*Beta adrenergic receptor kinase-2

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G ... The beta adrenergic receptor kinase-2 was cloned from mice and rats in 1991 and the human gene was cloned in 1993. Gene linkage ... Beta-adrenergic receptor kinase 2 (beta-ARK-2) also known as G-protein-coupled receptor kinase 3 (GRK3) is an enzyme that in ... "Entrez Gene: ADRBK2 adrenergic, beta, receptor kinase 2". Benovic JL, Onorato JJ, Arriza JL, Stone WC, Lohse M, Jenkins NA, ...

*Beta-2 adrenergic receptor

"Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-3 adrenergic ... "Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta- ... In contrast, Beta-1 adrenergic receptors are coupled only to Gs, and stimulation of these results in a more diffuse cellular ...

*AKAP12

Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases ... AKAP12 has been shown to interact with Beta-2 adrenergic receptor. GRCh38: Ensembl release 89: ENSG00000131016 - Ensembl, May ... Shih M, Lin F, Scott JD, Wang HY, Malbon CC (1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases and ... scaffold binding to the beta2-adrenergic receptor". EMBO J. 22 (24): 6419-29. doi:10.1093/emboj/cdg628. PMC 291823 . PMID ...

*Beta adrenergic receptor kinase

"Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors". J ... Beta adrenergic receptor kinase has been shown to interact with: Beta-gamma complex, G protein GIT1, GNAQ, PDE6G, PRKCB1 and ... Beta adrenergic receptor kinase (also referred to as βARK or BARK) is a serine/threonine intracellular kinase. It is activated ... beta-Adrenergic Receptor Kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Human ADRBK1 genome ...

*Beta-adrenergic-receptor kinase

... beta-adrenergic-receptor] kinase, beta-adrenergic receptor-specific kinase, beta-AR kinase, beta-ARK, beta-ARK 1, beta-ARK 2, ... beta-adrenergic receptor] Thus, the two substrates of this enzyme are ATP and beta-adrenergic receptor, whereas its two ... beta-adrenergic receptor] phosphotransferase. Other names in common use include ATP:beta-adrenergic-receptor phosphotransferase ... beta-receptor kinase, GRK2, GRK3, beta-adrenergic-receptor kinase (phosphorylating), beta2ARK, betaARK1, beta-adrenoceptor ...

*Adrenergic receptor

Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 Cannon WB, Rosenbluth A (31 May 1933). "Studies On Conditions ... Basic Neurochemistry: α- and β-Adrenergic Receptors Brief overview of functions of the β3 receptor Theory of receptor ... ISBN 0-443-06911-5. Alpha receptors illustrated The Adrenergic Receptors "Adrenoceptors". IUPHAR Database of Receptors and Ion ... a Gq coupled receptor) and α2 (a Gi coupled receptor). Phenylephrine is a selective agonist of the α receptor. β receptors have ...

*Dopexamine

Effects of depexamine may be suppressed by concomitant use with ß2-adrenergic and dopamine receptor antagonists requires ... a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors". British Journal of Pharmacology. 85 (3): 599-608. ... It is not an α-adrenergic agonist, does not cause vasoconstriction, and is not a pressor agent. As of 2004 there was some ... Dopexamine stimulates beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also ...

*ARF6

... "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45 ... A pseudogene of this gene is located on chromosome 7. ARF6 can interact with βarrestin upon receptor activation. Arf6 has been ... D'Souza-Schorey C, Li G, Colombo MI, Stahl PD (1995). "A regulatory role for ARF6 in receptor-mediated endocytosis". Science. ... "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem. 278 (36): 33818-30 ...

*Beta-2 adrenergic antagonist

... is an adrenergic antagonist which blocks the beta-2 adrenergic receptors of cells, with either high specificity (an antagonist ... ICI-118,551 Butaxamine Propranolol Betablocker Beta-2 adrenergic receptor Beta2-adrenergic agonist Bilski, AJ; Halliday, SE; ... Fitzgerald, JD; Wale, JL (1983). "The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551)". J Cardiovasc ... A Beta-2 adrenergic antagonist (β2-adrenoceptor antagonist) ...

*CYTH2

... "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45 ... links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor ... "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45 ... CYTH2 has been shown to interact with Arrestin beta 2 and Arrestin beta 1. GRCh38: Ensembl release 89: ENSG00000105443 - ...

*Discovery and development of beta2 agonists

Beta2-adrenergic agonist Alpha-adrenergic agonist Asthma Beta blocker Beta-1 adrenergic receptor Beta-2 adrenergic receptor ... β1 receptors make up to 75% of all beta receptors and are predominantly located in the heart. β2 receptors are found in ... It also influences the specificity for the β-receptor subtypes. Direct-acting analog binds the β-adrenergic receptors directly ... β-receptors are membrane-bound receptors coupled to G-proteins. Three types of β-receptors have been identified by molecular ...

*Beta-1 adrenergic receptor

The beta-1 adrenergic receptor (β1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the ... "The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by ... "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1- ... "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1- ...

*SAG (gene)

... and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286-8. doi:10.1006/geno.1994.1497. PMID 7695743. ... 1996). "Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic ... "Acidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, ... Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein- ...

*ATG10

Feldman RD, Hunninghake GW, McArdle WL (1987). "Beta-adrenergic-receptor-mediated suppression of interleukin 2 receptors in ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). " ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using ...

*60S acidic ribosomal protein P2

2002). "Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal ... 150 (2): 243-250. doi:10.1016/0378-1119(94)90433-2. PMID 7821789. Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5 ... 35 (2): 203-211. doi:10.1016/S1357-2725(02)00133-4. PMID 12479870. Shu H, Chen S, Bi Q, et al. (2004). "Identification of ... 3.0.CO;2-5. PMID 10508479. Tchórzewski M, Boldyreff B, Issinger O, Grankowski N (2000). "Analysis of the protein-protein ...

*Arrestin beta 2

... like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the ... Lefkowitz RJ (July 1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor ... and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286-8. doi:10.1006/geno.1994.1497. PMID 7695743. ... "beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this ...

*FZD1

... adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor". Naunyn-Schmiedeberg's Archives ... DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (May 2002). "The Frizzled-1/(beta(2))- ... "Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... Zilberberg A, Yaniv A, Gazit A (Apr 2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 ( ...

*Tachyphylaxis

... adrenergic receptor on the response to regular use of albuterol in asthma". American Journal of Respiratory and Critical Care ... Polymorphisms of the beta-2 receptor play a role in tachyphylaxis. Expression of the Gly-16 allele (glycine at position 16) ... However, with regular beta-2 agonist use, asthmatic Arg-16 individuals experience a significant decline in bronchodilator ... It has been proposed that the tachyphylactic effect of regular exposure to exogenous beta-2 agonists is more apparent in Arg-16 ...

*Optogenetics

Kim, J. M.; Hwa, J.; Garriga, P.; Reeves, P. J.; RajBhandary, U. L.; Khorana, H. G. (2005). "Light-driven activation of beta 2- ... adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops". ... Building on prior work fusing vertebrate opsins to specific G-protein coupled receptors a family of chimeric single-component ... May 2007). "Remote control of neuronal activity with a light-gated glutamate receptor". Neuron. 54 (4): 535-45. doi:10.1016/j. ...

*AKAP5

... receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci. 22 (1 ... adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol. 10 (7): 409-12. doi:10.1016/S0960- ... The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase ... 2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex". Neuron. 27 (1): 107-19. doi:10.1016/S0896-6273( ...

*Beta-adrenergic agonist

"The beta-adrenergic receptors". Yoo, B.; et al. "Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII ... In general, pure beta-adrenergic agonists have the opposite function of beta blockers. Beta adrenoreceptor agonist ligands ... Beta adrenergic agonists or beta agonists are medications that relax muscles of the airways, which widen the airways and result ... Most agonists of the beta receptors are selective for one or more beta-adrenoreceptors. For example, patients with low heart ...

*GPCR oligomer

Limbird LE, Meyts PD, Lefkowitz RJ (June 1975). "Beta-adrenergic receptors: evidence for negative cooperativity". Biochem. ... and hetero-oligomerization of β2-adrenergic receptor in receptor trafficking, signaling pathways and receptor pharmacology". ... Receptor homodimers - which consist of two identical GPCRs - are the simplest homomeric GPCR oligomers. Receptor heterodimers ... In 1991, the phenomenon of receptor crosstalk was observed between adenosine A2A (A2A) and dopamine D2 receptor (DRD2) thus ...

*G protein-coupled receptor

Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ (June 1990). "beta-Arrestin: a protein that regulates beta-adrenergic ... transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors ( ... G protein-coupled receptors database List of MeSH codes (D12.776) Metabotropic receptor Orphan receptor Pepducins, a class of ... This was followed immediately by a higher resolution structure of the same receptor (2RH1​). This human β2-adrenergic receptor ...

*Dopamine receptor D5

It has been shown that M1-Muscarinic receptors cooperate with D5 receptors and beta-2 adrenergic receptors to consolidate cued ... It belongs to the D1-like receptor family along with the D1 receptor subtype. D5 receptor is a subtype of the dopamine receptor ... D5 receptor is highly homologous to the D1 receptor. Their amino acid sequences are 49% to 80% identical. D5 receptor has a ... SCH 23390 D5 receptor has been shown to form heteromers with D2 receptors. Co-activation of these receptors within the ...

*Penbutolol

... is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making ... Penbutolol is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making ... Penbutolol acts on the β1 adrenergic receptors in both the heart and the kidney. When β1 receptors are activated by a ... Blocking β adrenergic receptors decreases the heart rate and cardiac output to lower arterial blood pressure. β blockers also ...

*Meldonium

Studies have shown that meldonium increases cognition and mental performance by reducing amyloid beta deposition in the ... oxide production via stimulation of the M3 muscarinic acetylcholine receptor or specific gamma-butyrobetaine ester receptors. ... known as beta oxidation). Carnitine is mainly absorbed from the diet, but can be formed through biosynthesis. To produce ... fatty acid transport is reduced and the accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ...