chain diseases and other B-cell ... The physiology of B cells is intimately connected with the function of their B-cell receptor. In B cells, the balance of ...
*  CRKL
Ingham RJ, Krebs DL, Barbazuk SM, Turck CW, Hirai H, Matsuda M, Gold MR (December 1996). "B cell antigen receptor signaling ... "Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: ... in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The ... in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The ...
*  Piers Nash
2007). "Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor". Journal of Immunology. 179 (7 ... Harper, J.Wade (2002). "A phosphorylation-driven ubiquitination switch for cell-cycle control". Trends in Cell Biology. 12 (3 ... IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome". Cell Communication and Signaling ... This article was the focus of the following reviews and comments: Ferrell, James E. (2001). "Cell cycleSix steps to destruction ...
*  Naive T cell
When a recognized antigen binds to the T cell antigen receptor (TCR) located in the cell membrane of Th0 cells, these cells are ... "Vitamin D controls T cell antigen receptor signaling and activation of human T cells" (PDF). Nat. Immunol. 11 (4): 344-9. doi: ... A naïve T cell (Th0 cell) is a T cell that has differentiated in bone marrow, and successfully undergone the positive and ... Among these are the naïve forms of helper T cells (CD4+) and cytotoxic T cells (CD8+). A naïve T cell is considered mature and ...
*  P110δ
In T cells, the antigen receptor (TCR) and costimulatory receptors (CD28 and ICOS) are thought to be main receptors responsible ... In immune cells, antigen receptors, cytokine receptors and costimulatory and accessory receptors stimulate tyrosine kinase ... They also lack to B cell subsets: B1 cells (found in body cavities such as the peritoneum) and marginal zone B cells, found in ... "Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice". Science. 297 (5583): 1031-4. doi: ...
*  LYN
In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor ... Yamamoto T, Yamanashi Y, Toyoshima K (Apr 1993). "Association of Src-family kinase Lyn with B-cell antigen receptor". ... in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The ... "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". The Journal ...
*  Phage display
Then the expression of single chain Fv's (scFv), and single chain T cell receptors (scTCR) were expressed both with and without ... Instead, one could cleave in a section between the bead and the antigen to elute. Since the pIII is intact it does not matter ... The use of a helper phage can be eliminated by using 'bacterial packaging cell line' technology. Elution can be done combining ... Endemann H, Model P (July 1995). "Location of filamentous phage minor coat proteins in phage and in infected cells". J. Mol. ...
*  PIP4K2A
Niiro H, Clark EA (November 2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and ... cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of ...