... is a pyrazole-based synthetic cannabinoid that is presumed to be an agonist of the CB1 receptor and has been sold online as a ... It may be considered an analog of the traditional pyrazole cannabinoid receptor 1 antagonist rimonabant. The pharmacological ... Cannabinoids, Designer drugs, Fluoroarenes, Pyrazoles, Pyrazolecarboxamides, Organofluorides, All stub articles, Cannabinoid ... 5-fluoro-3,5-AB-PFUPPYCA has been detected in synthetic cannabinoid smoke blends in the USA as early as December 30, 2021, ...

... is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online ...

... is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online ...

It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki = 0.72 μM), and selectivity vs. the CB2 ... CB1 receptor agonists, GABAA receptor positive allosteric modulators, Monoamine oxidase inhibitors). ... The CB1 receptor affinity of yangonin suggests that the endocannabinoid system might contribute to the complex human ... The plant-derived yangonin is a novel CB1 receptor ligand". Pharmacological Research. 66 (2): 163-169. doi:10.1016/j.phrs. ...

Sex differences in cannabinoid receptor-1 (CB1) pharmacology in mice selectively bred for high voluntary wheel-running behavior ...

... may refer to USS Inflict (AM-251) AM-251 a CB1 cannabinoid receptor antagonist This disambiguation page lists articles ...

... is a drug that acts as a reasonably potent agonist for the cannabinoid receptors. It is a full agonist at CB1 with an EC50 of ... Uchiyama N, Kawamura M, Kikura-Hanajiri R, Goda Y (2012). "Identification of two new-type synthetic cannabinoids, N-(1- ... Structurally, it closely resembles cannabinoid compounds from a University of Connecticut patent, but with a simple pentyl ... October 2016). "Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on "tetrad", sensorimotor, neurological and ...

... which acts as a cannabinoid agonist at both the CB1 and CB2 receptors The maximum break, the highest possible break in snooker ...

September 2005). "Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4- ... 4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor". Journal of Medicinal Chemistry. 45 (7): 1447-59. doi: ... "3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects ... June 2002). "Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor ...

... is a drug which acts as both a non-selective agonist of the CB1 and CB2 cannabinoid receptors, and also as a blocker of T ... "Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands". Molecular Pain. 7: ... NMP-7 has an agonist EC50 of 96.9nM at CB1 and 10.5nM at CB2, and an IC50 of 1.84μM for blocking Cav3.2 T-type calcium channels ... Cannabinoids, Carbazoles, All stub articles, Cannabinoid stubs). ...

... differently than human cannabinoid receptors with MDA-19 binding to human CB1 receptors 6.9x higher than rat CB1 receptors. MDA ... 2.1 and CB1 receptors at Ki = 1130 +/- 574 nM binding to rat CB1 receptors 6.9x weaker than human CB1 receptors but increased ... in human cannabinoid receptors but functions differently in rat cannabinoid receptors binding to rat cannabinoid CB2 receptors ... MDA-19 is an agonist at human CB1 and CB2 receptors as well as rat CB1 receptors but functions as an inverse agonist in rat CB2 ...

... (COR-167) is a drug which acts as a potent and selective cannabinoid CB2 receptor agonist, based on a quinolone-3- ... with 190 times selectivity for CB2 over the related CB1 receptor. It has analgesic effects in animal studies, as well as ... 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic ... and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ...

Cannabinoid stubs, JWH cannabinoids, Naphthoylindoles, CB1 receptor agonists, CB2 receptor agonists). ... It is a potent and selective ligand for the CB2 receptor, but a weaker ligand for the CB1 receptor. It has a binding affinity ... In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-120 are Schedule I Controlled ... receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists". Bioorganic ...

... was found to be a directly acting cannabinoid receptor agonist with a Ki of 17.4nM at CB1 and 211nM at CB2, and produces ... 7-OH-CBD Abnormal cannabidiol Cannabinoid receptors Cannabidiphorol Cis-THC HU-211 HUF-101 KLS-13019 O-1656 O-1871 O-1918 NESS- ... binding to cannabinoid receptor, and evaluation of their antiinflammatory activity". Journal of Medicinal Chemistry. 49 (3): ... synthesis and binding to cannabinoid receptors". Organic & Biomolecular Chemistry. 3 (6): 1116-23. doi:10.1039/B416943C. PMID ...

"Cannabinoid Receptor Modulators, Their Processes of Preparation, and use of Cannabinoid Receptor Modulators for Treating ... with a Ki of 8 nM at CB2 and 500x selectivity over the related CB1 receptor. It has antiinflammatory effects and inhibits ... September 2002). "C-3 Amido-indole cannabinoid receptor modulators". Bioorganic & Medicinal Chemistry Letters. 12 (17): 2399- ... that acts as a potent and selective agonist for the cannabinoid receptor CB2, ...

Its effects have been observed to act on the cannabinoid receptors (specifically on CB1 receptors, which are part of the ... AM cannabinoids, All stub articles, Alkene stubs, Cannabinoid stubs, Biochemistry stubs, Alcohol stubs). ...

Its binding affinity, Ki at the CB1 receptor is 42 nM, around the same as that of THC, but its analgesic potency in vivo was ... JWH-200 (WIN 55,225) is an analgesic chemical from the aminoalkylindole family that acts as a cannabinoid receptor agonist. ... "Order Amending Schedule II to the Controlled Drugs and Substances Act (Synthetic Cannabinoids)". Government of Canada. 29 July ... "Schedules of Controlled Substances: Temporary Placement of Four Synthetic Cannabinoids Into Schedule I". DEA Office of ...

JWH cannabinoids, CB1 receptor agonists, 1-Naphthyl compounds, Indoles, All stub articles, Cannabinoid stubs). ... It is several times weaker than JWH-018, having a binding affinity at the CB1 receptor of 22 nM, though some derivatives ... JWH-175 is a drug from the naphthylmethylindole family which acts as a cannabinoid receptor agonist. It was invented by the ... In the United States, all CB1 receptor agonists of the 3-(1-naphthylmethane)indole class such as JWH-175 are Schedule I ...

It is selective for CB2, with Ki values of 0.64 nM at CB2 vs 270 nM at the psychoactive CB1 receptor, but while it exhibits ... A-836,339 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist. ... January 2009). "Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl- ... Cannabinoids, Thiazoles, Carboxamides, Ethers, Cyclopropanes, All stub articles, Cannabinoid stubs). ...

Cannabimimetic Agents means, collectively, any chemical that is a cannabinoid receptor type 1 (CB1) or cannabinoid receptor ... It is a potent agonist at both the CB1 and CB2 receptors, with a binding affinity of 0.041 nM at the CB1 receptor, making it ... HU-243 (AM-4056) is a synthetic cannabinoid drug that is a single enantiomer of the hydrogenated derivative of the commonly ... or another synthetic Schedule I cannabinoids such as CP-47,497, and therefore sales or possession could potentially be ...

In 2006, it was discovered that 8,9-dihydrocannabidiol binds very weakly to the CB1 receptor with a binding affinity higher ... Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity". Journal of Medicinal Chemistry. 49 (3): ... but has potential anti-inflammatory effects independent of its cannabinoid receptor action. Hexahydrocannabinol (hydrogenated ... H2CBD (DiHydroCBD, partially hydrogenated CBD) are cannabinoids that were first synthesized by the Todd group in 1940 by ...

AM cannabinoids, Aminoalkylindoles, Nitrobenzenes, Piperidines, Designer drugs, CB1 receptor agonists, CB2 receptor agonists, ... AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28 nM at CB2 and ... In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as AM-1221 are Schedule I Controlled ... Design and synthesis of selective cannabinoid receptor ligands: Aminoalkylindole and other heterocyclic analogs (Ph.D. ...

Cannabinoids, CB1 receptor antagonists, Pfizer brands, All stub articles, Cannabinoid stubs). ... as many commonly used cannabinoid receptor antagonists also block the CB2 receptor to some extent. Dow RL, Carpino PA, Hadcock ... PF-514273 is a drug developed by Pfizer, which acts as an extremely selective antagonist for the CB1 receptor, with ... bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity". Journal of Medicinal Chemistry. 52 (9): ...

Cannabimimetic Agents means, collectively, any chemical that is a cannabinoid receptor type 1 (CB1) or cannabinoid receptor ... Cannabicyclohexanol (CCH, CP 47,497 dimethyloctyl homologue, (C8)-CP 47,497) is a cannabinoid receptor agonist drug, developed ... by analogy with other related cannabinoid compounds can be expected to have widely varying affinity for cannabinoid receptors, ... cannabicyclohexanol Synthetic cannabinoids (C6)-CP 47,497 (C7)-CP 47,497 also known as CP 47,497 (C9)-CP 47,497 JWH-138 O-1871 ...

2009). "Cannabinoid Receptor Ligands and Structure-Activity Relationships.". The Cannabinoid Receptors. Part I. Humana Press. ... with a Ki of 0.6 nM at CB1, and very potent cannabinoid effects in animal studies. AM-2232 O-1057 O-1812 Singer M, Ryan WJ, ... O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, ...

... is a potent agonist at both CB1 and CB2 receptors with a Ki of 0.32nM at CB1 and 0.52nM at CB2, and its particularly high ... "Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'". Journal of ... AMG-3 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC ... Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A (March 1998). "Pharmacophoric requirements for cannabinoid ...

However while it was found to have good selectivity over the related CB1 and CB2 cannabinoid receptors as well as a number of ... CID16020046 is a compound which acts as an inverse agonist at the former orphan receptor GPR55, and may be the first selective ... It has antiinflammatory actions, has been used to study the interaction between GPR55 mediated and CB1 mediated activity, and ... April 2020). "2 versus GPR55 receptors". British Journal of Pharmacology. 177 (8): 1865-1880. doi:10.1111/bph.14958. PMC ...

... is a drug that acts as a reasonably selective agonist of the peripheral cannabinoid receptor CB2, with sub-nanomolar affinity ... and 490x selectivity over the related CB1 receptor. In animal studies it has both analgesic and anti-allodynia effects. The 9- ... "Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the ... AM cannabinoids, Benzochromenes, Coumarins, All stub articles, Cannabinoid stubs). ...

CB1 receptor agonists, CB2 receptor agonists, Designer drugs, Naphthoylpyrroles, All stub articles, Cannabinoid stubs). ... receptors, binding ~1.76 times stronger to the CB2 receptor than to the CB1 receptor. JWH-368 was first synthesized in 2006 by ... new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters. 16 (20): 5432-5 ... List of JWH cannabinoids Synthetic cannabinoid Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR (October 2006). "1- ...

... is an indazole-based synthetic cannabinoid that is a potent agonist of the CB1 receptor and has been sold online as a designer ... Cannabinoids, Designer drugs, Indazolecarboxamides, All stub articles, Cannabinoid stubs). ... September 2016). "Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, ... "Fragmentation of synthetic cannabinoids with an isopropyl group or a tert-butyl group ionized by electron impact and ...

... a binding affinity of 145nM at the CB1 receptor and potential anti-inflammatory effects independent of its cannabinoid receptor ... In contrast, CBD has been found to bind to the CB1 receptor as an inverse agonist/antagonist with a Ki ranging from 3.3 to 4.8 ... Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity". Journal of Medicinal Chemistry. 49 (3): ... H4CBD (Hydrogenated CBD, Tetrahydrocannibidiol), is a cannabinoid that was first synthesized by the Todd group in 1940 derived ...

... with a Ki of 8.5nM at the CB1 cannabinoid receptor. The Δ3/Δ6a(10a) isomer was synthesised in 1941, but was found to be ... JWH-138 (THC-Octyl, Δ8-THC-C8) is a synthetic cannabinoid first synthesised by John W. Huffman, ... WO application 2020232545, Abdur-Rashid, Kamaluddin; Jia, Wenli & Abdur-Rashid, Kareem, "Catalytic cannabinoid processes and ... "intoxicating cannabinoid" in Colorado under the name tetrahydrocannabioctyl, but it is unclear if it has been identified as a ...

... is a drug that acts as a potent agonist for the cannabinoid receptors, with EC50 values of 2.6 nM at CB1 and 3.0 nM ... Cannabinoids, Designer drugs, Fluoroarenes, Indolecarboxamides, All stub articles, Cannabinoid stubs). ... September 2015). "Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA ...

... and the cannabinoid CB1 receptor are regulated in the fish brain after a nociceptive event. Somatosensory evoked potentials ( ... Fifty-eight receptors were located on the face and head of the rainbow trout. Twenty-two of these receptors could be classified ... These fulfilled criteria include a suitable nervous system and sensory receptors, opioid receptors and reduced responses to ... Has a suitable nervous system and sensory receptors Has opioid receptors and shows reduced responses to noxious stimuli when ...

... is a drug that acts as a potent agonist for the cannabinoid receptors, with EC50 values of 21 nM at CB1 and 15 nM at ... Cannabinoids, Designer drugs, Fluoroarenes, Indolecarboxamides, All stub articles, Cannabinoid stubs). ... September 2015). "Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA ...

... the cannabinoids bind to these receptors in the same way. Previous studies have shown that CB1 receptors located on the nerve ... CB1 cannabinoid receptors - which are known to be present in the brain - exist in the endothelial cells which line the gut, it ... "Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing". ... CB2, another cannabinoid receptor predominantly expressed by immune cells, was detected in the gut of people with IBD at a ...

These distinct effects are mediated primarily by CB1 cannabinoid receptors in the central nervous system, and CB2 cannabinoid ... CB1 receptor agonists, CB2 receptor agonists, Glycine receptor agonists, Glycine receptor antagonists, Euphoriants, Arachidonyl ... although no CB receptors have been found in any insects. Both the CB1 and CB2 receptors (the bonding site of anandamide) seem ... the complex is further directed to the cannabinoid receptor (CB1) and out. Black pepper contains the alkaloid guineesine, which ...

It is thought to act as a CB1 agonist, in a similar manner to other cannabinoid derivatives. While DMHP itself has been subject ... to relatively little study since the characterization of the cannabinoid receptors, the structural isomer 1,2-dimethylheptyl-Δ8 ... The original cannabinoid distillate (the precursor to EA 2233, called EA-1476 or "Red oil"), known today as THC Delta-9, was ... Since the 1930s, cannabis and cannabinoids had consistently been seen by the public as dangerous and addictive drugs. DMHP was ...

Through testing in mouse models, it has been shown that activation of the CB-1 receptor helps reduce reactions associated with ... Reduction of Bone Cancer Pain by Activation of Spinal Cannabinoid Receptor 1 and Its Expression in the Superficial Dorsal Horn ... Thus, a new target for potential treatments is activation of the CB-1 receptor. Modern research and techniques are attempting ... Treatments focusing on biological components such as cannabinoid receptors are being tested for effectiveness. ...

Another cannabinoid called cannabigerol acts as an antagonist at cannabinoid (CB1) and serotonin (5HT1A) receptors, ... dose-dependent buildup of cannabinoids and related effects of cannabinoid toxicity the functionality of cannabinoid receptors ... Cannabinoid hyperemesis was first reported in the Adelaide Hills of South Australia in 2004. The name "cannabinoid hyperemesis ... A urine drug screen can be useful for objectively determining the presence of cannabinoids in a person's system. Cannabinoid ...

... (also known as APP-CHMINACA) is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a ... Cannabinoids, Designer drugs, Indazolecarboxamides, All stub articles, Cannabinoid stubs). ... Presley BC, Logan BK, Jansen-Varnum SA (April 2020). "In Vitro Metabolic Profile Elucidation of Synthetic Cannabinoid APP- ...

"Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'". Journal of ... AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6 nM at CB1 vs 3.1 nM at CB2. O ... AMG-1 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC ... relationship of side-chain conformation to cannabinoid receptor affinity and pharmacological potency". Journal of Medicinal ...

It is a potent agonist of the CB1 receptor with a binding affinity of Ki = 0.289 nM and was originally developed by Pfizer in ... It was identified in cannabinoid blends in Japan in early 2015. There have been a number of reported cases of deaths and ... "Synthetic cannabinoid users can exhibit bizarre and violent behaviors, hospitalizations after use increase in Alabama over past ... Trecki J, Gerona RR, Schwartz MD (July 2015). "Synthetic Cannabinoid-Related Illnesses and Deaths". The New England Journal of ...

"Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'". Journal of ... AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.45 nM at CB1 vs 1.92 nM at CB2 ... AMG-36 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC ... Cannabinoids, Benzochromenes, Phenols, Cyclopentanes, All stub articles, Cannabinoid stubs). ...

... is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been ... Cannabinoids, Designer drugs, Organofluorides, Indazoles, Cyclopropanes, All stub articles, Cannabinoid stubs). ...

JWH cannabinoids, CB1 receptor agonists, All stub articles, Cannabinoid stubs). ... and more than 22 times selectivity over the CB1. In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole ... "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol ... JWH-048 is a selective cannabinoid ligand, with a bindining affinity of Ki = 0.5 ± 0.1 nM for the CB2 subtype, ...

... (CRA13, SAB-378) is a cannabinoid drug, which acts as a potent agonist at both the CB1 and CB2 receptors, but has poor ... Gardin A, Kucher K, Kiese B, Appel-Dingemanse S (April 2009). "Cannabinoid receptor agonist 13, a novel cannabinoid agonist: ... a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on ... August 2007). "Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist ...

... is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been ... Cannabinoids, Designer drugs, Indolecarboxamides, Fluoroarenes, All stub articles, Cannabinoid stubs). ... "Going deeper into the toxicokinetics of synthetic cannabinoids: in vitro contribution of human carboxylesterases". Archives of ...

JWH cannabinoids, Designer drugs, CB1 receptor agonists, CB2 receptor agonists). ... Its affinity for CB2 receptors is 13.8 nM, while its affinity for CB1 is 383 nM, meaning that it binds almost 28 times more ... In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-015 are Schedule I Controlled ... Ghosh S, Preet A, Groopman JE, Ganju RK (July 2006). "Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis ...

... which acts as a potent and selective cannabinoid CB2 receptor agonist, with 1400x selectivity for CB2 over the related CB1 ... February 2008). "Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action". ... November 2007). "N-Alkylidenearylcarboxamides as new potent and selective CB(2) cannabinoid receptor agonists with good oral ... receptor. Unlike most cannabinoid agonists, CBS-0550 has good solubility in water, and in animal studies it was found to ...

Like Δ9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB1 with significantly higher binding affinity (Ki ... "Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis ... which is inactive at the CB1 receptors; and further glucuronidated to form 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid ... Emax = 70%). In an analysis by the University of Rhode Island on cannabinoids it was found that 11-OH-Δ9-THC had the 3rd ...

... acting as a potent agonist at the CB1 receptor and a partial agonist at CB2. It has poor blood-brain barrier penetration, and ... "A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of ... Cannabinoids, Benzimidazoles, Peripherally selective drugs, All stub articles, Cannabinoid stubs). ... AZ-11713908 is a drug developed by AstraZeneca which is a peripherally selective cannabinoid agonist, ...

Testing established that serinolamide A is an active cannabinoid agonist with moderate potency, having a Ki of 1300 nM at CB1 ... and five fold selectivity over the related CB2 receptor. Methanandamide O-1812 Perrottetinene Gutiérrez M, Pereira AR, Debonsi ... Cannabinoids, Fatty acid amides, All stub articles, Alkene stubs, Cannabinoid stubs). ...

... is a coumarin derivative which is an agonist at the cannabinoid receptors CB1 and CB2, with a CB1 Ki of 32nM and a ... a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists". Journal of ... It is also a weak antagonist at the related receptor GPR55, with an IC50 of 6350nM, but has no significant affinity for GPR18. ... Rempel V, Volz N, Gläser F, Nieger M, Bräse S, Müller CE (June 2013). "Antagonists for the orphan G-protein-coupled receptor ...

Contrary to the previous statement, activation of the CB1 receptor by cannabinoids causes an inhibition of GABA, the exact ... The third receptor is the δ-opioid receptor (DOR). The delta receptor is the least studied out of the 3 main opioid receptors. ... The μ-opioid receptor is a G-protein coupled receptor. When the μ-opioid receptor is activated, it causes pain relief, euphoria ... In low doses, GHB mainly binds to the GHB receptor and weakly binds to the GABAB receptor. The GHB receptor is an excitatory G ...

... (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. The human ... Discovery and development of Cannabinoid Receptor 1 Antagonists Cannabinoid receptor Cannabinoid receptor type 2 (CB2) GRCh38: ... Selective CB1 agonists may be used to isolate the effects of the receptor from the CB1 receptor, as most cannabinoids and ... CB1-D2, OX1-CB1, μOR-CB1, while many more may only be stable enough to exist in vivo. The CB1 receptor possesses an allosteric ...

... is a potent selective CB2 receptor agonist with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors. It was ... Additionally, cannabinoids at this receptor completely abolish neurotoxicity related to microglia activation in rat models.[ ... Bow EW, Rimoldi JM (28 June 2016). "The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation". ... binding 677nM at Cb1 and 3.4nM at CB2 while 3-(1',1'-Dimethylbutyl)-delta-8-THC itself binds 65nM at CB1. Structurally the only ...

... produces effects typical of other cannabinoid receptor agonists in animals. It has a somewhat higher oral ... Bow EW, Rimoldi JM (2016). "The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation". Perspectives ... the Δ8 and Δ9 isomers are both known to be cannabinoid receptor agonists, and Δ8-parahexyl has the code number JWH-124, while ... but as there has been no research published using parahexyl since the discovery of the CB1 receptor, this has not been ...

... is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 26.0 nM ... JWH cannabinoids, 1-Naphthyl compounds, Indenes, Polycyclic aromatic hydrocarbons, CB1 receptor agonists). ... In the United States, CB1 receptor agonists of the 1-(1-naphthylmethylene)indene class such as JWH-176 and JWH-171 are Schedule ... Cannabinoids. Handbook of Experimental Pharmacology. Vol. 168. Springer. p. 269. ISBN 3-540-22565-X. Huffman JW, Padgett LW (10 ...

It is described as a mixed agonist/antagonist at the cannabinoid receptor CB1, meaning that it acts as an antagonist when co- ... Griffin G, Wray EJ, Martin BR, Abood ME (October 1999). "Cannabinoid agonists and antagonists discriminated by receptor binding ... April 1999). "An investigation into the structural determinants of cannabinoid receptor ligand efficacy". British Journal of ... Cannabinoids, Benzochromenes, Phenols, Alkyne derivatives, Nitriles, All stub articles, Cannabinoid stubs). ...