"Identification of a mutated receptor-like protein tyrosine phosphatase kappa as a novel, class II HLA-restricted melanoma ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ... "The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1". Protein Sci. 15 (6): 1500-5. ... "Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function". J Biol Chem. 280 (52): ...

... alpha 1 Protein kinase, AMP-activated, alpha 1 Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting ... class II, DP alpha 1 Major histocompatibility complex, class II, DQ alpha 1 Myosin light chain A1, an actin-binding protein ... A receptor, alpha 1 Gap junction protein, alpha 1 GDNF family receptor alpha 1 Glutathione S-transferase A1 Glycine receptor, ... a human protein Outer membrane phospholipase A1, a bacterial protein receptors α-1-Adrenoceptor, an adrenergic receptor with ...

"The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1". Protein Sci. 15 (6): 1500- ... The class II PTPs contain only one member, low-molecular-weight phosphotyrosine phosphatase (LMPTP). Cdc25 phosphatases (dTyr ... a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate Protein tyrosine (pTyr) phosphorylation is a common post ... Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes ...

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have ... "Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 ... "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". J. Biol. Chem. 277 (42 ... an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases". Mol. Cell. Biol. 10 (12): 6316- ...

In addition to HLA-DR, the protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (1p13.2 - PTPN22), "CT/TT" genotype ... Anti-topoisomerase antibodies can be classified according to their immunoglobulin class (IgM, IgG or IgA). IgG-ATA is found ... 2006). "Association of the protein tyrosine phosphatase, non-receptor type 8 R620W polymorphism with anti-topoisomerase I- and ... Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA ...

The PI3K is activated by G protein-coupled receptors and tyrosine kinase receptors. Class I PI3Ks are heterodimeric molecules ... P3 phosphatase PTEN that antagonises PI3K signaling is absent from many tumours. In addition, the epidermal growth factor ... The PI3K family is divided into four different classes: Class I, Class II, Class III, and Class IV. The classifications are ... Class II comprises three catalytic isoforms (C2α, C2β, and C2γ), but, unlike Classes I and III, no regulatory proteins. Class ...

Two important classes of tyrosine kinase in tyrosine phosphorylation are receptor tyrosine kinase and nonreceptor tyrosine ... and opposing the action of the tyrosine kinases were 108 protein phosphatases that can remove phosphate from P.Tyr in proteins ... whereas protein tyrosine phosphatases (PTPs) remove the phosphate group from phosphotyrosine. Tyrosine phosphorylation of ... Receptor tyrosine kinases are type I transmembrane proteins possessing an N-terminal extracellular domain, which can bind ...

The PD-1 protein in humans is encoded by the PDCD1 gene. PD-1 is a cell surface receptor that belongs to the immunoglobulin ... This is consistent with binding of SHP-1 and SHP-2 phosphatases to the cytoplasmic tail of PD-1 upon ligand binding. In ... Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-1 inhibitors, a new class of ... The intracellular tail contains two phosphorylation sites located in an immunoreceptor tyrosine-based inhibitory motif and an ...

Harrod TR, Justement LB (2003). "Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology ... Lin D, Gish GD, Songyang Z, Pawson T (1999). "The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif ... SDCBP has been shown to interact with: EFNB1, GRIK1, GRIK2, Interleukin 5 receptor alpha subunit, Merlin, RAB5A, SOX4, TRAF6, ... Syntenin-1 is a protein that in humans is encoded by the SDCBP gene. The protein encoded by this gene was initially identified ...

"High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages". J. ... This is analogous to the self signals provided by MHC class I molecules to NK cells via Ig-like or Ly49 receptors. NB. Protein ... 1996). "Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule". J. ... 1998). "Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in ...

"Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of ... It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action ... "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of ... "Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". The Journal of ...

For instance, the MAPKKK ASK-1 is activated by a receptor-tyrosine kinase specific for a tumor necrosis factor. Since MAPKKK ... Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, MKKK, M3K, or, MAP3K) is a serine/threonine-specific protein ... Several classes of MAPKKK exist, and all of them are upstream of MAP kinases. There are three main classes of MAP Kinases and ... A common phosphatase used in ASK-1 regulation is PP5. MAPKKKs contain a docking domain which is different from their active ...

A-5 protein, and receptor protein-tyrosine phosphatase mu) C-terminal neuropilin The structure of B1 domain (coagulation factor ... first documented to regulate neurogenesis and angiogenesis by complexing with Plexin receptors/class-3 semaphorin ligands and ... Neuropilin is a protein receptor active in neurons. There are two forms of Neuropilins, NRP-1 and NRP-2. Neuropilins are ... Neuropilin-1 is a therapeutic target protein in the treatment for leukemia and lymphoma, since It has been shown that there is ...

... the bradykinin receptor B2 has been shown to interact directly with a protein tyrosine phosphatase. The presence of a tyrosine- ... G protein-coupled receptors database List of MeSH codes (D12.776) Metabotropic receptor Orphan receptor Pepducins, a class of ... transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors ( ... October 2002). "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved ...

... homeobox protein transcription factor CDX2; e) Protein tyrosine phosphatase receptor-type R gene PTPRR; f) transcriptional ... Education Program. 2013: 118-25. doi:10.1182/asheducation-2013.1.118. PMID 24319172. S2CID 24762855. Kar A, Gutierrez-Hartmann ... The table includes abbreviations for tyrosine kinase receptor (TK receptor), non-receptor tyrosine kinase (non-receptor TK), ... "PTPRR protein tyrosine phosphatase, receptor type R (human0". Entrez Gene. "IGH immunoglobulin heavy locus (human )". Entrez ...

... that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion". Mol. Cell. ... Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling ... Malik KF, Jaffe H, Brady J, Young WS (1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the ... "Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins". Biochemistry. ...

Protein tyrosine phosphatases (PTPs) restore nRTKs to their basal state of activity. In some cases PTPs positively regulate ... "Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of ... to tyrosine residues in proteins. Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that ... Unlike the receptor tyrosine kinases (RTKs), the second subgroup of tyrosine kinases, the non-receptor tyrosine kinases are ...

April 2022). "Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor". Cell Metabolism. 34 (4): 549 ... Members of this class are derived from a cleavage event that also generates a much larger, functionally unrelated, nonhormonal ... Asprosin's orexigenic effects are mediated through binding to protein tyrosine phosphatase receptor delta (PTPRD). Genetic ... The first indication that asprosin was in fact a cerebrospinal fluid (CSF) protein, in addition to being a plasma protein, was ...

Ostman A, Böhmer FD (June 2001). "Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases". Trends in ... RTK class III (PDGF receptor family) RTK class IV (VEGF receptors family) RTK class V (FGF receptor family) RTK class VI (CCK ... RTK class VII (NGF receptor family) RTK class VIII (HGF receptor family) RTK class IX (Eph receptor family) RTK class X (AXL ... RTK class XI (TIE receptor family) RTK class XII (RYK receptor family) RTK class XIII (DDR receptor family) RTK class XIV (RET ...

Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6". The Journal of ... September 2004). "Control of vesicle fusion by a tyrosine phosphatase". Nature Cell Biology. 6 (9): 831-9. doi:10.1038/ncb1164 ... "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex". Biochemical and Biophysical ... The protein domain Syntaxin 6 N terminal protein domain is a soluble N-ethylmaleimide-sensitive factor attachment protein ...

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene. The protein ... Lin D, Gish GD, Songyang Z, Pawson T (1999). "The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif ... "Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)". Gross, C; ... "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP- ...

"Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)". Brain Research. 1116 (1 ... "Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus". Genes and Immunity. 3 (4): 205-10. doi:10.1038/sj.gene. ... The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus ... Desmoglein-1 is a protein that in humans is encoded by the DSG1 gene. Desmoglein-1 is expressed everywhere in the skin ...

"Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of ... "The B-cell antigen receptor of the five immunoglobulin classes". Nature. 352 (6338): 777-81. Bibcode:1991Natur.352..777V. doi: ... "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". The Journal ... "Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor ...

... these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits. Heterotrimeric G proteins ... G12/G13 alpha subunits G protein-coupled receptor Heterotrimeric G protein Rho family of GTPases GRCh38: Ensembl release 89: ... interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353-8. doi ... Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia ...

Receptor tyrosine kinases; Tyrosine kinase associated receptors; Receptor-like tyrosine phosphatases; Receptor serine/threonine ... Two most abundant classes of transmembrane receptors are GPCR and single-pass transmembrane proteins. In some receptors, such ... Adrenergic receptor Olfactory receptors Receptor tyrosine kinases Epidermal growth factor receptor Insulin Receptor Fibroblast ... Nerve Growth Factor Receptor NMDA receptor Several Immune receptors Toll-like receptor T cell receptor CD28 SCIMP protein ...

"The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP- ... Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene. This gene is a member of the ... Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence ... interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E". The Journal of Biological Chemistry ...

Zap70 is able to phosphorylate multiple tyrosine residues of the transmembrane protein LAT. LAT is a scaffold protein ... CD8, on the other hand, specific for MHC class I, is expressed on cytotoxic T cells. Binding of the co-receptor to the MHC ... Tonic TCR signalling is avoided by the presence of phosphatase CD45 that removes phosphorylation from tyrosine residues and ... UMich Orientation of Proteins in Membranes protein/pdbid-2hac - Zeta-zeta dimer of T-cell receptor T-Cell+Receptor at the U.S. ...

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS ... Dopamine receptors can also transactivate Receptor tyrosine kinases. Beta Arrestin recruitment is mediated by G-protein kinases ... cAMP mediated protein kinase A activity also results in the phosphorylation of DARPP-32, an inhibitor of protein phosphatase 1 ... The D2 class of receptors produce the opposite effect, as they are Gαi and/or Gαo coupled receptors, which blocks the activity ...

2000). "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the ... 2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins". Nature. 403 (6769 ... 1996). "Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha". J. Biol. ... 1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc ...

Controlling mechanisms are mainly aimed at inhibition of JAK kinase activity by SHP-1 tyrosine phosphatase with SH2 binding ... lessons learned from the IL-3/IL-5/GM-CSF receptor family". Cytokine & Growth Factor Reviews. 12 (1): 19-25. doi:10.1016/S1359- ... and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue". Biology of Reproduction. 53 ... which can be found in other cytokine receptors (growth hormone receptor, erythropoietin receptor). In the membrane distant part ...

"The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase ... belongs to a new class of ubiquitin-binding proteins". J. Biol. Chem. 271 (34): 20235-7. doi:10.1074/jbc.271.34.20235. PMID ... Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo protein that targets other proteins that bind to ... of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor ...