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*  Adiponectin receptor
... which are bound and activated by adiponectin: Adiponectin receptor 1 (AdipoR1, PAQR1) Adiponectin receptor 2 (AdipoR2, PAQR2) ... The adiponectin receptors (AdipoRs) include the following two receptors, ... A Novel Membrane Receptor Family Defined by an Ancient7-Transmembrane Pass Motif". Journal of Molecular Evolution. 61 (3): 372- ... They are members of the progestin and adipoQ receptor (PAQR) family. In 2016, the University of Tokyo announced it was ...
*  Adiponectin receptor 2
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate ... ADP-400 Adiponectin receptor Adiponectin receptor 1 GRCh38: Ensembl release 89: ENSG00000006831 - Ensembl, May 2017 GRCm38: ... Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene. It is a member of the progestin ... Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ...
*  Adiponectin receptor 1
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate ... Adiponectin ADP-355 ADP-399 AdipoRon (-)-Arctigenin Arctiin Gramine Matairesinol ADP-400 Adiponectin receptor Adiponectin ... "Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order ... "Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors". Biochemical and Biophysical ...
*  AdipoRon
... synthetic small-molecule agonist of the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) (Kd = 1.8 μM and ... small-molecule agonist of the adiponectin receptors to be identified. Adiponectin receptor agonists such as AdipoRon have ... As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. ... Holland, W. L.; Scherer, P. E. (2013). "Ronning After the Adiponectin Receptors". Science. 342 (6165): 1460-1461. doi:10.1126/ ...
*  APPL1
"APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function". Nature Cell Biology. 8 (5): 516-23. doi ... EGF receptor) which is dependent on Rab5 activation. PTB domain of APPL1 regulates many cell signalling events in specific ... Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A (May 2007). "Adiponectin-induced endothelial nitric oxide ... Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C (May 2003). "APPL suppresses androgen receptor transactivation via ...
*  APPL2
2006). "APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function". Nat. Cell Biol. 8 (5): 516-23. ...
*  Arctiin
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... They have been found to act as agonists of the adiponectin receptor 1. Arvind Saklani; Manas Ranjan Sahoo; Prabhu Dutt Mishra; ...
*  Gramine
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... Gramine has been found to act as an agonist of the adiponectin receptor 1 (AdipoR1). The LD50 of gramine is 44.6 mg/ kg iv in ...
*  Matairesinol
... has been found to act as an agonist of the adiponectin receptor 1 (AdipoR1). Matairesinol at Sigma-Aldrich ... "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLoS ONE. 8 ...
*  Arctigenin
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... It has been found to act as an agonist of adiponectin receptor 1 (AdipoR1). Hayashi, K.; Narutaki, K.; Nagaoka, Y.; Hayashi, T ...
*  Deoxyschizandrin
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... Deoxyschizandrin has been found to act as an agonist of the adiponectin receptor 2 (AdipoR2). Chang, R; Li, Y; Yang, X; Yue, Y ...
*  Parthenolide
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... induces MITF M isoform downregulation and senescence in MITF-Mhigh melanoma cells Agonist of the adiponectin receptor 2 ( ...
*  Taxifolin
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... Taxifolin has been found to act as an agonist of the adiponectin receptor 2 (AdipoR2). The enzyme taxifolin 8-monooxygenase ... Katavic PL, Lamb K, Navarro H, Prisinzano TE (August 2007). "Flavonoids as opioid receptor ligands: identification and ... has been found to act as a non-selective antagonist of the opioid receptors, albeit with somewhat weak affinity. ...
*  Christos Socrates Mantzoros
Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans. Mol Cancer ... Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of ... The Mantzoros group also demonstrated a direct effect of adiponectin and adiponectin receptors on endometrial cancer in humans ... Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA. 2008 Oct 1; ...
*  G protein-coupled receptor
Similar to GPCRs, the adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) also possess 7 transmembrane domains. However, ... transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors ( ... G protein-coupled receptors database List of MeSH codes (D12.776) Metabotropic receptor Orphan receptor Pepducins, a class of ... is a receptor that can bind with stimulative signal molecules, while inhibitory hormone receptor (Ri) is a receptor that can ...
*  Nicolas Bazan
They discovered that adiponectin receptor 1 (AdipoR1) is a regulator of these RPE cell functions and demonstrated that AdipoR1 ... Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival. Nat Commun. 2015;6:6228 https ... NMDA receptor-stimulated release of arachidonic acid: Mechanisms for the Bazan Effect. In Cell Signal Transduction, Second ... the PAF receptor. Moreover, his laboratory found that PAF modulates glutamate release and is a retrograde messenger of long- ...
*  Adiponectin
... and one receptor similar to the cadherin family: Adiponectin receptor 1 (AdipoR1) Adiponectin receptor 2 (AdipoR2) T-cadherin ... Nishio S, Gibert Y, Bernard L, Brunet F, Triqueneaux G, Laudet V (June 2008). "Adiponectin and adiponectin receptor genes are ... Adiponectin binds to a number of receptors. So far, two receptors have been identified with homology to G protein-coupled ... A small molecule adiponectin receptor AdipoR1 and AdipoR2 agonist, AdipoRon, has been reported. Interestingly, in 2016, the ...
*  Beta-3 adrenergic receptor
... adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-alpha expressions in adipose ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic ... The beta-3 adrenergic receptor (β3 adrenoreceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the ... "Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes". ...
*  T-cadherin
Two membrane adiponectin receptors with distant homology to seven-transmembrane spanning G-protein-coupled receptors, namely ... The properties of T-cadherin as an LDL receptor were markedly different from the presently known types of LDL receptors. LDL ... High-molecular weight (HMW) complexes of adiponectin were suggested to be a specific ligand for T-cadherin. Adiponectin ( ... Adiponectin binding to T-cadherin on vascular cells is associated with NF-kappa B activation. ...
*  Guide to Pharmacology
... sigma receptors and adiponectin receptors Information for each target group is subdivided into families based on classification ... Catalytic receptors Enzymes G protein-coupled receptors Ion channels Kinases Nuclear receptors Transporters Other protein ... Other features include 'Hot topic' news items and a recent receptor-ligand pairing list. The Guide to PHARMACOLOGY includes an ... As with the original IUPHAR-DB, the International Union of Basic and Clinical Pharmacology (IUPHAR) Committee on Receptor ...
*  Progestin and adipoQ receptor
It includes at least 11 receptors (PAQR1-PAQR11), including the adiponectin (adipoQ) receptors (AdipoRs), the membrane ... The progestin and adipoQ receptor (PAQR) family is a group of receptors related to but distinct from the G protein-coupled ... A Novel Membrane Receptor Family Defined by an Ancient7-Transmembrane Pass Motif". Journal of Molecular Evolution. 61 (3): 372- ... progesterone receptors (mPRs), and others. PAQR1 (AdipoR1) PAQR2 (AdipoR2) PAQR5 (mPRγ) PAQR6 (mPRδ) PAQR7 (mPRα) PAQR8 (mPRβ) ...
*  Santa Cruz Biotechnology
"Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies". J Clin ... "The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells". ...
*  Harvey Lodish
... the erythropoietin receptor, two subunits of the TGFß receptor, and several adipocyte-specific proteins including adiponectin ( ... Current efforts of his group focus on: Erythropoiesis - activation of and signal transduction by the erythropoietin receptor in ... and clarified the role of pH changes in delivery of iron to cells and recycling of the transferrin receptor. His group has ... and a family of adiponectin homologs. Elucidating the roles of microRNAs in regulating hematopoiesis and fat and muscle cell ...
*  Chemerin
... and reduces the expression of GLUT4 and adiponectin, while increasing expression of IL-6 and insulin receptor. Furthermore, ... These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor ... RARRES2 is thought to act as a cell surface receptor. Chemerin is a chemoattractant protein that acts as a ligand for the G ... "Entrez Gene: RARRES2 retinoic acid receptor responder (tazarotene induced) 2". Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, ...
*  Caloric restriction mimetic
Adiponectin (together with leptin, it regulates adipose tissue metabolism. It is activated by PPAR inhibitors such as ... It enhances the sensitivity of insulin receptors on the surface of muscle and fat cells and activates genes that reduce the ... Peroxisome proliferator-activated receptor gamma inhibitors, such as Rosiglitazone and Gugulipids, working as insulin ... It also blocks the beneficial actions of adiponectin. Rimonabant inhibits these and so it reduces appetite, balances energy, ...
*  Hyperinsulinemia
As more GLUT4 receptors are present on the membrane more glucose is taken up into cells decreasing blood glucose levels which ... Weyer "et al,." (2011) reported that hyperinsulinemia is strongly associated with low adiponectin concentrations in obese ... the cells of the body become resistant to the effects of insulin as the receptors which bind to the hormone become less ... on improving insulin sensitivity is not well understood however it is thought that exercise causes the glucose receptor GLUT4 ...