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*  Midkine
A molecular complex containing receptor-type tyrosine phosphatase zeta (PTPζ), low density lipoprotein receptor-related protein ... "Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases ... 1999). "A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. ... 2000). "LDL receptor-related protein as a component of the midkine receptor". Biochem. Biophys. Res. Commun. 270 (3): 936-41. ...
*  Protein primary structure
Similar to phosphorylated tyrosines, sulfated tyrosines are used for specific recognition, e.g., in chemokine receptors on the ... Such reactions are catalyzed by kinases and the reverse reaction is catalyzed by phosphatases. The phosphorylated tyrosines are ... Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure ... The protein is activated by cleaving off the inhibitory peptide. Some proteins even have the power to cleave themselves. ...
*  PTK7
Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is ... Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack ... Banga SS, Ozer HL, Park SK, Lee ST (1997). "Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to ... "Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its ...
*  Non-receptor tyrosine kinase
... to tyrosine residues in proteins. Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that ... Unlike the receptor tyrosine kinases (RTKs), the second subgroup of tyrosine kinases, the non-receptor tyrosine kinases are ... Non-receptor tyrosine kinases do not contain only a tyrosine kinase domain, nRTKs also possess domains that mediate protein- ... Thirty-two non-receptor tyrosine kinases have been identified in human cells (EC 2.7.10.2). Non-receptor tyrosine kinases ...
*  MST1R
1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 ... 2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid ... "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. 8 (5): 1195-202. PMID 8386824. "Entrez Gene: ... It is related to the c-MET receptor tyrosine kinase. MST1R has been shown to interact with Grb2. GRCh38: Ensembl release 89: ...
*  Signal transduction
Receptor tyrosine kinases (RTKs) are transmembrane proteins with an intracellular kinase domain and an extracellular domain ... Roskoski R (Jun 2004). "The ErbB/HER receptor protein-tyrosine kinases and cancer". Biochemical and Biophysical Research ... Histidine-specific protein kinases are structurally distinct from other protein kinases and are found in prokaryotes, fungi, ... Intracellular receptors, such as nuclear receptors and cytoplasmic receptors, are soluble proteins localized within their ...
*  EPHA8
Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta". Curr. Opin. Neurobiol. 8 (1): 117-27. doi: ... Park S, Sánchez MP (1997). "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three ... This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related ... Park S, Frisén J, Barbacid M (1997). "Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors ...
*  EPH receptor B2
Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is ... new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene. 6 (6): 1057-61. PMID 1648701. "Entrez Gene: ... Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. Ephrin receptors and their ligands, the ... "Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells". ...
*  EPH receptor A2
... an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases". Mol. Cell. Biol. 10 (12): 6316- ... This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have ... "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". J. Biol. Chem. 269 ( ... "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". J. Biol. Chem. 269 ( ...
*  PIK3R2
"Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of ... "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site". Oncogene ... "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the ... "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein ...
*  EPH receptor A4
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have ... 1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases". Oncogene. 10 (5): 897- ... Aasheim HC, Terstappen LW, Logtenberg T (1997). "Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in ... EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene. ...
*  EPH receptor A5
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have ... 1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases". Oncogene. 10 (5): 897- ... "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment ... Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor ...
*  EPHA7
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have ... the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor ... 1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases". Oncogene. 10 (5): 897- ... Ciossek T, Ullrich A (1997). "Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1". ...
*  Ephrin
Eph receptors in turn compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Since ephrin ligands ( ... a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases". Cell. 82 (3): 359-370. doi:10.1016/0092-8674(95) ... Ephrins (also known as ephrin ligands or Eph family receptor interacting proteins) are a family of proteins that serve as the ... The ephrin protein family of class A and class B guides ligands with the EphB family cell-surface receptors to provide a steady ...
*  Ephrin B3
The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. EPH receptors typically ... a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics. 41 (1): 17- ... 1996). "Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor ... as opposed to the cell with the receptor. Upon receptor-ligand interaction the tyrosine residues become phosphorylated and ...
*  Ephrin receptor
... an EPH family receptor protein tyrosine kinase, in various human tumors". Cancer Res. 54 (14): 3645-50. PMID 8033077. Easty DJ ... Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their corresponding ephrin ... The Eph receptors were initially identified in 1987 following a search for tyrosine kinases with possible roles in cancer, ... George SE, Simokat K, Hardin J, Chisholm AD (Mar 1998). "The VAB-1 Eph receptor tyrosine kinase functions in neural and ...
*  Ephrin B2
The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been ... "Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk". Proceedings of the National Academy of ... "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 ( ... "Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during ...
*  Major sperm protein
MSP binds to VAB-1 which is an Eph receptor protein-tyrosine kinase on oocytes. In absence of MSP, the VAB-1 Eph receptor ... This protein is distributed in vesicles throughout the pseudopodal membrane. Tyrosine kinases, which are pH sensitive, ... The major sperm protein (MSP) is a nematode specific small protein of 126 amino acids with a molecular weight of 14 kDa. It is ... It is the most abundant protein present in nematode sperm, comprising 15% of the total protein and more than 40% of the soluble ...
*  EPH receptor B4
Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene ... 1996). "Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium". Biochem. ... 1994). "Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis ... "Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung ...
*  RET proto-oncogene
"The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ... "Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7". J. Biol. ... anchored co-receptor. The co-receptors themselves are classified as members of the GDNF receptor-α (GFRα) protein family. ... The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF ...
*  Ephrin A4
The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been ... 1995). "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins". Oncogene. 10 ... "Characterization of ephrin-A1 and ephrin-A4 as ligands for the EphA8 receptor protein tyrosine kinase". Mol. Cells. 9 (4): 440- ... "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 ( ...
*  SORBS2
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. In non-muscle ... ArgBP2 protein, also referred to as Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the ... Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ...
*  ROS1
The protein may function as a growth or differentiation factor receptor. ROS1 is a receptor tyrosine kinase (encoded by the ... The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. ... "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces ... Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly ...
*  VAV3
2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and ... "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces ... 2002). "Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation". J. Exp. Med. 195 (2): 189 ... "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. United ...
*  GRB10
"The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ... Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is ... "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ... this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases ...
*  Proto-oncogene tyrosine-protein kinase Src
... adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. Most studies have looked at ... A number of tyrosine kinase inhibitors that target c-Src tyrosine kinase (as well as related tyrosine kinases) have been ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ... The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by CSK. ...
*  GAS6
Prieto AL, Weber JL, Lai C (2000). "Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing ... "The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases ... "Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6". Nature. ... "Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by ...