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*  Hepatocyte growth factor
Epidermal growth factor Insulin-like growth factor 1 Epithelial-mesenchymal transition Madin-Darby Canine Kidney Cells GRCh38: ... "Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor". The EMBO Journal. 10 (10): ... Hepatocyte growth factor (HGF) (or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is ... Hepatocyte growth factor at the US National Library of Medicine Medical Subject Headings (MeSH) Hepatocyte growth factor on the ...
*  Epidermal growth factor receptor
"Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor". Growth ... "Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor". Biochemistry. ... The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor ... "Bi-directional signaling between gastrointestinal peptide hormone receptors and epidermal growth factor receptor". Growth ...
*  Epidermal growth factor
... has been shown to interact with epidermal growth factor receptor. Recombinant human epidermal growth ... Epidermal growth factor can be found in urine, saliva, milk, and plasma. The production of epidermal growth factor has been ... Supply of Epidermal Growth Factor EGF at the Human Protein Reference Database. Epidermal growth factor at the US National ... Epidermal growth factor (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is a 6-kDa ...
*  Saliva
Herbst RS (2004). "Review of epidermal growth factor receptor biology". International Journal of Radiation Oncology, Biology, ... Epidermal growth factor (EGF) Various enzymes; there are three major enzymes found in saliva: α-amylase (EC3.2.1.1), or ptyalin ... Researchers at the University of Florida at Gainesville have discovered a protein called nerve growth factor (NGF) in the ... It is the liquid medium in which chemicals are carried to taste receptor cells (mostly associated with lingual papillae). ...
*  Ubiquitin-interacting motif
Vertebrate hepatocyte growth factor-regulated tyrosine kinase substrate (HRS). Mammalian epidermal growth factor receptor ... Mammalian epidermal growth factor receptor substrate EPS15R. Drosophila melanogaster (Fruit fly) liquid facets (lqf), an epsin ... substrate 15 (EPS15), which is involved in cell growth regulation. ...
*  Tooth decay
CS1 maint: Multiple names: authors list (link) Herbst RS (2004). "Review of epidermal growth factor receptor biology". ... Growth factors, especially TGF-β, are thought to initiate the production of reparative dentin by fibroblasts and mesenchymal ... Possible contributing factors that have been investigated include systemic factors such as high levels of dioxins or ... However, the risk factors and stages of development are similar. Initially, it may appear as a small chalky area (smooth ...
*  Pathophysiology of heart failure
October 2003). "Aldosterone stimulates epidermal growth factor receptor expression". J. Biol. Chem. 278 (44): 43060-66. doi: ... and also by epidermal growth factor (EGF), which is a target of the signaling pathway activated by aldosterone Reduced ... Many of these remodelling effects seem to be mediated by transforming growth factor beta (TGF-beta), which is a common ... Binding to beta-1 receptors in the myocardium increases the heart rate and makes contractions more forceful in an attempt to ...
*  Stomach
Herbst RS (2004). "Review of epidermal growth factor receptor biology". International Journal of Radiation Oncology, Biology, ... Epidermal growth factor (EGF) results in cellular proliferation, differentiation, and survival. EGF is a low-molecular-weight ... The human stomach can "taste" sodium glutamate using glutamate receptors and this information is passed to the lateral ... The stomach can also sense, independently of tongue and oral taste receptors, glucose, carbohydrates, proteins, and fats. This ...
*  John Mendelsohn (doctor)
... growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth ... Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad ... "Targeting the epidermal growth factor receptor for cancer therapy". Journal of Clinical Oncology. Retrieved March 2, 2011. " ... "Epidermal growth factor receptor family and chemosensitization". Journal of the National Cancer Institute. Retrieved March 2, ...
*  Tesevatinib
... including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular ... June 15, 2007). "Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647". Clin. Cancer ... June 15, 2007). "Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647". Clinical ... endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). The drug activity was initially studied in non-small cell ...
*  ErbB
... and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using ... "Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor α". ... "Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor ... There are 11 growth factors that activate ErbB receptors. The ability ('+') or inability ('-') of each growth factor to ...
*  CBL (gene)
"Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK ... "Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and ... "cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855-66. doi:10.1038/sj.onc.1202499. PMID ... "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ...
*  Immunohistochemistry
Among the overexpressed targets are members of the epidermal growth factor receptor (EGFR) family, transmembrane proteins with ... Harari, P M (December 2004). "Epidermal growth factor receptor inhibition strategies in oncology". Endocrine-Related Cancer. ... September 2006). "Assessment of epidermal growth factor receptor (EGFR) expression in primary colorectal carcinomas and their ... The presence of hormone receptors can be used to determine if a tumor is potentially responsive to antihormonal therapy. One of ...
*  GRB2
EPH receptor A2, ETV6, Epidermal growth factor receptor, Erythropoietin receptor, FRS2, Fas ligand, GAB1, GAB2, Glycoprotein ... The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and ... Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and ... Liu YF, Deth RC, Devys D (Mar 1997). "SH3 domain-dependent association of huntingtin with epidermal growth factor receptor ...
*  CBLB (gene)
CBLB has been shown to interact with: CRKL, Epidermal growth factor receptor, Grb2, NEDD4, PIK3R1, and SH3KBP1. GRCh38: Ensembl ... 2001). "Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex". J. Biol. Chem. 276 ... 1999). "cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855-66. doi:10.1038/sj.onc.1202499. ... "cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855-66. doi:10.1038/sj.onc.1202499. PMID ...
*  CBLC
2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK ... 1999). "Cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855-66. doi:10.1038/sj.onc.1202499. ... CBLC has been shown to interact with FYN and Epidermal growth factor receptor. GRCh38: Ensembl release 89: ENSG00000142273 - ... 2002). "C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". J ...
*  Menadione
It was reported, that menadione topical lotion reduces epidermal growth factor receptor inhibitor-related side effects by the ... Tianhong Li & Roman Perez-Soler (2009). "Skin toxicities associated with epidermal growth factor receptor inhibitors". Targeted ...
*  Lipid raft
Epidermal growth factor (EGF) binds to EGF receptor, also known as HER-1 or ErbB1, to initiate transmembrane signaling.Lipid ... Mineo, Chieko; Gill, Gordon N.; Anderson, Richard G.W. (1999). "Regulated migration of epidermal growth factor receptor from ... "Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding". J Biol Chem. 277: ... Miljan, Erik A; Bremer, Eric G. (2002). "Regulation of growth factor receptors by gangliosides". Sci STKE. 160: RE15. doi: ...
*  Necitumumab
It binds to the epidermal growth factor receptor (EGFR). The US FDA approved necitumumab under the brand name Portrazza for use ...
*  Alzheimer's disease research
"Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss". Proceedings of the National ... "Epidermal growth factor receptor: mechanisms of activation and signalling". Experimental Cell Research. 284 (1): 31-53. doi: ... and NetworkAnalyst showed that epidermal growth factor (EGF) and its receptors were strongly associated with pathogenesis of AD ... R7 is a prodrug of 7,8-dihydroxyflavone, an agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). R7 ...
*  Argos (EGFR Inhibitor)
Argos is a secreted protein that is an inhibitor of the epidermal growth factor receptor (EGFR) pathway in Drosophila ... Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA (August 2004). "Argos inhibits epidermal growth factor receptor ... Argos binds the epidermal growth factor domain of Spitz, preventing interaction between Spitz and EGFR. Argos does not directly ... receptor. EGFR inhibitor Freeman M, Klämbt C, Goodman CS, Rubin GM (June 1992). "The argos gene encodes a diffusible factor ...
*  Adaptor-related protein complex 2, alpha 1
Sakaguchi K, Okabayashi Y, Kasuga M (2001). "Shc mediates ligand-induced internalization of epidermal growth factor receptors ... Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J ... 1999). "A beta-turn endocytic code is required for optimal internalization of the growth hormone receptor but not for alpha- ... 2001). "Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor ...
*  Targeted therapy of lung cancer
Riely GJ, Politi KA, Miller VA, Pao W (December 2006). "Update on epidermal growth factor receptor mutations in non-small cell ... Shigematsu H, Gazdar AF (January 2006). "Somatic mutations of epidermal growth factor receptor signaling pathway in lung ... "Epidermal growth factor receptor mutations in small cell lung cancer". Clinical Cancer Research. 14 (19): 6092-6. doi:10.1158/ ... "Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with ...
*  Erlotinib
It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). It is marketed in the ... 2008 September 16; 99(6). Raymond E, Faivre S, Armand J (2000). "Epidermal growth factor receptor tyrosine kinase as a target ... Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and ... Kobayashi, K.; Hagiwara, K. (2013). "Epidermal growth factor receptor (EGFR) mutation and personalized therapy in advanced ...
*  EPS8
Epidermal growth factor receptor kinase substrate 8 is an enzyme that in humans is encoded by the EPS8 gene. This gene encodes ... "Entrez Gene: EPS8 epidermal growth factor receptor pathway substrate 8". Offenhäuser N, Borgonovo A, Disanza A, Romano P, ... a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals". EMBO J. 12 (10): 3799- ... Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor- ...
*  Proto-oncogene tyrosine-protein kinase Src
Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2), also known as erbB2, is correlated with a worse prognosis ... Biscardi JS, Belsches AP, Parsons SJ (April 1998). "Characterization of human epidermal growth factor receptor and c-Src ... Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor ( ... PDGFR) pathway and epidermal growth factor receptor (EGFR). When src is activated, it promotes survival, angiogenesis, ...
*  Combined small-cell lung carcinoma
October 2008). "Epidermal growth factor receptor mutations in small cell lung cancer". Clin. Cancer Res. 14 (19): 6092-6. doi: ... Riely GJ, Politi KA, Miller VA, Pao W (December 2006). "Update on epidermal growth factor receptor mutations in non-small cell ... November 2007). "Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell ... September 2010). "Small-cell carcinoma with an epidermal growth factor receptor mutation in a never-smoker with gefitinib- ...