Loading...
*  PLXNB1
Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB ... Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand ... Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras ... Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL (2002). "The semaphorin receptor plexin-B1 signals through a direct interaction ...
*  MMP16
Rozanov DV, Hahn-Dantona E, Strickland DK, Strongin AY (2004). "The low density lipoprotein receptor-related protein LRP is ... 55 (2): 89-98. doi:10.1002/pros.10194. PMID 12661033. Takino T, Koshikawa N, Miyamori H (2003). "Cleavage of metastasis ... 1354 (2): 159-70. doi:10.1016/s0167-4781(97)00120-6. PMID 9396633. Terp GE, Christensen IT, Jørgensen FS (2000). "Structural ... Wang SC, Lien HC, Xia W (2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB- ...
*  Breast development
"Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis". Cell Growth ... "Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor α and prolactin receptor expression and ... At least one way that they do this is by reducing the expression of the estrogen receptor in breast tissue. In the absence of ... Growth hormone receptor (GHR) knockout mice also show greatly impaired lobuloalveolar development. In addition to their role in ...
*  Epidermal growth factor receptor
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor ... The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members ... Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI (August 2007). "ErbB receptors: from oncogenes to targeted ... Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE (June 1999). "ErbB receptor-induced activation of stat transcription ...
*  TP53RK
303 (2): 399-405. doi:10.1016/S0006-291X(03)00333-4. PMID 12659830. Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed ... 154 (2): 452-64. doi:10.1016/j.cell.2013.06.022. PMC 3717207 . PMID 23870131. "Infection and Immunity Immunophenotyping (3i) ... "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2". Cancer Cell. 6 (3): 251-61. ... "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial ...
*  DDX10
24 (2): 144-52. doi:10.1038/72799. PMID 10655059. Ikeda T, Ikeda K, Sasaki K, et al. (1999). "The inv(11)(p15q22) chromosome ... 33 (2): 199-206. doi:10.1006/geno.1996.0184. PMID 8660968. "Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10". ... 2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2". Cancer Cell. 6 (3): ...
*  HER2/neu
The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. One of which is erbB-2, and the other members ... 4:4483 Receptor, erbB-2 at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 ( ... HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this ...
*  ErbB
The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named ... Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are ... The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB- ... "Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor". PLoS One. ...
*  List of MeSH codes (D12.776)
... receptor, erbb-3 MeSH D12.776.624.664.700.800 - receptor, macrophage colony-stimulating factor MeSH D12.776.624.664.700.830 - ... estrogen receptor alpha MeSH D12.776.826.750.350.262 - estrogen receptor beta MeSH D12.776.826.750.350.350 - receptors, ... Retinoid X receptor alpha MeSH D12.776.826.701.500.625 - Retinoid X receptor beta MeSH D12.776.826.701.500.750 - Retinoid X ... thyroid hormone receptors alpha MeSH D12.776.624.664.700.830.750 - thyroid hormone receptors beta MeSH D12.776.624.664.700.915 ...
*  DNAJA3
... has been shown to interact with: ErbB-2 receptor tyrosine kinase MK5 HSPA9 HSPA8, JAK2, and RASA1 ENSG00000103423 GRCh38 ... In neuromuscular junctions, only the short isoform clusters acetylcholine receptors for efficient synaptic transmission. The ... 2.0.CO;2. ISSN 1466-1268. PMC 312896 . PMID 11147971. Sarkar S, Pollack BP, Lin KT, et al. (2002). "hTid-1, a human DnaJ ... 278 (1-2): 201-10. doi:10.1016/S0378-1119(01)00720-X. PMID 11707338. Cheng H, Cenciarelli C, Shao Z, et al. (2002). "Human T ...
*  List of MeSH codes (D23)
... receptor, erbb-2 MeSH D23.101.840.721 --- receptor, erbb-3 MeSH D23.101.840.800 --- synaptophysin MeSH D23.101.840.870 --- ... receptors, complement 3d MeSH D23.050.301.264.035.690 --- receptors, ige MeSH D23.050.301.264.035.695 --- receptors, igg MeSH ... receptors, complement 3d MeSH D23.101.100.110.690 --- receptors, ige MeSH D23.101.100.110.695 --- receptors, igg MeSH D23.101. ... receptors, interleukin-4 MeSH D23.050.301.264.035.710 --- receptors, interleukin-6 MeSH D23.050.301.264.035.715 --- receptors, ...
*  List of MeSH codes (D12.776.543)
... receptor, erbb-3 MeSH D12.776.543.750.060.468 -- receptor, igf type 1 MeSH D12.776.543.750.060.484 -- receptor, insulin MeSH ... receptor, epidermal growth factor MeSH D12.776.543.750.750.400.350 -- receptor, erbb-2 MeSH D12.776.543.750.750.400.360 -- ... receptor, erbb-3 MeSH D12.776.543.750.750.400.370 -- receptors, fibroblast growth factor MeSH D12.776.543.750.750.400.370.500 ... receptor, epidermal growth factor MeSH D12.776.543.750.060.374 -- receptor, erbb-2 MeSH D12.776.543.750.060.437 -- ...
*  Saliva testing
... c-erbB-2, epidermal growth factor receptor, cathepsin-D, and p53 in saliva among women with breast carcinoma". Cancer Invest. ... "The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study". Clin. Cancer Res ... 2:681. Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM (2009). "Dietary ... 2: 136-40. doi:10.1016/j.niox.2009.10.007. CS1 maint: Multiple names: authors list (link) Webb AJ, Patel N, Loukogeorgakis S, ...
*  ERBB4
Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor ... Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced ... Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like ... Chow NH, Liu HS, Yang HB, Chan SH, Su IJ (Jun 1997). "Expression patterns of erbB receptor family in normal urothelium and ...
*  Index of biochemistry articles
... epidermal growth factor receptor - Epidiorite - epigenetics - Epinephrine - equine gonadotropin - erbA gene - erbB gene - erbB- ... G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc fusion protein - galanin - gamete - gamma- ... CXCR4 receptor - cyclic AMP receptor - cyclic AMP receptor protein - cyclic AMP-responsive DNA-binding protein - cyclic ... leukotriene B4 receptor - LH - LH receptor - LHRH receptor - life - life form - Ligand - light reactions - Lineweaver-Burke- ...
*  ERBB3
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound ... ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ... Epidermal growth factor receptor family Epidermal growth factor receptor Receptor tyrosine-kinases GRCh38: Ensembl release 89: ... 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0 ...
*  List of MeSH codes (D08)
... receptor, erbb-3 MeSH D08.811.913.696.620.682.725.400.185 --- receptor, igf type 1 MeSH D08.811.913.696.620.682.725.400.200 ... receptor, epidermal growth factor MeSH D08.811.913.696.620.682.725.400.150 --- receptor, erbb-2 MeSH D08.811.913.696.620.682. ... activin receptors, type i MeSH D08.811.913.696.620.682.700.062.750 --- activin receptors, type ii MeSH D08.811.913.696.620.682. ... receptor, platelet-derived growth factor beta MeSH D08.811.913.696.620.682.725.400.925 --- receptors, tie MeSH D08.811.913.696. ...
*  Neuregulin 2
1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0 ... Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, ... "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0. PMID ... 2005). "Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated ...
*  Potato carboxypeptidase inhibitor
PCI inhibits tumor cell growth.a Mechanism of action is inhibition of receptor dimerization and receptor trans- ... PCI blocks the formation and activation of ErbB1/ErbB-2 (EGFR and HER2) heterodimers that have a prominent role in carcinoma ... 226 (2): 169-84. doi:10.1016/j.canlet.2005.01.025. PMID 16039955. ^a Nagashima M, Werner M, Wang M, et al. (May 2000). "An ... 2 (10): 835-7. doi:10.1038/nsb1095-835. PMID 7552703. ^a Blanco-Aparicio C, Molina MA, Fernández-Salas E, et al. (May 1998). " ...
*  ERRFI1
ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking ... a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene ... Hackel PO, Gishizky M, Ullrich A (2002). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biol. ...
*  PTGES3
Freeman BC, Felts SJ, Toft DO, Yamamoto KR (2000). "The p23 molecular chaperones act at a late step in intracellular receptor ... Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-221. doi:10.1016/S0378- ... 1997). "Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is ... Cox MB, Miller CA (2002). "The p23 co-chaperone facilitates dioxin receptor signaling in a yeast model system". Toxicol. Lett. ...
*  Megakaryocyte-associated tyrosine kinase
Yamashita, H; Avraham S; Jiang S; Dikic I; Avraham H (May 1999). "The Csk homologous kinase associates with TrkA receptors and ... 2002). "Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function ... 1999). "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells". J. Biol. ... 1994). "Characterization of mouse non-receptor tyrosine kinase gene, HYL". Oncogene. 9 (11): 3371-4. PMID 7936664. Maruyama K, ...
*  GATA3
... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... It has been suggested that GATA-3 is regulated in CD4+ T cells at a transcriptional level through the IL-4 receptor, as well as ... Marine J, Winoto A (Aug 1991). "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements ... Wilson BJ, Giguère V (2008). "Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor ...
*  FOXA1
... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... 2009). "Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor ... 2009). "Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours". ... "Differential oestrogen receptor binding is associated with clinical outcome in breast cancer". Nature. 481 (7381): 389-93. doi: ...
*  Epidermal growth factor
... (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is a 6-kDa ... "Role of the N-terminus of epidermal growth factor in ErbB-2/ErbB-3 binding studied by phage display". Biochemistry. 41 (27): ... EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface. This stimulates ligand- ... Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA (May 2006). "The epidermal growth factor receptors and their family of ligands: their ...
*  Afatinib
It is mainly used to treat cases of NSCLC that harbour mutations in the epidermal growth factor receptor (EGFR) gene. It has ... an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab". ... Minkovsky N, Berezov A (December 2008). "BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors ... Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive ...