Loading...
*  Vorapaxar
... (brand name Zontivity, formerly known as SCH 530348) is a thrombin receptor (protease-activated receptor, PAR-1) ... Vorapaxar is a new anti-platelet drug that is part of the PAR-1 antagonist family, a new class of anti-platelet drug. It ... 2012). "Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes". New England Journal of Medicine. 366 (1): 20-33. ... This family of medication, PAR-1 antagonists in general has been associated with an increased risk of intracranial bleeding ...
*  Coagulation factor II receptor
Proteolytic cleavage leads to the activation of the receptor. PAR-1 has multifaceted effects and plays a key role in mediating ... Tellez C, Bar-Eli M (May 2003). "Role and regulation of the thrombin receptor (PAR-1) in human melanoma". Oncogene. 22 (20): ... Howell DC, Laurent GJ, Chambers RC (Apr 2002). "Role of thrombin and its major cellular receptor, protease-activated receptor-1 ... receptor is a protein that in humans is encoded by the F2R gene. PAR1 is a G protein-coupled receptor involved in the ...
*  F2RL2
Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2 ... 1998). "The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization ... 2003). "The pattern of expression of protease-activated receptors (PARs) during early trophoblast development". J. Pathol. 200 ... 1997). "Protease-activated receptor 3 is a second thrombin receptor in humans". Nature. 386 (6624): 502-6. doi:10.1038/386502a0 ...
*  F2RL3
Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in ... 2002). "Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release ... Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors ... receptor-like 3". Leger AJ, Covic L, Kuliopulos A (2006). "Protease-activated receptors in cardiovascular diseases". ...
*  List of MeSH codes (D12.776.395)
... receptor, par-1 MeSH D12.776.395.550.625.800.800 -- thrombomodulin MeSH D12.776.395.550.625.905 -- p-selectin MeSH D12.776. ... receptors, thrombin MeSH D12.776.395.550.625.800.780 -- platelet glycoprotein gpib-ix complex MeSH D12.776.395.550.625.800.790 ... receptors, lymphocyte homing MeSH D12.776.395.550.200.625.144 -- antigens, cd44 MeSH D12.776.395.550.200.625.347 -- integrin ... desmoglein 1 MeSH D12.776.395.550.200.200.500.500.625 -- desmoglein 2 MeSH D12.776.395.550.200.200.500.500.750 -- desmoglein 3 ...
*  List of MeSH codes (D12.776.543)
... receptor, par-2 MeSH D12.776.543.750.792.500 -- receptors, thrombin MeSH D12.776.543.750.792.500.500 -- receptor, par-1 MeSH ... receptors, serotonin, 5-ht4 MeSH D12.776.543.750.100.875.500 -- receptor, par-1 MeSH D12.776.543.750.100.900.500 -- receptors, ... receptors, thyrotropin-releasing hormone MeSH D12.776.543.750.750.850.399 -- receptor, par-1 MeSH D12.776.543.750.750.850.800 ... receptor, erbb-2 MeSH D12.776.543.750.060.437 -- receptor, erbb-3 MeSH D12.776.543.750.060.468 -- receptor, igf type 1 MeSH ...
*  Multiple electrode aggregometry
Thrombin receptor activating peptide-6 (TRAP-6) activates platelets through the thrombin receptor protease activated receptor-1 ... PAR-1). Binding of TRAP-6 to PAR-1 causes a conformational change in the GPIIb/IIIa receptors on platelets, giving them high ... Activation of the P2Y1 receptor initiates platelet aggregation in response to ADP. The P2Y1 receptor is required for ADP- ... When it is added to saline-diluted whole blood in the test cuvette, it stimulates the ADP receptors on platelets, activating ...
*  Thrombin
Acting via its specific cell membrane receptors (protease activated receptors: PAR-1, PAR-3 and PAR-4), which are abundantly ... Howell DC, Laurent GJ, Chambers RC (April 2002). "Role of thrombin and its major cellular receptor, protease-activated receptor ... Han X, Lan X, Li Q, Gao Y, Zhu W, Cheng T, Maruyama T, Wang J (June 2016). "Inhibition of prostaglandin E2 receptor EP3 ... De Cristofaro R, De Candia E (June 2003). "Thrombin domains: structure, function and interaction with platelet receptors". ...
*  Protease-activated receptor 2
Mirza H, Yatsula V, Bahou WF (April 1996). "The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human ... Additionally, these receptors can be activated by exogenous proteases, such as house dust mite protein Der P9. These receptors ... Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein ... "Protease-Activated Receptors: PAR2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
*  Protein C
The activation of protein C is strongly promoted by thrombomodulin and endothelial protein C receptor (EPCR), the latter of ... When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, ... Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (June 2002). "Activation of endothelial cell protease activated receptor 1 ... In 2002, Science published an article that first showed protein C activates protease-activated receptor-1 (PAR-1) and this ...
*  Antiplatelet drug
... affects the ADP-dependent activation of IIb/IIIa complex Glycoprotein IIb/IIIa receptor antagonists block a receptor on the ... PAR-1) antagonists Vorapaxar (Zontivity) Glycoprotein IIB/IIIA inhibitors (intravenous use only) Abciximab (ReoPro) ... receptor inhibitors Clopidogrel (Plavix) Prasugrel (Effient) Ticagrelor (Brilinta) Ticlopidine (Ticlid) Phosphodiesterase ... Thromboxane inhibitors Thromboxane synthase inhibitors Thromboxane receptor antagonists Terutroban Prevention and treatment of ...
*  Poliovirus receptor-related 1
Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 ... Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a ... Cocchi F, Lopez M, Menotti L, Aoubala M, Dubreuil P, Campadelli-Fiume G (1999). "The V domain of herpesvirus Ig-like receptor ( ... Subfamily Related to the Poliovirus Receptor Has the Attributes of a Bona Fide Receptor for Herpes Simplex Virus Types 1 and 2 ...
*  Tachykinin receptor 2
Zhao A, Shea-Donohue T (Oct 2003). "PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors". ... Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are ... "Tachykinin Receptors: NK2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... Substance-K receptor is a protein that in humans is encoded by the TACR2 gene. This gene belongs to a family of genes that ...
*  Protease-activated receptor
... which binds intramolecularly to activate the receptor. Four types of PAR receptors have been identified by molecular cloning, ... In the cleaved state, part of the receptor itself acts as the agonist, causing a physiological response. Most of the PAR family ... It has been determined that a large group of proteases cleave and activate PARs receptors, including proteases from: a) the ... In this sense, here we report that TFF3 isolated from human breast milk activates PAR-2 receptors of intestinal epithelial ...
*  A-77636
"Effects of full D1 dopamine receptor agonists on firing rates in the globus pallidus and substantia nigra pars compacta in vivo ... "Persistent activation of the dopamine D1 receptor contributes to prolonged receptor desensitization: studies with A-77636". The ... "Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors". Neuropharmacology. ... A-77636 is a synthetic drug which acts as a selective D1 receptor full agonist. It has nootropic, anorectic, rewarding and ...
*  F11 receptor
Itoh M, Sasaki H, Furuse M, Ozaki H, Kita T, Tsukita S (Aug 2001). "Junctional adhesion molecule (JAM) binds to PAR-3: a ... a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor ... cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor". The Biochemical Journal ... F11 receptor has been shown to interact with MLLT4, CASK and Tight junction protein 1. GRCh38: Ensembl release 89: ...
*  PAR1
... may refer to: PAR1 (gene) par-1 gene, Serine/threonine-protein kinase par-1 in Caenorhabditis elegans is required for ... asymmetric cell division of zygote after fertilization Coagulation factor II receptor Parchive, a data archive format PAR1, one ...
*  FLOT2
Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis ... is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". ... is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". ... is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal ...
*  NCRUPAR
It is located upstream of the PAR-1 gene and upregulates PAR-1 expression. Long noncoding RNA Madamanchi NR, Hu ZY, Li F, ... 2002). "A noncoding RNA regulates human protease-activated receptor-1 gene during embryogenesis". Biochim Biophys Acta. 1576 (3 ...
*  J-113,397
Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal ... J-113,397 is an opioid drug which was the first compound found to be a highly selective antagonist for the nociceptin receptor ... 2008 Mar;54(3):564-8. PMID 18082848 Marti M, Trapella C, Viaro R, Morari M. The nociceptin/orphanin FQ receptor antagonist J- ... PMID 17287504 Viaro R, Sanchez-Pernaute R, Marti M, Trapella C, Isacson O, Morari M. Nociceptin/orphanin FQ receptor blockade ...
*  Pleiotrophin
or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. Pleiotrophin binds to cell- ... 1994). "Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as ... surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection. GRCh38: Ensembl release 89: ... 68 (1): 57-64. doi:10.1016/0306-4522(95)00110-5. PMID 7477935. Yeh HJ, He YY, Xu J, Hsu CY, Deuel TF (1998). "Upregulation of ...
*  CBD-DMH
Abnormal cannabidiol Cannabinoid receptors HU-211 HUF-101 O-1871 O-1918 NESS-040C5 Leite JR, Carlini EA, Lander N, Mechoulam R ... doi:10.1039/B416943C Razdan RK, Pars HG, Thompson WR, Granchelli FE (1974). "Lithium-ammonia reduction of tetrahydrocannabinols ... was found to be a directly acting cannabinoid receptor agonist with a Ki of 17.4nM at CB1 and 211nM at CB2, and produces ... binding to cannabinoid receptor, and evaluation of their antiinflammatory activity. J Med Chem. 2006 Feb 9;49(3):1113-7. PMID ...
*  Poliovirus receptor-related 3
Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 ... Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily ... PVRL3 poliovirus receptor-related 3". Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, ... "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing ...
*  Pepducin
Kuliopulos A, Covic L (December 2003). "Blocking receptors on the inside: pepducin-based intervention of PAR signaling and ... Pepducins employ lipidated fragments of intracellular G protein-coupled receptor loops to modulate GPCR action in targeted cell ... Pepducins are cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G ... O'Callaghan, K.; Kuliopulos, A.; Covic, L. (2012). "Turning Receptors On and Off with Intracellular Pepducins: New Insights ...
*  GABA receptor
Tomiko SA, Taraskevich PS, Douglas WW (February 1983). "GABA acts directly on cells of pituitary pars intermedia to alter ... GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein- ... Over-excitation of this receptor induces receptor remodeling and the eventual invagination of the GABA receptor. As a result, ... Members of this superfamily, which includes nicotinic acetylcholine receptors, GABAA receptors, glycine and 5-HT3 receptors, ...
*  Cushing's syndrome
This atrophy is associated with areas of high glucocorticoid receptor concentrations such as the hippocampus and correlates ... For more information on the form in horses, see pituitary pars intermedia dysfunction. Addison's disease Adrenal insufficiency ... Mifepristone is a powerful glucocorticoid type II receptor antagonist and, since it does not interfere with normal cortisol ... 86 (1): 117-23. doi:10.1210/jcem.86.1.7093. PMID 11231987. Ezzat S, Asa SL, Couldwell WT, et al. (2004). "The prevalence of ...