Loading...
*  Brain-derived neurotrophic factor
The TrkB receptor is encoded by the NTRK2 gene and is member of a receptor family of tyrosine kinases that includes TrkA and ... While the TrkB receptor interacts with BDNF in a ligand-specific manner, all neurotrophins can interact with the p75 receptor. ... Recent studies have revealed a truncated isoform of the TrkB receptor (t-TrkB) may act as a dominant negative to the p75 ... BDNF signaling leads to the autophosphorylation of the intracellular domain of the TrkB receptor (ICD-TrkB). Upon ...
*  N-Acetylserotonin
It also has biological activity in its own right, including acting as a melatonin receptor agonist, an agonist of the TrkB, and ... February 2010). "N-acetylserotonin activates TrkB receptor in a circadian rhythm". Proceedings of the National Academy of ... NAS has been shown to act as a potent TrkB receptor agonist, while serotonin and melatonin do not. Subchronic and chronic ... blockage of TrkB abolished this effect suggesting that it is TrkB-dependent. NAS was also found to significantly enhance NPC ...
*  LINGO1
Further more it binds to BDNF receptor and TrkB inhibiting the activation of TkrB by binding of BNDF after the induction of ... LINGO-1 is a co-receptor that interacts with the ligand-binding Nogo-66 receptor (NogoR) in the Nogo receptor signaling complex ... The Nogo receptor complex is formed when Nogo-66 binds to its receptor. LINGO-1 is an homotetramer which forms a ternary ... LINGO-1 is a functional component of the Nogo (neurite outgrowth inhibitor) receptor also known as the reticulon 4 receptor. It ...
*  Low-affinity nerve growth factor receptor
TrkB, or TrkC signaling in cells that also express those receptors. LNGFR functions in a complex with Nogo receptor (NgR, ... LNGFR is a member of the tumor necrosis factor receptor (TNF receptor)superfamily - indeed, LNGFR was the first member of this ... NGF is released from the target cells, binds to and activates its high-affinity receptor tropomyosin receptor kinase A (TrkA), ... The low-affinity nerve growth factor receptor (nerve growth factor receptor (TNFR superfamily, member 16), also called the ...
*  Diosmetin
It has been found to act as a weak TrkB receptor agonist. Diosmetin is the diosmin aglycone. Tropomyosin receptor kinase B § ... "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone". Proc. Natl. Acad. Sci. U.S.A. 107 (6): ...
*  7,8-Dihydroxyflavone
Jiang M, Peng Q, Liu X, Jin J, Hou Z, Zhang J, Mori S, Ross CA, Ye K, Duan W (2013). "Small-molecule TrkB receptor agonists ... Zeng Y, Wang X, Wang Q, Liu S, Hu X, McClintock SM (2013). "Small molecules activating TrkB receptor for treating a variety of ... It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 ... In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects ...
*  7,8,3'-Trihydroxyflavone
7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived ... a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo". ... "Protection of Spiral Ganglion Neurons from Degeneration Using Small-Molecule TrkB Receptor Agonists". Journal of Neuroscience. ... hydroxy group on the B-ring enhances TrkB agonistic activity. 7,8,3'-THF has been tested in vivo and was found to produce TrkB- ...
*  Role of microglia in disease
BDNF released from microglia induces neuronal hyperexcitability through interaction with the TrkB receptor. Therapeutic ... A causal role for microglia in the pathogenesis of neuropathic pain has been demonstrated through P2X4 receptor. P2X4 receptors ... "HIV-1 can enter the microglial cell via CD4 receptors and chemokine co-receptors such as CCR3, CCR5, and CXCR4, with CCR5 being ... The chemokine receptor, CX3CR1, is expressed by microglia in the central nervous system. Fractalkine (CX3CL1) is the exclusive ...
*  Neurotrophin-4
It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. Tropomyosin receptor kinase B ... 2006). "Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults". Mol. Hum. Reprod ... 2008). "Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/ ... 2008). "Neurotrophins and their receptors stimulate melanoma cell proliferation and migration". J. Invest. Dermatol. 128 (8): ...
*  Tropomyosin receptor kinase B
... (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or ... Each type of Trk receptor tends to bind specific neurotrophins: TrkA is the receptor for NGF, TrkB the receptor for BDNF and NT ... Other examples of tyrosine kinase receptors include the insulin receptor, the IGF1 receptor, the MuSK protein receptor, the ... The TrkB receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable ...
*  Neurotrophin
... given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB). Mice born without the ... 2010). "Neurotrophin receptor TrkA and TrkC cause neuronal death whereas TrkB does not". Nature. 467: 59-63. doi:10.1038/ ... Neurotrophin-4 (NT-4) is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. It is also ... There are two classes of receptors for neurotrophins: p75 and the "Trk" family of Tyrosine kinases receptors. Nerve growth ...
*  Trk receptor
Each type of Trk receptor tends to bind specific neurotrophins: TrkA is the receptor for NGF, TrkB the receptor for BDNF and NT ... The three most common types of trk receptors are trkA, trkB, and trkC. Each of these receptor types has different binding ... In a similar study on a mouse mutant with reduced expression of trkB receptors, LTP of CA1 cells reduced significantly. TrkB ... Trk receptors All neurotrophins bind to a class of highly homologous receptor tyrosine kinases known as Trk receptors, of which ...
*  NUMB (gene)
Numb binds to TrkB receptors to act as an endocytic regulator of TrkB and promote aPKC activation by acting as a scaffolding ... BDNF can function as a chemotactic factor for neural precursors during migration by activating TrkB receptors. ... Endocytosis supports the relocalization of the chemotactic receptor to the front of the cell to promote receptor-mediated ... Notch is a transmembrane signaling receptor that is activated by DSL family ligands. Notch binds the ligands Delta and Serrate ...
*  Amitriptyline
"Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic ... and 5-HT7 receptors, the α1-adrenergic receptor, the histamine H1 and H2 receptors, and the muscarinic acetylcholine receptors ... Recently, amitriptyline has been demonstrated to act as an agonist of the TrkA and TrkB receptors. It promotes the ... and as an agonist of the sigma σ1 receptor. It has also been shown to be a relatively weak NMDA receptor antagonist via the ...
*  4'-Dimethylamino-7,8-dihydroxyflavone
"Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease". ... "Small Molecules Activating TrkB Receptor for Treating a Variety of CNS Disorders". CNS & Neurological Disorders - Drug Targets ... Tropomyosin receptor kinase B § Agonists Liu, Xia; Chan, Chi-Bun; Jang, Sung-Wuk; Pradoldej, Sompol; Huang, Junjian; He, Kunyan ... 4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF) is a synthetic flavone and selective small-molecule agonist of TrkB, the ...
*  Tropomyosin receptor kinase A
Each type of Trk receptor tends to bind specific neurotrophins: TrkA is the receptor for NGF, TrkB the receptor for BDNF and NT ... "Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic ... Trk receptors All neurotrophins bind to a class of highly homologous receptor tyrosine kinases known as Trk receptors, of which ... It is a selective pan-trk receptor tyrosine kinase inhibitor (TKI) targeting gene fusions in trkA, trkB, and trkC (coded by ...
*  P2RX4
BDNF released from microglia induces neuronal hyperexcitability through interaction with the TrkB receptor. More importantly, ... The P2X4 receptor has a typical P2X receptor structure. The zebrafish P2X4 receptor was the first purinergic receptor to be ... The desensitization of P2X4 receptors is intermediate when compared to P2X1 and P2X2 receptors. P2X4 receptors respond to ATP, ... The P2X4 receptor is a ligand-gated cation channel that opens in response to ATP binding. The P2X4 receptor has high calcium ...
*  Molecular and epigenetic mechanisms of alcoholism
BDNF binds TrkB receptors whose subsequent activation results in dimerization and autophosphorylation of the receptor. In its ... receptors are glutamate receptors particularly important in long-term potentiation in neurons. These receptors have been linked ... Another family of receptors, metabotropic glutamate receptors (mGluR), may also contribute by activating MAPK pathways and ... In chronic ethanol users, ethanol binds to GABA receptors causing the down-regulation of GABA receptors; which are now less ...
*  HIOC
... is a small-molecule agent which acts as a selective TrkB receptor agonist (active at at least 100 nM; prominent activation ... as producing long-lasting activation of the TrkB receptor and downstream signaling kinases associated with the receptor. HIOC ... Tropomyosin receptor kinase B § Agonists Longo, Frank M.; Massa, Stephen M. (2013). "Small-molecule modulation of neurotrophin ... In animal studies, HIOC was found to robustly protect against glutamate-induced excitotoxicity, an action which was TrkB- ...
*  Semax
... and its signaling receptor TrkB in the hippocampus, and rapidly activates serotonergic and dopaminergic brain systems. In ... Semax did not antagonize α-MSH at the MC3 receptor, though this receptor could still be a target of the drug. As for the MC1 ... In addition to actions at receptors, Semax, as well as a related peptide drug, Selank, have been found to inhibit enzymes ... Specifically, there is a report of Semax competitively antagonizing the action of the melanocortin receptor full agonist α- ...
*  Dendritic spine
... s express glutamate receptors (e.g. AMPA receptor and NMDA receptor) on their surface. The TrkB receptor for ... NMDA receptors, which have a high permeability for calcium, only conduct ions if the membrane potential is suffiently ... Glutamate receptors (GluRs) are localized to the postsynaptic density, and are anchored by cytoskeletal elements to the ... BDNF partially determines spine levels, and low levels of AMPA receptor activity is necessary to maintain spine survival, and ...
*  Larotrectinib
It is an inhibitor of tropomyosin kinase receptors TrkA, TrkB, and TrkC. It was discovered by Array BioPharma and licensed to ...
*  Chloride potassium symporter 5
KCC2 is transcriptionally downregulated following central nervous system injury by the TrkB receptor signalling transduction ... Thus, during embryonic development, the chloride gradient is such that stimulation of GABAA receptors and glycine receptors at ... At this stage, GABAA receptors and glycine receptors act as excitatory rather than inhibitory effectors on postsynaptic neurons ... the chloride gradient across the cellular membrane is reversed such that GABAA receptor and glycine receptor stimulation causes ...
*  Neurotrophin-3
... given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB - see below). Mice born ... NT-3 also binds a second-receptor type besides Trk receptors, called the LNGFR (for "low affinity nerve growth factor receptor ... there are other related Trk receptors, TrkA and TrkB. Also as mentioned, there are other neurotrophic factors structurally ... NT-3 is capable of binding and signaling through a TrkC-related receptors called TrkB. Finally, ...
*  Neurotrophic factors
... and shares the TrkB receptor with NT-4. The brain-derived neurotrophic factor/TrkB system promotes thymocyte survival, as ... Later studies determined GDNF uses a receptor tyrosine kinase and a high-affinity ligand-binding co-receptor GFRα. GDNF has an ... The ephrins are a family of neurotrophic factors that signal through eph receptors, a class of receptor tyrosine kinases; the ... has the unique receptor, TrkC. In fact, the discovery of the different receptors helped differentiate scientists understanding ...
*  Signaling peptide receptor
An example is the tropomyosin receptor kinase B (TrkB), which is bound and activated by the neurotrophic protein brain-derived ... Neuropeptide receptor Neurotransmitter receptor Peptide receptor at the US National Library of Medicine Medical Subject ... A signaling peptide/protein receptor is a type of receptor which binds one or more signaling peptides or signaling proteins. ... neurotrophic factor (BDNF). Another example is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide ...