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*  Beta-3 adrenergic receptor
Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic ... is a beta-adrenergic receptor, and also denotes the human gene encoding it. Actions of the β3 receptor include Enhancement of ... Beta adrenergic receptors are involved in the epinephrine- and norepinephrine-induced activation of adenylate cyclase through ... "Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 ...
*  ICI-118,551
"Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic ... Hillman KL, Doze VA, Porter JE (August 2005). "Functional characterization of the beta-adrenergic receptor subtypes expressed ... ICI-118,551 is a selective β2 adrenergic receptor (adrenoreceptor) antagonist. ICI binds to the β2 subtype with at least 100 ... therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, ...
*  Arotinolol
... (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. It also acts ... "β-adrenergic blocking, antiarrhythmic compound S-596". It is used in the treatment of high blood pressure and essential tremor ... as a β3 receptor agonist. A 1979 publication suggests arotinolol as having first been described in the scientific literature by ... Zhao, Jin; Golozoubova, Valeria; Cannon, Barbara; Nedergaard, Jan (July 2001). "Arotinolol is a weak partial agonist on beta 3- ...
*  Beta-adrenergic agonist
"The beta-adrenergic receptors". Yoo, B.; et al. "Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII ... In general, pure beta-adrenergic agonists have the opposite function of beta blockers. Beta adrenoreceptor agonist ligands ... Beta adrenergic agonists or beta agonists are medications that relax muscles of the airways, which widen the airways and result ... Most agonists of the beta receptors are selective for one or more beta-adrenoreceptors. For example, patients with low heart ...
*  Beta-3 adrenergic antagonist
... adrenergic receptor antagonists". The Journal of Pharmacology and Experimental Therapeutics. 290 (2): 649-55. PMID 10411574. ... is an adrenergic antagonist which blocks the Beta-3 adrenergic receptors of cells, with either high specificity (an antagonist ... SR 59230A Carvedilol Betablocker Beta-3 adrenergic receptor Candelore MR, Deng L, Tota L, Guan XM, Amend A, Liu Y, Newbold R, ... Cascieri MA, Weber AE (Aug 1999). "Potent and selective human beta(3)- ...
*  Adrenergic receptor
Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 Cannon WB, Rosenbluth A (31 May 1933). "Studies On Conditions ... Basic Neurochemistry: α- and β-Adrenergic Receptors Brief overview of functions of the β3 receptor Theory of receptor ... ISBN 0-443-06911-5. Alpha receptors illustrated The Adrenergic Receptors "Adrenoceptors". IUPHAR Database of Receptors and Ion ... a Gq coupled receptor) and α2 (a Gi coupled receptor). Phenylephrine is a selective agonist of the α receptor. β receptors have ...
*  Thermogenin
Schleiff E, Shore GC, Goping IS (Mar 1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific ... Fatty acids cause the following signaling cascade: Sympathetic nervous system terminals release Norepinephrine onto a Beta-3 ... adrenergic receptor on the plasma membrane. This activates adenylyl cyclase, which catalyses the conversion of ATP to cyclic ... variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in ...
*  SR 59230A
"Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A ... Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective β3-adrenergic receptor antagonist ... Bellantuono V, Cassano G, Lippe C (August 2008). "The adrenergic receptor subtypes present in frog (Rana esculenta) skin". Comp ... Bexis S, Docherty JR (April 2009). "Role of alpha(1)- and beta(3)-adrenoceptors in the modulation by SR59230A of the effects of ...
*  Solabegron
... (code name GW-427,353) is a drug which acts as a selective agonist for the β3 adrenergic receptor. It is being ... 2008). "Randomized, double-blind, placebo (PLA)-controlled, crossover study to evaluate efficacy and safety of the beta 3- ... Astellas Pharma has developed the first commercially available β3 adrenergic receptor, mirabegron, which is now licensed in ... selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog". ...
*  Beta-1 adrenergic receptor
Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-2 adrenergic receptor Beta-3 adrenergic ... The beta-1 adrenergic receptor (β1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the ... "The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by ... "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1- ...
*  Beta-2 adrenergic receptor
Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-3 adrenergic ... The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor ... "Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 ... Frielle T, Caron MG, Lefkowitz RJ (May 1989). "Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by ...
*  Beta adrenergic receptor kinase
"Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors". J ... "Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, ... Beta adrenergic receptor kinase has been shown to interact with: Beta-gamma complex, G protein GIT1, GNAQ, PDE6G, PRKCB1 and ... Beta adrenergic receptor kinase (also referred to as βARK or BARK) is a serine/threonine intracellular kinase. It is activated ...
*  Beta-adrenergic-receptor kinase
... beta-adrenergic-receptor] kinase, beta-adrenergic receptor-specific kinase, beta-AR kinase, beta-ARK, beta-ARK 1, beta-ARK 2, ... beta-adrenergic receptor] Thus, the two substrates of this enzyme are ATP and beta-adrenergic receptor, whereas its two ... beta-adrenergic receptor] phosphotransferase. Other names in common use include ATP:beta-adrenergic-receptor phosphotransferase ... beta-receptor kinase, GRK2, GRK3, beta-adrenergic-receptor kinase (phosphorylating), beta2ARK, betaARK1, beta-adrenoceptor ...
*  Beta adrenergic receptor kinase-2
Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the ... Beta-adrenergic receptor kinase 2 (beta-ARK-2) also known as G-protein-coupled receptor kinase 3 (GRK3) is an enzyme that in ... The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G ... 1991). "Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor ...
*  Alfred G. Gilman
beta-Adrenergic and PGE1 receptors in parental and hybrid cells". The Journal of Biological Chemistry. 252 (4): 1293-302. PMID ... Haga, T; Haga, K; Gilman, AG (1977). "Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild ... Ross, EM; Maguire, ME; Sturgill, TW; Biltonen, RL; Gilman, AG (1977). "Relationship between the beta-adrenergic receptor and ... "The crystal structure of β2-adrenergic receptor, a classic GPCR was at last revealed". Nature. 450: 355-356. doi:10.1038/ ...
*  Nadoxolol
... is an antiarrhythmic agent, chemically related in structure to beta-adrenergic receptor blocker drugs such as ... an intermediate in the synthesis of beta-adrenergic receptor blockers". Bioorganic Chemistry. 31 (3): 259-69. PMID 12818235. ...
*  Flestolol
... is a short-acting beta adrenergic receptor antagonist. Acylation of glycidol (2) with the acid chloride 1 produces ... 1. Novel .beta.-blockers with ultrashort duration of action". Journal of Medicinal Chemistry. 27 (8): 1007. doi:10.1021/ ... 81 (3): 309-22. PMID 8235065. Kam, Sheung Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J ... the ester 3. Reaction of that intermediate with amine 4, obtained by reaction of 1,1-dimethylethylenediamine with urea, gives ...
*  Sodium-hydrogen antiporter 3 regulator 1
... of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors ... 1998). "A C-terminal motif found in the β2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance ... "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance ... 1998). "The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange". Nature ...
*  Discovery and development of beta-blockers
β adrenergic receptor antagonists (also called beta-blockers or β-blockers) were initially developed in the 1960s, for the ... β-blockers can be selective for either β1, β2 adrenergic receptor, or to be non-selective. By blocking β1 receptor it is ... β1-receptors are located in the heart and consist of about 75% of all β-receptors. β2-receptors can be found in the smooth ... A few of the non-selective β-blockers A few of the selective β1-blockers The β-adrenergic receptor antagonists all have similar ...
*  Adrenergic receptor autoantibodies
Beta-1 adrenergic receptors are the primary receptor of the heart and, therefore, autoantibodies to these receptors have been ... Adrenergic receptor autoantibodies The adrenergic receptors (or adrenoreceptors) are a class of cell membrane-bound protein ... The work of endocrinology labs have correlated autoantibodies to the beta-adrenergic receptors with Postural Orthostatic ... "Autoantibody Activation of Beta-Adrenergic and Muscarinic Receptors Contributes to an "Autoimmune" Orthostatic Hypotension". ...
*  GNAQ
... has been shown to interact with: Beta adrenergic receptor kinase, Bruton's tyrosine kinase, RGS16, RGS4 RIC8A, and Sodium- ... 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP ... Petit A, Geoffroy P, Bélisle S (1997). "Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 ... Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (1996). "The human thyrotropin receptor: a ...
*  Beta blocker
... β2 and β3 receptors. β1-adrenergic receptors are located mainly in the heart and in the kidneys. β2-adrenergic receptors are ... β3-adrenergic receptors are located in fat cells. Beta receptors are found on cells of the heart muscles, smooth muscles, ... Beta blockers, due to their antagonism at beta-1 adrenergic receptors, inhibit both the synthesis of new melatonin and its ... but receptor selectivity diminishes at higher doses. Beta blockade, especially of the beta-1 receptor at the macula densa, ...
*  G beta-gamma complex
"Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors". ... April 2004). "Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts". ... June 1998). "Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene ... Heart failure can be characterized by a loss of β adrenergic receptor (βAR) signalling in heart cells. When the βAR is ...
*  Formaldehyde dehydrogenase
... increased beta adrenergic receptor numbers in lung and heart, diminished tachyphylaxis to β2-adrenergic receptor agonists, ... "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2". Cell. 129 (3): 511 ... 1 (3): 154-8. doi:10.1038/nchembio720. PMID 16408020. Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS (March 2001). "A ... 178 (1-3): 29-35. doi:10.1016/j.cbi.2008.10.050. PMID 19038239. Barglow KT, Knutson CG, Wishnok JS, Tannenbaum SR, Marletta MA ...
*  Cocaine intoxication
"Reflections on beta-adrenergic receptor blockers and cocaine use. A case in point". Revista Española De Cardiología. 62 (4): ... "Death temporally related to the use of a Beta adrenergic receptor antagonist in cocaine associated myocardial infarction". ... "Potentiation of Cocaine-Induced Coronary Vasoconstriction by Beta-Adrenergic Blockade". Annals of Internal Medicine. 112 (12): ... "Comparison of in-hospital outcomes for beta-blocker use versus non-beta blocker use in patients presenting with cocaine- ...
*  Meldonium
... has also been found to induce anticonvulsant and antihypnotic effects involving alpha 2-adrenergic receptors as well ... Studies have shown that meldonium increases cognition and mental performance by reducing amyloid beta deposition in the ... oxide production via stimulation of the M3 muscarinic acetylcholine receptor or specific gamma-butyrobetaine ester receptors. ... known as beta oxidation). Carnitine is mainly absorbed from the diet, but can be formed through biosynthesis. To produce ...