Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones ... G protein-coupled receptors, Cholecystokinin receptors, All stub articles, Cell biology stubs). ... Cholecystokinin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... Beinfeld M, Chen Q, Gao F, Liddle RA, Miller LJ, Rehfeld J (2019-09-16). "Cholecystokinin receptors (version 2019.4) in the ...
Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene ... "Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor ... "Entrez Gene: CCKAR cholecystokinin A receptor". Pellegrini M, Mierke DF (Nov 1999). "Molecular complex of cholecystokinin-8 and ... "Cholecystokinin Receptors: CCK1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene ... The cholecystokinin B receptor is stimulated by CCK and gastrin in the stomach during digestion. The cholecystokinin B receptor ... "Entrez Gene: CCKBR cholecystokinin B receptor". Altar CA, Boyar WC (Apr 1989). "Brain CCK-B receptors mediate the suppression ... "Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin". The ...
Watson S, Arkinstall S (1994). "Cholecystokinin (CCK) and gastrin". The G-protein linked receptor factsbook. London: Academic ... of proteins is defined by the peptide hormones gastrin and cholecystokinin. Gastrin and cholecystokinin (CCK) are structurally ... CCK; GAST; Baldwin GS, Patel O, Shulkes A (February 2010). "Evolution of gastrointestinal hormones: the cholecystokinin/gastrin ... The gastrin family (also known as the gastrin/cholecystokinin family) ...
... shown to interact with the Cholecystokinin A receptor located mainly on pancreatic acinar cells and Cholecystokinin B receptor ... "Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... Cholecystokinin is a member of the gastrin/cholecystokinin family of peptide hormones and is very similar in structure to ... Media related to Cholecystokinin at Wikimedia Commons Cholecystokinin at the U.S. National Library of Medicine Medical Subject ...
de Tullio P, Delarge J, Pirotte B (June 1999). "Recent advances in the chemistry of cholecystokinin receptor ligands (agonists ... Berna MJ, Tapia JA, Sancho V, Jensen RT (December 2007). "Progress in developing cholecystokinin (CCK)/gastrin receptor ligands ... de Tullio P, Delarge J, Pirotte B (January 2000). "Therapeutic and chemical developments of cholecystokinin receptor ligands". ... November 1987). "Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists". ...
Hill DR, Woodruff GN (September 1990). "Differentiation of central cholecystokinin receptor binding sites using the non-peptide ... Cooper SJ, Dourish CT (December 1990). "Multiple cholecystokinin (CCK) receptors and CCK-monoamine interactions are ... lacking affinity for GABAA receptors and instead acting as an CCKA receptor antagonist. It increases appetite and accelerates ... It is also widely used in scientific research into the CCKA receptor. Devazepide is synthesised in a similar manner to other ...
... adenosine A1 receptors, muscarinic M3 receptors, serotonin 5-HT1A receptors, neuropeptide Y receptors, cholecystokinin A ... CB1 receptors formed homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors ... "Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... As orexin receptors efficiently signal via endocannabinoid production to CB1 receptors, dimerization could be an effective way ...
It acts as a selective antagonist for the cholecystokinin receptor CCKA, and has been used as a lead compound for the ... Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists. Journal of Medicinal Chemistry. 1987 Jul;30( ... Molecular modelling of asperlicin derived cholecystokinin A receptor antagonists. European Journal of Pharmacology. 1992 Aug 3; ... Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility. Journal of Medicinal ...
"Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor". British Journal of Pharmacology. 159 (5 ... Insulin release is stimulated also by beta-2 receptor stimulation and inhibited by alpha-1 receptor stimulation. In addition, ... the insulin receptor (IR), present in the cell membrane. The receptor molecule contains an α- and β subunits. Two molecules are ... because insulin release is inhibited by α2-adrenergic receptors and stimulated by β2-adrenergic receptors. The net effect of ...
... hyperalgesia is believed to involve the activation of cholecystokinin receptors. Stewart-Williams and Podd argue that ... For example, an expectation of pain may induce anxiety, which in turn causes the release of cholecystokinin, which facilitates ...
"Synthesis of bicyclic dipeptide mimetics for the cholecystokinin and opioid receptors". Tetrahedron Letters. 45 (21): 4139-4142 ...
Wank, SA (Nov 1995). "Cholecystokinin receptors". The American Journal of Physiology. 269 (5 Pt 1): G628-46. doi:10.1152/ajpgi. ... The five main types of muscarinic receptors: The M1 muscarinic receptors (CHRM1) are located in the neural system. The M2 ... The M4 muscarinic receptors: Postganglionic cholinergic nerves, possible CNS effects The M5 muscarinic receptors: Possible ... The ACh acts on two types of receptors, the muscarinic and nicotinic cholinergic receptors. Most transmissions occur in two ...
A cholecystokinin receptor antagonist is a specific type of receptor antagonist which blocks the receptor sites for the peptide ... Antagonists for the CCK receptors can thus have multiple functions in both the gut and brain. The best known CCK receptor ... Newer drugs have since been developed which are selective for one or other of the CCK receptors. Selective CCKA receptor ... However by far the main focus of CCK receptor antagonist research has focused on the development of selective CCKB receptor ...
Attoub S, Moizo L, Sobhani I, Laigneau JP, Lewin MJ, Bado A (Jun 2001). "The H3 receptor is involved in cholecystokinin ... histamine receptor antagonists H3-receptor antagonist Histamine H1-receptor Histamine H2-receptor Histamine H4-receptor GRCh38 ... 1997 H3 receptors shown to modulate ischemic norepinephrine release in animals. 1999 H3 receptor cloned 2000 H3 receptors ... the H3 receptor is a G-protein coupled receptor. The H3 receptor is coupled to the Gi G-protein, so it leads to inhibition of ...
"Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors". Brain. 132 (3): 778- ... NK1 agonism induced hypersensitivity is dependent on 5-HT3 receptors, and modulated by GABAA and NMDA receptors as well. ... Serotonin receptors have been hypothesized to play a bidirectional role in the modulation of pain. Based on previous ... To find out more about the role of NMDA receptors in RVM pain facilitation, intrathecal MK-801 was administered before a RVM SP ...
"Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus". Neuron. 95 (3): 564-576. ... The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled ... derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling ... The 5-HT2A receptor is known primarily to couple to the Gαq signal transduction pathway. Upon receptor stimulation with agonist ...
February 1997). "Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor". Journal of ... Cholecystokinin tetrapeptide (CCK-4, tetragastrin, Trp-Met-Asp-Phe-NH2) is a peptide fragment derived from the larger peptide ... Léna I, Dh tel H, Garbay C, Daugé V (January 2001). "Involvement of D2 dopamine receptors in the opposing effects of two CCK-B ... Kalindjian SB, McDonald IM (2007). "Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand". ...
... binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors ...
"Somatostatin is released in response to cholecystokinin by activation of type A CCK receptors". Peptides. 15 (2): 223-7. doi: ... Examples include: Secretin Cholecystokinin You C, Chey W (1987). "Secretin is an enterogastrone in humans". Dig Dis Sci. 32 (5 ...
... is a potential therapeutic agent for thyroid carcinoma by targeting cancer-promoting cholecystokinin receptors. ... "Preclinical Evaluation of Radiolabeled DOTA-Derivatized Cyclic Minigastrin Analogs for Targeting Cholecystokinin Receptor ... Peptide Receptor Radionuclide Therapy (PRRT) A radioactively labeled analogue of minigastrin, PP-F11, conjugated with NOTA, ... DOTA, or NODAGA was studied to view the effects they have on peptide receptor radionuclide therapy (PRRT) and cancer cell ...
"5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin ... 5-HT1 receptor 5-HT2 receptor 5-HT4 receptor 5-HT5 receptor 5-HT6 receptor 5-HT7 receptor Barnes NM, Hales TG, Lummis SC, ... The 5-HT3 receptor differs markedly in structure and mechanism from the other 5-HT receptor subtypes, which are all G-protein- ... or serotonin receptors) which are G protein-coupled receptors. This ion channel is cation-selective and mediates neuronal ...
She took an interruption of studies, moved to Cambridge and started working on cholecystokinin receptors.[citation needed] When ... GABA benzodiazepins and NK1 receptors in alcoholism and opiate dependence. She was elected Secretary of the British Association ...
September 1990). "Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic ... "The cholecystokinin-B receptor antagonist CI-988 failed to affect CCK-4 induced symptoms in panic disorder patients". ... a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically ... CI-988 (PD-134,308) is a drug which acts as a cholecystokinin antagonist, selective for the CCKB subtype. In animal studies it ...
It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative ... The anuran BB4 receptor homologue is termed frog BB4 (fBB4). Iwabuchi et al. 2003 discovered a chicken (Gallus domesticus) ... Yamada K, Wada E, Wada K (November 2000). "Bombesin-like peptides: studies on food intake and social behaviour with receptor ... Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States ...
This gastric accommodation activates stretch receptors in the proximal (upper) portion of the stomach. These receptors then ... Cholecystokinin (CCK) is gut peptide produced by the duodenum in response to fat and proteins. CCK has the effect of slowing ... This inhibition causes increased stretch of the stomach, increasing activation of proximal gastric stretch receptors. It also ...
"Expression of Cholecystokinin and its Receptors in the Intestinal Tract of Type 2 Diabetes Patients and Healthy Controls". The ... In rats (Rattus rattus) the short-chain fatty acid receptor GPR43 is expressed both by this cell type and by mast cells of the ... I cells secrete cholecystokinin (CCK), and have the highest mucosal density in the duodenum with a decreasing amount throughout ... Drucker DJ, Nauck MA (November 2006). "The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase- ...
"Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag ... "Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag ... Snyder, S. H.; Katims, J. J.; Annau, Z.; Bruns, R. F.; Daly, J. W. (May 1981). "Adenosine receptors and behavioral actions of ... Radulovacki, M; Trbovic, SM; Carley, DW (1998). "Serotonin 5-HT3-receptor antagonist GR 38032F suppresses sleep apneas in rats ...
Rodríguez-Membrilla A, Martínez V, Vergara P. Peripheral and central cholecystokinin receptors regulate postprandial intestinal ...
The intestines also contain receptors that send satiety signals to the brain. The hormone cholecystokinin is secreted by the ... Leptin targets the receptors on the arcuate nucleus and suppresses the secretion of MCH and orexin. The arcuate nucleus also ... The stomach contains receptors to allow us to know when we are full. ... Little, TJ; Horowitz, M; Feinle-Bisset, C. (2005). "Role of cholecystokinin in appetite control and body weight regulation". ...