Loading...
*  Alpha-1A adrenergic receptor
1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic ... "Entrez Gene: ADRA1A adrenergic, alpha-1A-, receptor". Roberts LR, Fish PV, Ian Storer R, Whitlock GA (April 2009). "6,7-Dihydro ... Hoehe MR, Berrettini WH, Schwinn DA, Hsieh WT (1993). "A two-allele PstI RFLP for the alpha-1C adrenergic receptor gene (ADRA1C ...
*  Alpha-1 adrenergic receptor
Note that only active muscle α1-adrenergic receptors will be blocked. Resting muscle will not have its α1-adrenergic receptors ... In contrast to α2-adrenergic receptors, α1-adrenergic-receptors in the arterial vasculature of skeletal muscle are more ... The α1-adrenergic receptor has several general functions in common with the α2-adrenergic receptor, but also has specific ... α1-Adrenergic receptors are members of the G protein-coupled receptor superfamily. Upon activation, a heterotrimeric G protein ...
*  Post-traumatic amnesia
Administering a norepinephrine receptor agonist (a substance that initiates a cell response when it binds with a receptor) to ... The alpha-1 adrenergic receptor is specifically implicated. Although it has not yet been thoroughly investigated, there is ... these findings are based on the effects of other commonly prescribed drugs that happen to block noradrenergic receptors. ... 1 - 2 weeks - The injury is very severe, and recovery is likely to take many months. The patient is likely to experience long- ...
*  Cushing reflex
The nature of receptors mediating the Cushing response is also unknown. Some research suggests the existence of intracranial ... alpha-1 adrenergic receptors, causing constriction of the body's arteries. This constriction raises the total resistance of ... 31 (1): 8-17. doi:10.1161/01.res.31.1.8. PMID 4402639. Guyton, Arthur; Hall, John (2006). "Chapter 18: Nervous Regulation of ... Part 1: Observations at the time of intracranial hypertension". Acta Neurochir. 79 (2-4): 125-31. doi:10.1007/bf01407456. PMID ...
*  Pausinystalia johimbe
Among other alkaloids is corynanthine, an alpha-1 adrenergic receptor blocker and raubasine. Extracts from the bark of yohimbe ... ISBN 9789290814955 Doxey, JC; Lane AC; Roach AG; Virdee NK (Feb 1984). "Comparison of the alpha-adrenoceptor antagonist ...
*  Bronchospasm
Beta blockers bind into the β2 receptors and block the action of epinephrine and norepinephrine from binding to its receptors, ... Beta2-adrenergic agonists are recommended for bronchospasm. Short acting (SABA) Terbutaline Salbutamol Levosalbutamol Long ... Both of these medications activate alpha-1 adrenergic receptors that result in smooth muscle constriction. Non-selective beta ... all of which act as receptor antagonists of muscarinic acetylcholine receptors) are effective for treating asthma and COPD- ...
*  Prazosin
... alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord". Journal of chemical neuroanatomy. 13 (2): ... and syncope are associated with the body's poor ability to control blood pressure without active alpha-adrenergic receptors. ... A larger controlled Phase II "Clinical Trial of the Adrenergic Alpha-1 Antagonist Prazosin for Alcohol Dependence" is currently ... These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of ...
*  Bunazosin
Systemic Alpha-1 adrenergic receptor antagonists have been implicated in Intraoperative Floppy Iris Syndrome (IFIS). Bunazosin ... Bunazosin (INN) is an alpha 1 antagonist. Bunazosin was initially developed to treat benign prostatic hyperplasia (BPH). It has ...
*  Auditory cortex
alpha-1 adrenergic receptor activation, by norepinephrine, decreases glutamatergic excitatory postsynaptic potentials at AMPA ... receptors. The auditory cortex is the most highly organized processing unit of sound in the brain. This cortex area is the ... Dinh, L; Nguyen T; Salgado H; Atzori M (2009). "Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4- ... 1169 (1): 209-213. doi:10.1111/j.1749-6632.2009.04864.x. Archived from the original (PDF) on 15 April 2012. Retrieved 11 ...
*  Amitriptyline
... and 5-HT7 receptors, the α1-adrenergic receptor, the histamine H1 and H2 receptors, and the muscarinic acetylcholine receptors ... histamine H1 and alpha 1-adrenergic receptors in vitro". Schizophr. Res. 37 (1): 107-22. doi:10.1016/s0920-9964(98)00146-7. ... Bylund DB, Snyder SH (1976). "Beta adrenergic receptor binding in membrane preparations from mammalian brain". Mol. Pharmacol. ... and as an agonist of the sigma σ1 receptor. It has also been shown to be a relatively weak NMDA receptor antagonist via the ...
*  Alpha-1 blocker
Silodosin shows high affinity and selectivity for alpha-1a adrenergic receptors found in the prostate which ensures that it ... DrugDigest - Alpha blockers RxList.com - Tamsulosin alpha-Adrenergic Blockers at the US National Library of Medicine Medical ... Silodosin is the most selective for alpha-1a receptors. The affinity and selectivity for alpha-1 receptors seems to be ... also called alpha-adrenergic blocking agents) constitute a variety of drugs that block alpha-1-adrenergic receptors in arteries ...
*  2C-H
It was found to be an active Alpha-1 adrenergic receptor agonist in rabbit ear arteries. It has binding affinity towards 5-HT2C ... It exhibits binding affinity against rat 5-hydroxytryptamine 2C receptors using [3H]mesulergine as a radioligand. As of October ... and 5-HT2A receptors in rats. It features competitive antagonist activity at 5-HT serotonin receptor in Sprague-Dawley rat ... It exhibits agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with ...
*  Adrenalone
... is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Formerly, it was also used to prolong the ... It is the ketone form of epinephrine (adrenaline). Contrary to epinephrine, adrenalone mainly acts on alpha-1 adrenergic ... receptors, but has little affinity for beta receptors. The drug is largely obsolete, being superseded by other hemostatics such ... which is partly a consequence of the vasoconstriction caused by the drug via alpha-1 adrenergic receptors. In an (unspecified) ...
*  Dopamine (medication)
... dopamine mainly triggers dopamine receptors and β1-adrenergic receptors while at high doses it works via α-adrenergic receptors ... Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in ... and β2 adrenergic receptors. "Dopamine: Biological activity". IUPHAR/BPS guide to pharmacology. International Union of Basic ... Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine ...
*  Table of neurotransmitter actions in the ANS
Elliott, J. (1997). "Alpha-adrenoceptors in equine digital veins: Evidence for the presence of both alpha1 and alpha2-receptors ... "Effects of 3-Adrenergic Receptor Activation on Rat Urinary Bladder Hyperactivity Induced by Ovariectomy". Journal of ... Sagrada, A; Fargeas, M J; Bueno, L (1987). "Involvement of alpha-1 and alpha-2 adrenoceptors in the postlaparotomy intestinal ... ISBN 0-7817-7311-3. Schmitz, JM; Graham, RM; Sagalowsky, A; Pettinger, WA (1981). "Renal alpha-1 and alpha-2 adrenergic ...
*  Arteriole
... and pulmonary circulation vasodilate in response to these hormones when they act on beta-adrenergic receptors. Generally, ... are vasoconstrictive acting on alpha 1-adrenergic receptors. However, the arterioles of skeletal muscle, cardiac muscle, ... ISBN 0-13-981176-1. Riva, CE; Grunwald, JE; Petrig, BL (1986). "Autoregulation of human retinal blood flow. An investigation ...
*  Postural orthostatic tachycardia syndrome
The selective alpha 1 agonist phenylephrine has been used successfully to enhance venous return and stroke volume in some ... "Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments". Archives of ... In these patients the selective Alpha-1 Adrenergic receptor agonist Midodrine may increase venous return, enhance stroke volume ... POTS is more common in women, with a female-to-male ratio of 5:1. Most people with POTS are aged between 20 and 40, with an ...
*  L-765,314
Hillman KL, Doze VA, Porter JE (June 2007). "Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of ... alpha(1D)-, and alpha(2)-adrenoceptors". European Journal of Pharmacology. 613 (1-3): 86-92. doi:10.1016/j.ejphar.2009.04.011. ... It has mainly been used to investigate the role of α1B receptors in the regulation of blood pressure. The α1B receptor is also ... a potent and selective alpha1b adrenergic receptor antagonist ". Journal of Medicinal Chemistry. 41 (8): 1205-8. doi:10.1021/ ...
*  Filtration fraction
... which is possibly activated by alpha 1 adrenergic receptors. Severe haemorrhage will also result in an increased filtration ...
*  Alpha-1B adrenergic receptor
1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also ... 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis ... "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. ...
*  Alpha-1D adrenergic receptor
This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a ... 1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also ... 1995). "Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells". ...
*  Olanzapine
Due to compensatory changes at dopamine, serotonin, adrenergic and histamine receptor sites in the central nervous system, ... histamine H1 and alpha 1-adrenergic receptors in vitro". Schizophr. Res. 37 (1): 107-22. doi:10.1016/s0920-9964(98)00146-7. ... due to its high affinity for the D1 receptor over the D2 receptor. Antagonizing H1 histamine receptors causes sedation and may ... Additionally, olanzapine also exhibits a relatively low affinity for serotonin 5-HT1, GABAA, beta-adrenergic receptors, and ...
*  WB-4101
... is a compound which acts as an antagonist at the α1B-adrenergic receptor. It was one of the first selective antagonists ... 1969 Mar;12(2):326-9. PMID 5791620 Morrow AL, Creese I. Characterization of alpha 1-adrenergic receptor subtypes in rat brain: ... developed for this receptor and was invented in 1969, but is still commonly used in research into adrenergic receptors, ... Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety. Pharmaceutica Acta Helvetiae. 2000 Mar;74(2- ...
*  Synephrine
The potency of synephrine at adrenergic receptors of the β-class (regardless of sub-type) is much lower than at α-receptors. ... differences in activity at alpha-1 and alpha-2 adrenergic receptors." J. Pharmacol. Exp. Ther. 224 559-566. T. Hibino, M. ... An adrenergic antagonist selective for α1 receptors. Reversal of reserpine-induced hypothermia by a drug is a classical test ... The binding of racemic synephrine to cloned human adrenergic receptors has been examined: Ma and co-workers found that ...
*  Gq alpha subunit
... such as M3 receptor. The common polybasic domain in the C-tail of Gq-coupled receptors is necessary for the receptor-G protein ... the G-protein coupled receptors: 5-HT2 serotonergic receptors Alpha-1 adrenergic receptor Vasopressin type 1 receptors: 1A and ... Further reading: function of protein kinase C From modulatory neurotransmitter receptors (amine receptors belonging to ... and M5 muscarinic receptors Trace amine-associated receptor 1 It has been shown that Gq proteins are preassembled (pre-coupled ...
*  Meldonium
... has also been found to induce anticonvulsant and antihypnotic effects involving alpha 2-adrenergic receptors as well ... oxide production via stimulation of the M3 muscarinic acetylcholine receptor or specific gamma-butyrobetaine ester receptors. ... 5 (2): 1-3. doi:10.1016/j.jshs.2016.06.008. Liepinsh E, Vilskersts R, Zvejniece L, Svalbe B, Skapare E, Kuka J, Cirule H, ... Since 1 January 2016, it has been on the World Anti-Doping Agency (WADA) list of substances banned from use by athletes. ...