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*  Alpha-1A adrenergic receptor
1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene ... a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype". J. Pharmacol. Exp. Ther. 274 (1): ... There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G- ...
*  Alpha-2 adrenergic receptor
... signal through the α2-adrenergic receptor in the central and peripheral nervous systems. The α2A adrenergic receptor is ... where it sits alongside the more plentiful α1-adrenergic receptor. The α2-adrenergic receptor binds both norepinephrine ... adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. ... "Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists". J. Lipid Res ...
*  Alpha-2A adrenergic receptor
The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the ... the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor ... ADRA2A adrenergic, alpha-2A-, receptor". "α2A-adrenoceptor". IUPHAR Database of Receptors and Ion Channels. International Union ... Handy DE, Gavras H (Nov 1992). "Promoter region of the human alpha 2A adrenergic receptor gene". The Journal of Biological ...
*  Rotarod performance test
Evidence for a role of rat R alpha-2A adrenergic receptors in the control of nociception, motor behavior and hippocampal ... "Vestibular dysfunction in vitamin D receptor mutant mice". J Steroid Biochem Mol Biol. 114 (3-5): 161-6. doi:10.1016/j.jsbmb. ... 2 (4): 765-87. Millan, MJ; Bervoets, K; Rivet, JM; Widdowson, P; Renouard, A; Le Marouille-Girardon, S; Gobert, A (Sep 1994). " ... 11 (2): 187-96. doi:10.1089/neu.1994.11.187. Bogo, V; Hill, TA; Young, RW (Dec 1981). "Comparison of accelerod and rotarod ...
*  Table of neurotransmitter actions in the ANS
Elliott, J. (1997). "Alpha-adrenoceptors in equine digital veins: Evidence for the presence of both alpha1 and alpha2-receptors ... "Effects of 3-Adrenergic Receptor Activation on Rat Urinary Bladder Hyperactivity Induced by Ovariectomy". Journal of ... Sagrada, A; Fargeas, M J; Bueno, L (1987). "Involvement of alpha-1 and alpha-2 adrenoceptors in the postlaparotomy intestinal ... ISBN 0-7817-7311-3. Schmitz, JM; Graham, RM; Sagalowsky, A; Pettinger, WA (1981). "Renal alpha-1 and alpha-2 adrenergic ...
*  RDS-127
It acts as a D2-like receptor agonist and also has some serotonin and adrenergic agonist effects, as well as some ... Rezaki YE, Ilhan M (1991). "Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7- ... Sahin I, Tuncer M, Ilhan M (March 1990). "Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n- ... Arnerić SP, Long JP (May 1984). "Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7- ...
*  GNAI2
McClue SJ, Milligan G (Sep 1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 ... Osawa S, Dhanasekaran N, Woon CW, Johnson GL (Nov 1990). "G alpha i-G alpha s chimeras define the function of alpha chain ... GNAI2 has been shown to interact with: EYA2, GPSM2, Interleukin 8 receptor, alpha, MDFI, RGS5, and RIC8A. GRCh38: Ensembl ... Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha". The Journal ...
*  Methyldopa
... α-methylnorepinephrine is an agonist of presynaptic central nervous system α2 adrenergic receptors. Activation of these ... Methyldopa is in the alpha-2 adrenergic receptor agonist family of medication. It works by stimulating the brain to decrease ... with increased use of other safer and more tolerable agents such as alpha blockers, beta blockers, and calcium channel blockers ... This inhibition results in reduced dopaminergic and adrenergic neurotransmission in the peripheral nervous system. This effect ...
*  Rauwolscine
... acts predominantly as a α2-adrenergic receptor antagonist. It has also been shown to function as a 5-HT1A receptor ... Perry BD, U'Prichard DC (December 1981). "[3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha ... receptor". Naunyn-Schmiedeberg's Archives of Pharmacology. 357 (1): 17-24. doi:10.1007/PL00005133. PMID 9459568. ... "Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins". The FASEB Journal. 22 (8 ...
*  Attention deficit hyperactivity disorder
The DRD4 receptor is a G protein-coupled receptor that inhibits adenylyl cyclase. The DRD4-7R mutation results in a wide range ... Medications used include stimulants, atomoxetine, alpha-2 adrenergic receptor agonists, and sometimes antidepressants. In those ... The 7 repeat variant of dopamine receptor D4 (DRD4-7R) causes increased inhibitory effects induced by dopamine and is ... Conversely, methylphenidate, …showed poor efficacy at the TAAR1 receptor. In this respect it is worth noting that the ...
*  Margaret Hamburg
Chronic morphine administration increases the apparent number of alpha-2 adrenergic receptors in rat brain. Nature 291: 493-495 ... 116(Supplement 2): 59-63 Frieden, T.R., Fujiwara, P.I., Washko, R.M. and Hamburg, M.A. (1995) Turning the tide on tuberculosis ... Pugh, Tony (2/5/2015). "FDA commissioner Margaret Hamburg to step down in March". McClatchy DC. McClatchy Washington Bureau. ... 18(2): 27-30 Hamburg, M.A. (2001). Challenges facing public health agencies. Public Health Reports. Vol. ...
*  Alpha-2C adrenergic receptor
The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes ... Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit ... Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go". J. Biol. Chem. 267 ( ... ADRA2C adrenergic, alpha-2C-, receptor". Crassous PA, Cardinaletti C, Carrieri A, Bruni B, Di Vaira M, Gentili F, Ghelfi F, ...
*  Alpha-2B adrenergic receptor
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic ... Klein U, Ramirez MT, Kobilka BK, von Zastrow M (Aug 1997). "A novel interaction between adrenergic receptors and the alpha- ... McClue SJ, Milligan G (Sep 1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 ... α2-adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in ...
*  Tetrahydropalmatine
... alpha adrenergic and serotonin receptors. The Ki values for l-THP at D1 and D2 dopamine receptors are approximately 124 nM (D1 ... including alpha-1 adrenergic receptors, at which it functions as an antagonist, and GABA-A receptors, through positive ... Along with dopamine receptors, l-THP has been reported to interact with a number of other receptor types, ... In the case of 5-HT1A receptors, l-THP binds with a Ki of approximately 340 nM. Animal experiments have shown that the sedative ...
*  History of catecholamine research
... he called alpha adrenotropic receptor (now α-adrenoceptor or α-adrenergic receptor), while the receptor with the second rank ... now β-adrenoceptor or β-adrenergic receptor). ″This concept of two fundamental types of receptors is directly opposed to the ... that the adrenotropic inhibitory receptors and the cardiac chronotropic and inotropic adrenergic receptors are functionally ... J. W. Black; A. F. Crowther; R. G. Shanks; A. C. Dornhorst (1964). "A new adrenergic beta-receptor antagonist". The Lancet. 283 ...
*  Synephrine
The potency of synephrine at adrenergic receptors of the β-class (regardless of sub-type) is much lower than at α-receptors. ... differences in activity at alpha-1 and alpha-2 adrenergic receptors." J. Pharmacol. Exp. Ther. 224 559-566. T. Hibino, M. ... An adrenergic antagonist selective for α1 receptors. Reversal of reserpine-induced hypothermia by a drug is a classical test ... The binding of racemic synephrine to cloned human adrenergic receptors has been examined: Ma and co-workers found that ...
*  Delirium tremens
... as well as inhibiting NMDA receptors. This combined with desensitization of alpha-2 adrenergic receptors, results in a ... and tranquilizers such as barbiturates and benzodiazepines function as positive allosteric modulators at GABAA receptors, the ... January 2, 1945, reprinted February 17, 2015. Accessed February 15, 2017. "If you read the book, which was a best-seller last ...
*  Brimonidine/timolol
... a non-selective beta-adrenergic receptor inhibitor. Elevated IOP is considered the only modifiable risk factor in the ... Combigan is composed of brimonidine, a selective alpha-2 adrenergic receptor agonist, and timolol, ... It is a combination of brimonidine (an α2 adrenergic agonist) and timolol (a β adrenergic blocker), in concentrations of 0.2% ... 21 (2): 14. 2008. PMID 18326089. Lee, AJ; McCluskey, P (2008). "Fixed combination of topical brimonidine 0.2% and timolol 0.5% ...
*  Meldonium
... has also been found to induce anticonvulsant and antihypnotic effects involving alpha 2-adrenergic receptors as well ... oxide production via stimulation of the M3 muscarinic acetylcholine receptor or specific gamma-butyrobetaine ester receptors. ... 5 (2): 1-3. doi:10.1016/j.jshs.2016.06.008. Liepinsh E, Vilskersts R, Zvejniece L, Svalbe B, Skapare E, Kuka J, Cirule H, ... 11 (2): 151-68. doi:10.1111/j.1527-3458.2005.tb00267.x. PMID 16007237. Kuka J, Vilskersts R, Cirule H, Makrecka M, Pugovics O, ...
*  Alpha blocker
However, the most common type of alpha blocker is usually an α1 blocker. Non-selective α-adrenergic receptor antagonists ... are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors). Historically, alpha- ... Alpha-Blockers)" (PDF). British Hypertension Society. "CV Pharmacology , Alpha-Adrenoceptor Antagonists (Alpha-Blockers)". ... This is done by binding to the alpha receptors in smooth muscle or blood vessels. α-blockers can bind both reversibly and ...
*  4-NEMD
... ethyl-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors". Journal of Medicinal Chemistry. 37 (15): 2328-33. doi: ... Hong, SS; Romstedt, KJ; Feller, DR; Hsu, FL; George, C; Cupps, TL; Lyon, RA; Miller, DD (1992). "Resolution and adrenergic ... Like other alpha-2 agonists, it produces sedative and muscle relaxant effects but without producing respiratory depression. It ... 4-NEMD is a potent sedative drug which acts as a selective alpha-2 adrenergic agonist. It is closely related to dexmedetomidine ...
*  Adrenergic receptor
ISBN 0-443-06911-5. Alpha receptors illustrated The Adrenergic Receptors "Adrenoceptors". IUPHAR Database of Receptors and Ion ... Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 Cannon WB, Rosenbluth A (31 May 1933). "Studies On Conditions ... Basic Neurochemistry: α- and β-Adrenergic Receptors Brief overview of functions of the β3 receptor Theory of receptor ... a Gq coupled receptor) and α2 (a Gi coupled receptor). Phenylephrine is a selective agonist of the α receptor. β receptors have ...
*  Olney's lesions
In medical settings, NMDA receptor antagonists are used as anesthetics, so GABAA receptor positive allosteric modulators are ... Drugs that work to suppress NAN include anticholinergics, benzodiazepines, barbiturates and agonists at the alpha-2 adrenergic ... Jansen writes: Neuroscience portal NMDA receptor NMDA receptor antagonist Dissociative Neurotoxic drug Olney J, Labruyere J, ... receptor in the brain, such as clonidine. Conversely, coadministration of NMDA-antagonists with alpha-2 adrenergic antagonists ...
*  Biology of depression
... and decreased alpha 1 receptor density. Furthermore, norepinephrine transporter knockout in mice models increase their ... Finding indicative of decreased adrenergic activity in depression have been reported. Findings include decreased activity of ... 5-HT2A receptor binding appears to be unregulated in depressed patients. Studies on 5-HTT binding are variable but tend towards ... 5-HT1A receptor binding literature is inconsistent however it leans towards a general decrease in the mesiotemporal cortex. ...
*  Ephedrine
... works by turning on the α and β adrenergic receptors. Ephedrine was first isolated in 1885. It is on the World Health ... Pharmacological Effects of Ephedrine Alkaloids on Human {alpha}1- and {alpha}2-Adrenergic Receptor Subtypes Archived 2011-03-05 ... of the adrenergic receptor system by increasing the activity of norepinephrine at the postsynaptic α and β receptors. The ... on adrenergic receptors. It is most usually marketed as the hydrochloride or sulfate salt. Ephedrine exhibits optical isomerism ...
*  Fungal mating pheromone receptors
... is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand alpha ... Fungal pheromone mating factor receptors form a distinct family of G-protein-coupled receptors. Mating factor receptors STE2 ... Burkholder AC, Hartwell LH (1985). "The yeast alpha-factor receptor: structural properties deduced from the sequence of the ... and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisae alpha-factor receptor in ...
*  Guanabenz
... (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 adrenergic receptor ...